TW202321450A - 一種核酸、含有該核酸的組合物與綴合物及製備方法和用途 - Google Patents

一種核酸、含有該核酸的組合物與綴合物及製備方法和用途 Download PDF

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TW202321450A
TW202321450A TW111126698A TW111126698A TW202321450A TW 202321450 A TW202321450 A TW 202321450A TW 111126698 A TW111126698 A TW 111126698A TW 111126698 A TW111126698 A TW 111126698A TW 202321450 A TW202321450 A TW 202321450A
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nucleotide sequence
nucleotide
sirna
cdata
seq
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TW111126698A
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子才 梁
鴻雁 張
高山
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大陸商蘇州瑞博生物技術股份有限公司
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2320/30—Special therapeutic applications
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TW111126698A 2021-07-16 2022-07-15 一種核酸、含有該核酸的組合物與綴合物及製備方法和用途 TW202321450A (zh)

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CN202110807464 2021-07-16

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TW202321450A true TW202321450A (zh) 2023-06-01

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US (1) US20240325428A1 (https=)
EP (1) EP4372085A4 (https=)
JP (1) JP2024525800A (https=)
KR (1) KR20240034787A (https=)
CN (2) CN117580953B (https=)
AU (1) AU2022309416A1 (https=)
CA (1) CA3225015A1 (https=)
MX (1) MX2024000650A (https=)
TW (1) TW202321450A (https=)
WO (1) WO2023284559A1 (https=)

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Publication number Priority date Publication date Assignee Title
CN119421952A (zh) * 2022-06-27 2025-02-11 大睿生物医药科技(上海)有限公司 抑制载脂蛋白C3表达的siRNA
WO2024188174A1 (zh) * 2023-03-10 2024-09-19 苏州瑞博生物技术股份有限公司 一种药物组合物及其用途
TW202508607A (zh) * 2023-05-19 2025-03-01 大陸商北京炫景瑞醫藥科技有限公司 雙股寡核苷酸及其共軛物和用途

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WO2009073809A2 (en) 2007-12-04 2009-06-11 Alnylam Pharmaceuticals, Inc. Carbohydrate conjugates as delivery agents for oligonucleotides
US9023820B2 (en) * 2009-01-26 2015-05-05 Protiva Biotherapeutics, Inc. Compositions and methods for silencing apolipoprotein C-III expression
CN103380113B (zh) 2010-11-15 2018-03-30 生命科技公司 含胺的转染试剂及其制备和使用方法
AU2013299717B2 (en) 2012-08-06 2018-06-28 Alnylam Pharmaceuticals, Inc. Carbohydrate conjugated RNA agents and process for their preparation
EP3564374A1 (en) * 2013-06-21 2019-11-06 Ionis Pharmaceuticals, Inc. Compositions and methods for modulation of target nucleic acids
WO2015006740A2 (en) 2013-07-11 2015-01-15 Alnylam Pharmaceuticals, Inc. Oligonucleotide-ligand conjugates and process for their preparation
WO2015051366A2 (en) * 2013-10-04 2015-04-09 Novartis Ag Novel formats for organic compounds for use in rna interference
US20170051286A1 (en) * 2014-05-01 2017-02-23 Larry J. Smith METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
EP3736334A1 (en) * 2014-07-16 2020-11-11 Arrowhead Pharmaceuticals, Inc. Rnai compositions to treat apoc3-related diseases
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CN120330183A (zh) * 2017-06-02 2025-07-18 波涛生命科学有限公司 寡核苷酸组合物及其使用方法
KR20240161202A (ko) * 2017-09-11 2024-11-12 애로우헤드 파마슈티컬스 인코포레이티드 아포지단백질 C-III (APOC3)의 발현을 억제하기 위한 RNAi 작용제 및 조성물
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CN117580953A (zh) 2024-02-20
CN120989078A (zh) 2025-11-21
EP4372085A4 (en) 2026-01-21
AU2022309416A1 (en) 2024-02-01
CN117580953B (zh) 2025-07-18
WO2023284559A1 (zh) 2023-01-19
US20240325428A1 (en) 2024-10-03
EP4372085A1 (en) 2024-05-22
CA3225015A1 (en) 2023-01-19
KR20240034787A (ko) 2024-03-14
MX2024000650A (es) 2024-01-31
JP2024525800A (ja) 2024-07-12

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