TW202308665A - 雙鏈寡核苷酸、含雙鏈寡核苷酸的組合物與綴合物及製備方法和用途 - Google Patents
雙鏈寡核苷酸、含雙鏈寡核苷酸的組合物與綴合物及製備方法和用途 Download PDFInfo
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| CN117384907A (zh) * | 2023-12-11 | 2024-01-12 | 上海鼎新基因科技有限公司 | 抑制PCSK9表达的siRNA分子及其应用 |
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| US11597744B2 (en) | 2017-06-30 | 2023-03-07 | Sirius Therapeutics, Inc. | Chiral phosphoramidite auxiliaries and methods of their use |
| JP7606758B2 (ja) * | 2019-05-22 | 2024-12-26 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、薬物組成物及び複合体ならびに調製方法と使用 |
| CN119421952A (zh) * | 2022-06-27 | 2025-02-11 | 大睿生物医药科技(上海)有限公司 | 抑制载脂蛋白C3表达的siRNA |
| WO2024140101A1 (zh) * | 2022-12-28 | 2024-07-04 | 北京炫景瑞医药科技有限公司 | 修饰的双链寡核苷酸分子、修饰的双链寡核苷酸缀合物及其用途 |
| TW202508607A (zh) * | 2023-05-19 | 2025-03-01 | 大陸商北京炫景瑞醫藥科技有限公司 | 雙股寡核苷酸及其共軛物和用途 |
| TW202509216A (zh) * | 2023-07-14 | 2025-03-01 | 大陸商北京安龍生物醫藥有限公司 | 靶向血管收縮素原的寡核苷酸及其用途 |
| CN121548643A (zh) * | 2023-08-08 | 2026-02-17 | 苏州炫景生物科技有限公司 | Fto抑制剂组合物及其应用 |
| CN118147134B (zh) * | 2023-11-06 | 2025-02-25 | 北京悦康科创医药科技股份有限公司 | 靶向调控PCSK9基因表达的siRNA及其应用 |
| CN118516348B (zh) * | 2024-07-23 | 2025-01-17 | 深川生物科技(山东)股份公司 | 单链核酸或双链核酸及在制备治疗杜氏肌营养不良的药物中的应用 |
| CN118979036B (zh) * | 2024-08-01 | 2025-08-19 | 北京尧景基因技术有限公司 | 抑制APP基因表达的siRNA及其缀合物和应用 |
| WO2026052079A1 (zh) * | 2024-09-07 | 2026-03-12 | 苏州瑞博生物技术股份有限公司 | 寡核苷酸、寡核苷酸缀合物及组合物和用途 |
| CN118995718B (zh) * | 2024-10-24 | 2025-04-11 | 苏州炫景生物科技有限公司 | 含有末端核苷酸修饰的双链寡核苷酸及其在抑制agt基因表达中的应用 |
| CN119410644A (zh) * | 2025-01-08 | 2025-02-11 | 北京安龙生物医药有限公司 | 修饰的双链寡核苷酸及其缀合物和组合物 |
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| US20100069461A1 (en) * | 2005-11-09 | 2010-03-18 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of factor v leiden mutant gene |
| CA2658183A1 (en) * | 2006-07-17 | 2008-01-24 | Sirna Therapeutics Inc. | Rna interference mediated inhibition of proprotein convertase subtilisin kexin 9 (pcsk9) gene expression using short interfering nucleic acid (sina) |
| WO2009073809A2 (en) | 2007-12-04 | 2009-06-11 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| CN102140458B (zh) | 2010-01-29 | 2013-05-22 | 苏州瑞博生物技术有限公司 | 小干扰核酸和药物组合物及其制药应用 |
| CN103380113B (zh) | 2010-11-15 | 2018-03-30 | 生命科技公司 | 含胺的转染试剂及其制备和使用方法 |
| AU2013299717B2 (en) | 2012-08-06 | 2018-06-28 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugated RNA agents and process for their preparation |
| WO2015006740A2 (en) | 2013-07-11 | 2015-01-15 | Alnylam Pharmaceuticals, Inc. | Oligonucleotide-ligand conjugates and process for their preparation |
| EP3118315A4 (en) * | 2014-03-13 | 2017-11-15 | Kyowa Hakko Kirin Co., Ltd. | Nucleic acid that inhibits expression of irf5 |
| EP3719127A4 (en) * | 2017-12-01 | 2021-10-20 | Suzhou Ribo Life Science Co., Ltd. | NUCLEIC ACID, COMPOSITION AND CONJUGATE WITH IT, MANUFACTURING METHOD AND USE |
| CN110944675B9 (zh) * | 2017-12-01 | 2024-08-09 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| CA3083970A1 (en) * | 2017-12-01 | 2019-06-06 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof |
| DK3719128T3 (da) * | 2017-12-01 | 2025-03-03 | Suzhou Ribo Life Science Co Ltd | Dobbelt-strenget oligonukleotid, sammensætning og konjugat bestaende dobbelt-strenget oligonukleotid, fremgangsmåde herfor og anvendelse heraf |
| EP3719126B1 (en) * | 2017-12-01 | 2025-01-01 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof |
| AU2018394875B2 (en) | 2017-12-29 | 2023-08-03 | Suzhou Ribo Life Science Co., Ltd. | Conjugates and preparation and use thereof |
| WO2020135673A1 (zh) * | 2018-12-28 | 2020-07-02 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
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Cited By (2)
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| CN117384907A (zh) * | 2023-12-11 | 2024-01-12 | 上海鼎新基因科技有限公司 | 抑制PCSK9表达的siRNA分子及其应用 |
| CN117384907B (zh) * | 2023-12-11 | 2024-03-29 | 上海鼎新基因科技有限公司 | 抑制PCSK9表达的siRNA分子及其应用 |
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| WO2023284763A1 (zh) | 2023-01-19 |
| JP2024528634A (ja) | 2024-07-30 |
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