TW490308B - Inhaler and actuator for the inhaler - Google Patents

Inhaler and actuator for the inhaler Download PDF

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Publication number
TW490308B
TW490308B TW087119013A TW87119013A TW490308B TW 490308 B TW490308 B TW 490308B TW 087119013 A TW087119013 A TW 087119013A TW 87119013 A TW87119013 A TW 87119013A TW 490308 B TW490308 B TW 490308B
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scope
actuator
patent application
item
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TW087119013A
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Darren Hodson
Jorgen Rasmussen
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Astra Pharma Prod
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/0021Mouthpieces therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/0021Mouthpieces therefor
    • A61M15/0025Mouthpieces therefor with caps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • A61M15/0068Indicating or counting the number of dispensed doses or of remaining doses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/009Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0091Inhalators mechanically breath-triggered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/27General characteristics of the apparatus preventing use
    • A61M2205/273General characteristics of the apparatus preventing use preventing reuse, e.g. of disposables
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/59Aesthetic features, e.g. distraction means to prevent fears of child patients

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Nozzles (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

五、發明說明(1) 以 本發明係關於用吸入法供給藥物 及關於包括弓丨動器之吸入器。 及入益之引動器 在相當長時間内,人們已知道引 霧器之容器輪送已計量之藥物 ;::於從按鈕式喷 只具-容器之引動器之後,引動之㈣。在使用 此,乃因為某些輸送之藥物經過 二二:以必需如 動器之噴口塊和吸嘴内。 奴4間之後會沉積在引 本發明之目的係設置兩部份構造之 構造係用具有不同成份之材 :二而且兩部份 不使其破壞,*者就不可分離。此兩做成:如果 用引動器,從而保證在使用具單 防止重複使 動器必須丢掉,並且還可以製造—系;;=器之後、:引 為:將第-部份設置為系列之通用件,而將f方沄 有不同成份之材料做出I具有選將:q份周具 所輸送之藥物,第二部份可以染色或I姓二般為,根據 或裝飾。此外,第二部份可以做成具;表:加工 理r 5Γ文件包括第一部份之通: = 於製定管 us-Α- 5 5 2 0 1 6 6揭示了用於按鈕式噴霧器矣壯史 E包括作為獨立部份之吸嘴和殼體,吸嘴二二一,二 接,但是在指定設置在另一裝置内時,,八又:上每連 將匣之兩部份用具有不同成份之材料做出亚不求和建礒 因此,本發明設置一引動器,係用於用吸入法輸送藥物
1111· C:\Program F iles\Patent\55820. ptd
第5頁 __p_:111 ^U8 五、發明說明^ Λ / 时,匕括:主體,係包括管狀元件 — w S有樂物,並且具有從其伸展之n t :’作為與主體分別做出之一部份 ’及出口總 物引向使用者之嘴,及-噴口塊以用;:;:!…將藥 卫將藥物輸送入吸嘴;其中,至少主秘^納谷态之閥桿, j少-部份係做成:在將出口總成從::=口總成之-之 展:以便防止重複使用引動器;其特c或破 成:用具有不同成份之材料組成。·’、、.主脰和出口總 較佳為,在管狀元件之一 管狀元件之長度方向呈孔,用於在橫截於 較佳為,在管狀元件之出;總成。 孔而裝配。 在使用時容器通過 較佳為,主體還包括在管狀 :成:在容器裝在管狀元件内時件之㈣,底腳係 立,而管狀元件通常垂直地伸展。便弓|動器能無支撐地豎 在一具體實施例中,底腳之底 於容納使用者之姆指或手 m ^面包括一凹進部份,用 在另一呈M奋浐彳丨由 9 進部份較佳為凹形。 較^1二!:t ’底腳之底表面係平直。 ί ’引動裔遇包括呼吸操作機構。 。。較佳為’引動器還包括—致 态。 、j °° 尤其樂物計量 在較佳具體貫施例中,主轉、 測器之一,或二者皆備。 呼吸麵作機或一致性監 在尤為較佳具體實施例中,麻 底一腳包括呼吸操作機構和一
C:\Program Files\Patent\55820. ptd 第6頁 490308 五、發明說明(3) 致性監測器之一,或二者皆 較佳為,出口總成係做成 車父佳為,噴口包括孔,而 以及做成將噴霧引入吸嘴之 較佳為’出口總成係做成 壞。 在較佳具體實施例中,在 成:在出口總成從主體分離 在尤為較佳具體實施例中 至少包括一元件,係將吸嘴 而且至少一連接吸嘴之下部 成:在出口總成從主體分離 較佳為,主體和出口總成 在一具體實施例中,主體 料組成。 在另一具體實施例中,主 材料組成,但包括不同之諸 在尤為較佳具體實施例中 顏色。 本發明也引伸及包括上述 入器。 較佳為吸入器係加壓式計 本發明之較佳具體實施例 文中描述,其中: 備。 單個整體模製件。 孔具有容納容器之閥桿之孔, 噴霧孔。 :在從主體分離時就變形或破 吸嘴與喷口塊之間之連接係做 時至少部份地破壞。 ’在吸嘴與噴口塊之間之連接 之下部與噴口塊之上部連接, 與噴口塊之下部之元件係做 時就破壞。 係做成能快速地裝配在一起。 和出口總成係用完全不同之材 體和出口總成係用相同之基體 如色彩顏料之添加物。 版 ,主體和出口總成係有不同之 弓丨動器和含有藥物之容器之吸 量藥物吸入器。 以只參考所附圖式之方式在下
490308 _案號87119013_年月ί曰 修正 _ 五、發明說明(4) \ 圖1表示根據本發明較佳具體實施:¾,之吸入器之透視 圖, 圖2表不圖1吸入之側視圖; 圖3表示圖1吸入器之正視圖; 圖4表示圖1吸入器之後視圖; 圖5表示圖1吸入器之俯視圖; 圖6表示圖1吸入器之底視圖; 圖7表示圖1吸入器之沿A — A斷面之水平斷面圖; 圖8表示圖7所示斷面之局部放大視圖; 圖9表示圖1吸入器之沿B —B斷面之垂直斷面圖; 圖10表示圖9所示斷面之局部放大視圖; 圖1 1表示圖1吸入器之引動器之出口總成之透視圖; 圖12表不圖11出口總成之俯視圖, 圖1 3表示圖1 1出口總成之底視圖; 圖1 4表示圖1 1出口總成之側視圖; 圖1 5表示圖1 1出口總成之後視圖; 圖1 6表示圖1 1出口總成之正視圖。 元件符號說明 2 主體 4 出口總成 6 蓋帽 7 喷霧器容器 8 管狀元件 10 11 閥桿 12 底腳 12a 凹進部份 14 側向孔 16 相對之凸台 18 管狀段 20 喷口塊 22 圓周形凸緣
O:\55\55820.ptc 第8頁 1999. 10.04.008 490308 _案號87119013_年;月、、 日 ’」修正 五、發明說明(5) 24 第 一 臂 26 第二 臂 28、 30 掣 子 元 件 28a 、30a 第- -表面 28b 、30b 第 二 表面 34 第三 臂 35 掣 子 元 件 35a 第- -表面 36 > 38 連 接 元 件 40 管狀 子L 42 喷 霧 孔 44 第四 臂 46 掣 子 元 件 44a 表面 吸入 器 包 括 引 動 器,引 動器包括主 體2, 裝配在主體2下 部之出口總成4和蓋帽6,以及裝配在主體2内之含有藥物 之按鈕式喷霧器容器7。 主體2包括管狀元件8,管狀元件8之上端具有孔1 0,容 器7具有從其伸展之閥桿11,容器7裝入孔1 0而使用;以及 底腳1 2,係具有包括凹進部份1 2 a之底表面,在此具體實 施例中,凹進部份係凹形,專用於容納使用者之姆指。在
O:\55\55820.ptc 第8a頁 1999. 10.04.009 五、發明說明(5) 另-具體實施例中,底腳12可做出大體平直之底表面 用於使引動器能無支撐地豎立在平直表面i,以便在 引動,不使用時’能以豎立狀態而存放。這在容器7裝 引動器2時特別有利,因為存放容器7時最好使閥桿J朝 向下。管狀元件8之另一端即下端係封閉,並且包括側向 孔1 4,在此具體實施例中側向孔丨4係卵形,出口總成4係 裝在側向孔1 4内。 ’' 主,2還包括一對相對之凸台丨6,凸台丨6從鄰近側向孔 1 4之官狀元件8之内表面向内伸展。凸台丨6係配置在側向 孑L1 4之側面,並且由此而向後作間隔配置。 出口總成4包括管狀段1 8,管狀段1 8之主要部份界定吸 嘴’在使用時使用者之嘴唇咬牢吸嘴,而喷口塊2 〇與管狀 段1 8連接。 管狀段18包括在徑向向外之圓周形凸緣22。當出口總成 4全部裝入主體2内時,凸緣22緊貼側向孔1 4,以便使管狀 段18之主要部份向主體2外面伸展。 出口總成4還包括第一臂24和第二臂26,係從管狀段18 之相應側向後伸展。第一臂24和第二臂26各包括掣子元件 2 8和3 0,當出口總成4全部插入主體2時,掣子元件2 8和3 0 係用予與管狀元件8之内表面上之凸台16嚙合。第一臂24 和第二臂26之掣子元件28和30各包括第一表面28a和30a, 第一表面28a和30a具有朝向後面之部份起導向表面作用, 第二表面2 8 b和3 0 b係大體與出口總成4之縱向轴線垂直’ 起鎖緊表面作用。
C:\Program Files\Patent\55820. ptd 第9頁 490308 五、發明說明(6) 出口總成4還包括第三臂34,係從管狀段18之頂部向後 伸展。第二臂34包括向外凸台形式之掣子元件μ,當出口 ,成全部插入主體2時,掣子元件35在界定側向孔14之一 邛伤官狀元件8之後面嚙合。如同第一臂24和第二臂26之 掣子兀件28和30 —樣,第三臂34之掣子元件35包括第一表 面35a,第一表面35a具有朝向後面之部份起導向表面作 用,而第二表面35b係大體與出口總成4之縱向軸線垂直, 起鎖緊表面作用。 第二和第二對連接元件36和38將喷口塊2〇與管狀段18連 接第對連接元件36伸展於喷口塊2〇之下部鱼管狀段18 之:部之間。如下文所述,在此具體實施例中Ϊ下部連接 ::36ί糸做f :在出口總成4從主體2拉出時就破壞或永久 ^ ^弟一對运接兀件38伸展於噴口塊20之上部與管狀段 之上部之間。噴口塊20包括管狀孔40,當出口她成4全 :::入主體2時,管狀孔40沿管狀元件8之縱向轴=王。 二狀孔40之上端係開口,而在其下端則包: 42。謂孔42係做成將噴霧引入管狀段18。在此 例中,管狀孔40係用於容納容器7之閥桿丨丨。八版貝鈀 出口總成4還包括第四臂44,係從噴口塊2 :伸展。第四臂之遠端包括擎子元件46,當出二方= 广插入主體2時,掣子元件46在界定側向孔14之_;二=^ 狀兀件8之後面嚙合。第四臂44擎 邛伤官 …,包括表面46a係大體與出彳成子 起鎖緊表面作用。 竿由、來垂直,
在製造中,出u她a、」 耷,帘壯笠々 心 和主體2係根據基於引動器之顏 ^ M ^ j, 1Λ / 進仃選擇。出口總成4全部插入主up 之側向孔1 4,直到屮σ^ β -,. ,π農到出口總成4弟一和第二臂24和26之掣子 兀件28和30,|伞㈣卞 t 6喻合’而出口總成4之第三*第四臂34和44之掣子心元凸 件35和46,、在界定側向孔14之管狀元件8之相應部份之後 面嚙口然後,容器7通過上部孔1〇而進入主體2之管 件8曰以便奋器7之閥桿丨丨固定在喷口塊2 〇之管狀孔μ内。 於是吸入器備就待用。 由於設置掣子元件,出口總成係固定在主體2内,而且 出口總成4不可能無損傷地從主體2拆離。如上所述,出口 總成係做成··如果從主體2拉出就破壞或永久變形,從而 使出口總成4和引動器不能使用。在此具體實施例中,其 貫現方法係將連接管狀段1 8和出口總成4之下部連接元件 36做成:在將出口總成4從主體2拉出時,連接元件36就破 壞或永久變形。 最後,熟知此項技藝之人士會理解:本發明係不只限於 所述之具體實施例,而是可在所附申請專利範圍之範圍内 以許多方式予以改進。
C:\ProgramFiles\Patent\55820.ptd 第 11 頁

Claims (1)

  1. 490308 六、申請專利範圍 包1括了?引動器,係,於一用吸入法輪送藥物之吸入器, 哭⑺〜主趙⑴’係包括—管狀元件(8)以用於容納-容 (。“)'·/器⑺含有藥物,並且具有-從其伸展之闕桿 份,包括Λ 口總成⑷,作為與主體(2)分別做出之-部 噴口U 用於將藥物引向—使用者之嘴,及- 哭⑺t〇) ’係用於容器7之闕桿⑴),並且將藥物從容 口口、( W迗入吸嘴; 成:ί:φ至t主體⑺和出口總成⑷之-之-部份係做 便防止曹、t 口 L成(4)從主體(2)分離時就變形或破壞,以 1吏卩万止重複使用引動器; 之材為:主體⑺和出口總成(4)係用具有不同成份 (i·之根m專利範圍第1項之引動器,其中,管狀元件 ϋ &側肖孔(14),用於在橫截於管狀元件⑻之 長又方向壬一角度地容納出口總成(4)。 肤3开申請專利範圍第1項或第2項之引動器,1中,管 =裝之配一端包括-孔⑽’在使 4.根據申請專利範圍第i項之引動器,其 叫g狀兀件(8 )通常垂直地伸展。 5 ·根據申請專利範圍第4項之引動器,其中, 之底表面包括一凹進部份(12a),—用於容納—使用者之一一 C:\Program Files\Patent\55820. ptd 第 12 頁 六、申請專利範圍 姆指或手指。 其中,凹進部份 其中,底腳(12) 還包相Γ f υ π 一呼吸操 (上,:::專利範圍第5項之引動器 利範圍第4項之引動器 作8機ξ據申請專利範圍第1項之引動器· j $據申請專利範圍第)項至第δ 遇匕括一一致性監測、Μ,項之引動器 1η扭秘+ 尤其一樂物計量哭0 1〇·根據申請專利範圍第 。。 主體(2)包括啤明扒从仏 項4弟9項之引動器,1中, 皆備。呼及#作機構和-致性監測器之-,;:者 u.根據申請專利範圍第4 器,其中,底腳ri w β<任一項之引動 一,或二者皆備。 双性監測器: 12」根據申請專利範圍第丨項之引動器,其 (4)係做成一單個整體模製件。 口總 1 3 ·根據申請專利範圍第1項之引動器,苴 a (20)包括一孔(40),孔(4〇)具有一孔用容納—容二口塊 閥桿⑴),及一喷霧孔(42),#做成將嘴霧引入二嘴。之 14 ·根據申請專利範圍第1項之引動器,其中,出口销 (4)係做成:在從主體(2 )分離時就變形或破壞。 、〜戌 1 5 ·根據申請專利範圍第丨4項之引動器,其中,在吸嘴 與噴口塊(20)之間之連接係做成」在出口總成(4)從主體 C:\Program Files\Patent\55820. ptd 第13頁 490308 六、申請專利範圍 (2 )分離時至少部份地破壞。 1 6 ·根據申請專利範圍第1 5項之引動器,其中,在吸嘴 與喷口塊(20)之間之連接至少包括一元件(36),係將一吸 嘴之下部與一喷口塊(2 0 )之下部連接;及至少一元件 (3 8 ),係將一吸嘴之上部與一喷口塊(2 Q )之上部連接;而 且至少一連接吸嘴之下部與一噴口塊(2 0 )之下部之元件 (36)係做成:在出口總成(4)從主體(2)分離時就破壞。 17.根據申請專利範圍第1項之引動器,其中,主體(2) 和出口總成(4)係做成能快速地裝配在一起。 1 8.根據申請專利範圍第1項之引動器,其中,主體(2 ) 和出口總成(4)係具有不同之顏色。. 1 9. 一吸入器,包括根據申請專利範圍第1項之引動器及 一含有藥物之容器(7)。 2 0.根據申請專利範圍第1 9項之吸入器,其中,吸入器 係一加壓式計量藥物吸入器。
    C:\Program Files\Patent\55820.ptd 第14頁
TW087119013A 1997-11-14 1998-11-17 Inhaler and actuator for the inhaler TW490308B (en)

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