TW202108581A - N-(5-(5-((1r,2s)-2氟環丙基)-1,2,4-㗁二唑-3-基)-2-甲基苯基)咪唑并[1,2-a]吡啶-3-甲醯胺之結晶型 - Google Patents
N-(5-(5-((1r,2s)-2氟環丙基)-1,2,4-㗁二唑-3-基)-2-甲基苯基)咪唑并[1,2-a]吡啶-3-甲醯胺之結晶型 Download PDFInfo
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- TW202108581A TW202108581A TW109115939A TW109115939A TW202108581A TW 202108581 A TW202108581 A TW 202108581A TW 109115939 A TW109115939 A TW 109115939A TW 109115939 A TW109115939 A TW 109115939A TW 202108581 A TW202108581 A TW 202108581A
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- pyridine
- fluorocyclopropyl
- imidazo
- carboxamide
- methylphenyl
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- HMKNKWJIRCGBBP-UHFFFAOYSA-N imidazo[1,2-a]pyridin-3-ylmethanamine Chemical compound C1=CC=CN2C(CN)=CN=C21 HMKNKWJIRCGBBP-UHFFFAOYSA-N 0.000 description 1
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- 239000011976 maleic acid Substances 0.000 description 1
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- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
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- 239000006186 oral dosage form Substances 0.000 description 1
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- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019086582 | 2019-05-13 | ||
| WOPCT/CN2019/086582 | 2019-05-13 |
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| TW202108581A true TW202108581A (zh) | 2021-03-01 |
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| US (1) | US20220194936A1 (https=) |
| EP (1) | EP3969453A4 (https=) |
| JP (1) | JP2022533340A (https=) |
| KR (1) | KR20220007650A (https=) |
| CN (1) | CN114096538A (https=) |
| AU (1) | AU2020274564A1 (https=) |
| BR (1) | BR112021022685A2 (https=) |
| CA (1) | CA3139552A1 (https=) |
| IL (1) | IL287877A (https=) |
| MA (1) | MA55976A (https=) |
| MX (1) | MX2021013814A (https=) |
| SG (1) | SG11202112281UA (https=) |
| TW (1) | TW202108581A (https=) |
| WO (1) | WO2020228746A1 (https=) |
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| WO2022016021A1 (en) * | 2020-07-15 | 2022-01-20 | Third Harmonic Bio, Inc. | Crystalline forms of a selective c-kit kinase inhibitor |
| US20220175740A1 (en) * | 2020-11-19 | 2022-06-09 | Novartis Ag | Pharmaceutical compositions of a selective c-kit kinase inhibitor and methods for making and using same |
| EP4247368A4 (en) * | 2020-11-19 | 2024-10-23 | Third Harmonic Bio, Inc. | PHARMACEUTICAL COMPOSITIONS OF A SELECTIVE C-KIT KINASE INHIBITOR AND METHODS FOR THE PREPARATION AND USE THEREOF |
| IL321144A (en) | 2022-11-30 | 2025-07-01 | Blueprint Medicines Corp | History of N-phenyl-pyrazolo[5,1-A]pyridine-3-carboxamide as wild-type C-KIT kinase inhibitors for the treatment of erectile dysfunction |
| TW202542157A (zh) * | 2024-01-04 | 2025-11-01 | 大陸商上海翰森生物醫藥科技有限公司 | 多環類衍生物抑制劑、其製備方法和應用 |
| WO2025256609A1 (en) * | 2024-06-13 | 2025-12-18 | Third Harmonic Bio, Inc. | Crystalline forms of a selective c-kit kinase inhibitor |
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| JP2014525450A (ja) * | 2011-09-01 | 2014-09-29 | アイアールエム・リミテッド・ライアビリティ・カンパニー | ｃ−Ｋｉｔキナーゼ阻害剤としての化合物および組成物 |
| US9199981B2 (en) * | 2011-09-01 | 2015-12-01 | Novartis Ag | Compounds and compositions as C-kit kinase inhibitors |
| EA201490537A1 (ru) * | 2011-09-01 | 2014-07-30 | АйАрЭм ЭлЭлСи | СОЕДИНЕНИЯ И КОМПОЗИЦИИ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗЫ C-Kit |
| EP2751104B1 (en) * | 2011-09-01 | 2019-09-25 | Novartis AG | Compounds and compositions as c-kit kinase inhibitors |
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2020
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- 2020-05-13 MX MX2021013814A patent/MX2021013814A/es unknown
- 2020-05-13 BR BR112021022685A patent/BR112021022685A2/pt unknown
- 2020-05-13 AU AU2020274564A patent/AU2020274564A1/en not_active Abandoned
- 2020-05-13 SG SG11202112281UA patent/SG11202112281UA/en unknown
- 2020-05-13 TW TW109115939A patent/TW202108581A/zh unknown
- 2020-05-13 CA CA3139552A patent/CA3139552A1/en active Pending
- 2020-05-13 WO PCT/CN2020/090060 patent/WO2020228746A1/en not_active Ceased
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- 2020-05-13 EP EP20805948.5A patent/EP3969453A4/en not_active Withdrawn
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2021
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2022533340A (ja) | 2022-07-22 |
| BR112021022685A2 (pt) | 2022-03-29 |
| KR20220007650A (ko) | 2022-01-18 |
| CN114096538A (zh) | 2022-02-25 |
| WO2020228746A1 (en) | 2020-11-19 |
| SG11202112281UA (en) | 2021-12-30 |
| IL287877A (en) | 2022-01-01 |
| MX2021013814A (es) | 2022-02-10 |
| EP3969453A4 (en) | 2023-01-18 |
| AU2020274564A1 (en) | 2021-12-09 |
| EP3969453A1 (en) | 2022-03-23 |
| MA55976A (fr) | 2022-03-23 |
| US20220194936A1 (en) | 2022-06-23 |
| CA3139552A1 (en) | 2020-11-19 |
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