JP2023537271A - チオフェンｈｓｄ１７ｂ１３阻害剤とその使用 - Google Patents

チオフェンｈｓｄ１７ｂ１３阻害剤とその使用 Download PDF

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Publication number
JP2023537271A
JP2023537271A JP2023504724A JP2023504724A JP2023537271A JP 2023537271 A JP2023537271 A JP 2023537271A JP 2023504724 A JP2023504724 A JP 2023504724A JP 2023504724 A JP2023504724 A JP 2023504724A JP 2023537271 A JP2023537271 A JP 2023537271A
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alkyl
heterocycloalkyl
aryl
cycloalkyl
heteroaryl
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Japanese (ja)
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JP2023537271A5 (enExample
Inventor
オディンゴ，ジョシュア
クマル アナンダン，サンパース
ケイ ウェブ シュー，ヘザー
フローリオ，ヴィンセント
ジャナルダン タントリ，スブラマニアム
ジェヤラージ デュライスワミ，アシサヤマニ
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イニファーム，インク．
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Publication of JP2023537271A publication Critical patent/JP2023537271A/ja
Publication of JP2023537271A5 publication Critical patent/JP2023537271A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2023504724A 2020-07-24 2021-07-23 チオフェンｈｓｄ１７ｂ１３阻害剤とその使用 Pending JP2023537271A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063056165P 2020-07-24 2020-07-24
US63/056,165 2020-07-24
US202063113555P 2020-11-13 2020-11-13
US63/113,555 2020-11-13
PCT/US2021/042960 WO2022020714A1 (en) 2020-07-24 2021-07-23 Thiophene hsd17b13 inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
JP2023537271A true JP2023537271A (ja) 2023-08-31
JP2023537271A5 JP2023537271A5 (enExample) 2024-07-18

Family

ID=79729016

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JP2023504724A Pending JP2023537271A (ja) 2020-07-24 2021-07-23 チオフェンｈｓｄ１７ｂ１３阻害剤とその使用

Country Status (6)

Country Link
US (1) US12673930B2 (enExample)
EP (1) EP4185381A4 (enExample)
JP (1) JP2023537271A (enExample)
CN (1) CN116323578A (enExample)
TW (1) TW202220967A (enExample)
WO (1) WO2022020714A1 (enExample)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
JP2023537271A (ja) 2020-07-24 2023-08-31 イニファーム，インク． チオフェンｈｓｄ１７ｂ１３阻害剤とその使用
CN116670118B (zh) 2020-11-13 2026-02-06 伊尼制药公司 二氯苯酚hsd17b13抑制剂及其用途
US12617772B2 (en) 2021-04-05 2026-05-05 Inipharm, Inc. Hydroxypyridine HSD17B13 inhibitors and uses thereof
CA3229569A1 (en) 2021-08-20 2023-02-23 Enanta Pharmaceuticals, Inc. 17-beta-hydroxysteroid dehydrogenase type 13 inhibitors and methods of use thereof
CN118647606A (zh) * 2021-12-15 2024-09-13 百时美施贵宝公司 作为rxfp1激动剂的苯并噻吩衍生物
EP4469451A4 (en) * 2022-01-26 2025-12-24 Inipharm Inc HSD17B13 2-SUBSTITUTE THIAZOLES INHIBITORS AND RELATED USES
HRP20251564T1 (hr) * 2022-05-19 2026-01-30 Astrazeneca Ab Amidni heteroaromatski spojevi korisni u liječenju bolesti jetre
US20250340546A1 (en) 2022-06-09 2025-11-06 Boehringer Ingelheim International Gmbh Hsd17b13 inhibitors

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US20090023710A1 (en) * 2005-07-04 2009-01-22 Nigel Vicker Compound
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Also Published As

Publication number Publication date
CN116323578A (zh) 2023-06-23
WO2022020714A1 (en) 2022-01-27
EP4185381A4 (en) 2024-08-21
US20230278978A1 (en) 2023-09-07
US12673930B2 (en) 2026-07-07
EP4185381A1 (en) 2023-05-31
TW202220967A (zh) 2022-06-01

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