TW202342445A - 用於製備n-(1-甲基環丙基)-2-(3-吡啶基)-2h-吲唑-4-甲醯胺及其中間體的方法 - Google Patents

用於製備n-(1-甲基環丙基)-2-(3-吡啶基)-2h-吲唑-4-甲醯胺及其中間體的方法 Download PDF

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TW202342445A
TW202342445A TW112104076A TW112104076A TW202342445A TW 202342445 A TW202342445 A TW 202342445A TW 112104076 A TW112104076 A TW 112104076A TW 112104076 A TW112104076 A TW 112104076A TW 202342445 A TW202342445 A TW 202342445A
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compound
aspects
reaction
base
solvent system
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TW112104076A
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伊万 謝爾蓋耶維奇 巴爾迪切夫
阿瓦 亞曼德 艾爾
克里斯蒂安 霍夫曼
潔西卡 L 克林肯伯格
卡勒 松德葛德
克里斯蒂娜 S 斯托弗
傑克 K 文瑟
泰 瓦格勒
喬納森 凱姆
布萊恩 羅施
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美商富曼西公司
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Publication of TW202342445A publication Critical patent/TW202342445A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/12—Powders or granules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
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    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
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    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
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    • B01J31/22—Organic complexes
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    • C07C209/46—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acids or esters thereof in presence of ammonia or amines
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    • C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides
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    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
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    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Materials Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
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  • Agronomy & Crop Science (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Toxicology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Insects & Arthropods (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
TW112104076A 2022-02-17 2023-02-06 用於製備n-(1-甲基環丙基)-2-(3-吡啶基)-2h-吲唑-4-甲醯胺及其中間體的方法 TW202342445A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263311276P 2022-02-17 2022-02-17
US63/311,276 2022-02-17

Publications (1)

Publication Number Publication Date
TW202342445A true TW202342445A (zh) 2023-11-01

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TW112104076A TW202342445A (zh) 2022-02-17 2023-02-06 用於製備n-(1-甲基環丙基)-2-(3-吡啶基)-2h-吲唑-4-甲醯胺及其中間體的方法
TW112104067A TW202342438A (zh) 2022-02-17 2023-02-06 用於製備n-(1-甲基環丙基)-2-(3-吡啶基)-2h-吲唑-4-甲醯胺及其中間體之方法
TW112104943A TW202344496A (zh) 2022-02-17 2023-02-13 用於製備n-(1-甲基環丙基)-2-(3-吡啶基)-2h-吲唑-4-甲醯胺及其中間體之方法

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TW112104067A TW202342438A (zh) 2022-02-17 2023-02-06 用於製備n-(1-甲基環丙基)-2-(3-吡啶基)-2h-吲唑-4-甲醯胺及其中間體之方法
TW112104943A TW202344496A (zh) 2022-02-17 2023-02-13 用於製備n-(1-甲基環丙基)-2-(3-吡啶基)-2h-吲唑-4-甲醯胺及其中間體之方法

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US (3) US20250154124A1 (enExample)
EP (3) EP4479393A1 (enExample)
JP (3) JP2025507561A (enExample)
KR (3) KR20240152343A (enExample)
CN (3) CN118715212A (enExample)
AR (3) AR128559A1 (enExample)
AU (3) AU2023222774A1 (enExample)
IL (3) IL314592A (enExample)
MX (3) MX2024010071A (enExample)
PY (3) PY2311482A (enExample)
TW (3) TW202342445A (enExample)
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CN122301706A (zh) * 2026-06-01 2026-06-30 福安药业集团重庆博圣制药有限公司 盐酸氯普鲁卡因及其中间体的制备方法与应用

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TWI652014B (zh) 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
CN107635984B (zh) * 2015-03-11 2021-04-13 Fmc公司 杂环取代的二环唑杀有害生物剂
KR102536024B1 (ko) * 2015-03-12 2023-05-24 에프엠씨 코포레이션 헤테로환-치환 이환 아졸 살충제
TWI873157B (zh) * 2019-07-11 2025-02-21 美商富曼西公司 包含吲唑之殺蟲混合物
CN111349111A (zh) * 2020-03-23 2020-06-30 安徽省逸欣铭医药科技有限公司 一种喷他佐辛前药、其制备方法及其用途

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MX2024010028A (es) 2024-08-22
UY40150A (es) 2023-09-15
JP2025507560A (ja) 2025-03-21
CN118715213A (zh) 2024-09-27
AR128557A1 (es) 2024-05-22
MX2024010029A (es) 2024-08-22
US20250163010A1 (en) 2025-05-22
IL314592A (en) 2024-09-01
EP4479393A1 (en) 2024-12-25
KR20240152344A (ko) 2024-10-21
AU2023220077A1 (en) 2024-08-22
UY40152A (es) 2023-09-15
PY2311474A (es) 2023-09-14
US20250179043A1 (en) 2025-06-05
EP4479394A1 (en) 2024-12-25
AU2023222774A1 (en) 2024-08-22
AR128559A1 (es) 2024-05-22
PY2311479A (es) 2023-10-05
WO2023158770A1 (en) 2023-08-24
WO2023158769A1 (en) 2023-08-24
AR128561A1 (es) 2024-05-22
KR20240152345A (ko) 2024-10-21
AU2023221271A1 (en) 2024-08-22
EP4479395A1 (en) 2024-12-25
IL314647A (en) 2024-09-01
CN118679154A (zh) 2024-09-20
MX2024010071A (es) 2024-08-20
TW202342438A (zh) 2023-11-01
CN118715212A (zh) 2024-09-27
UY40151A (es) 2023-09-15
JP2025507562A (ja) 2025-03-21
JP2025507561A (ja) 2025-03-21
KR20240152343A (ko) 2024-10-21
WO2023158771A1 (en) 2023-08-24
US20250154124A1 (en) 2025-05-15
TW202344496A (zh) 2023-11-16
PY2311482A (es) 2024-02-29
IL314649A (en) 2024-09-01

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