TW526206B - Reshaped human antibody to human medulloblastoma cells - Google Patents
Reshaped human antibody to human medulloblastoma cells Download PDFInfo
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- TW526206B TW526206B TW083110754A TW83110754A TW526206B TW 526206 B TW526206 B TW 526206B TW 083110754 A TW083110754 A TW 083110754A TW 83110754 A TW83110754 A TW 83110754A TW 526206 B TW526206 B TW 526206B
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- 208000000172 Medulloblastoma Diseases 0.000 title abstract 5
- 150000001413 amino acids Chemical group 0.000 claims description 125
- 238000011049 filling Methods 0.000 claims description 71
- 210000002706 plastid Anatomy 0.000 claims description 69
- 210000001185 bone marrow Anatomy 0.000 claims description 55
- 201000000053 blastoma Diseases 0.000 claims description 49
- 201000008184 embryoma Diseases 0.000 claims description 49
- 238000000034 method Methods 0.000 claims description 41
- 108010089804 glycyl-threonine Proteins 0.000 claims description 36
- 239000013604 expression vector Substances 0.000 claims description 34
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- DHBKYZYFEXXUAK-ONGXEEELSA-N Ala-Phe-Gly Chemical compound OC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)C)CC1=CC=CC=C1 DHBKYZYFEXXUAK-ONGXEEELSA-N 0.000 claims description 19
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- SOEGEPHNZOISMT-BYPYZUCNSA-N Gly-Ser-Gly Chemical compound NCC(=O)N[C@@H](CO)C(=O)NCC(O)=O SOEGEPHNZOISMT-BYPYZUCNSA-N 0.000 claims description 19
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- 108010063718 gamma-glutamylaspartic acid Proteins 0.000 claims description 4
- XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Chemical compound NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 claims description 4
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29107893 | 1993-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW526206B true TW526206B (en) | 2003-04-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW083110754A TW526206B (en) | 1993-11-19 | 1994-11-18 | Reshaped human antibody to human medulloblastoma cells |
Country Status (5)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998009651A1 (fr) * | 1996-09-03 | 1998-03-12 | Chugai Seiyaku Kabushiki Kaisha | COMPLEXES D'ANTICORPS ANTI-INTEGRINE α3 |
| CN1314803C (zh) * | 2001-06-22 | 2007-05-09 | 中外制药株式会社 | 含有抗磷脂酰肌醇蛋白聚糖3抗体的细胞生长抑制剂 |
| ATE543509T1 (de) * | 2001-08-13 | 2012-02-15 | Univ Florida | Material und verfahren zur förderung der reparatur von nervengewebe |
| EP2808032B1 (en) * | 2005-12-12 | 2018-08-01 | AC Immune S.A. | A beta 1-42 specific monoclonal antibodies with therapeutic properties |
| CL2007002070A1 (es) | 2006-07-14 | 2008-02-08 | Ac Immune S A Genentech Inc | Anticuerpo quimerico o humanizado, o fragmentos de ellos, que se adhieren especificamente a por lo menos un epitopo en la proteina beta-amiloide; molecula de acido nucleico que lo codifica; composicion que lo comprende; su uso para tratar enfermedade |
| US8048420B2 (en) * | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| RU2567151C2 (ru) * | 2007-06-12 | 2015-11-10 | Ац Иммуне С.А. | Гуманизированные антитела к амилоиду бета |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| ES2612788T3 (es) * | 2007-10-05 | 2017-05-18 | Genentech, Inc. | Métodos y composiciones para el diagnóstico y tratamiento de la amiloidosis |
| SG10201505369QA (en) | 2007-10-05 | 2015-08-28 | Genentech Inc | Use of anti-amyloid beta antibody in ocular diseases |
| BRPI0818623A2 (pt) * | 2007-10-05 | 2017-05-23 | Ac Immune Sa | composição farmacêutica, e, métodos para reduzir a carga da placa na camada de célula de gânglio retinal de um animal, para reduzir a quantidade de placas na camada de célula de gânglio retinal de um animal, para diminuir a quantidade total de amilóide-beta solúvel na camada de célula de gânglio retinal de um animal, para prevenir, tratar e/ou aliviar os efeitos de uma doença ocular associada com anormalidades patológicas/mudanças no tecido do sistema visual, para monitorar doença ocular residual mínima associada com anormalidades patológicas/mudanças nos tecidos do sistema visual, para predizer responsividade de um paciente, e para reter ou diminuir a pressão ocular nos olhos de um animal |
| CA2711863C (en) | 2008-01-10 | 2014-06-10 | Shionogi & Co., Ltd. | Antibody directed against pcrv |
| MY164579A (en) | 2010-07-30 | 2018-01-15 | Ac Immune Sa | Safe and functional humanized antibodies |
| MX2016009690A (es) | 2014-02-03 | 2017-03-03 | Nat Cancer Ct | Anticuerpos monoclonal anti-factor de tejido. |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| WO2019230856A1 (ja) | 2018-05-31 | 2019-12-05 | 塩野義製薬株式会社 | Ｎａｖ１．７モノクローナル抗体 |
| BR112021011431A2 (pt) | 2018-12-27 | 2021-11-23 | Univ Osaka | Anticorpo monoclonal ou um fragmento de anticorpo do mesmo que se liga ao ccr8, seu uso, bem como composição farmacêutica, polinucleotídeo, vetor de expressão e kit |
| US20230256092A1 (en) | 2020-06-30 | 2023-08-17 | Shionogi & Co., Ltd. | Combined use of anti-ccr8 antibody and chemotherapeutic agent |
| AU2022377536B2 (en) | 2021-11-01 | 2024-10-24 | Shionogi & Co., Ltd. | NOVEL Nav1.7 MONOCLONAL ANTIBODY |
| CN119384505A (zh) | 2022-06-03 | 2025-01-28 | 盐野义制药株式会社 | 与大麻素1型受体结合的抗体 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| US5132405A (en) * | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| HU218140B (hu) * | 1991-04-25 | 2000-06-28 | Chugai Seiyaku Kabushiki Kaisha | Humán interleukin-6-receptorral szembeni átalakított humán antitest |
| CA2078539C (en) * | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
| DE4225853A1 (de) * | 1992-08-05 | 1994-02-10 | Behringwerke Ag | Granulozytenbindende Antikörperfragmente, ihre Herstellung und Verwendung |
-
1994
- 1994-10-19 EP EP94930341A patent/EP0729976A1/en not_active Withdrawn
- 1994-10-19 US US08/646,265 patent/US6214973B1/en not_active Expired - Lifetime
- 1994-10-19 AU AU79493/94A patent/AU7949394A/en not_active Abandoned
- 1994-10-19 WO PCT/JP1994/001763 patent/WO1995014041A1/ja not_active Application Discontinuation
- 1994-11-18 TW TW083110754A patent/TW526206B/zh active
-
2000
- 2000-12-29 US US09/749,873 patent/US20030023045A1/en not_active Abandoned
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2004
- 2004-05-06 US US10/839,799 patent/US7563599B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20030023045A1 (en) | 2003-01-30 |
| AU7949394A (en) | 1995-06-06 |
| EP0729976A4 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1996-10-16 |
| US20050249726A1 (en) | 2005-11-10 |
| US7563599B2 (en) | 2009-07-21 |
| US6214973B1 (en) | 2001-04-10 |
| EP0729976A1 (en) | 1996-09-04 |
| WO1995014041A1 (fr) | 1995-05-26 |
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