|
US6346614B1
(en)
*
|
1992-07-23 |
2002-02-12 |
Hybridon, Inc. |
Hybrid oligonucleotide phosphorothioates
|
|
US6608035B1
(en)
*
|
1994-10-25 |
2003-08-19 |
Hybridon, Inc. |
Method of down-regulating gene expression
|
|
US6645943B1
(en)
|
1994-10-25 |
2003-11-11 |
Hybridon, Inc. |
Method of down-regulating gene expression
|
|
EP0882061B1
(en)
|
1996-02-14 |
2004-05-19 |
Isis Pharmaceuticals, Inc. |
Sugar-modified gapped oligonucleotides
|
|
US20030036516A1
(en)
*
|
1997-09-10 |
2003-02-20 |
Sudhir Agrawal |
Method for using oligonucleotides having modified cpg dinucleotides
|
|
US20010049436A1
(en)
*
|
1998-04-01 |
2001-12-06 |
Wen-Qiang Zhou |
Mixed-backbone oligonucleotides containing pops blocks to obtain reduced phosphorothioate content
|
|
US20040063618A1
(en)
*
|
2002-09-30 |
2004-04-01 |
Muthiah Manoharan |
Peptide nucleic acids having improved uptake and tissue distribution
|
|
US20040186071A1
(en)
|
1998-04-13 |
2004-09-23 |
Bennett C. Frank |
Antisense modulation of CD40 expression
|
|
US20030220486A1
(en)
*
|
1999-04-01 |
2003-11-27 |
Wen-Qiang Zhou |
Mixed backbone oligonucleotides containing pops blocks to obtain reduced phosphorothioate content
|
|
US7276489B2
(en)
*
|
2002-10-24 |
2007-10-02 |
Idera Pharmaceuticals, Inc. |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
|
|
CA2498777C
(en)
*
|
2002-09-13 |
2015-01-13 |
Replicor, Inc. |
Non-sequence complementary antiviral oligonucleotides
|
|
US20050196382A1
(en)
*
|
2002-09-13 |
2005-09-08 |
Replicor, Inc. |
Antiviral oligonucleotides targeting viral families
|
|
KR101123489B1
(ko)
*
|
2003-01-16 |
2012-03-28 |
이데라 파마슈티칼즈, 인코포레이티드 |
개질된 면역자극성 디뉴클레오티드를 이용한 올리고뉴클레오티드-기재 화합물의 면역자극 특성의 조절
|
|
KR20060012622A
(ko)
*
|
2003-05-16 |
2006-02-08 |
하이브리돈, 인코포레이티드 |
화학요법제와 함께 이뮤노머를 사용하는 상승적 암 치료방법
|
|
KR101137572B1
(ko)
|
2003-06-11 |
2012-05-30 |
이데라 파마슈티칼즈, 인코포레이티드 |
안정화된 면역조절 올리고뉴클레오티드
|
|
EP1648913A4
(en)
|
2003-07-15 |
2008-09-10 |
Idera Pharmaceuticals Inc |
SYNERGISTIC STIMULATION OF THE IMMUNE SYSTEM WITH IMMUNOSTIMULATING OLIGONUCLEOTIDES AND / OR IMMUNOMER COMPOUNDS RELATED TO CYTOKINES AND / OR CHEMOTHERAPEAN MEDICAMENTS OR RADIATION THERAPY
|
|
AU2004304770B2
(en)
|
2003-12-08 |
2010-05-06 |
Idera Pharmaceuticals, Inc. |
Modulation of immunostimulatory properties by small oligonucleotide-based compounds
|
|
JP2007523173A
(ja)
*
|
2004-02-20 |
2007-08-16 |
イデラ ファーマシューティカルズ インコーポレイテッド |
修飾免疫調節オリゴヌクレオチドにより誘導された強力な粘膜免疫応答
|
|
KR101147147B1
(ko)
*
|
2004-04-01 |
2012-05-25 |
머크 샤프 앤드 돔 코포레이션 |
Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
|
|
US7427405B2
(en)
*
|
2004-06-15 |
2008-09-23 |
Idera Pharmaceuticals, Inc. |
Immunostimulatory oligonucleotide multimers
|
|
HUE036894T2
(hu)
*
|
2004-06-15 |
2018-08-28 |
Idera Pharmaceuticals Inc |
Immunstimuláló oligonukleotid multimerek
|
|
US7935811B2
(en)
|
2004-11-22 |
2011-05-03 |
Dharmacon, Inc. |
Apparatus and system having dry gene silencing compositions
|
|
US20060166234A1
(en)
|
2004-11-22 |
2006-07-27 |
Barbara Robertson |
Apparatus and system having dry control gene silencing compositions
|
|
US7923207B2
(en)
|
2004-11-22 |
2011-04-12 |
Dharmacon, Inc. |
Apparatus and system having dry gene silencing pools
|
|
US8003619B2
(en)
|
2004-12-09 |
2011-08-23 |
Alnylam Pharmaceuticals, Inc. |
Method of stimulating an immune response and inhibiting expression of a gene using an oligonucleotide
|
|
DE602006004578D1
(de)
|
2005-05-05 |
2009-02-12 |
Antisense Pharma Gmbh |
Verwendung von tgf-beta2 antisense oligonukleotiden
|
|
PL2380584T3
(pl)
|
2005-07-01 |
2014-03-31 |
Index Pharmaceuticals Ab |
Sposób do immunostymulacji
|
|
US8148341B2
(en)
|
2005-07-01 |
2012-04-03 |
Index Pharmaceuticals Ab |
Method for modulating responsiveness to steroids
|
|
CA2625969A1
(en)
*
|
2005-10-28 |
2007-05-03 |
Index Pharmaceuticals Ab |
Composition and method for the prevention, treatment and/or alleviation of an inflammatory disease
|
|
US7470674B2
(en)
*
|
2005-11-07 |
2008-12-30 |
Idera Pharmaceuticals, Inc. |
Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
|
|
CA2628306C
(en)
|
2005-11-07 |
2014-06-17 |
Sudhir Agrawal |
Immunostimulatory oligonucleotide-based compounds with glycerol-linked dinucleotides and modified guanosines at cpg and uses thereof
|
|
US7776834B2
(en)
*
|
2005-11-07 |
2010-08-17 |
Idera Pharmaceuticals, Inc. |
Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
|
|
CN101379195B
(zh)
*
|
2005-12-20 |
2012-05-09 |
艾德拉药物股份有限公司 |
含有不同长度回文片段的回文免疫调节性寡核苷酸(imotm)的免疫刺激活性
|
|
WO2007084237A2
(en)
*
|
2005-12-20 |
2007-07-26 |
Idera Pharmaceuticals, Inc. |
Novel synthetic agonists of toll-like receptors containing cg dinucleotide modifications
|
|
LT2056845T
(lt)
|
2006-08-08 |
2017-11-27 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
5` fosfato oligonukleotidų struktūra ir panaudojimas
|
|
EP1920775B1
(en)
|
2006-10-10 |
2012-12-19 |
Gunther Prof. Dr. Hartmann |
5'Triphosphate oligonucleotide induces anti-viral response
|
|
EP2081949B1
(en)
|
2006-09-22 |
2014-12-10 |
GE Healthcare Dharmacon, Inc. |
Tripartite oligonucleotide complexes and methods for gene silencing by rna interference
|
|
WO2009067243A2
(en)
|
2007-11-20 |
2009-05-28 |
Isis Pharmaceuticals Inc. |
Modulation of cd40 expression
|
|
US8188060B2
(en)
|
2008-02-11 |
2012-05-29 |
Dharmacon, Inc. |
Duplex oligonucleotides with enhanced functionality in gene regulation
|
|
EP2297323A1
(en)
|
2008-05-21 |
2011-03-23 |
Hartmann, Gunther |
5' triphosphate oligonucleotide with blunt end and uses thereof
|
|
DK2470656T3
(da)
|
2009-08-27 |
2015-06-22 |
Idera Pharmaceuticals Inc |
Sammensætning til hæmning af genekspression og anvendelser heraf
|
|
US20120270930A1
(en)
|
2009-10-29 |
2012-10-25 |
Academisch Ziekenhuis Leiden H.O.D.N. Lumc |
Methods and compositions for dysferlin exon-skipping
|
|
WO2011109427A2
(en)
|
2010-03-01 |
2011-09-09 |
Alnylam Pharmaceuticals, Inc. |
Improving the biological activity of sirna through modulation of its thermodynamic profile
|
|
EP2453017A1
(en)
|
2010-11-12 |
2012-05-16 |
Antisense Pharma GmbH |
Oligonucleotides for use in prophylaxis and/or treatment of TGF-beta1 and TGF-beta2, TGF-beta2 and TGF-beta3, TGF-beta1 and TGF-beta3, or TGF-beta1, TGF-beta2, and TGF-beta3 mRNA overexpressing diseases
|
|
US9920317B2
(en)
|
2010-11-12 |
2018-03-20 |
The General Hospital Corporation |
Polycomb-associated non-coding RNAs
|
|
EP3260540A1
(en)
|
2010-11-12 |
2017-12-27 |
The General Hospital Corporation |
Polycomb-associated non-coding rnas
|
|
US8877722B2
(en)
|
2011-03-25 |
2014-11-04 |
Idera Pharmaceuticals, Inc. |
Compositions for inhibiting gene expression and uses thereof
|
|
EP2508530A1
(en)
|
2011-03-28 |
2012-10-10 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Purification of triphosphorylated oligonucleotides using capture tags
|
|
WO2013040429A1
(en)
|
2011-09-14 |
2013-03-21 |
Rana Therapeutics Inc. |
Multimeric oligonucleotide compounds
|
|
US10174323B2
(en)
|
2012-05-16 |
2019-01-08 |
The General Hospital Corporation |
Compositions and methods for modulating ATP2A2 expression
|
|
WO2013173599A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating hemoglobin gene family expression
|
|
KR20160074368A
(ko)
|
2012-05-16 |
2016-06-28 |
라나 테라퓨틱스, 인크. |
Utrn 발현을 조절하기 위한 조성물 및 방법
|
|
US10837014B2
(en)
|
2012-05-16 |
2020-11-17 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating SMN gene family expression
|
|
WO2013173608A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating mecp2 expression
|
|
CN104540947A
(zh)
|
2012-05-16 |
2015-04-22 |
Rana医疗有限公司 |
用于调节smn基因家族表达的组合物和方法
|
|
WO2014030066A2
(en)
|
2012-08-22 |
2014-02-27 |
Bernitz Mats Nilsson |
Methods for identifying nucleic acid sequences
|
|
WO2014043544A1
(en)
|
2012-09-14 |
2014-03-20 |
Rana Therapeutics, Inc. |
Multimeric oligonucleotide compounds
|
|
EP2712870A1
(en)
|
2012-09-27 |
2014-04-02 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Novel RIG-I ligands and methods for producing them
|
|
EP4029508A1
(en)
|
2014-10-10 |
2022-07-20 |
Idera Pharmaceuticals, Inc. |
Treatment of cancer using tlr9 agonists and checkpoint inhibitors
|
|
EP3212824A4
(en)
|
2014-10-30 |
2018-08-08 |
The General Hospital Corporation |
Methods for modulating atrx-dependent gene repression
|
|
WO2016130943A1
(en)
|
2015-02-13 |
2016-08-18 |
Rana Therapeutics, Inc. |
Hybrid oligonucleotides and uses thereof
|
|
WO2016149455A2
(en)
|
2015-03-17 |
2016-09-22 |
The General Hospital Corporation |
The rna interactome of polycomb repressive complex 1 (prc1)
|
|
CA2995990C
(en)
|
2015-08-21 |
2021-11-16 |
Pfizer Inc. |
Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
|
|
UY39713A
(es)
|
2021-04-01 |
2022-10-31 |
Biogen Ma Inc |
Administracion de acido nucleico al sistema nervioso central
|
|
WO2025088117A1
(en)
|
2023-10-25 |
2025-05-01 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Ribonucleic acid construct capable of inducing an immune response, as well as pharmaceutical composition and kit comprising same
|
|
WO2025158069A1
(en)
|
2024-01-25 |
2025-07-31 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
CONSTRUCT COMPRISING mRNA-STRAND AND RETINOIC ACID-INDUCIBLE GENE I (RIG-I)-LIGAND(S), PHARMACEUTICAL COMPOSITION AND KIT COMPRISING THE SAME
|