TW202330923A

TW202330923A - 用於預防及／或治療ｃｏｖｉｄ－１９之組成物和方法

用於預防及／或治療ｃｏｖｉｄ－１９之組成物和方法 Download PDF

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Publication number: TW202330923A
Authority: TW; Taiwan
Prior art keywords: nucleic acid; mol; oxy; methyl; bis
Prior art date: 2021-09-28

Application number

TW111136145A

Other languages

English (en)

Chinese (zh)

Inventor

艾瑞克馬爾庫森

朱麥艾比奧

納塔利亞馬汀歐洛茲克

有田祐子

Original Assignee

加拿大商普羅維登斯醫療控股公司

Priority date

2021-09-28

Filing date

2022-09-23

Publication date

2023-08-01

2022-09-23 Application filed by 加拿大商普羅維登斯醫療控股公司 filed Critical 加拿大商普羅維登斯醫療控股公司

2023-08-01 Publication of TW202330923A publication Critical patent/TW202330923A/zh

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SVTXPUOSPIOBGE-BENRWUELSA-N ethyl (z)-19-(dimethylamino)heptacos-9-enoate Chemical compound CCCCCCCCC(N(C)C)CCCCCCCC\C=C/CCCCCCCC(=O)OCC SVTXPUOSPIOBGE-BENRWUELSA-N 0.000 description 1
HXYWULKDHNHOSX-OWBHPGMISA-N ethyl (z)-21-[(dimethylamino)methyl]triacont-9-enoate Chemical compound CCCCCCCCCC(CN(C)C)CCCCCCCCCC\C=C/CCCCCCCC(=O)OCC HXYWULKDHNHOSX-OWBHPGMISA-N 0.000 description 1
GOFHROMUNWMCLI-UHFFFAOYSA-N ethyl 6-[2-[9-(dimethylamino)heptadecyl]cyclopropyl]hexanoate Chemical compound CCCCCCCCC(N(C)C)CCCCCCCCC1CC1CCCCCC(=O)OCC GOFHROMUNWMCLI-UHFFFAOYSA-N 0.000 description 1
CEPFTOYXIDDHOR-UHFFFAOYSA-N ethyl 6-[2-[9-(dimethylamino)hexadecyl]cyclopropyl]hexanoate Chemical compound CCCCCCCC(N(C)C)CCCCCCCCC1CC1CCCCCC(=O)OCC CEPFTOYXIDDHOR-UHFFFAOYSA-N 0.000 description 1
LKYCMNHGQAUQAG-UHFFFAOYSA-N ethyl 6-[2-[9-(dimethylamino)octadecyl]cyclopropyl]hexanoate Chemical compound CCCCCCCCCC(N(C)C)CCCCCCCCC1CC1CCCCCC(=O)OCC LKYCMNHGQAUQAG-UHFFFAOYSA-N 0.000 description 1
KQRJZVHSTOFHME-UHFFFAOYSA-N ethyl 6-[2-[9-[(dimethylamino)methyl]heptadecyl]cyclopropyl]hexanoate Chemical compound CCCCCCCCC(CN(C)C)CCCCCCCCC1CC1CCCCCC(=O)OCC KQRJZVHSTOFHME-UHFFFAOYSA-N 0.000 description 1
MVFUZUMRKXTYKI-UHFFFAOYSA-N ethyl 6-[2-[9-[(dimethylamino)methyl]octadecyl]cyclopropyl]hexanoate Chemical compound CCCCCCCCCC(CN(C)C)CCCCCCCCC1CC1CCCCCC(=O)OCC MVFUZUMRKXTYKI-UHFFFAOYSA-N 0.000 description 1
CHRHYFMHCCKVTQ-UHFFFAOYSA-N ethyl 8-[2-[7-(dimethylamino)hexadecyl]cyclopropyl]octanoate Chemical compound CCCCCCCCCC(N(C)C)CCCCCCC1CC1CCCCCCCC(=O)OCC CHRHYFMHCCKVTQ-UHFFFAOYSA-N 0.000 description 1
MFEBYDNFRLWUTK-UHFFFAOYSA-N ethyl 8-[2-[7-[(dimethylamino)methyl]hexadecyl]cyclopropyl]octanoate Chemical compound CCCCCCCCCC(CN(C)C)CCCCCCC1CC1CCCCCCCC(=O)OCC MFEBYDNFRLWUTK-UHFFFAOYSA-N 0.000 description 1
XWXPVCFRRZJODH-UHFFFAOYSA-N ethyl 8-[2-[9-(dimethylamino)heptadecyl]cyclopropyl]octanoate Chemical compound CCCCCCCCC(N(C)C)CCCCCCCCC1CC1CCCCCCCC(=O)OCC XWXPVCFRRZJODH-UHFFFAOYSA-N 0.000 description 1
YLWJMTMECIMSTM-UHFFFAOYSA-N ethyl 8-[2-[9-(dimethylamino)hexadecyl]cyclopropyl]octanoate Chemical compound CCCCCCCC(N(C)C)CCCCCCCCC1CC1CCCCCCCC(=O)OCC YLWJMTMECIMSTM-UHFFFAOYSA-N 0.000 description 1
RSKKVNQPLHHMRZ-UHFFFAOYSA-N ethyl 8-[2-[9-(dimethylamino)octadecyl]cyclopropyl]octanoate Chemical compound CCCCCCCCCC(N(C)C)CCCCCCCCC1CC1CCCCCCCC(=O)OCC RSKKVNQPLHHMRZ-UHFFFAOYSA-N 0.000 description 1
PTYXCNHTKUQRRJ-UHFFFAOYSA-N ethyl 8-[2-[9-(dimethylamino)pentadecyl]cyclopropyl]octanoate Chemical compound CCCCCCC(N(C)C)CCCCCCCCC1CC1CCCCCCCC(=O)OCC PTYXCNHTKUQRRJ-UHFFFAOYSA-N 0.000 description 1
OXNHQCNPMUMHKM-UHFFFAOYSA-N ethyl 8-[2-[9-[(dimethylamino)methyl]heptadecyl]cyclopropyl]octanoate Chemical compound CCCCCCCCC(CN(C)C)CCCCCCCCC1CC1CCCCCCCC(=O)OCC OXNHQCNPMUMHKM-UHFFFAOYSA-N 0.000 description 1
GLJZVMUAUMABEZ-UHFFFAOYSA-N ethyl 8-[2-[9-[(dimethylamino)methyl]hexadecyl]cyclopropyl]octanoate Chemical compound CCCCCCCC(CN(C)C)CCCCCCCCC1CC1CCCCCCCC(=O)OCC GLJZVMUAUMABEZ-UHFFFAOYSA-N 0.000 description 1
UFZQOIHCYHMZJJ-UHFFFAOYSA-N ethyl 8-[2-[9-[(dimethylamino)methyl]octadecyl]cyclopropyl]octanoate Chemical compound CCCCCCCCCC(CN(C)C)CCCCCCCCC1CC1CCCCCCCC(=O)OCC UFZQOIHCYHMZJJ-UHFFFAOYSA-N 0.000 description 1
DTGGPPXRKNULQV-UHFFFAOYSA-N ethyl 8-[2-[9-[(dimethylamino)methyl]pentadecyl]cyclopropyl]octanoate Chemical compound CCCCCCC(CN(C)C)CCCCCCCCC1CC1CCCCCCCC(=O)OCC DTGGPPXRKNULQV-UHFFFAOYSA-N 0.000 description 1
LVGKNOAMLMIIKO-UHFFFAOYSA-N ethyl octadec-9-enoate Chemical compound CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 description 1
230000017188 evasion or tolerance of host immune response Effects 0.000 description 1
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238000002474 experimental method Methods 0.000 description 1
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239000012467 final product Substances 0.000 description 1
235000004426 flaxseed Nutrition 0.000 description 1
238000000684 flow cytometry Methods 0.000 description 1
125000001153 fluoro group Chemical group F* 0.000 description 1
ZHNUHDYFZUAESO-UHFFFAOYSA-N formamide Substances NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 1
239000013022 formulation composition Substances 0.000 description 1
230000000799 fusogenic effect Effects 0.000 description 1
150000002270 gangliosides Chemical class 0.000 description 1
238000001502 gel electrophoresis Methods 0.000 description 1
229930195712 glutamate Natural products 0.000 description 1
229940049906 glutamate Drugs 0.000 description 1
150000002306 glutamic acid derivatives Chemical class 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
235000021312 gluten Nutrition 0.000 description 1
229960004956 glycerylphosphorylcholine Drugs 0.000 description 1
125000003827 glycol group Chemical group 0.000 description 1
230000013595 glycosylation Effects 0.000 description 1
238000006206 glycosylation reaction Methods 0.000 description 1
RQFCJASXJCIDSX-UUOKFMHZSA-N guanosine 5'-monophosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O RQFCJASXJCIDSX-UUOKFMHZSA-N 0.000 description 1
210000004209 hair Anatomy 0.000 description 1
125000005843 halogen group Chemical group 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
231100000869 headache Toxicity 0.000 description 1
210000002216 heart Anatomy 0.000 description 1
YCOZIPAWZNQLMR-UHFFFAOYSA-N heptane - octane Natural products CCCCCCCCCCCCCCC YCOZIPAWZNQLMR-UHFFFAOYSA-N 0.000 description 1
QEKCBKVWQYEUGY-UHFFFAOYSA-N heptyl hexanoate Chemical compound CCCCCCCOC(=O)CCCCC QEKCBKVWQYEUGY-UHFFFAOYSA-N 0.000 description 1
125000005446 heptyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 description 1
125000005842 heteroatom Chemical group 0.000 description 1
125000000623 heterocyclic group Chemical group 0.000 description 1
FBPFZTCFMRRESA-UHFFFAOYSA-N hexane-1,2,3,4,5,6-hexol Chemical compound OCC(O)C(O)C(O)C(O)CO FBPFZTCFMRRESA-UHFFFAOYSA-N 0.000 description 1
235000012907 honey Nutrition 0.000 description 1
235000020256 human milk Nutrition 0.000 description 1
210000004251 human milk Anatomy 0.000 description 1
229920002674 hyaluronan Polymers 0.000 description 1
229960003160 hyaluronic acid Drugs 0.000 description 1
229960002773 hyaluronidase Drugs 0.000 description 1
150000002430 hydrocarbons Chemical group 0.000 description 1
210000002865 immune cell Anatomy 0.000 description 1
238000003018 immunoassay Methods 0.000 description 1
238000003364 immunohistochemistry Methods 0.000 description 1
239000003547 immunosorbent Substances 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000000099 in vitro assay Methods 0.000 description 1
238000005462 in vivo assay Methods 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
230000006698 induction Effects 0.000 description 1
239000012678 infectious agent Substances 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000015788 innate immune response Effects 0.000 description 1
229940125396 insulin Drugs 0.000 description 1
229940047122 interleukins Drugs 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
238000002372 labelling Methods 0.000 description 1
238000011031 large-scale manufacturing process Methods 0.000 description 1
239000003446 ligand Substances 0.000 description 1
IIYFAKIEWZDVMP-UHFFFAOYSA-N linear paraffin C13 Natural products CCCCCCCCCCCCC IIYFAKIEWZDVMP-UHFFFAOYSA-N 0.000 description 1
235000020778 linoleic acid Nutrition 0.000 description 1
DTOSIQBPPRVQHS-PDBXOOCHSA-M linolenate Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC([O-])=O DTOSIQBPPRVQHS-PDBXOOCHSA-M 0.000 description 1
KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 1
108010051201 lipid I Proteins 0.000 description 1
125000003473 lipid group Chemical group 0.000 description 1
210000005229 liver cell Anatomy 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
210000002751 lymph Anatomy 0.000 description 1
229960003646 lysine Drugs 0.000 description 1
150000002669 lysines Chemical class 0.000 description 1
VLBPIWYTPAXCFJ-XMMPIXPASA-N lysophosphatidylcholine O-16:0/0:0 Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](O)COP([O-])(=O)OCC[N+](C)(C)C VLBPIWYTPAXCFJ-XMMPIXPASA-N 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
125000002960 margaryl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
238000004949 mass spectrometry Methods 0.000 description 1
238000013178 mathematical model Methods 0.000 description 1
HLZXTFWTDIBXDF-UHFFFAOYSA-N mcm5sU Natural products COC(=O)Cc1cn(C2OC(CO)C(O)C2O)c(=S)[nH]c1=O HLZXTFWTDIBXDF-UHFFFAOYSA-N 0.000 description 1
230000002175 menstrual effect Effects 0.000 description 1
229960001252 methamphetamine Drugs 0.000 description 1
MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
SALHOVCUAISLEP-LUAWRHEFSA-N methyl (z)-16-[2-(dimethylamino)-3-heptoxypropoxy]hexadec-7-enoate Chemical compound CCCCCCCOCC(N(C)C)COCCCCCCCC\C=C/CCCCCC(=O)OC SALHOVCUAISLEP-LUAWRHEFSA-N 0.000 description 1
MKOPQGOLLWSFNH-LUAWRHEFSA-N methyl (z)-16-[2-(dimethylamino)-3-hexoxypropoxy]hexadec-7-enoate Chemical compound CCCCCCOCC(N(C)C)COCCCCCCCC\C=C/CCCCCC(=O)OC MKOPQGOLLWSFNH-LUAWRHEFSA-N 0.000 description 1
UTEHHFHXPJIZGB-LUAWRHEFSA-N methyl (z)-17-[2-(dimethylamino)-3-octoxypropoxy]heptadec-8-enoate Chemical compound CCCCCCCCOCC(N(C)C)COCCCCCCCC\C=C/CCCCCCC(=O)OC UTEHHFHXPJIZGB-LUAWRHEFSA-N 0.000 description 1
NLWSVJBGMGALFA-LUAWRHEFSA-N methyl (z)-19-(dimethylamino)heptacos-9-enoate Chemical compound CCCCCCCCC(N(C)C)CCCCCCCC\C=C/CCCCCCCC(=O)OC NLWSVJBGMGALFA-LUAWRHEFSA-N 0.000 description 1
GROYRLVQQIOMDZ-LUAWRHEFSA-N methyl (z)-19-[(dimethylamino)methyl]heptacos-9-enoate Chemical compound CCCCCCCCC(CN(C)C)CCCCCCCC\C=C/CCCCCCCC(=O)OC GROYRLVQQIOMDZ-LUAWRHEFSA-N 0.000 description 1
HKAIEGLTCJPXKR-QBFSEMIESA-N methyl (z)-21-(dimethylamino)nonacos-9-enoate Chemical compound CCCCCCCCC(N(C)C)CCCCCCCCCC\C=C/CCCCCCCC(=O)OC HKAIEGLTCJPXKR-QBFSEMIESA-N 0.000 description 1
AFOCBPLEWCCESK-BENRWUELSA-N methyl (z)-21-[(dimethylamino)methyl]heptacos-9-enoate Chemical compound CCCCCCC(CN(C)C)CCCCCCCCCC\C=C/CCCCCCCC(=O)OC AFOCBPLEWCCESK-BENRWUELSA-N 0.000 description 1
IAGXVAGJKRZUMA-QBFSEMIESA-N methyl (z)-21-[2-(dimethylamino)ethyl]triacont-9-enoate Chemical compound CCCCCCCCCC(CCN(C)C)CCCCCCCCCC\C=C/CCCCCCCC(=O)OC IAGXVAGJKRZUMA-QBFSEMIESA-N 0.000 description 1
LSZCXBZHIRAFLB-UHFFFAOYSA-N methyl 10-[2-[7-(dimethylamino)hexadecyl]cyclopropyl]decanoate Chemical compound CCCCCCCCCC(N(C)C)CCCCCCC1CC1CCCCCCCCCC(=O)OC LSZCXBZHIRAFLB-UHFFFAOYSA-N 0.000 description 1
XOTXNXXJZCFUOA-UGKPPGOTSA-N methyl 2-[1-[(2r,3r,4r,5r)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]acetate Chemical compound CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(CC(=O)OC)=C1 XOTXNXXJZCFUOA-UGKPPGOTSA-N 0.000 description 1
AHIQDGXXLZVOGZ-UGKPPGOTSA-N methyl 3-[1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]prop-2-enoate Chemical compound O=C1NC(=O)C(C=CC(=O)OC)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 AHIQDGXXLZVOGZ-UGKPPGOTSA-N 0.000 description 1
RBGUZWYJBFOEHT-UTJQPWESSA-N methyl 4-[2-(dimethylamino)-3-[(9z,12z)-octadeca-9,12-dienoxy]propoxy]butanoate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCCOCC(N(C)C)COCCCC(=O)OC RBGUZWYJBFOEHT-UTJQPWESSA-N 0.000 description 1
FEPLDHDZJMDMNH-UHFFFAOYSA-N methyl 4-[2-(dimethylamino)-3-[8-(2-octylcyclopropyl)octoxy]propoxy]butanoate Chemical compound CCCCCCCCC1CC1CCCCCCCCOCC(COCCCC(=O)OC)N(C)C FEPLDHDZJMDMNH-UHFFFAOYSA-N 0.000 description 1
LMSPVNJLKPHPEY-SEYXRHQNSA-N methyl 5-[2-(dimethylamino)-3-[(z)-octadec-9-enoxy]propoxy]pentanoate Chemical compound CCCCCCCC\C=C/CCCCCCCCOCC(N(C)C)COCCCCC(=O)OC LMSPVNJLKPHPEY-SEYXRHQNSA-N 0.000 description 1
HAXQTUGIJJZBJD-UHFFFAOYSA-N methyl 5-[2-(dimethylamino)-3-[8-(2-octylcyclopropyl)octoxy]propoxy]pentanoate Chemical compound CCCCCCCCC1CC1CCCCCCCCOCC(COCCCCC(=O)OC)N(C)C HAXQTUGIJJZBJD-UHFFFAOYSA-N 0.000 description 1
FQUCFAWGXDRIKK-UHFFFAOYSA-N methyl 5-[2-(dimethylamino)-3-[8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octoxy]propoxy]pentanoate Chemical compound CCCCCC1CC1CC1C(CCCCCCCCOCC(COCCCCC(=O)OC)N(C)C)C1 FQUCFAWGXDRIKK-UHFFFAOYSA-N 0.000 description 1
GHBXPYPJURKOSS-SEYXRHQNSA-N methyl 6-[2-(dimethylamino)-3-[(z)-octadec-9-enoxy]propoxy]hexanoate Chemical compound CCCCCCCC\C=C/CCCCCCCCOCC(N(C)C)COCCCCCC(=O)OC GHBXPYPJURKOSS-SEYXRHQNSA-N 0.000 description 1
PHDWLOCIKVSIQS-UHFFFAOYSA-N methyl 6-[2-(dimethylamino)-3-[8-(2-octylcyclopropyl)octoxy]propoxy]hexanoate Chemical compound CCCCCCCCC1CC1CCCCCCCCOCC(COCCCCCC(=O)OC)N(C)C PHDWLOCIKVSIQS-UHFFFAOYSA-N 0.000 description 1
IDFNTXOYTBVDKX-UHFFFAOYSA-N methyl 6-[2-(dimethylamino)-3-[8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octoxy]propoxy]hexanoate Chemical compound CCCCCC1CC1CC1C(CCCCCCCCOCC(COCCCCCC(=O)OC)N(C)C)C1 IDFNTXOYTBVDKX-UHFFFAOYSA-N 0.000 description 1
IHHKTQHAGALEAD-UHFFFAOYSA-N methyl 6-[2-[8-[2-(dimethylamino)-3-hexoxypropoxy]octyl]cyclopropyl]hexanoate Chemical compound CCCCCCOCC(N(C)C)COCCCCCCCCC1CC1CCCCCC(=O)OC IHHKTQHAGALEAD-UHFFFAOYSA-N 0.000 description 1
IUBHULJBPNIKKK-UHFFFAOYSA-N methyl 7-[2-(dimethylamino)-3-[8-(2-octylcyclopropyl)octoxy]propoxy]heptanoate Chemical compound CCCCCCCCC1CC1CCCCCCCCOCC(COCCCCCCC(=O)OC)N(C)C IUBHULJBPNIKKK-UHFFFAOYSA-N 0.000 description 1
HPLLUCKKDZLRND-UHFFFAOYSA-N methyl 7-[2-(dimethylamino)-3-[8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octoxy]propoxy]heptanoate Chemical compound CCCCCC1CC1CC1C(CCCCCCCCOCC(COCCCCCCC(=O)OC)N(C)C)C1 HPLLUCKKDZLRND-UHFFFAOYSA-N 0.000 description 1
AXQCFIORDVKODQ-UHFFFAOYSA-N methyl 8-[2-(dimethylamino)-3-[8-(2-octylcyclopropyl)octoxy]propoxy]octanoate Chemical compound CCCCCCCCC1CC1CCCCCCCCOCC(COCCCCCCCC(=O)OC)N(C)C AXQCFIORDVKODQ-UHFFFAOYSA-N 0.000 description 1
UMGLSTWNVHKXHG-UHFFFAOYSA-N methyl 8-[2-[11-(dimethylamino)octadecyl]cyclopropyl]octanoate Chemical compound CCCCCCCC(N(C)C)CCCCCCCCCCC1CC1CCCCCCCC(=O)OC UMGLSTWNVHKXHG-UHFFFAOYSA-N 0.000 description 1
GXAIJCFWTDYUPH-UHFFFAOYSA-N methyl 8-[2-[9-(dimethylamino)hexadecyl]cyclopropyl]octanoate Chemical compound CCCCCCCC(N(C)C)CCCCCCCCC1CC1CCCCCCCC(=O)OC GXAIJCFWTDYUPH-UHFFFAOYSA-N 0.000 description 1
JZWGJQLKUWIPJD-UHFFFAOYSA-N methyl 8-[2-[9-(dimethylamino)octadecyl]cyclopropyl]octanoate Chemical compound CCCCCCCCCC(N(C)C)CCCCCCCCC1CC1CCCCCCCC(=O)OC JZWGJQLKUWIPJD-UHFFFAOYSA-N 0.000 description 1
QDDCTZDCABUBSA-UHFFFAOYSA-N methyl 8-[2-[9-(dimethylamino)pentadecyl]cyclopropyl]octanoate Chemical compound CCCCCCC(N(C)C)CCCCCCCCC1CC1CCCCCCCC(=O)OC QDDCTZDCABUBSA-UHFFFAOYSA-N 0.000 description 1
PIQQVIDIKKQJAW-UHFFFAOYSA-N methyl 8-[2-[9-[(dimethylamino)methyl]heptadecyl]cyclopropyl]octanoate Chemical compound CCCCCCCCC(CN(C)C)CCCCCCCCC1CC1CCCCCCCC(=O)OC PIQQVIDIKKQJAW-UHFFFAOYSA-N 0.000 description 1
DNGUJGGSBNKROR-UHFFFAOYSA-N methyl 8-[2-[9-[(dimethylamino)methyl]hexadecyl]cyclopropyl]octanoate Chemical compound CCCCCCCC(CN(C)C)CCCCCCCCC1CC1CCCCCCCC(=O)OC DNGUJGGSBNKROR-UHFFFAOYSA-N 0.000 description 1
VYHBATGIVKPGMA-UHFFFAOYSA-N methyl 8-[2-[9-[(dimethylamino)methyl]octadecyl]cyclopropyl]octanoate Chemical compound CCCCCCCCCC(CN(C)C)CCCCCCCCC1CC1CCCCCCCC(=O)OC VYHBATGIVKPGMA-UHFFFAOYSA-N 0.000 description 1
ZEKMEHSJHTXPHP-UHFFFAOYSA-N methyl 8-[2-[9-[(dimethylamino)methyl]pentadecyl]cyclopropyl]octanoate Chemical compound CCCCCCC(CN(C)C)CCCCCCCCC1CC1CCCCCCCC(=O)OC ZEKMEHSJHTXPHP-UHFFFAOYSA-N 0.000 description 1
SYHJIULZELWDNL-UHFFFAOYSA-N methyl 8-[2-[9-[2-(dimethylamino)ethyl]heptadecyl]cyclopropyl]octanoate Chemical compound CCCCCCCCC(CCN(C)C)CCCCCCCCC1CC1CCCCCCCC(=O)OC SYHJIULZELWDNL-UHFFFAOYSA-N 0.000 description 1
QVGMAKGMJGJZIP-UHFFFAOYSA-N methyl 8-[2-[9-[2-(dimethylamino)ethyl]hexadecyl]cyclopropyl]octanoate Chemical compound CCCCCCCC(CCN(C)C)CCCCCCCCC1CC1CCCCCCCC(=O)OC QVGMAKGMJGJZIP-UHFFFAOYSA-N 0.000 description 1
CAAULPUQFIIOTL-UHFFFAOYSA-N methyl dihydrogen phosphate Chemical compound COP(O)(O)=O CAAULPUQFIIOTL-UHFFFAOYSA-N 0.000 description 1
ZWNPUELCBZVMDA-UHFFFAOYSA-N methyl non-2-enoate Chemical compound CCCCCCC=CC(=O)OC ZWNPUELCBZVMDA-UHFFFAOYSA-N 0.000 description 1
230000011987 methylation Effects 0.000 description 1
YACKEPLHDIMKIO-UHFFFAOYSA-N methylphosphonic acid Chemical compound CP(O)(O)=O YACKEPLHDIMKIO-UHFFFAOYSA-N 0.000 description 1
239000000693 micelle Substances 0.000 description 1
101150084874 mimG gene Proteins 0.000 description 1
230000003278 mimic effect Effects 0.000 description 1
238000002156 mixing Methods 0.000 description 1
238000009126 molecular therapy Methods 0.000 description 1
210000001616 monocyte Anatomy 0.000 description 1
210000003097 mucus Anatomy 0.000 description 1
210000005012 myelin Anatomy 0.000 description 1
210000000066 myeloid cell Anatomy 0.000 description 1
XVUQPECVOGMPRU-ZPPAUJSGSA-N n,n-dimethyl-1,2-bis[(9z,12z)-octadeca-9,12-dienoxy]propan-1-amine Chemical compound CCCCC\C=C/C\C=C/CCCCCCCCOC(C)C(N(C)C)OCCCCCCCC\C=C/C\C=C/CCCCC XVUQPECVOGMPRU-ZPPAUJSGSA-N 0.000 description 1
SXIBBHQQGHVDTJ-UHFFFAOYSA-N n,n-dimethyl-1-octoxy-3-[8-(2-octylcyclopropyl)octoxy]propan-2-amine Chemical compound CCCCCCCCOCC(N(C)C)COCCCCCCCCC1CC1CCCCCCCC SXIBBHQQGHVDTJ-UHFFFAOYSA-N 0.000 description 1
UKXOXMLXFQEEQJ-KWXKLSQISA-N n,n-dimethyl-2,3-bis[[(9z,12z)-octadeca-9,12-dienyl]sulfanyl]propan-1-amine Chemical compound CCCCC\C=C/C\C=C/CCCCCCCCSCC(CN(C)C)SCCCCCCCC\C=C/C\C=C/CCCCC UKXOXMLXFQEEQJ-KWXKLSQISA-N 0.000 description 1
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