TW202328435A - 表現ｔｌｒ受體之經修飾的免疫細胞 - Google Patents

表現ｔｌｒ受體之經修飾的免疫細胞 Download PDF

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TW202328435A
TW202328435A TW111131118A TW111131118A TW202328435A TW 202328435 A TW202328435 A TW 202328435A TW 111131118 A TW111131118 A TW 111131118A TW 111131118 A TW111131118 A TW 111131118A TW 202328435 A TW202328435 A TW 202328435A
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Taiwan
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tlr
polypeptide
cells
modified immune
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TW111131118A
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Chinese (zh)
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朱延亮
蔣慶玲
涂中原
張亞峰
武術
曉虎 范
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大陸商南京傳奇生物科技有限公司
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TW111131118A 2021-08-18 2022-08-18 表現ｔｌｒ受體之經修飾的免疫細胞 TW202328435A (zh)

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Application Number Priority Date Filing Date Title
WOPCT/CN2021/113239 2021-08-18
CN2021113239 2021-08-18
CN2021122129 2021-09-30
WOPCT/CN2021/122129 2021-09-30
WOPCT/CN2021/133061 2021-11-25
CN2021133061 2021-11-25
WOPCT/CN2022/112578 2022-08-15
CN2022112578 2022-08-15

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US (1) US20240350545A1 (https=)
EP (1) EP4392463A4 (https=)
JP (1) JP2024534783A (https=)
KR (1) KR20240055733A (https=)
CN (1) CN117580870A (https=)
AU (1) AU2022330883A1 (https=)
CA (1) CA3229493A1 (https=)
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WO2024251225A1 (en) * 2023-06-07 2024-12-12 Nanjing Legend Biotech Co., Ltd. Rapamycin resistant cells and methods of use thereof
WO2025011462A1 (en) * 2023-07-07 2025-01-16 Overland Therapeutics (Us) Inc. Single domain antibodies for gprc5d

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GB201513540D0 (en) * 2015-07-31 2015-09-16 King S College London Therapeutic agents
US10093717B2 (en) * 2015-08-07 2018-10-09 Shenzhen In Vivo Biomedicine Technology Limited Company Chimeric antigen receptor containing a toll-like receptor intracellular domain
CN106220736B (zh) * 2016-07-20 2020-01-10 深圳市体内生物医药科技有限公司 一种嵌合抗原受体、表达其的细胞及其制备方法和用途
MA46862A (fr) * 2016-11-17 2019-09-25 Bluebird Bio Inc Convertisseur de signaux tgf béta
CN106749675B (zh) * 2016-12-27 2022-05-27 深圳市体内生物医药科技有限公司 一种重组慢病毒及其应用
WO2020140973A1 (en) * 2019-01-03 2020-07-09 Nanjing Legend Biotech Co., Ltd. Modified immune cells expressing flagellin polypeptide
WO2020183158A1 (en) * 2019-03-11 2020-09-17 Leucid Bio Ltd MUC1 PARALLEL CAR (pCAR) THERAPEUTIC AGENTS
CN110904048A (zh) * 2019-12-04 2020-03-24 合肥中科干细胞再生医学有限公司 一种car-cd123t2嵌合抗原受体t细胞及其应用
CN111875710A (zh) * 2020-07-31 2020-11-03 广东昭泰体内生物医药科技有限公司 异质性肿瘤治疗用免疫细胞及其应用
CN112210018A (zh) * 2020-10-12 2021-01-12 广东昭泰体内生物医药科技有限公司 一种靶向gpc3的嵌合抗原受体及其应用

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