TW295587B - - Google Patents

Info

Publication number

TW295587B

TW295587B TW83100925A TW83100925A TW295587B TW 295587 B TW295587 B TW 295587B TW 83100925 A TW83100925 A TW 83100925A TW 83100925 A TW83100925 A TW 83100925A TW 295587 B TW295587 B TW 295587B

Authority

TW

Taiwan

Prior art keywords

formula

compound

ministry

page

amino

Prior art date

1992-12-02

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 15
• 229940122361 Bisphosphonate Drugs 0.000 claims 5
• 239000002253 acid Substances 0.000 claims 5
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
• -1 aminoiminomethyl Chemical group 0.000 claims 4
• 150000004663 bisphosphonates Chemical class 0.000 claims 4
• 239000012442 inert solvent Substances 0.000 claims 3
• PCTMTFRHKVHKIS-BMFZQQSSSA-N (1s,3r,4e,6e,8e,10e,12e,14e,16e,18s,19r,20r,21s,25r,27r,30r,31r,33s,35r,37s,38r)-3-[(2r,3s,4s,5s,6r)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,30,31,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10 Chemical compound C1C=C2C[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2.O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 PCTMTFRHKVHKIS-BMFZQQSSSA-N 0.000 claims 2
• PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 2
• XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims 2
• FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 claims 1
• 241000219112 Cucumis Species 0.000 claims 1
• 235000015510 Cucumis melo subsp melo Nutrition 0.000 claims 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
• 101100065246 Mus musculus Enc1 gene Proteins 0.000 claims 1
• 239000013543 active substance Substances 0.000 claims 1
• 230000003412 degenerative effect Effects 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 150000002148 esters Chemical class 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 229910052739 hydrogen Inorganic materials 0.000 claims 1
• 239000001257 hydrogen Substances 0.000 claims 1
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
• 230000003902 lesion Effects 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 229910052759 nickel Inorganic materials 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
• 229910000073 phosphorus hydride Inorganic materials 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 239000013589 supplement Substances 0.000 claims 1