CA3229493A1 - Modified immune cells expressing tlr receptors - Google Patents

Modified immune cells expressing tlr receptors Download PDF

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Publication number
CA3229493A1
CA3229493A1 CA3229493A CA3229493A CA3229493A1 CA 3229493 A1 CA3229493 A1 CA 3229493A1 CA 3229493 A CA3229493 A CA 3229493A CA 3229493 A CA3229493 A CA 3229493A CA 3229493 A1 CA3229493 A1 CA 3229493A1
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Canada
Prior art keywords
domain
cell
tlr
polypeptide
modified immune
Prior art date
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Pending
Application number
CA3229493A
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English (en)
French (fr)
Inventor
Yanliang ZHU
Qingling JIANG
Zhongyuan TU
Yafeng Zhang
Shu Wu
Xiaohu FAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Legend Biotech Ireland Ltd
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Legend Biotech Ireland Ltd
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Application filed by Legend Biotech Ireland Ltd filed Critical Legend Biotech Ireland Ltd
Publication of CA3229493A1 publication Critical patent/CA3229493A1/en
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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CA3229493A 2021-08-18 2022-08-18 Modified immune cells expressing tlr receptors Pending CA3229493A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
CNPCT/CN2021/113239 2021-08-18
CN2021113239 2021-08-18
CN2021122129 2021-09-30
CNPCT/CN2021/122129 2021-09-30
CN2021133061 2021-11-25
CNPCT/CN2021/133061 2021-11-25
CN2022112578 2022-08-15
CNPCT/CN2022/112578 2022-08-15
PCT/CN2022/113170 WO2023020558A1 (en) 2021-08-18 2022-08-18 Modified immune cells expressing tlr receptors

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CA3229493A1 true CA3229493A1 (en) 2023-02-23

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CA3229493A Pending CA3229493A1 (en) 2021-08-18 2022-08-18 Modified immune cells expressing tlr receptors

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US (1) US20240350545A1 (https=)
EP (1) EP4392463A4 (https=)
JP (1) JP2024534783A (https=)
KR (1) KR20240055733A (https=)
CN (1) CN117580870A (https=)
AU (1) AU2022330883A1 (https=)
CA (1) CA3229493A1 (https=)
TW (1) TW202328435A (https=)
WO (1) WO2023020558A1 (https=)

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WO2024251225A1 (en) * 2023-06-07 2024-12-12 Nanjing Legend Biotech Co., Ltd. Rapamycin resistant cells and methods of use thereof
WO2025011462A1 (en) * 2023-07-07 2025-01-16 Overland Therapeutics (Us) Inc. Single domain antibodies for gprc5d

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GB201513540D0 (en) * 2015-07-31 2015-09-16 King S College London Therapeutic agents
US10093717B2 (en) * 2015-08-07 2018-10-09 Shenzhen In Vivo Biomedicine Technology Limited Company Chimeric antigen receptor containing a toll-like receptor intracellular domain
CN106220736B (zh) * 2016-07-20 2020-01-10 深圳市体内生物医药科技有限公司 一种嵌合抗原受体、表达其的细胞及其制备方法和用途
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