TWI756638B - Use of preparing a pharmaceutical composition for external use to treat itching or allergic symptoms and preparation method of the pharmaceutical composition for external use - Google Patents

Abstract

The present invention discloses an application for preparing a medicinal composition for external use to treat itching or allergic symptoms, characterized in that the medicinal composition for external use comprises tuckahoe, nepeta, fangfeng, kochia, white fresh skin, phellodendri, chuanxiong, angelica, He Shou Wu, Angelica, Bai Bu, Sophora Radix, Bletilla striata and Evening Primrose Oil. In this way, the external pharmaceutical composition with the above-mentioned ingredients can produce anti-inflammatory, blood-activating and moisturizing, and skin-repairing effects after being applied to the wound or the place where the disease occurs.

Description

Use and external use of preparing a pharmaceutical composition for external use to treat itching or allergic symptoms Preparation method of pharmaceutical composition

The present invention belongs to the field of pharmaceuticals, in particular to a pharmaceutical composition which can be applied on the skin to treat itching or allergic symptoms and a preparation method thereof.

According to press, uremic pruritus is a common and troublesome symptom in patients with end-stage renal disease (ESRD). The prevalence of pruritus varies considerably from year to year in adult dialysis patients, and some studies suggest that an increase in dialysis efficiency may reduce the prevalence, explaining that the prevalence increased from 50% and 90% in 1980 and 1993 to subsequent studies. The report showed 22-57%; another large study (the Dialysis Outcomes and Practice Patterns Study [DOPPS]) showed that the prevalence of uremic scrapie in adult dialysis patients was 42%.

Uremic pruritus is best seen on the back, but it may also occur on the arms, head, and abdomen. Many patients also suffer from generalized pruritus. The frequency of occurrence ranges from a few minutes a day to almost uninterrupted persistent itching, allergic reactions. Wait. Common features are worsening at night, which affects sleep quality. This situation occurs in patients with more severe uric pruritus, and even makes the patient feel tired and depressed; high temperature (especially in the case of profuse sweating) and Stress can also exacerbate itching symptoms. In addition, some patients experience increased itching during dialysis, while others decrease.

Moreover, patients with pruritus are prone to dry skin, scaly manifestations or epidermal cracking, as repeated scratching produces significant skin changes, such as excoriations, simple moss Ringworm (lichen simplex), pruritus nodularis (pruritus nodularis), keratotic papules (keratotic papules), follicular hyperkeratosis (follicular hyperkeratosis) and acquired perforating dermatosis (Acquired perforating dermatosis, APD).

Because itching is very common in dialysis patients, unless there is consistent and convincing evidence that the patient's itching is from other causes, it is clinically assumed that the patient's itching is from uremic itching. Features that can be referred to in clinical diagnosis include: pruritus at the start of dialysis, persistent symptoms, markedly elevated concentrations of calcium, phosphorus, and magnesium ions, parathyroid hormone, and serum urea nitrogen.

In addition, because the pathophysiological mechanism of uremic pruritus has not been fully studied, it is still not possible to find the most effective treatment method. improve. Pruritus is treated with oral antihistamines and gabapentin, topical emollients or topical analgesics, ultraviolet B (UVB) phototherapy, and kidney transplantation. However, there are many patients with refractory uremic pruritus who have received the above treatment methods and have no significant effect, and it is not easy to wait for kidney transplantation. At present, the most widely used topical treatments for uremic itching are as follows:

1. Emollients are the preferred topical treatment for uric itching, and are recommended for patients with xerosis symptoms on physical examination.

2. Topical pain relievers (such as pramoxine) can relieve itching. In a randomized trial sponsored by a pharmaceutical company that included 28 hemodialysis patients comparing twice-daily use of pramoxine with emollients alone, it was found that those who used pramoxine had greater improvement in itching (61 and 12 percent, respectively). Pramoxine proved safe and convenient in this trial. Recommended for patients with persistent itching despite regular use of emollients.

3. Essential oils (essential oils) to increase the water content of the stratum corneum. In a 2-week, randomized, placebo-controlled study, patients were divided into two groups, one group received a 2.2% gamma-lynolenic acid cream three times a day, and the other group received a placebo The cream was applied three times a day, and it was found that the use of the linoleic acid cream was more effective in reducing itching symptoms than the placebo group.

However, there are still many patients who use the above topical treatment of Western medicine to improve itching temporarily, but the severe itching cannot be well controlled for a long time. Moreover, the above-mentioned treatment methods cannot effectively repair the itchiness that has occurred on the skin. Wounds cause slow wound healing, and at the same time, itching makes wounds more difficult to heal. Therefore, whether the treatment method is different from traditional Western medicine has become a goal that the medical community needs to think about and study.

In view of this, the inventors feel that they are not perfect and exhausted their painstaking research, and relying on their accumulated experience in the industry for many years, and then provide a preparation of a pharmaceutical composition for external use to treat itching or allergic symptoms. Use and external medicine The preparation method of the composition is expected to improve the above-mentioned deficiencies of the prior art.

One object of the present invention is to provide a method for preparing a medicinal composition for external use to treat itching or allergic symptoms and a method for preparing the medicinal composition for external use. , can also aid in wound repair.

Therefore, the present invention discloses a method for preparing a medicinal composition for external use to treat itching or allergic symptoms, characterized in that: the medicinal composition for external use comprises tuckahoe, nepeta, fenfeng, kochi, white fresh skin, phellodendron, chuanxiong, Angelica, Polygonum, Angelica, Baibu, Sophora Radix, Bletilla striata and Evening Primrose Oil.

Preferably, 13 parts by weight of Poria cocos, 10 parts by weight of Nepeta, 5 parts by weight of windproof, 5 parts by weight of Kochia, 5 parts by weight of white fresh skin, 5 parts by weight of Cortex Phellodendri 5 parts by weight of Radix Chuanxiong, 5 parts by weight of Angelica sinensis, 5 parts by weight of Polygonum multiflorum, 5 parts by weight of Angelica Radix, 5 parts by weight of Baibu Department, 5 parts by weight of Sophora flavescens It is 5 parts by weight, and the Bletilla striata is 5 parts by weight.

Preferably, the administration mode of the external pharmaceutical composition is selected from one of the following groups or a combination thereof: essential oil, lotion, cream, solution, suspension or ointment.

Preferably, pruritus or allergic symptoms refer to excoriations, lichen simplex, pruritus nodularis, keratotic papules and hair follicles caused by uremic pruritus Follicular hyperkeratosis (follicular hyperkeratosis) and acquired penetrating dermatosis (Acquired perforating dermatosis, APD) or onychomycosis.

In addition, the present invention discloses a preparation method of a pharmaceutical composition for external use for treating itching or allergic symptoms. 5 parts by weight of Kochia seeds, 5 parts by weight of white fresh skin, 5 parts by weight of Cork, 5 parts by weight of Chuanxiong, 5 parts by weight of Angelica sinensis, 5 parts by weight of Polygonum multiflorum, 5 parts by weight Radix Angelicae Dahuricae, 5 parts by weight of 100 parts, 5 parts by weight of Sophora flavescens and 5 parts by weight of Bletilla striata; after adding the above ingredients into evening primrose oil, keep boiling at 90~100 degrees and cook for 2 hours; and after the oil extraction The external pharmaceutical composition can be obtained after filtering the impurities again.

In some embodiments, the pharmaceutical composition for external use is formed by adding 300 grams of refined shea butter and 140 grams of refined beeswax to form the pharmaceutical composition for external use in the form of an ointment.

In certain embodiments, the pharmaceutical composition for external use is further added with refined shea butter and olive emulsifying wax, and the weight ratio of refined shea butter and olive emulsifying wax is 15:4, heated to melt Then pure water is added, and the volume ratio of the external medicinal composition to pure water is 10 to 31, and the external medicinal composition of cream type can be formed by continuous stirring.

In certain embodiments, the pharmaceutical composition for external use is further added with refined shea butter and olive emulsifying wax, and the weight ratio of refined shea butter and olive emulsifying wax is 5 to 2, heated to melting and then added Pure water, and the volume ratio of the pharmaceutical composition for external use to pure water is 5 to 19, and continuous stirring can form the pharmaceutical composition for external use in an emulsion type.

Preferably, the volume of the evening primrose oil added is 1100 ml.

In this way, through the above-mentioned preparation method and the prepared pharmaceutical composition for external use, after being applied to the wound or the place where the disease occurs, the effects of anti-inflammatory, invigorating blood and moisturizing, and skin repair can be produced. The medicinal composition composed of pure natural Kampo herbs can stay on the wound or itching for a longer time, which is more conducive to the repair of the wound and enhances the effect of relieving itching. It also does not cause other adverse changes to the skin, such as allergies, and is much milder than traditional western medicine compounds, which shows the practicability and innovation of the present invention.

Fig. 1 is a schematic diagram of the itching scale before and after treatment according to the first embodiment of the present invention.

Fig. 2 is a graph showing the improvement of skin lesions before and after treatment according to the first embodiment of the present invention.

FIG. 3 is a schematic diagram of the itching scale before and after treatment according to the second embodiment of the present invention.

Fig. 4 is a graph showing the improvement of skin lesions before and after treatment according to the second embodiment of the present invention.

Fig. 5 is a graph showing the improvement of onychomycosis before and after treatment according to the third embodiment of the present invention.

In order to enable those skilled in the art to clearly understand the content of the present invention, please refer to the following descriptions and drawings.

The following are different examples to demonstrate the actual efficacy of the pharmaceutical composition for external use provided by the present invention. , Chuanxiong, Angelica, Polygonum multiflorum, Angelica dahurica, Baibu, Sophora flavescens and Bletilla striata, and the preparation method of the medicinal composition for external use used in these examples is to take 13 parts by weight of Tuckahoe, 10 parts by weight of Nepeta , 5 parts by weight of windproof, 5 parts by weight of Kochia seeds, 5 parts by weight of white fresh skin, 5 parts by weight of Treats, 5 parts by weight of Chuanxiong, 5 parts by weight of Angelica sinensis, 5 parts by weight of 5 parts by weight of Polygonum multiflorum, 5 parts by weight of Angelica dahurica, 5 parts by weight of Bai Bu Bu, 5 parts by weight of Sophora flavescens and 5 parts by weight of Bletilla striata, and after adding the above-mentioned ingredients to 1100 ml of top evening primrose oil, heated and boiled to maintain 90～100 degree boiled for 2 hours, then filter the impurities after oil extraction to obtain the external medicinal composition, at this time the external medicinal composition is presented in the form of essential oil, and in these embodiments, in the form of an ointment dosage form. Therefore, the external medicinal composition of the essential oil type will be processed again, that is, the external medicinal composition will be shaped after adding 300 grams of pure natural refined shea butter and 140 grams of pure natural refined beeswax. The pharmaceutical composition for external use is formed into a paste, and an appropriate amount is applied to the affected part according to the condition of the patient.

In addition, the pharmaceutical composition for external use can also be presented in the form of emulsion, cream, solution or suspension, and the pharmaceutical composition for external use in the form of cream is to add refined shea butter and olive to the pharmaceutical composition for external use Emulsifying wax, and the weight ratio of refined shea butter and olive emulsifying wax is 15 to 4, and pure water is added after being heated to melting, and the volume ratio of this external pharmaceutical composition to pure water is 10 to 31, continuing The external pharmaceutical composition in cream form can be formed by stirring. The practice of this external medicinal composition of emulsion type is to add refined shea butter and olive emulsifying wax in this external medicinal composition, and the weight ratio of refined shea butter and olive emulsifying wax is 5 to 2, heating After melting, pure water is added, and The volume ratio of the external pharmaceutical composition to pure water is 5 to 19, and the external pharmaceutical composition of emulsion type can be formed by continuous stirring.

first embodiment

Please refer to Fig. 1 and Fig. 2, which are schematic diagrams of the itching scale before and after treatment and a graph of the improvement of skin lesions before and after treatment according to the first embodiment of the present invention. As shown in the figure, the patient in this example has been on hemodialysis for 10 years, and has been itching for 9 years. He often scratches until he bleeds. His clothes are always stained with blood, and his body is full of uremia and scratches, as shown in Figure 2. As indicated by 20181121, scratching and insomnia in the middle of the night also affected the person beside the bed. For the past 9 years, I have sought medical treatment everywhere, and I have tried various treatments to no avail. When Mr. Xiao first came to see the doctor, he was evaluated on the itch scale, as shown in 20181017 on the left side of Figure 1, which belonged to a very serious level. After receiving the smear treatment of the external pharmaceutical composition, the degree of itching was greatly reduced, and the sleep quality was also greatly improved, as shown by the continuous downward movement of the curve in Figure 1, the skin wound was improved and closed, as shown in Figure 2 In the comparison of the photos of the two groups of 20181121 and 20190419, it can also be seen that the improvement of the skin lesions is recorded in detail in the picture. From the above, it can be seen that the external pharmaceutical composition has sufficient repairing and inhibiting powers on itching, wounds and diseases, and compared with traditional treatment methods, it also has an effect that is unprecedented in the prior art.

Second Embodiment

Please refer to Fig. 3 and Fig. 4, which are schematic diagrams of the itching scale before and after treatment and a graph of improvement of skin lesions before and after treatment according to the second embodiment of the present invention. As shown in the figure, the patient in this example has been through peritoneal dialysis for 6 years and has had itching for 2 years. When Mr. Li first came to see the doctor, he was evaluated by the pruritus scale, which belonged to a very serious level, such as the third grade. As shown in 20181205 on the left side of the picture, the itching seriously affects the patient's sleep, and there are large areas of skin penetrating sores on the arms, as shown in 20191205 on the far left of the fourth picture, the wound cannot be closed for a long time except for itching, and it is often necessary to The itching was relieved only by cutting the wound with a knife and bleeding black. However, after receiving the smearing treatment of the external pharmaceutical composition, the degree of itching was greatly reduced, as shown in the curve in Figure 3. Although the line oscillates, it still continues to move downward to the right, and the skin wound has also been significantly improved and closed, as shown in Figure 4. It can also be seen that the improvement of the skin lesions is recorded in detail in the figure.

Third Embodiment

Please refer to FIG. 5 , which is a graph showing the improvement of onychomycosis before and after treatment according to the third embodiment of the present invention. In addition to treating itching, allergies and repairing wounds, the pharmaceutical composition for external use can also be used to treat onychomycosis. As shown in Figure 5, the onychomycosis (onychomycosis) of the patient in this example is yellow in color, Thickened and easily brittle and fragmented, it has not been completely cured for 40 years (as shown in 20190505). However, after applying the topical pharmaceutical composition for two months, the turbidity and thickening of the nails have been significantly improved, and the nails are fragmented. Nails also improved significantly, as shown in the comparison of photos taken in these four time periods from 20190505 to 20190714.

To sum up, through the medicinal composition for external use provided by the present invention and the preparation method thereof, as long as the medicinal composition for external use is applied to the affected part, the wound repair can be achieved, and the effects of relieving itching and desensitization can be achieved at the same time. It is made of natural Kampo herbal ingredients, so it will not cause damage to the patient's body like Western medicine, so you can feel more at ease in medication. In addition, although the various components used in the present invention are medicinal materials that can be used in traditional Chinese medicine, the present invention focuses more on the composition ratio of these medicinal materials and the efficacy and use that can be achieved. The efficacy that the external medicinal composition provided by the invention can achieve is the best, and after combining the ingredients of traditional Chinese medicine (medicinal materials) and the auxiliary ingredients of the West (evening primrose oil), it is presented in different ways (emulsion, cream, Essential oils, ointments, etc.), and then make a product that combines traditional Chinese and Western medicine, which is completely different from the traditional Western medicine compound treatment, and the effect is greatly enhanced, showing the practicability and innovation of the present invention.

However, the above descriptions are only preferred embodiments of the present invention, and are not intended to limit the scope of implementation of the present invention; therefore, equivalent changes and modifications made without departing from the spirit and scope of the present invention should be included in the within the scope of the patent of the present invention.

Claims (8)

An application for preparing a medicinal composition for external use to treat itching or allergic symptoms, characterized in that: the medicinal composition for external use is composed of Tuckahoe, Nepeta, Fangfeng, Kochia, Baixianpi, Phellodendri, Chuanxiong, Angelica, Polygonum Radix, Angelica Radix et Rhizoma , Bai Bu, Sophora flavescens, Bletilla striata and Evening Primrose oil; among them, pruritus or allergic symptoms refers to excoriations, lichen simplex, pruritus nodularis caused by uremic prurigo , keratotic papules (keratotic papules) follicular hyperkeratosis (follicular hyperkeratosis) and acquired penetrating dermatosis (Acquired perforating dermatosis, APD). The use as described in item 1 of the scope of application for patent application, wherein, 13 parts by weight of tuckahoe, 10 parts by weight of nepeta, 5 parts by weight of windproof, 5 parts by weight of Kochia 5 parts by weight of fresh skin, 5 parts by weight of Cork, 5 parts by weight of Chuanxiong, 5 parts by weight of Angelica, 5 parts by weight of Polygonum multiflorum, 5 parts by weight of Angelica The part is 5 parts by weight, the Sophora flavescens is 5 parts by weight, and the Bletilla striata is 5 parts by weight. The use according to item 2 of the claimed scope, wherein the administration mode of the external pharmaceutical composition is selected from one of the following groups or a combination thereof: essential oil, lotion, cream, solution, suspension or ointment. A preparation method of a pharmaceutical composition for external use for treating itching or allergic symptoms, the steps comprising: taking 13 parts by weight of Tuckahoe, 10 parts by weight of Nepeta, 5 parts by weight of windproof, 5 parts by weight of ground Fructus, 5 parts by weight of fresh white skin, 5 parts by weight of Cork, 5 parts by weight of Sichuan Xiong, 5 parts by weight of Angelica sinensis, 5 parts by weight of Polygonum multiflorum, 5 parts by weight of Angelica Radix, 5 parts by weight of Baizhi, 5 parts by weight of Sophora flavescens and 5 parts by weight of Bletilla striata; adding the above components After the evening primrose oil is heated and boiled, it is maintained at 90 to 100 degrees and boiled for 2 hours; and after the oil is extracted and the impurities are filtered, the pharmaceutical composition for external use can be obtained; wherein, itching or allergic symptoms refer to the epidermis caused by uric pruritus Excoriations, lichen simplex, pruritus nodularis, keratotic papules, follicular hyperkeratosis, and acquired penetrating dermatosis perforating dermatosis, APD). The preparation method as described in item 4 of the scope of the application, wherein the added volume of evening primrose oil is 1100 ml. The preparation method as described in item 5 of the scope of the application, wherein the external medicinal composition is formed by adding 300 grams of refined shea butter and 140 grams of refined beeswax to form the external medicinal combination in the form of an ointment. thing. The preparation method as described in item 5 of the scope of the application, wherein the external medicinal composition is further added with refined shea butter and olive emulsified wax, and the weight ratio of refined shea butter and olive emulsified wax is 15:1 4. After heating to melting, pure water is added, and the volume ratio of the external medicinal composition to pure water is 10:31, and the external medicinal composition of cream type can be formed by continuous stirring. The preparation method as described in item 5 of the scope of the application, wherein the pharmaceutical composition for external use is further added with refined shea butter and olive emulsifying wax, and the weight ratio of refined shea butter and olive emulsifying wax is 5:5 2. After heating to melting, pure water is added, and the volume ratio of the external pharmaceutical composition to pure water is 5:19, and the external pharmaceutical composition of emulsion type can be formed by continuous stirring.

Images