US20130133643A1 - Inhalation Device - Google Patents
Inhalation Device Download PDFInfo
- Publication number
- US20130133643A1 US20130133643A1 US13/678,893 US201213678893A US2013133643A1 US 20130133643 A1 US20130133643 A1 US 20130133643A1 US 201213678893 A US201213678893 A US 201213678893A US 2013133643 A1 US2013133643 A1 US 2013133643A1
- Authority
- US
- United States
- Prior art keywords
- actuator
- outlet assembly
- main body
- canister
- foot
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003814 drug Substances 0.000 claims abstract description 25
- 238000003780 insertion Methods 0.000 claims description 3
- 230000037431 insertion Effects 0.000 claims description 3
- 239000000463 material Substances 0.000 description 7
- 239000007921 spray Substances 0.000 description 5
- 230000000295 complement effect Effects 0.000 description 4
- 239000000443 aerosol Substances 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 238000010276 construction Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000005034 decoration Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229940071648 metered dose inhaler Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
- A61M15/0025—Mouthpieces therefor with caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/27—General characteristics of the apparatus preventing use
- A61M2205/273—General characteristics of the apparatus preventing use preventing reuse, e.g. of disposables
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/59—Aesthetic features, e.g. distraction means to prevent fears of child patients
Definitions
- the present invention relates to an actuator for an inhaler for administering medicament by inhalation and to an inhaler including the same.
- actuators have been known for delivering metered doses of medicament from aerosol canisters.
- these actuators comprise a single integral moulding in plastic material. After use with only one canister the actuator is discarded. This is desirable, since some medicaments which are delivered, will, over time, become deposited in the nozzle block and the mouthpiece of the actuator.
- One problem with such integral moulding actuators is related to the fact that they often have to be provided in a number of different colours to indicate the medicament being delivered. In order to secure that the colour indication cannot be removed or fade away, a range of differently coloured actuators are conventionally moulded by using plastic material of different colour. However, even though all actuators are made of the same plastic material, they differ in composition as they all include different dyes or pigments. Due to this, each actuator in the range must undergo extensive evaluation in the regulatory phase.
- U.S. Pat. No. 5,520,166 discloses a cassette for use in an aerosol delivery device.
- the cassette comprises, as separate parts, a mouthpiece and an elongated housing to one end of which the mouthpiece is attached.
- the cassette is intended to be located within another device.
- the mouthpiece effectively is attached as a lid at one end of the housing.
- the outlet assembly as a common part to the range and forming the main body from a material having different constitution and optionally any shape.
- the main body can be coloured or have a particular surface finish or decoration according to the medicament to be delivered.
- the second part can be formed to have a particular shape, such as that of an animal which may appeal to young children.
- Such two part construction is also advantageous for preparing regulatory documentation for each member of the range of actuators, as the documentation basically will be the identical for all members in the range including data relating to the common outlet assembly.
- the outlet assembly can be provided as a replaceable part, whereby the main body is reused with several canisters, but the outlet assembly is replaced when changing canister. In this way the amount of waste is reduced, and in order to reduce the amount further, the material volume of the outlet assembly should be minimised.
- an actuator with a replaceable outlet assembly makes it possible for patients to keep a “personalized” actuator for a longer period of time without risk for deteriorated performance due to medications deposited in the nozzle block etc without the need for extensive cleaning, simply by replacing the outlet assembly when switching canister.
- the outlet assembly is arranged to deform or optionally break when removed from the main body, whereby it must be replaced
- the outlet assembly which most likely is of another colour than the main body, constitutes as small part of the actuator external surface as possible.
- the present invention provides an actuator for an inhaler for delivering medicament by inhalation, comprising: a main body comprising a tubular member for receiving a canister containing medicament and having a valve stem extending therefrom; and an outlet assembly, as a part formed separately of the main body, comprising a mouthpiece for guiding medicament to the mouth of a user and a nozzle block for receiving the valve stem of the canister and delivering medicament from the canister into the mouthpiece; wherein the main body is provided with an outlet opening for receiving the outlet assembly in a position wherein the mouthpiece extends outside the outlet opening and the nozzle block is inserted through the outlet opening and arranged in position for receiving the valve stem of the canister.
- the outlet assembly In such an actuator, only the mouth piece section of the outlet assembly extends outside the main body, thereby minimising its exposed external surface, while still comprising all the parts of the actuator that comes in contact with the medicament. Moreover, the outlet assembly according to this embodiment will be comprised of a very small volume of material.
- the outlet opening is a lateral opening at one end of the tubular member and arranged to receive the outlet assembly at an angle transverse to the length of the tubular member.
- the shape of the outlet opening is complementary to a tubular section of the outlet assembly mouth piece.
- the main body comprises guide means for guiding the outlet assembly to the correct position during insertion.
- the outlet assembly comprises a radial outwardly directed peripheral stop flange.
- the part of the outlet assembly to be inserted through the outlet opening at least partly is of general conical shape, with a leading end of small cross-sectional area, compared to the outlet opening, followed by a gradually larger section terminated by the mouth piece, to facilitate the insertion.
- the outlet assembly according to the present invention is well suited for high speed assembly, but in order to further facilitate assembly, the part of the outlet assembly to be inserted into the outlet opening is given a conical shape, whereby the assembly line tolerances need not to be excessively high. Moreover, the guide means and the stop flange ensures that the outlet assembly will be fitted in exactly the right position without the need for any advanced control of the assembly line.
- the outlet assembly is formed as a single integral moulding.
- the nozzle block includes a bore having an opening for receiving the valve stem of a canister and a spray orifice configured to direct a spray into the mouthpiece.
- the main body and the outlet assembly are configured so as to snap-fit together in that they are provided with complementary snap catch members.
- the snap catch members of both the main body and the outlet assembly are arranged inside the actuator in the assembled state.
- At least a part of the outlet assembly is configured so as to deform and optionally break on withdrawal of the outlet assembly from the main body so as to prevent re-use of the inhaler.
- the nozzle block is connected and supported by the mouthpiece providing an essentially free flow of air about the nozzle block.
- the nozzle block is attached to the mouthpiece by a connection having at least one member connecting a lower part of the mouthpiece with a lower part of the nozzle block and at least one member connecting an upper part of the mouthpiece with an upper part of the nozzle block, leaving there between an open path for flow of air during inhalation.
- snap catch members provides for reliable high speed assembly, whereby the two parts of the actuator are assembled in one single step, while the actuator still being robust and reliable. Moreover, when the snap catch arrangement is arranged inside the actuator, it does not contribute to the external appearance of the actuator, at the same time as it makes tampering more difficult.
- the tubular member of the main body has an end surface adjacent to the outlet opening and wherein the nozzle block is supported by said end surface.
- the bottom surface is provided with an alignment and support member for guiding the nozzle block to the correct position and for supporting the same in the generally vertical direction of the tubular member.
- the outlet assembly comprises a nozzle block alignment and support member that is complementary to the alignment and support member of the main body, the complementary support means being so arranged to take up the transversal force applied on the nozzle block during actuation of a canister.
- the material volume of the outlet assembly can be further reduced, as the forces applied on the nozzle block support members are lowered in the critical direction(s).
- the bottom surface is formed as a foot which is configured such that, with a canister fitted therein, the actuator will stand unsupported with the tubular member extending generally vertically.
- the actuator comprises, one or both of a breath actuation mechanism and a compliance monitor, in particular a dose counter.
- the main body comprises one or both of the breath actuation mechanism and the compliance monitor, preferably, the foot comprises one or both of the breath actuation mechanism and the compliance monitor.
- the present invention also extends to an inhaler comprising the above-described actuator and a canister containing medicament, a main body and an outlet assembly
- the inhaler is a pressurised metered dose inhaler.
- FIG. 1 illustrates a perspective view of an inhaler in accordance with a preferred embodiment of the present invention
- FIG. 2 illustrates a side view of the inhaler of FIG. 1 ;
- FIG. 3 illustrates a front view of the inhaler of FIG. 1 ;
- FIG. 4 illustrates a rear view of the inhaler of FIG. 1 ;
- FIG. 5 illustrates a plan view of the inhaler of FIG. 1 ;
- FIG. 6 illustrates an underneath plan view of the inhaler of FIG. 1 ;
- FIG. 7 illustrates a horizontal sectional view (along section A-A) of the inhaler of FIG. 1 ;
- FIG. 8 illustrates in enlarged scale a fragmentary view of the section illustrated in FIG. 7 ;
- FIG. 9 illustrates a vertical sectional view (along section B-B) of the inhaler of FIG. 1 ;
- FIG. 10 illustrates in enlarged scale a fragmentary view of the section illustrated in FIG. 9 ;
- FIG. 11 illustrates a perspective view of the outlet assembly of the actuator of the inhaler of FIG. 1 ;
- FIG. 12 illustrates a plan view of the outlet assembly of FIG. 11 ;
- FIG. 13 illustrates an underneath plan view of the outlet assembly of FIG. 11 ;
- FIG. 14 illustrates a side view of the outlet assembly of FIG. 11 ;
- FIG. 15 illustrates a rear view of the outlet assembly of FIG. 11 ;
- FIG. 16 illustrates a front view of the outlet assembly of FIG. 11 .
- the inhaler comprises an actuator, which comprises a main body 2 , an outlet assembly 4 fitted to a lower part of the main body 2 and a cap 6 , and an aerosol canister 7 containing medicament fitted therein.
- the main body 2 comprises a tubular member 8 having an opening 10 at one, the upper. end thereof into which a canister 7 having a valve stem 11 extending therefrom is in use fitted, and a foot 12 having a bottom surface which includes a recess 12 a, in this embodiment concave in shape, for receiving typically a thumb of a user.
- the foot 12 can be formed with a substantially flat bottom surface.
- the foot 12 serves to allow the actuator to stand unsupported on a flat surface such that, when the actuator is not in use, it can be stored in an upright position. This is particularly advantageous when a canister 7 is fitted therein, since such canisters 7 should, ideally, be stored with the valve stem 11 directed downwards.
- the other, lower, end of the tubular member 8 is closed and includes a lateral opening 14 , in this embodiment ovoid in shape, into which the outlet assembly 4 is fitted.
- the main body 2 further comprises a pair of opposing projections 16 which extend inwardly from the inner surface of the tubular member 8 adjacent the lateral opening 14 .
- the projections 16 are disposed to the sides of the lateral opening 14 and are spaced rearwardly therefrom.
- the outlet assembly 4 comprises a tubular section 18 , a major part of which defines the mouthpiece which is in use gripped by the lips of a user, and a nozzle block 20 connected thereto.
- the tubular section 18 includes a radial outwardly-directed peripheral flange 22 .
- the flange 22 abuts the lateral opening 14 such that the major part of the tubular section 18 extends outwardly of the main body 2 .
- the outlet assembly 4 further comprises first and second arms 24 , 26 which extend rearwardly form respective sides of the tubular section 18 .
- Each of the first and second arms 24 , 26 includes a catch member 28 , 30 which is adapted to engage with a respective one of the projections 16 on the inner surface of the tubular member 8 when the outlet assembly 4 is inserted fully into the main body 2 .
- the catch members 28 , 30 on the first and second arms 24 , 26 each include a first surface 28 a, 30 a which has a rearwardly directed component and acts as a guiding surface, and a second surface 28 b, 30 b which is substantially orthogonally directed to the longitudinal axis of the outlet assembly 4 and acts as a locking surface.
- the outlet assembly 4 further comprises a third arm 34 which extends rearwardly from the top of the tubular section 18 .
- the third arm 34 includes a catch member 35 in the form of an outwardly-directed projection, which, when the outlet assembly 4 is inserted fully into the main body 2 , engages behind a part of the tubular member 8 defining the lateral opening 14 .
- the catch member 35 on the third arm 34 as with the catch members 28 , 30 on the first and second arms 24 , 26 , includes a first surface 35 a which has a rearwardly directed component and acts as a guiding surface, and a second surface 35 b which is substantially orthogonally directed to the longitudinal axis of the outlet assembly 4 and acts as a locking surface.
- the nozzle block 20 is connected to the tubular section 18 by first and second pairs of connecting elements 36 , 38 .
- the first pair of connecting elements 36 extend between a lower part of the nozzle block 20 and a lower part of the tubular section 18 .
- the lower connecting elements 36 are configured to break or be permanently deformed on withdrawal of the outlet assembly 4 from the main body 2 .
- the second pair of connecting elements 38 extend between an upper part of the nozzle block 20 and an upper part of the tubular section 18 .
- the nozzle block 20 includes a tubular bore 40 which extends along the longitudinal axis of the tubular member 8 when the outlet assembly 4 is inserted fully into the main body 2 .
- the tubular bore 40 is open at one, the upper, end and includes a laterally-directed spray orifice 42 at the other, lower, end.
- the spray orifice 42 is configured to direct a spray into the tubular section 18 .
- the tubular bore 40 is adapted to receive the valve stem 11 of a canister 7 .
- the outlet assembly 4 further comprises a fourth arm 44 which extends forwardly and downwardly from the nozzle block 20 .
- the distal end of the fourth arm 44 includes a catch member 46 which, when the outlet assembly 4 is inserted fully into the main body 2 , engages behind a part of the tubular member 8 defining the lateral opening 14 .
- the catch member 46 on the fourth arm 44 includes a surface 46 a which is substantially orthogonally directed to the longitudinal axis of the outlet assembly 4 and acts as a locking surface.
- an outlet assembly 4 and a main body 2 are selected according to the requirements, based on colour, shape, etc., for the actuator.
- the outlet assembly 4 is then inserted into the lateral opening 14 in the main body 2 until the catch members 28 , 30 on the first and second arms 24 , 26 of the outlet assembly 4 engage with the respective projections 16 on the inner side surface of the tubular member 8 of the main body 2 , and the catch members 34 , 46 on the third and fourth arms 34 , 44 of the outlet assembly 4 engage behind respective parts of the tubular member 8 defining the lateral opening 14 .
- a canister 7 is then passed into the tubular member 8 of the main body 2 through the upper opening 10 such that the valve stem 11 of the canister 7 is located in the tubular bore 40 in the nozzle block 20 .
- the inhaler is then ready for use.
- the outlet assembly 4 is held in the main body 2 and the outlet assembly 4 cannot be non-destruct ably detached from the main body 2 .
- the outlet assembly 4 is configured to break or be permanently deformed if withdrawn from the main body 2 and thereby render the outlet assembly 4 and hence the actuator unusable. In this embodiment this is achieved by configuring the lower connecting elements 36 connecting the tubular section 18 and the nozzle block 20 of the outlet assembly 4 to break or be permanently deformed on withdrawal of the outlet assembly 4 from the main body 2 .
Abstract
An actuator for an inhaler for delivering medicament by inhalation, comprising: a main body comprising a tubular member for receiving a canister containing medicament and having a valve stem extending therefrom; and an outlet assembly, as a part formed separately of the main body, comprising a mouthpiece for guiding medicament to the mouth of a user and a nozzle block for receiving the valve stem of the canister and delivering medicament from the canister into the mouthpiece; wherein the main body is provided with an outlet opening for receiving the outlet assembly in a position wherein the mouthpiece extends outside the outlet opening and the nozzle block is inserted through the outlet opening and arranged in position for receiving the valve stem of the canister. There is also disclosed an inhaler comprising the above-described actuator and a canister containing medicament, a main body and an outlet assembly.
Description
- The present invention relates to an actuator for an inhaler for administering medicament by inhalation and to an inhaler including the same.
- For some time, actuators have been known for delivering metered doses of medicament from aerosol canisters. Conventionally, these actuators comprise a single integral moulding in plastic material. After use with only one canister the actuator is discarded. This is desirable, since some medicaments which are delivered, will, over time, become deposited in the nozzle block and the mouthpiece of the actuator. One problem with such integral moulding actuators, is related to the fact that they often have to be provided in a number of different colours to indicate the medicament being delivered. In order to secure that the colour indication cannot be removed or fade away, a range of differently coloured actuators are conventionally moulded by using plastic material of different colour. However, even though all actuators are made of the same plastic material, they differ in composition as they all include different dyes or pigments. Due to this, each actuator in the range must undergo extensive evaluation in the regulatory phase.
- U.S. Pat. No. 5,520,166 discloses a cassette for use in an aerosol delivery device. The cassette comprises, as separate parts, a mouthpiece and an elongated housing to one end of which the mouthpiece is attached. The cassette is intended to be located within another device. The mouthpiece effectively is attached as a lid at one end of the housing.
- It is an aim of the present invention to provide an actuator of two-part construction, with an outlet assembly comprising those components which come into contact with medicament and a main body comprising the remainder. In this way, it is possible to allow for the manufacture of a range of actuators by providing the outlet assembly as a common part to the range and forming the main body from a material having different constitution and optionally any shape. Typically, the main body can be coloured or have a particular surface finish or decoration according to the medicament to be delivered. In addition, the second part can be formed to have a particular shape, such as that of an animal which may appeal to young children. Such two part construction is also advantageous for preparing regulatory documentation for each member of the range of actuators, as the documentation basically will be the identical for all members in the range including data relating to the common outlet assembly.
- The outlet assembly can be provided as a replaceable part, whereby the main body is reused with several canisters, but the outlet assembly is replaced when changing canister. In this way the amount of waste is reduced, and in order to reduce the amount further, the material volume of the outlet assembly should be minimised. Moreover, an actuator with a replaceable outlet assembly makes it possible for patients to keep a “personalized” actuator for a longer period of time without risk for deteriorated performance due to medications deposited in the nozzle block etc without the need for extensive cleaning, simply by replacing the outlet assembly when switching canister. According to one embodiment, the outlet assembly is arranged to deform or optionally break when removed from the main body, whereby it must be replaced
- In order to maximise the freedom of design of the main body, it is desired that the outlet assembly, which most likely is of another colour than the main body, constitutes as small part of the actuator external surface as possible.
- Accordingly, the present invention provides an actuator for an inhaler for delivering medicament by inhalation, comprising: a main body comprising a tubular member for receiving a canister containing medicament and having a valve stem extending therefrom; and an outlet assembly, as a part formed separately of the main body, comprising a mouthpiece for guiding medicament to the mouth of a user and a nozzle block for receiving the valve stem of the canister and delivering medicament from the canister into the mouthpiece; wherein the main body is provided with an outlet opening for receiving the outlet assembly in a position wherein the mouthpiece extends outside the outlet opening and the nozzle block is inserted through the outlet opening and arranged in position for receiving the valve stem of the canister.
- In such an actuator, only the mouth piece section of the outlet assembly extends outside the main body, thereby minimising its exposed external surface, while still comprising all the parts of the actuator that comes in contact with the medicament. Moreover, the outlet assembly according to this embodiment will be comprised of a very small volume of material.
- Preferably, the outlet opening is a lateral opening at one end of the tubular member and arranged to receive the outlet assembly at an angle transverse to the length of the tubular member.
- Preferably, the shape of the outlet opening is complementary to a tubular section of the outlet assembly mouth piece.
- Preferably, the main body comprises guide means for guiding the outlet assembly to the correct position during insertion.
- Preferably, the outlet assembly comprises a radial outwardly directed peripheral stop flange.
- Preferably, the part of the outlet assembly to be inserted through the outlet opening at least partly is of general conical shape, with a leading end of small cross-sectional area, compared to the outlet opening, followed by a gradually larger section terminated by the mouth piece, to facilitate the insertion.
- The outlet assembly according to the present invention is well suited for high speed assembly, but in order to further facilitate assembly, the part of the outlet assembly to be inserted into the outlet opening is given a conical shape, whereby the assembly line tolerances need not to be excessively high. Moreover, the guide means and the stop flange ensures that the outlet assembly will be fitted in exactly the right position without the need for any advanced control of the assembly line.
- Preferably, the outlet assembly is formed as a single integral moulding.
- Preferably, the nozzle block includes a bore having an opening for receiving the valve stem of a canister and a spray orifice configured to direct a spray into the mouthpiece.
- Preferably, the main body and the outlet assembly are configured so as to snap-fit together in that they are provided with complementary snap catch members.
- According to one embodiment, the snap catch members of both the main body and the outlet assembly are arranged inside the actuator in the assembled state.
- Preferably, at least a part of the outlet assembly is configured so as to deform and optionally break on withdrawal of the outlet assembly from the main body so as to prevent re-use of the inhaler.
- Preferably, the nozzle block is connected and supported by the mouthpiece providing an essentially free flow of air about the nozzle block.
- Preferably, the nozzle block is attached to the mouthpiece by a connection having at least one member connecting a lower part of the mouthpiece with a lower part of the nozzle block and at least one member connecting an upper part of the mouthpiece with an upper part of the nozzle block, leaving there between an open path for flow of air during inhalation.
- In line with the aim of the present invention, snap catch members provides for reliable high speed assembly, whereby the two parts of the actuator are assembled in one single step, while the actuator still being robust and reliable. Moreover, when the snap catch arrangement is arranged inside the actuator, it does not contribute to the external appearance of the actuator, at the same time as it makes tampering more difficult.
- Preferably, the tubular member of the main body has an end surface adjacent to the outlet opening and wherein the nozzle block is supported by said end surface.
- According to one embodiment, the bottom surface is provided with an alignment and support member for guiding the nozzle block to the correct position and for supporting the same in the generally vertical direction of the tubular member.
- According to another embodiment, the outlet assembly comprises a nozzle block alignment and support member that is complementary to the alignment and support member of the main body, the complementary support means being so arranged to take up the transversal force applied on the nozzle block during actuation of a canister.
- By the provision of a support for the nozzle block, the material volume of the outlet assembly can be further reduced, as the forces applied on the nozzle block support members are lowered in the critical direction(s).
- According to one embodiment, the bottom surface is formed as a foot which is configured such that, with a canister fitted therein, the actuator will stand unsupported with the tubular member extending generally vertically.
- Preferably, the actuator comprises, one or both of a breath actuation mechanism and a compliance monitor, in particular a dose counter. According to one embodiment the main body comprises one or both of the breath actuation mechanism and the compliance monitor, preferably, the foot comprises one or both of the breath actuation mechanism and the compliance monitor.
- The present invention also extends to an inhaler comprising the above-described actuator and a canister containing medicament, a main body and an outlet assembly
- Preferably, the inhaler is a pressurised metered dose inhaler.
- A preferred embodiment of the present invention will now be described herein below by way of example only with reference to the accompanying drawings, in which:
-
FIG. 1 illustrates a perspective view of an inhaler in accordance with a preferred embodiment of the present invention; -
FIG. 2 illustrates a side view of the inhaler ofFIG. 1 ; -
FIG. 3 illustrates a front view of the inhaler ofFIG. 1 ; -
FIG. 4 illustrates a rear view of the inhaler ofFIG. 1 ; -
FIG. 5 illustrates a plan view of the inhaler ofFIG. 1 ; -
FIG. 6 illustrates an underneath plan view of the inhaler ofFIG. 1 ; -
FIG. 7 illustrates a horizontal sectional view (along section A-A) of the inhaler ofFIG. 1 ; -
FIG. 8 illustrates in enlarged scale a fragmentary view of the section illustrated inFIG. 7 ; -
FIG. 9 illustrates a vertical sectional view (along section B-B) of the inhaler ofFIG. 1 ; -
FIG. 10 illustrates in enlarged scale a fragmentary view of the section illustrated inFIG. 9 ; -
FIG. 11 illustrates a perspective view of the outlet assembly of the actuator of the inhaler ofFIG. 1 ; -
FIG. 12 illustrates a plan view of the outlet assembly ofFIG. 11 ; -
FIG. 13 illustrates an underneath plan view of the outlet assembly ofFIG. 11 ; -
FIG. 14 illustrates a side view of the outlet assembly ofFIG. 11 ; -
FIG. 15 illustrates a rear view of the outlet assembly ofFIG. 11 ; and -
FIG. 16 illustrates a front view of the outlet assembly ofFIG. 11 . - The inhaler comprises an actuator, which comprises a
main body 2, an outlet assembly 4 fitted to a lower part of themain body 2 and acap 6, and anaerosol canister 7 containing medicament fitted therein. - The
main body 2 comprises atubular member 8 having anopening 10 at one, the upper. end thereof into which acanister 7 having avalve stem 11 extending therefrom is in use fitted, and afoot 12 having a bottom surface which includes arecess 12 a, in this embodiment concave in shape, for receiving typically a thumb of a user. In an alternative embodiment thefoot 12 can be formed with a substantially flat bottom surface. Thefoot 12 serves to allow the actuator to stand unsupported on a flat surface such that, when the actuator is not in use, it can be stored in an upright position. This is particularly advantageous when acanister 7 is fitted therein, sincesuch canisters 7 should, ideally, be stored with thevalve stem 11 directed downwards. The other, lower, end of thetubular member 8 is closed and includes alateral opening 14, in this embodiment ovoid in shape, into which the outlet assembly 4 is fitted. - The
main body 2 further comprises a pair of opposingprojections 16 which extend inwardly from the inner surface of thetubular member 8 adjacent thelateral opening 14. Theprojections 16 are disposed to the sides of thelateral opening 14 and are spaced rearwardly therefrom. - The outlet assembly 4 comprises a
tubular section 18, a major part of which defines the mouthpiece which is in use gripped by the lips of a user, and anozzle block 20 connected thereto. - The
tubular section 18 includes a radial outwardly-directedperipheral flange 22. When the outlet assembly 4 is inserted fully into themain body 2, theflange 22 abuts thelateral opening 14 such that the major part of thetubular section 18 extends outwardly of themain body 2. - The outlet assembly 4 further comprises first and
second arms tubular section 18. Each of the first andsecond arms catch member projections 16 on the inner surface of thetubular member 8 when the outlet assembly 4 is inserted fully into themain body 2. Thecatch members second arms first surface second surface - The outlet assembly 4 further comprises a
third arm 34 which extends rearwardly from the top of thetubular section 18. Thethird arm 34 includes acatch member 35 in the form of an outwardly-directed projection, which, when the outlet assembly 4 is inserted fully into themain body 2, engages behind a part of thetubular member 8 defining thelateral opening 14. Thecatch member 35 on thethird arm 34, as with thecatch members second arms first surface 35 a which has a rearwardly directed component and acts as a guiding surface, and asecond surface 35 b which is substantially orthogonally directed to the longitudinal axis of the outlet assembly 4 and acts as a locking surface. - The
nozzle block 20 is connected to thetubular section 18 by first and second pairs of connectingelements elements 36 extend between a lower part of thenozzle block 20 and a lower part of thetubular section 18. As will be described herein below, in this embodiment the lower connectingelements 36 are configured to break or be permanently deformed on withdrawal of the outlet assembly 4 from themain body 2. The second pair of connectingelements 38 extend between an upper part of thenozzle block 20 and an upper part of thetubular section 18. Thenozzle block 20 includes atubular bore 40 which extends along the longitudinal axis of thetubular member 8 when the outlet assembly 4 is inserted fully into themain body 2. The tubular bore 40 is open at one, the upper, end and includes a laterally-directedspray orifice 42 at the other, lower, end. Thespray orifice 42 is configured to direct a spray into thetubular section 18. In this embodiment the tubular bore 40 is adapted to receive thevalve stem 11 of acanister 7. - The outlet assembly 4 further comprises a
fourth arm 44 which extends forwardly and downwardly from thenozzle block 20. The distal end of thefourth arm 44 includes acatch member 46 which, when the outlet assembly 4 is inserted fully into themain body 2, engages behind a part of thetubular member 8 defining thelateral opening 14. Thecatch member 46 on thefourth arm 44 includes asurface 46 a which is substantially orthogonally directed to the longitudinal axis of the outlet assembly 4 and acts as a locking surface. - In manufacture, an outlet assembly 4 and a
main body 2 are selected according to the requirements, based on colour, shape, etc., for the actuator. The outlet assembly 4 is then inserted into thelateral opening 14 in themain body 2 until thecatch members second arms respective projections 16 on the inner side surface of thetubular member 8 of themain body 2, and thecatch members fourth arms tubular member 8 defining thelateral opening 14. Acanister 7 is then passed into thetubular member 8 of themain body 2 through theupper opening 10 such that thevalve stem 11 of thecanister 7 is located in the tubular bore 40 in thenozzle block 20. The inhaler is then ready for use. - By the provision of catch members the outlet assembly 4 is held in the
main body 2 and the outlet assembly 4 cannot be non-destruct ably detached from themain body 2. As mentioned herein above, the outlet assembly 4 is configured to break or be permanently deformed if withdrawn from themain body 2 and thereby render the outlet assembly 4 and hence the actuator unusable. In this embodiment this is achieved by configuring the lower connectingelements 36 connecting thetubular section 18 and thenozzle block 20 of the outlet assembly 4 to break or be permanently deformed on withdrawal of the outlet assembly 4 from themain body 2. - Finally, it will be understood by a person skilled in the art that the present invention is not limited to the described embodiment but can be modified in many different ways within the scope of the appended claims.
Claims (21)
1-53. (canceled)
54. An actuator for an inhaler for delivering medicament by inhalation, comprising:
a main body configured to receive a canister with a valve stem extending therefrom, wherein the main body includes an end portion formed as a foot that allows the actuator to stand unsupported with the main body extending generally vertically from the foot; and
an outlet assembly formed separate from the main body, wherein the outlet assembly has a mouthpiece with a nozzle block for receiving the valve stem of the canister.
55. The actuator of claim 54 , wherein the nozzle block is supported by the end surface.
56. The actuator of claim 54 , wherein the foot includes a recess configured to receive a digit of a user.
57. The actuator of claim 56 , wherein the recess is concave.
58. The actuator of claim 54 , wherein a bottom-most surface of the foot is substantially flat.
59. The actuator of claim 54 , wherein the nozzle block has a longitudinal axis that is generally parallel to a longitudinal axis of the main body.
60. The actuator of claim 54 , wherein the foot includes a breath actuation mechanism.
61. The actuator of claim 61 , wherein the foot includes a dose counter.
62. The actuator of claim 54 , wherein the outlet assembly includes a removable cap configured to cover at least a portion of the mouthpiece.
63. A disposable actuator for an inhaler for delivering medicament by inhalation, comprising:
a main body having a tubular member configured to receive a canister with a valve stem extending therefrom,
wherein the tubular member has an end surface formed as a foot configured such that the actuator will stand unsupported in an upright position with the valve stem facing downwards when receiving the canister; and
an outlet assembly formed separate from the main body, wherein the outlet assembly has a mouthpiece with a nozzle block for receiving the valve stem of the canister, and
wherein the outlet assembly is configured to removably couple to part of the tubular member located adjacent to the foot.
64. The actuator of claim 63 , wherein the foot includes a recess configured to receive a digit of a user.
65. The actuator of claim 64 , wherein the recess is concave.
66. The actuator of claim 65 , wherein a bottom surface of the foot is substantially flat.
67. The actuator of claim 63 , wherein the foot includes an element configured to transmit a compressive force to the nozzle block.
68. The actuator of claim 67 , wherein the element and the nozzle block are located on a longitudinal axis of the tubular member.
69. The actuator of claim 63 , wherein a portion of the outlet assembly is configured to be received within a lateral opening of the tubular member and a portion of the outlet assembly is configured to extend from the lateral opening.
70. An actuator for an inhaler for delivering medicament by inhalation, comprising:
a main body having a tubular member configured to receive a canister containing medicament that is dispensed through a valve stem extending from the canister,
wherein the tubular member has an end surface formed as a foot configured such that the actuator will stand unsupported with the tubular member extending generally vertically when receiving the canister;
a canister configured for insertion into the main body; and
an outlet assembly having a mouthpiece for guiding medicament to a mouth of a user and a nozzle block for receiving the valve stem of the canister and delivering medicament from the canister to the mouthpiece,
wherein the outlet assembly is configured to be removably coupled to the main body and the main body includes an outlet opening configured to receive at least a portion of the outlet assembly so that the mouthpiece extends through the outlet opening, and
wherein when the outlet assembly is coupled to the main body, the nozzle block is located centrally in an end region of the tubular member such that a first end of the nozzle block receives the valve stem of the canister and a second end of the nozzle block is located adjacent the foot.
71. The actuator of claim 70 , wherein the outlet assembly includes at least one anchor mechanism configured to engage with an inner surface of the tubular member so as to couple the outlet assembly to the tubular member.
72. The actuator of claim 70 , wherein the foot includes a centrally located recess configured to receive a finger of a user.
73. The actuator of claim 70 , wherein a bottom surface of the foot is substantially flat.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/678,893 US20130133643A1 (en) | 1997-11-14 | 2012-11-16 | Inhalation Device |
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
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SE9704185A SE9704185D0 (en) | 1997-11-14 | 1997-11-14 | Inhalation device |
SESE9704185-9 | 1997-11-14 | ||
PCT/SE1998/002038 WO1999025406A1 (en) | 1997-11-14 | 1998-11-11 | Inhalation device |
SEPCT/SE98/02038 | 1998-11-11 | ||
US21475799A | 1999-01-12 | 1999-01-12 | |
US09/986,941 US20020026938A1 (en) | 1997-11-14 | 2001-11-13 | Inhalation device |
US10/698,950 US7367333B2 (en) | 1997-11-14 | 2003-11-03 | Inhalation device |
US11/346,573 US8584668B2 (en) | 1997-11-14 | 2006-02-03 | Inhalation device |
US13/678,893 US20130133643A1 (en) | 1997-11-14 | 2012-11-16 | Inhalation Device |
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Application Number | Title | Priority Date | Filing Date |
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US11/346,573 Continuation US8584668B2 (en) | 1997-11-14 | 2006-02-03 | Inhalation device |
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Application Number | Title | Priority Date | Filing Date |
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US09/822,252 Abandoned US20010032644A1 (en) | 1997-11-14 | 2001-04-02 | Inhalation device |
US09/986,941 Abandoned US20020026938A1 (en) | 1997-11-14 | 2001-11-13 | Inhalation device |
US10/336,757 Expired - Fee Related US6805116B2 (en) | 1997-11-14 | 2003-01-06 | Inhalation device |
US10/698,950 Expired - Fee Related US7367333B2 (en) | 1997-11-14 | 2003-11-03 | Inhalation device |
US11/346,573 Expired - Fee Related US8584668B2 (en) | 1997-11-14 | 2006-02-03 | Inhalation device |
US13/678,893 Abandoned US20130133643A1 (en) | 1997-11-14 | 2012-11-16 | Inhalation Device |
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Application Number | Title | Priority Date | Filing Date |
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US09/822,252 Abandoned US20010032644A1 (en) | 1997-11-14 | 2001-04-02 | Inhalation device |
US09/986,941 Abandoned US20020026938A1 (en) | 1997-11-14 | 2001-11-13 | Inhalation device |
US10/336,757 Expired - Fee Related US6805116B2 (en) | 1997-11-14 | 2003-01-06 | Inhalation device |
US10/698,950 Expired - Fee Related US7367333B2 (en) | 1997-11-14 | 2003-11-03 | Inhalation device |
US11/346,573 Expired - Fee Related US8584668B2 (en) | 1997-11-14 | 2006-02-03 | Inhalation device |
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US (6) | US20010032644A1 (en) |
EP (2) | EP1028768A1 (en) |
JP (3) | JP4282229B2 (en) |
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CN (2) | CN1191871C (en) |
AU (2) | AU728125B2 (en) |
BR (2) | BR9814964A (en) |
CA (7) | CA2616784C (en) |
CZ (1) | CZ300930B6 (en) |
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SE (1) | SE9704185D0 (en) |
SK (1) | SK286209B6 (en) |
TR (1) | TR200001357T2 (en) |
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UA (1) | UA66820C2 (en) |
WO (2) | WO1999025407A1 (en) |
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- 1998-11-11 UA UA2000063450A patent/UA66820C2/en unknown
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- 1998-11-11 EP EP98956059A patent/EP1030704A1/en not_active Withdrawn
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- 1998-11-11 RU RU2000115309/14A patent/RU2198688C2/en not_active IP Right Cessation
- 1998-11-11 AU AU11836/99A patent/AU750351B2/en not_active Ceased
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2000
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2001
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2003
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US10245391B2 (en) | 2012-11-27 | 2019-04-02 | Pari Pharma Gmbh | Fluid reservoir for an aerosol generation device, combination of fluid reservoir and primary fluid package, and aerosol generation device for use with the fluid reservoir |
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US10569034B2 (en) | 2014-08-28 | 2020-02-25 | Norton (Waterford) Limited | Compliance monitoring module for a breath-actuated inhaler |
US10918816B2 (en) | 2014-08-28 | 2021-02-16 | Norton (Waterford) Limited | Compliance monitoring module for a breath-actuated inhaler |
US11040156B2 (en) | 2015-07-20 | 2021-06-22 | Pearl Therapeutics, Inc. | Aerosol delivery systems |
US20220211582A1 (en) * | 2017-04-14 | 2022-07-07 | Manan Shukla | Inhaler compliance device and monitoring system |
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