TW202321450A - 一種核酸、含有該核酸的組合物與綴合物及製備方法和用途 - Google Patents

一種核酸、含有該核酸的組合物與綴合物及製備方法和用途 Download PDF

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TW202321450A
TW202321450A TW111126698A TW111126698A TW202321450A TW 202321450 A TW202321450 A TW 202321450A TW 111126698 A TW111126698 A TW 111126698A TW 111126698 A TW111126698 A TW 111126698A TW 202321450 A TW202321450 A TW 202321450A
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nucleotide sequence
nucleotide
sirna
cdata
seq
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TW111126698A
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Chinese (zh)
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子才 梁
鴻雁 張
高山
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大陸商蘇州瑞博生物技術股份有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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TW111126698A 2021-07-16 2022-07-15 一種核酸、含有該核酸的組合物與綴合物及製備方法和用途 TW202321450A (zh)

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CN202110807464 2021-07-16
CN202110807464.3 2021-07-16

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TW202321450A true TW202321450A (zh) 2023-06-01

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US (1) US20240325428A1 (https=)
EP (1) EP4372085A4 (https=)
JP (1) JP2024525800A (https=)
KR (1) KR20240034787A (https=)
CN (2) CN117580953B (https=)
AU (1) AU2022309416A1 (https=)
CA (1) CA3225015A1 (https=)
MX (1) MX2024000650A (https=)
TW (1) TW202321450A (https=)
WO (1) WO2023284559A1 (https=)

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JP2025520796A (ja) * 2022-06-27 2025-07-03 大睿生物 アポリポタンパク質Ｃ３発現を阻害するｓｉＲＮＡ
WO2024188174A1 (zh) * 2023-03-10 2024-09-19 苏州瑞博生物技术股份有限公司 一种药物组合物及其用途
TW202508607A (zh) * 2023-05-19 2025-03-01 大陸商北京炫景瑞醫藥科技有限公司 雙股寡核苷酸及其共軛物和用途

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WO2009082607A2 (en) 2007-12-04 2009-07-02 Alnylam Pharmaceuticals, Inc. Targeting lipids
CA2750561C (en) * 2009-01-26 2017-10-10 Protiva Biotherapeutics, Inc. Compositions and methods for silencing apolipoprotein c-iii expression
US20120136073A1 (en) 2010-11-15 2012-05-31 Life Technologies Corporation Amine-Containing Transfection Reagents and methods for making and using same
AU2013299717B2 (en) 2012-08-06 2018-06-28 Alnylam Pharmaceuticals, Inc. Carbohydrate conjugated RNA agents and process for their preparation
EP3564374A1 (en) * 2013-06-21 2019-11-06 Ionis Pharmaceuticals, Inc. Compositions and methods for modulation of target nucleic acids
JP6702862B2 (ja) 2013-07-11 2020-06-03 アルニラム ファーマスーティカルズ インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オリゴヌクレオチド−リガンドコンジュゲートおよびそれらの調製方法
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JP2018511555A (ja) * 2015-02-27 2018-04-26 アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． リポジストロフィー集団におけるアポリポタンパク質Ｃ−ＩＩＩ（ＡｐｏＣＩＩＩ）発現の調節
JP2020522265A (ja) * 2017-06-02 2020-07-30 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． オリゴヌクレオチド組成物及びその使用方法
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JP2024525800A (ja) 2024-07-12
EP4372085A1 (en) 2024-05-22
KR20240034787A (ko) 2024-03-14
CN117580953B (zh) 2025-07-18
MX2024000650A (es) 2024-01-31
AU2022309416A1 (en) 2024-02-01
EP4372085A4 (en) 2026-01-21
WO2023284559A1 (zh) 2023-01-19
CN120989078A (zh) 2025-11-21
CN117580953A (zh) 2024-02-20
CA3225015A1 (en) 2023-01-19
US20240325428A1 (en) 2024-10-03

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