TW202334168A

TW202334168A - 大環化合物及其作為激酶抑制劑之用途

大環化合物及其作為激酶抑制劑之用途 Download PDF

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Publication number: TW202334168A
Authority: TW; Taiwan
Prior art keywords: alkyl; pharmaceutically acceptable; compound; acceptable salt; group
Prior art date: 2022-01-05

Application number

TW112100378A

Other languages

English (en)

Chinese (zh)

Inventor

景榮崔

元金芮

伊凡Ｗ羅傑斯

大勇翟

Original Assignee

美商榮山醫藥股份有限公司

Priority date

2022-01-05

Filing date

2023-01-05

Publication date

2023-09-01

2023-01-05 Application filed by 美商榮山醫藥股份有限公司 filed Critical 美商榮山醫藥股份有限公司

2023-09-01 Publication of TW202334168A publication Critical patent/TW202334168A/zh

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238000000034 method Methods 0.000 claims abstract description 34
201000010099 disease Diseases 0.000 claims abstract description 33
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 33
208000023275 Autoimmune disease Diseases 0.000 claims abstract description 22
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 19
150000001875 compounds Chemical class 0.000 claims description 168
125000000217 alkyl group Chemical group 0.000 claims description 161
229910052799 carbon Inorganic materials 0.000 claims description 139
229910052739 hydrogen Inorganic materials 0.000 claims description 121
150000003839 salts Chemical class 0.000 claims description 115
YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 78
229910052805 deuterium Inorganic materials 0.000 claims description 78
125000000592 heterocycloalkyl group Chemical group 0.000 claims description 73
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150000002367 halogens Chemical class 0.000 claims description 60
229910052736 halogen Inorganic materials 0.000 claims description 58
125000003118 aryl group Chemical group 0.000 claims description 57
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 54
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238000006467 substitution reaction Methods 0.000 claims description 33
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238000011282 treatment Methods 0.000 claims description 22
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239000001301 oxygen Substances 0.000 claims description 17
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239000003814 drug Substances 0.000 claims description 14
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ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 10
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125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 9
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125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 6
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239000001257 hydrogen Substances 0.000 claims description 3
125000006568 (C4-C7) heterocycloalkyl group Chemical group 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims description 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
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