JP2023537271A - チオフェンｈｓｄ１７ｂ１３阻害剤とその使用 - Google Patents

チオフェンｈｓｄ１７ｂ１３阻害剤とその使用 Download PDF

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Publication number
JP2023537271A
JP2023537271A JP2023504724A JP2023504724A JP2023537271A JP 2023537271 A JP2023537271 A JP 2023537271A JP 2023504724 A JP2023504724 A JP 2023504724A JP 2023504724 A JP2023504724 A JP 2023504724A JP 2023537271 A JP2023537271 A JP 2023537271A
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JP
Japan
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alkyl
heterocycloalkyl
aryl
cycloalkyl
heteroaryl
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JP2023504724A
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Japanese (ja)
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JP2023537271A5 (enExample
Inventor
オディンゴ，ジョシュア
クマル アナンダン，サンパース
ケイ ウェブ シュー，ヘザー
フローリオ，ヴィンセント
ジャナルダン タントリ，スブラマニアム
ジェヤラージ デュライスワミ，アシサヤマニ
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イニファーム，インク．
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Publication of JP2023537271A publication Critical patent/JP2023537271A/ja
Publication of JP2023537271A5 publication Critical patent/JP2023537271A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2023504724A 2020-07-24 2021-07-23 チオフェンｈｓｄ１７ｂ１３阻害剤とその使用 Pending JP2023537271A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063056165P 2020-07-24 2020-07-24
US63/056,165 2020-07-24
US202063113555P 2020-11-13 2020-11-13
US63/113,555 2020-11-13
PCT/US2021/042960 WO2022020714A1 (en) 2020-07-24 2021-07-23 Thiophene hsd17b13 inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
JP2023537271A true JP2023537271A (ja) 2023-08-31
JP2023537271A5 JP2023537271A5 (enExample) 2024-07-18

Family

ID=79729016

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023504724A Pending JP2023537271A (ja) 2020-07-24 2021-07-23 チオフェンｈｓｄ１７ｂ１３阻害剤とその使用

Country Status (6)

Country Link
US (1) US20230278978A1 (enExample)
EP (1) EP4185381A4 (enExample)
JP (1) JP2023537271A (enExample)
CN (1) CN116323578A (enExample)
TW (1) TW202220967A (enExample)
WO (1) WO2022020714A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4244210A4 (en) 2020-11-13 2024-10-30 Inipharm, Inc. Dichlorophenol hsd17b13 inhibitors and uses thereof
US12617772B2 (en) 2021-04-05 2026-05-05 Inipharm, Inc. Hydroxypyridine HSD17B13 inhibitors and uses thereof
JP2024534799A (ja) 2021-08-20 2024-09-26 エナンタ ファーマシューティカルズ インコーポレイテッド １７－ベータ－ヒドロキシステロイドデヒドロゲナーゼ１３型阻害剤及びその使用方法
KR20240122834A (ko) * 2021-12-15 2024-08-13 브리스톨-마이어스 스큅 컴퍼니 Rxfp1 효능제로서의 벤조티오펜 유도체
AU2023213627A1 (en) * 2022-01-26 2024-08-15 Inipharm, Inc. 2-substituted thiazole hsd17b13 inhibitors and uses thereof
EP4514782B1 (en) 2022-05-19 2025-09-10 Astrazeneca AB Amido heteroaromatic compounds useful in the treatment of liver diseases
WO2023237504A1 (en) 2022-06-09 2023-12-14 Boehringer Ingelheim International Gmbh Hsd17b13 inhibitors

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006040966A1 (ja) * 2004-10-08 2006-04-20 Astellas Pharma Inc. 芳香環縮合ピリミジン誘導体
US20090023710A1 (en) * 2005-07-04 2009-01-22 Nigel Vicker Compound
JP2013530240A (ja) * 2010-07-02 2013-07-25 ギリアード サイエンシーズ， インコーポレイテッド アポトーシスシグナル調節キナーゼ阻害剤
JP2014514257A (ja) * 2011-03-03 2014-06-19 ユニバーシテーテ デス ザールランデス 選択的１７ベータ−ヒドロキシステロイドデヒドロゲナーゼ２型阻害剤としてのビアリール誘導体
WO2018204775A1 (en) * 2017-05-05 2018-11-08 Hepanova, Inc. Amino-aryl-benzamide compounds and methods of use thereof
WO2019154956A1 (en) * 2018-02-08 2019-08-15 Enyo Pharma Non-fused thiophene derivatives and their uses
WO2019183329A1 (en) * 2018-03-21 2019-09-26 Ionis Pharmaceuticals, Inc. Modulation of hsd17b13 expression

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19642451A1 (de) * 1996-10-15 1998-04-16 Merck Patent Gmbh Aminothiophencarbonsäureamide
WO2004085382A1 (ja) * 2003-03-27 2004-10-07 Kirin Beer Kabushiki Kaisha 生体内リン輸送を阻害する化合物およびそれを含んでなる医薬
US7446195B2 (en) * 2005-08-17 2008-11-04 Schering Corporation High affinity thiophene-based and furan-based kinase ligands
ES2929283T3 (es) * 2012-05-04 2022-11-28 Us Health Moduladores del receptor de relaxina 1
CN105524053B (zh) * 2014-10-19 2020-06-05 广东东阳光药业有限公司 四氢苯并噻吩化合物
ES2969565T3 (es) * 2015-09-30 2024-12-13 Max Planck Ges Zur Foerderung Derwissenschaften E V Derivados heteroarílicos como inhibidores de la sepiapterina reductasa
KR101870968B1 (ko) * 2016-02-02 2018-06-25 부산대학교 산학협력단 Ppar, fxr 및 ampk 활성화 효능을 갖는 신규 티오펜 화합물 또는 이의 약제학적으로 허용 가능한 염 및 이의 의학적 용도
CA3033628C (en) * 2016-08-15 2021-01-12 Eli Lilly And Company Condensed thiophene derivatives useful as napi-iib inhibitors

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006040966A1 (ja) * 2004-10-08 2006-04-20 Astellas Pharma Inc. 芳香環縮合ピリミジン誘導体
US20090023710A1 (en) * 2005-07-04 2009-01-22 Nigel Vicker Compound
JP2013530240A (ja) * 2010-07-02 2013-07-25 ギリアード サイエンシーズ， インコーポレイテッド アポトーシスシグナル調節キナーゼ阻害剤
JP2014514257A (ja) * 2011-03-03 2014-06-19 ユニバーシテーテ デス ザールランデス 選択的１７ベータ−ヒドロキシステロイドデヒドロゲナーゼ２型阻害剤としてのビアリール誘導体
WO2018204775A1 (en) * 2017-05-05 2018-11-08 Hepanova, Inc. Amino-aryl-benzamide compounds and methods of use thereof
WO2019154956A1 (en) * 2018-02-08 2019-08-15 Enyo Pharma Non-fused thiophene derivatives and their uses
WO2019183329A1 (en) * 2018-03-21 2019-09-26 Ionis Pharmaceuticals, Inc. Modulation of hsd17b13 expression

Also Published As

Publication number Publication date
WO2022020714A1 (en) 2022-01-27
EP4185381A1 (en) 2023-05-31
EP4185381A4 (en) 2024-08-21
US20230278978A1 (en) 2023-09-07
CN116323578A (zh) 2023-06-23
TW202220967A (zh) 2022-06-01

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