TW202233832A - 針對假單胞菌屬之包含crispr-cas系統的噬菌體組合物及其使用方法 - Google Patents

針對假單胞菌屬之包含crispr-cas系統的噬菌體組合物及其使用方法 Download PDF

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TW202233832A
TW202233832A TW110141211A TW110141211A TW202233832A TW 202233832 A TW202233832 A TW 202233832A TW 110141211 A TW110141211 A TW 110141211A TW 110141211 A TW110141211 A TW 110141211A TW 202233832 A TW202233832 A TW 202233832A
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phage
virus
polypeptide
crispr
cas system
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TW110141211A
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Chinese (zh)
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大衛 G 奧斯特勞
保羅 M 葛羅佛羅
克特 賽爾
漢娜 惠特 杜森
拉娜 麥克米蘭
羅伯特 麥基
泰勒 彭克
肖恩 斯蒂爾
克里斯多夫 拉德納
哈利斯 加布里埃爾 奧
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美商羅卡斯生物科學公司
美商楊森研發有限責任公司
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Publication of TW202233832A publication Critical patent/TW202233832A/zh

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    • C12N15/09Recombinant DNA-technology
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    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • AHUMAN NECESSITIES
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/20Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/10011Details dsDNA Bacteriophages
    • C12N2795/10041Use of virus, viral particle or viral elements as a vector
    • C12N2795/10043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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TW110141211A 2020-11-05 2021-11-04 針對假單胞菌屬之包含crispr-cas系統的噬菌體組合物及其使用方法 TW202233832A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063110288P 2020-11-05 2020-11-05
US63/110,288 2020-11-05
US202163184728P 2021-05-05 2021-05-05
US63/184,728 2021-05-05

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TW202233832A true TW202233832A (zh) 2022-09-01

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TW110141211A TW202233832A (zh) 2020-11-05 2021-11-04 針對假單胞菌屬之包含crispr-cas系統的噬菌體組合物及其使用方法

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US (1) US20240011041A1 (https=)
EP (1) EP4240165A4 (https=)
JP (1) JP2023548581A (https=)
AU (1) AU2021373795A1 (https=)
CA (1) CA3197191A1 (https=)
TW (1) TW202233832A (https=)
UY (1) UY39506A (https=)
WO (1) WO2022098916A1 (https=)

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CN115960895B (zh) * 2022-08-09 2026-04-10 中国科学院微生物研究所 一种偶联的crispr和毒素-抗毒素元件及其在消杀耐药细菌中的应用
EP4712993A2 (en) * 2023-05-17 2026-03-25 The Regents of the University of California Phage therapy for alcohol-associated hepatitis
WO2025076308A1 (en) * 2023-10-06 2025-04-10 University Of Florida Research Foundation, Incorporated Compositions and methods for analyzing the effect of microbiota on host protein conformation and treating neurodegenerative diseases
CN117959655A (zh) * 2024-01-31 2024-05-03 四川大学 一种假单胞菌还原剂及其在钒还原中的应用和方法
WO2025206239A1 (ja) * 2024-03-28 2025-10-02 国立感染症研究所長が代表する日本国 組換えファージ及び遺伝子のスクリーニング方法

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CN107208070B (zh) * 2014-11-26 2021-09-07 技术创新动力基金(以色列)有限合伙公司 细菌基因的靶向消除
WO2016205276A1 (en) * 2015-06-15 2016-12-22 North Carolina State University Methods and compositions for efficient delivery of nucleic acids and rna-based antimicrobials
US9896696B2 (en) * 2016-02-15 2018-02-20 Benson Hill Biosystems, Inc. Compositions and methods for modifying genomes
GB201710126D0 (en) * 2017-06-25 2017-08-09 Snipr Tech Ltd Vectors & Methods
JP2020525049A (ja) * 2017-06-25 2020-08-27 エスエヌアイピーアール・テクノロジーズ・リミテッドSnipr Technologies Limited 微生物集団の変更及び細菌叢の改変
US20190160120A1 (en) * 2017-11-29 2019-05-30 Snipr Biome Aps Dna, methods etc
CA3099316A1 (en) * 2018-05-04 2019-11-07 Locus Biosciences, Inc. Methods and compositions for killing a target bacterium
WO2019227080A1 (en) * 2018-05-25 2019-11-28 Locus Biosciences, Inc. Methods and compositions for killing a target bacterium
CN114981418A (zh) * 2019-11-06 2022-08-30 洛可斯生物科学公司 包含crispr-cas系统的噬菌体组合物及其使用方法

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JP2023548581A (ja) 2023-11-17
UY39506A (es) 2022-05-31
EP4240165A1 (en) 2023-09-13
CA3197191A1 (en) 2022-05-12
AU2021373795A9 (en) 2024-10-03
WO2022098916A1 (en) 2022-05-12
AU2021373795A1 (en) 2023-06-22
US20240011041A1 (en) 2024-01-11
EP4240165A4 (en) 2025-04-02

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