TW202220967A - 噻吩hsd17b13抑制劑及其用途 - Google Patents
噻吩hsd17b13抑制劑及其用途 Download PDFInfo
- Publication number
- TW202220967A TW202220967A TW110127231A TW110127231A TW202220967A TW 202220967 A TW202220967 A TW 202220967A TW 110127231 A TW110127231 A TW 110127231A TW 110127231 A TW110127231 A TW 110127231A TW 202220967 A TW202220967 A TW 202220967A
- Authority
- TW
- Taiwan
- Prior art keywords
- alkyl
- heterocycloalkyl
- aryl
- cycloalkyl
- heteroaryl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063056165P | 2020-07-24 | 2020-07-24 | |
| US63/056,165 | 2020-07-24 | ||
| US202063113555P | 2020-11-13 | 2020-11-13 | |
| US63/113,555 | 2020-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202220967A true TW202220967A (zh) | 2022-06-01 |
Family
ID=79729016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW110127231A TW202220967A (zh) | 2020-07-24 | 2021-07-23 | 噻吩hsd17b13抑制劑及其用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12673930B2 (enExample) |
| EP (1) | EP4185381A4 (enExample) |
| JP (1) | JP2023537271A (enExample) |
| CN (1) | CN116323578A (enExample) |
| TW (1) | TW202220967A (enExample) |
| WO (1) | WO2022020714A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023537271A (ja) | 2020-07-24 | 2023-08-31 | イニファーム，インク． | チオフェンｈｓｄ１７ｂ１３阻害剤とその使用 |
| CN116670118B (zh) | 2020-11-13 | 2026-02-06 | 伊尼制药公司 | 二氯苯酚hsd17b13抑制剂及其用途 |
| US12617772B2 (en) | 2021-04-05 | 2026-05-05 | Inipharm, Inc. | Hydroxypyridine HSD17B13 inhibitors and uses thereof |
| CA3229569A1 (en) | 2021-08-20 | 2023-02-23 | Enanta Pharmaceuticals, Inc. | 17-beta-hydroxysteroid dehydrogenase type 13 inhibitors and methods of use thereof |
| CN118647606A (zh) * | 2021-12-15 | 2024-09-13 | 百时美施贵宝公司 | 作为rxfp1激动剂的苯并噻吩衍生物 |
| EP4469451A4 (en) * | 2022-01-26 | 2025-12-24 | Inipharm Inc | HSD17B13 2-SUBSTITUTE THIAZOLES INHIBITORS AND RELATED USES |
| HRP20251564T1 (hr) * | 2022-05-19 | 2026-01-30 | Astrazeneca Ab | Amidni heteroaromatski spojevi korisni u liječenju bolesti jetre |
| US20250340546A1 (en) | 2022-06-09 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Hsd17b13 inhibitors |
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| US2694711A (en) | 1952-12-02 | 1954-11-16 | American Cyanamid Co | Quinazolone antimalarial compounds |
| US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| DE19642451A1 (de) | 1996-10-15 | 1998-04-16 | Merck Patent Gmbh | Aminothiophencarbonsäureamide |
| JP4926473B2 (ja) | 2003-03-27 | 2012-05-09 | 協和発酵キリン株式会社 | 生体内リン輸送を阻害する化合物およびそれを含んでなる医薬 |
| JP2008506761A (ja) | 2004-07-22 | 2008-03-06 | アステックス、セラピューティックス、リミテッド | プロテインキナーゼ阻害剤としてのチアゾールおよびイソチアゾール誘導体 |
| US20070010537A1 (en) | 2004-08-20 | 2007-01-11 | Kazumasa Hamamura | Fused pyramidine derivative and use thereof |
| WO2006040966A1 (ja) | 2004-10-08 | 2006-04-20 | Astellas Pharma Inc. | 芳香環縮合ピリミジン誘導体 |
| US20090163521A1 (en) | 2005-06-28 | 2009-06-25 | Orchid Research Laboratories Limited | Novel Pyrazolopyrimidinone Derivatives |
| GB0513702D0 (en) | 2005-07-04 | 2005-08-10 | Sterix Ltd | Compound |
| EP1928865A1 (en) | 2005-08-17 | 2008-06-11 | Schering Corporation | Novel high affinity thiophene-based and furan-based kinase ligands |
| HUE035389T2 (en) | 2006-09-26 | 2018-05-02 | Celgene Corp | 5-substituted quinazolinone derivatives as anticancer agents |
| US20080255161A1 (en) | 2007-04-11 | 2008-10-16 | Dmitry Koltun | 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS |
| US8703768B2 (en) | 2010-06-09 | 2014-04-22 | Hoffmann-La Roche Inc. | Nitrogen containing heteroaryl compounds |
| US8440665B2 (en) | 2010-07-02 | 2013-05-14 | Gilead Sciences, Inc. | Apoptosis signal-regulating kinase inhibitors |
| US20120165330A1 (en) | 2010-12-22 | 2012-06-28 | Sirtris Pharmaceuticals, Inc. | Quinazolinone and related analogs as sirtuin modulators |
| CA2831978A1 (en) * | 2011-03-03 | 2012-09-07 | Universitat Des Saarlandes | Biaryl derivatives as selective 17beta-hydroxysteroid dehydrogenase type 2 inhibitors |
| CN103288771B (zh) | 2012-02-29 | 2014-12-03 | 中国中化股份有限公司 | 异噻唑类化合物及其作为杀菌剂的用途 |
| US9452973B2 (en) * | 2012-05-04 | 2016-09-27 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Modulators of the relaxin receptor 1 |
| AU2014205043B2 (en) | 2013-01-14 | 2018-10-04 | Deuterx, Llc | 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives |
| CN105524053B (zh) * | 2014-10-19 | 2020-06-05 | 广东东阳光药业有限公司 | 四氢苯并噻吩化合物 |
| WO2016081522A1 (en) | 2014-11-17 | 2016-05-26 | Rhode Island Hospital | Nanomaterial compositions, synthesis, and assembly |
| DK3356345T3 (da) * | 2015-09-30 | 2024-02-12 | Max Planck Gesellschaft | Heteroaryl-derivater som sepiapterin-reduktase-inhibitorer |
| EP3404024B1 (en) | 2016-01-14 | 2020-11-18 | Kangpu Biopharmaceuticals, Ltd. | Quinazolinone derivative, preparation method therefor, pharmaceutical composition, and applications |
| KR101870968B1 (ko) * | 2016-02-02 | 2018-06-25 | 부산대학교 산학협력단 | Ppar, fxr 및 ampk 활성화 효능을 갖는 신규 티오펜 화합물 또는 이의 약제학적으로 허용 가능한 염 및 이의 의학적 용도 |
| MX376202B (es) | 2016-08-15 | 2025-03-07 | Lilly Co Eli | Compuestos de tiofeno condensado utiles como inhibidores de napi-iib. |
| TWI762634B (zh) * | 2017-05-05 | 2022-05-01 | 大陸商上海赫普化醫藥技術有限公司 | 胺基-芳基-苯甲醯胺化合物及其使用方法 |
| EA202091897A1 (ru) * | 2018-02-08 | 2020-10-27 | Энио Фарма | Неконденсированные производные тиофена и их применение |
| US20210000906A1 (en) * | 2018-03-21 | 2021-01-07 | Ionis Pharmaceuticals, Inc. | Modulation of hsd17b13 expression |
| WO2020041741A1 (en) | 2018-08-24 | 2020-02-27 | Terns, Inc. | Thyroid hormone receptor beta agonist compounds |
| MA56457A (fr) | 2019-07-02 | 2022-05-11 | Regeneron Pharma | Modulateurs de hsd17b13 et leurs procédés d'utilisation |
| JP2023537271A (ja) | 2020-07-24 | 2023-08-31 | イニファーム，インク． | チオフェンｈｓｄ１７ｂ１３阻害剤とその使用 |
| CN116194440A (zh) | 2020-07-24 | 2023-05-30 | 伊尼制药公司 | 喹唑啉酮hsd17b13抑制剂及其用途 |
| IL299972A (en) | 2020-08-05 | 2023-03-01 | Enyo Pharma | Thiophane compounds for use in the treatment of renal fibrosis |
| WO2022040324A1 (en) | 2020-08-18 | 2022-02-24 | Metrea Biosciences, Inc. | COMPOUNDS AND METHODS OF MODULATING 17β-ΗYDROXYSTEROID DEHYDROGENASE TYPE 13 |
| MX2023003677A (es) | 2020-09-30 | 2023-06-22 | Fl2022 001 Inc | Inhibidores de hidroxiesteroide 17beta- deshidrogenasa 13 (hsd17b13) y usos de estos. |
| US20240083861A1 (en) | 2020-09-30 | 2024-03-14 | Fl2022-001, Inc. | Hsd17b13 inhibitors and uses thereof |
| EP4221701A1 (en) | 2020-09-30 | 2023-08-09 | FL2022-001, Inc. | Hsd17b13 inhibitors and uses thereof |
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| CN116670118B (zh) | 2020-11-13 | 2026-02-06 | 伊尼制药公司 | 二氯苯酚hsd17b13抑制剂及其用途 |
| EP4319872A4 (en) | 2021-04-05 | 2025-03-12 | Inipharm, Inc. | Thiazole/isothiazole hsd17b13 inhibitors and uses thereof |
| US12617772B2 (en) | 2021-04-05 | 2026-05-05 | Inipharm, Inc. | Hydroxypyridine HSD17B13 inhibitors and uses thereof |
| CA3229569A1 (en) | 2021-08-20 | 2023-02-23 | Enanta Pharmaceuticals, Inc. | 17-beta-hydroxysteroid dehydrogenase type 13 inhibitors and methods of use thereof |
| EP4469451A4 (en) | 2022-01-26 | 2025-12-24 | Inipharm Inc | HSD17B13 2-SUBSTITUTE THIAZOLES INHIBITORS AND RELATED USES |
| US20250340546A1 (en) | 2022-06-09 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Hsd17b13 inhibitors |
| CN118955491A (zh) | 2024-09-04 | 2024-11-15 | 广东药科大学 | 一类新型噻唑类hsd17b13抑制剂、其制备方法及其作为药物的用途 |
-
2021
- 2021-07-23 JP JP2023504724A patent/JP2023537271A/ja active Pending
- 2021-07-23 WO PCT/US2021/042960 patent/WO2022020714A1/en not_active Ceased
- 2021-07-23 US US18/006,059 patent/US12673930B2/en active Active
- 2021-07-23 CN CN202180065663.XA patent/CN116323578A/zh active Pending
- 2021-07-23 TW TW110127231A patent/TW202220967A/zh unknown
- 2021-07-23 EP EP21846586.2A patent/EP4185381A4/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN116323578A (zh) | 2023-06-23 |
| WO2022020714A1 (en) | 2022-01-27 |
| EP4185381A4 (en) | 2024-08-21 |
| JP2023537271A (ja) | 2023-08-31 |
| US20230278978A1 (en) | 2023-09-07 |
| US12673930B2 (en) | 2026-07-07 |
| EP4185381A1 (en) | 2023-05-31 |
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