JP2025503592A - 大環状化合物およびキナーゼ阻害剤としての使用 - Google Patents
大環状化合物およびキナーゼ阻害剤としての使用 Download PDFInfo
- Publication number
- JP2025503592A JP2025503592A JP2024540747A JP2024540747A JP2025503592A JP 2025503592 A JP2025503592 A JP 2025503592A JP 2024540747 A JP2024540747 A JP 2024540747A JP 2024540747 A JP2024540747 A JP 2024540747A JP 2025503592 A JP2025503592 A JP 2025503592A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharma
- acceptable salt
- ceutically acceptable
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263296705P | 2022-01-05 | 2022-01-05 | |
| US63/296,705 | 2022-01-05 | ||
| US202263435654P | 2022-12-28 | 2022-12-28 | |
| US63/435,654 | 2022-12-28 | ||
| PCT/US2023/060039 WO2023133375A1 (en) | 2022-01-05 | 2023-01-03 | Macrocyclic compounds and use as kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025503592A true JP2025503592A (ja) | 2025-02-04 |
| JP2025503592A5 JP2025503592A5 (https=) | 2026-01-14 |
Family
ID=87074235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024540747A Pending JP2025503592A (ja) | 2022-01-05 | 2023-01-03 | 大環状化合物およびキナーゼ阻害剤としての使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20250074920A1 (https=) |
| EP (1) | EP4460498A4 (https=) |
| JP (1) | JP2025503592A (https=) |
| KR (1) | KR20240131416A (https=) |
| AU (1) | AU2023204770A1 (https=) |
| CA (1) | CA3246487A1 (https=) |
| IL (1) | IL314070A (https=) |
| MX (1) | MX2024008413A (https=) |
| TW (1) | TW202334168A (https=) |
| WO (1) | WO2023133375A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2024266587A1 (en) * | 2023-05-02 | 2025-09-11 | Blossomhill Therapeutics, Inc. | Egfr inhibitors for treating disease |
| WO2025212729A1 (en) * | 2024-04-03 | 2025-10-09 | Blossomhill Therapeutics, Inc. | Macrocyclic compounds and their use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ME03376B (me) * | 2010-05-20 | 2020-01-20 | Array Biopharma Inc | Makrociklička jedinjenja kао inhibiтori trk kinaze |
| US20160031888A1 (en) * | 2013-03-13 | 2016-02-04 | Boston Biomedical, Inc. | 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer |
| ES2933350T3 (es) * | 2014-01-24 | 2023-02-06 | Turning Point Therapeutics Inc | Macrociclos de diarilo como moduladores de proteína quinasas |
| TWI707852B (zh) * | 2015-09-02 | 2020-10-21 | 美商林伯士拉克許米公司 | Tyk2 抑制劑及其用途 |
| EP4178958A4 (en) * | 2020-07-10 | 2024-12-11 | Blossomhill Therapeutics, Inc. | MACROCYCLES AND THEIR USE |
-
2023
- 2023-01-03 AU AU2023204770A patent/AU2023204770A1/en active Pending
- 2023-01-03 WO PCT/US2023/060039 patent/WO2023133375A1/en not_active Ceased
- 2023-01-03 MX MX2024008413A patent/MX2024008413A/es unknown
- 2023-01-03 KR KR1020247025807A patent/KR20240131416A/ko active Pending
- 2023-01-03 CA CA3246487A patent/CA3246487A1/en active Pending
- 2023-01-03 JP JP2024540747A patent/JP2025503592A/ja active Pending
- 2023-01-03 EP EP23737695.9A patent/EP4460498A4/en active Pending
- 2023-01-03 US US18/725,951 patent/US20250074920A1/en active Pending
- 2023-01-03 IL IL314070A patent/IL314070A/en unknown
- 2023-01-05 TW TW112100378A patent/TW202334168A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3246487A1 (en) | 2023-07-13 |
| MX2024008413A (es) | 2024-09-17 |
| US20250074920A1 (en) | 2025-03-06 |
| TW202334168A (zh) | 2023-09-01 |
| EP4460498A1 (en) | 2024-11-13 |
| EP4460498A4 (en) | 2026-03-25 |
| AU2023204770A1 (en) | 2024-07-18 |
| KR20240131416A (ko) | 2024-08-30 |
| WO2023133375A1 (en) | 2023-07-13 |
| IL314070A (en) | 2024-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20260105 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20260105 |