JP2024534783A - Tlr受容体を発現する改変された免疫細胞 - Google Patents

Tlr受容体を発現する改変された免疫細胞 Download PDF

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JP2024534783A
JP2024534783A JP2024509014A JP2024509014A JP2024534783A JP 2024534783 A JP2024534783 A JP 2024534783A JP 2024509014 A JP2024509014 A JP 2024509014A JP 2024509014 A JP2024509014 A JP 2024509014A JP 2024534783 A JP2024534783 A JP 2024534783A
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tlr
polypeptide
cells
modified immune
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ヤンリャン シュ
チンリン ジャン
ジョンユアン トゥ
ヤーフェン ジャン
シュウ ウー
シャオフ ファン
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レジェンド バイオテック アイルランド リミテッド
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JP2024509014A 2021-08-18 2022-08-18 Tlr受容体を発現する改変された免疫細胞 Pending JP2024534783A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
CNPCT/CN2021/113239 2021-08-18
CN2021113239 2021-08-18
CN2021122129 2021-09-30
CNPCT/CN2021/122129 2021-09-30
CN2021133061 2021-11-25
CNPCT/CN2021/133061 2021-11-25
CN2022112578 2022-08-15
CNPCT/CN2022/112578 2022-08-15
PCT/CN2022/113170 WO2023020558A1 (en) 2021-08-18 2022-08-18 Modified immune cells expressing tlr receptors

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JP2024534783A true JP2024534783A (ja) 2024-09-26
JP2024534783A5 JP2024534783A5 (https=) 2025-08-15

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CA (1) CA3229493A1 (https=)
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WO2024251225A1 (en) * 2023-06-07 2024-12-12 Nanjing Legend Biotech Co., Ltd. Rapamycin resistant cells and methods of use thereof
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GB201513540D0 (en) * 2015-07-31 2015-09-16 King S College London Therapeutic agents
US10093717B2 (en) * 2015-08-07 2018-10-09 Shenzhen In Vivo Biomedicine Technology Limited Company Chimeric antigen receptor containing a toll-like receptor intracellular domain
CN106220736B (zh) * 2016-07-20 2020-01-10 深圳市体内生物医药科技有限公司 一种嵌合抗原受体、表达其的细胞及其制备方法和用途
MA46862A (fr) * 2016-11-17 2019-09-25 Bluebird Bio Inc Convertisseur de signaux tgf béta
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WO2020140973A1 (en) * 2019-01-03 2020-07-09 Nanjing Legend Biotech Co., Ltd. Modified immune cells expressing flagellin polypeptide
WO2020183158A1 (en) * 2019-03-11 2020-09-17 Leucid Bio Ltd MUC1 PARALLEL CAR (pCAR) THERAPEUTIC AGENTS
CN110904048A (zh) * 2019-12-04 2020-03-24 合肥中科干细胞再生医学有限公司 一种car-cd123t2嵌合抗原受体t细胞及其应用
CN111875710A (zh) * 2020-07-31 2020-11-03 广东昭泰体内生物医药科技有限公司 异质性肿瘤治疗用免疫细胞及其应用
CN112210018A (zh) * 2020-10-12 2021-01-12 广东昭泰体内生物医药科技有限公司 一种靶向gpc3的嵌合抗原受体及其应用

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