TW202131939A - Pharmaceutical composition for itching stop and sensitizing relief and manufacturing method thereof wherein the composition includes nepeta, parsnip, Kochia scoparia, Cortex Dictamni and other herbal extracts - Google Patents

Abstract

The invention discloses a pharmaceutical composition for itching stop and sensitizing relief, which is characterized in that the pharmaceutical composition contains nepeta, parsnip, Kochia scoparia, Cortex Dictamni and other herbal extracts. The pharmaceutical composition with such ingredients may generate anti-inflammation, blood invigorating and nourishing, and skin repairing effects after being applied to wounds or places where diseases occur. Because of being composed of pure natural kampo herbs, the pharmaceutical composition can stay on wounds or itching places for a longer time and is more efficient to repairs of the wounds and the improvement of the anti-itching effect. At the same time, because of being composed of natural herbs, the pharmaceutical composition will not cause other damage to the skin, such as allergies, even if it stays on the wounds for a long time.

Description

Antipruritic and desensitizing medicinal composition and preparation method of its product

The present invention is in the field of pharmaceuticals, especially a pharmaceutical composition capable of relieving itching and desensitization and a preparation method of its product.

According to statistics, uremic pruritus (uremic pruritus) is a common and distressing symptom in patients with end-stage renal disease (ESRD). Its pathophysiology has not been fully understood, and although the symptoms can be relieved after treatment, it is very difficult to eradicate. The prevalence rate of uremia pruritus in adult dialysis patients varies considerably from year to year. Some studies suggest that the increase in dialysis efficiency may reduce the prevalence rate to explain its prevalence rate from 50 and 90% in 1980 and 1993 to follow-up studies. The report shows 22~57%; another large study (the Dialysis Outcomes and Practice Patterns Study [DOPPS]) shows that the prevalence rate of uremia in adult dialysis patients is 42%.

Uremia pruritus is most commonly found on the back, but arms, head and abdomen may also occur. There are also many patients with systemic pruritus. The frequency of occurrence ranges from a few minutes a day to almost uninterrupted persistent pruritus and allergies. Wait. Common features include deterioration at night, which affects the quality of sleep. This condition occurs in patients with more severe uremia and scrapie, and can even make the patient tired and depressed; and high temperature (especially in the case of a lot of sweating) and Stress can also aggravate the symptoms of itching. In addition, some patients experience increased itching during dialysis, while others are lessened.

In addition, patients with uremic pruritus are prone to dry skin, scaly appearance or epidermal cracking, because repeated scratching produces significant skin changes, such as epidermal exfoliation (excoriations), simple lichen simplex (lichen simplex), nodularity Pruritus nodularis, keratotic papules, follicular hyperkeratosis and Acquired perforating dermatosis (APD).

Because the symptoms of itching are very common in dialysis patients, unless there is consistent and convincing evidence that the patient's itching is due to other causes, clinically, it will be assumed that the patient's itching is from uremic itching. The characteristics that can be referred to in clinical diagnosis include: the occurrence of itching at the beginning of dialysis, the continuous uninterrupted symptoms, and the significant increase in the concentration of calcium, phosphorus and magnesium ions, parathyroid hormone, and serum urea nitrogen.

In addition, since the pathophysiology of uremia pruritus has not been fully studied, the most effective treatment is still not available. For patients with severe pruritus, even though the optimal Kt/V target is reached, pruritus is still not available. improve. Uremia and pruritus are treated with oral antihistamines and gabapentin, topical emollients or local analgesics, ultraviolet B (UVB) phototherapy, and kidney transplantation. However, there are many patients with intractable uremia and pruritus in the clinic, after receiving the above treatment methods, there is no significant effect, and it is not easy to wait for a kidney transplant. At present, the more widely used external treatment methods for the treatment of uremia and itching are as follows: 1. Emollients (emollients) are the first choice for topical treatment of uremia and itching, and it is more recommended for patients with symptoms of sjogren on physical examination. 2. Local analgesics (such as pramoxine) can relieve itching. In a randomized trial sponsored by a pharmaceutical company, which included 28 hemodialysis patients, comparing the use of pramoxine twice a day with the emollient alone, it was found that patients who used pramoxine improved significantly (61 and 12%, respectively). Pramoxine proved to be safe and convenient in this trial. It is recommended for patients who have been using emollients regularly and still have persistent itching. 3. Essential oils to increase the water content of the stratum corneum. In a 2-week, randomized, placebo-controlled study, patients were divided into two groups, one group was treated with 2.2% linoleic acid (γ-lynolenic acid) cream three times a day, and the other group was treated with placebo The cream was used three times a day, and it was found that the use of sublinoleic acid cream was more effective in reducing the symptoms of itching than the placebo group.

However, there are still many patients who use the above-mentioned external treatments of Western medicine to improve the itching situation for a while, but the intensity of itching can not be better controlled for a long time, and the above-mentioned treatment methods cannot effectively repair the existing skin. Wounds cause slow wound repair, and at the same time, itching makes it more difficult to heal wounds. Therefore, whether the treatment is different from traditional Western medicine has become a goal that the medical community needs to think about and study.

In view of this, the inventor feels that he is not perfect and exhausts his mental and painstaking research, and based on his accumulated experience in this industry for many years, he provides an antipruritic and desensitizing pharmaceutical composition and a preparation method of its product, in the hope that To improve the lack of the above-mentioned conventional technology.

One objective of the present invention is to provide an antipruritic and desensitizing medicinal composition and a preparation method of its product. The medicinal composition is made from pure natural Chinese herbal ingredients to achieve moisturizing and relieving itching and also help wound healing.

Therefore, the present invention discloses an antipruritic and desensitizing medicinal composition, which is characterized in that the medicinal composition contains nepeta, parsnip, Kochia scoparia, white fresh peel and other herbal essences.

Preferably, the method of administration of the pharmaceutical composition is selected from one or a combination of the following groups: essential oils, emulsions, creams, solutions, suspensions or ointments.

In addition, the present invention also provides a method for preparing antipruritic and desensitizing essential oils. The steps include: taking nepeta, parsnip, Kochia scoparia, white fresh peel and other herbal extracts; adding the above-mentioned ingredients to the plant extract oil, heating and boiling to maintain Boil at a certain temperature for a period of time; and after the oil is extracted and the impurities are filtered, the anti-itching and desensitizing essential oil can be obtained.

In addition, the present invention also provides a method for preparing antipruritic and desensitizing ointment. The steps include: taking nepeta, parsnip, Kochia scoparia, white fresh peel and other herbal extracts; adding the above-mentioned ingredients to the plant extract oil, heating and boiling to maintain Boil at a certain temperature for a period of time; after oil extraction, impurities are filtered; and refined vegetable oils and refined animal secretions are added and then shaped, the antipruritic and desensitizing ointment can be obtained.

In addition, the present invention also provides an anti-itch and desensitization cream or a preparation method of anti-itch and desensitization emulsion, the steps of which include: taking nepeta, parsnip, Kochia scoparia, white fresh peel and other herbal extracts; adding the above-mentioned ingredients to plant extracts After the oil is heated and boiled, it is maintained at a certain temperature and boiled for a period of time; after the oil is extracted, the impurities are filtered; the refined vegetable oil and vegetable emulsified wax are added, and heated to melt; and after adding pure water, continue to stir to obtain the anti-itching off Sensitive cream or the anti-itch and desensitizing lotion.

In this way, through the above-mentioned preparation method and the prepared pharmaceutical composition, it can produce anti-inflammatory, invigorating blood moisturizing, and repairing skin effects after being applied to the wound or the place where the disease occurs. The medicinal composition composed of natural Kampo herbs can stay longer on the wound or itching, which is more conducive to the repair of the wound and the improvement of the antipruritic effect. At the same time, due to the relationship of natural herbs, it can stay on the wound for a long time. Will not produce other undesirable changes to the skin, such as allergies.

In order to enable those with ordinary knowledge in the field to clearly understand the content of the present invention, please refer to the following description and drawings.

The following are different examples to show the actual effect of the pharmaceutical composition provided by the present invention, and the pharmaceutical composition provided by the present invention has nepeta, parsnip, Kochia scoparia, white fresh peel and other herbal essences And in these examples, ointment is used for application treatment, and the preparation method is as described in the content of the invention, but it can also be applied in the form of lotion, cream or essential oil, and the same effect can also be achieved.

The first embodiment

Please refer to Figures 1 and 2, which are schematic diagrams of the itching scale before and after treatment and diagrams of the improvement of skin lesions before and after treatment according to the first embodiment of the present invention. As shown in the figure, the patient in this example has been on hemodialysis for 10 years, has itchy for 9 years, often scratches until bleeding, the clothes on his body are always bloody, and his body is covered with uremic acne and scratches, as shown in Figure 2. According to 20181121, scratching and insomnia in the middle of the night also affected the person next to the pillow. In the past 9 years, I have sought medical treatment and tried a variety of treatments to no avail. When Mr. Xiao came to the doctor for the first time, he was evaluated by the Itching Scale. As shown in 20181017 on the left side of the first figure, it belongs to a very serious level. After receiving the application of the pharmaceutical composition, the degree of itching was greatly reduced, and the quality of sleep was also greatly improved, as shown by the continuous downward movement of the curve in the first figure, the skin wound improved and closed, as shown in the second figure. The photos of 20181121 and 20190419 are compared, and it can be seen that the improvement of the skin lesions is recorded in detail in the figure. It can be seen from the above that the pharmaceutical composition does have sufficient repairing power and inhibiting power for the degree of itching, wounds and diseases. Compared with the traditional treatment method, it also has the effect that the prior art has not achieved.

Second embodiment

Please refer to Figures 3 and 4, which are schematic diagrams of the pruritus scale before and after treatment and diagrams of the improvement of skin lesions before and after treatment according to the second embodiment of the present invention. As shown in the figure, the patient in this example has undergone peritoneal dialysis for 6 years and has itching for 2 years. When Mr. Li came to see the doctor for the first time, he was evaluated on the Itching Scale, which is a very serious grade, such as the third As shown in 20181205 on the left side of the picture, its itching seriously affects the patient’s sleep, and there are large areas of skin penetrating sores on the arm. As shown in the leftmost side of picture 4, 20191205, the wound has been unable to close the mouth for a long time except for itching, and it is often necessary Cut the wound with a blade to stop the itching with black blood flowing out. However, after receiving the application treatment of the pharmaceutical composition, the degree of itching was greatly reduced, as shown in the curve in Figure 3, although the curve oscillated but continued to move to the lower right, and the skin wound was also significantly improved and closed, just like In Figure 4, the photos taken in the four time periods of 20191205, 20190102, 20190128 and 20190325 are compared with each other. It can also be seen that the improvement of the skin lesions is recorded in detail in the figure.

The third embodiment

Please refer to Figure 5, which is a diagram showing the improvement of onychomycosis before and after treatment in the third embodiment of the present invention. In addition to treating itching, allergies and repairing wounds, the pharmaceutical composition can also be used to treat onychomycosis. Thick and fragile, it has not been completely cured for 40 years (as shown in 20190505). However, after two months of treatment with the pharmaceutical composition, the yellowing and thickening of the nails have been significantly improved, and the nails have also been broken. There is a significant improvement, as shown by the comparison of the photos taken in the 4 time periods from 20190505 to 20190714.

In summary, through the pharmaceutical composition provided by the present invention and the preparation method of its product, as long as the pharmaceutical composition is applied to the affected part, the wound can be repaired and the effect of relieving itching and desensitization can be achieved, and because it is pure It is made of natural Chinese herbal ingredients, so it is not as good as western medicine, which may cause damage to the patient's body, so it can be more assured in medicine.

However, the above are only the preferred embodiments of the present invention, and are not used to limit the scope of implementation of the present invention; therefore, equal changes and modifications made without departing from the spirit and scope of the present invention should be covered in Within the scope of the patent of the present invention.

Figure 1 is a schematic diagram of the pruritus scale before and after treatment in the first embodiment of the present invention. Figure 2 is a diagram showing the improvement of skin lesions before and after treatment in the first embodiment of the present invention. Figure 3 is a schematic diagram of the pruritus scale before and after treatment in the second embodiment of the present invention. Figure 4 is a diagram showing the improvement of skin lesions before and after treatment in the second embodiment of the present invention. Figure 5 is a diagram showing the improvement of onychomycosis before and after treatment in the third embodiment of the present invention.

Claims (5)

A pharmaceutical composition for relieving itching and desensitization, which is characterized in: The medical composition contains nepeta, parsnip, Kochia scoparia, white fresh peel and other herbal essences. The pharmaceutical composition of claim 1, wherein the method of administration of the pharmaceutical composition is selected from one or a combination of the following groups: essential oils, emulsions, creams, solutions, suspensions or ointments. A preparation method of antipruritic and desensitizing essential oil, the steps include: Take nepeta, parsnip, Kochia scoparia, white fresh peel and other herbal extracts; After adding the above-mentioned ingredients to the plant extract oil, it is heated and boiled and kept at a certain temperature for a period of time; and After the oil is extracted, the impurities can be filtered to obtain the antipruritic and desensitizing essential oil. A preparation method of antipruritic and desensitizing ointment, the steps include: Take nepeta, parsnip, Kochia scoparia, white fresh peel and other herbal extracts; After adding the above-mentioned ingredients to the plant extract oil, it is heated and boiled and kept at a certain temperature for a period of time; Filter impurities after oil extraction; and After adding refined vegetable oils and refined animal secretions, the anti-itch and desensitization ointment can be obtained. A preparation method of anti-itch and desensitization cream or anti-itch and desensitization lotion, the steps of which include: Take nepeta, parsnip, Kochia scoparia, white fresh peel and other herbal extracts; After adding the above-mentioned ingredients to the plant extract oil, it is heated and boiled and kept at a certain temperature for a period of time; Filter impurities after oil extraction; Add refined plant extract oil and plant emulsified wax, and heat to melt; and After adding pure water, continue to stir to obtain the anti-itch and desensitization cream or the anti-itch and desensitization emulsion.

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