CN114096538A - N-(5-(5-((1r,2s)-2-氟环丙基)-1,2,4-噁二唑-3-基)-2-甲基苯基)咪唑并[1,2-a]吡啶-3-甲酰胺的结晶型 - Google Patents

N-(5-(5-((1r,2s)-2-氟环丙基)-1,2,4-噁二唑-3-基)-2-甲基苯基)咪唑并[1,2-a]吡啶-3-甲酰胺的结晶型 Download PDF

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Publication number
CN114096538A
CN114096538A CN202080050607.4A CN202080050607A CN114096538A CN 114096538 A CN114096538 A CN 114096538A CN 202080050607 A CN202080050607 A CN 202080050607A CN 114096538 A CN114096538 A CN 114096538A
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China
Prior art keywords
fluorocyclopropyl
oxadiazol
imidazo
methylphenyl
pyridine
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Pending
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CN202080050607.4A
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Chinese (zh)
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王晓阳
A·科尔迪科夫斯基
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202080050607.4A 2019-05-13 2020-05-13 N-(5-(5-((1r,2s)-2-氟环丙基)-1,2,4-噁二唑-3-基)-2-甲基苯基)咪唑并[1,2-a]吡啶-3-甲酰胺的结晶型 Pending CN114096538A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2019086582 2019-05-13
CNPCT/CN2019/086582 2019-05-13
PCT/CN2020/090060 WO2020228746A1 (en) 2019-05-13 2020-05-13 Crystalline forms of n- (5- (5- ( (1r, 2s) -2-fluorocyclopropyl) -1, 2, 4-oxadiazol-3-yl) -2-methylphenyl) imidazo [1, 2-a] pyridine-3-carboxamide

Publications (1)

Publication Number Publication Date
CN114096538A true CN114096538A (zh) 2022-02-25

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CN202080050607.4A Pending CN114096538A (zh) 2019-05-13 2020-05-13 N-(5-(5-((1r,2s)-2-氟环丙基)-1,2,4-噁二唑-3-基)-2-甲基苯基)咪唑并[1,2-a]吡啶-3-甲酰胺的结晶型

Country Status (14)

Country Link
US (1) US20220194936A1 (https=)
EP (1) EP3969453A4 (https=)
JP (1) JP2022533340A (https=)
KR (1) KR20220007650A (https=)
CN (1) CN114096538A (https=)
AU (1) AU2020274564A1 (https=)
BR (1) BR112021022685A2 (https=)
CA (1) CA3139552A1 (https=)
IL (1) IL287877A (https=)
MA (1) MA55976A (https=)
MX (1) MX2021013814A (https=)
SG (1) SG11202112281UA (https=)
TW (1) TW202108581A (https=)
WO (1) WO2020228746A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025146196A1 (zh) * 2024-01-04 2025-07-10 上海翰森生物医药科技有限公司 多环类衍生物抑制剂、其制备方法和应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022016021A1 (en) * 2020-07-15 2022-01-20 Third Harmonic Bio, Inc. Crystalline forms of a selective c-kit kinase inhibitor
US20220175740A1 (en) * 2020-11-19 2022-06-09 Novartis Ag Pharmaceutical compositions of a selective c-kit kinase inhibitor and methods for making and using same
EP4247368A4 (en) * 2020-11-19 2024-10-23 Third Harmonic Bio, Inc. PHARMACEUTICAL COMPOSITIONS OF A SELECTIVE C-KIT KINASE INHIBITOR AND METHODS FOR THE PREPARATION AND USE THEREOF
IL321144A (en) 2022-11-30 2025-07-01 Blueprint Medicines Corp History of N-phenyl-pyrazolo[5,1-A]pyridine-3-carboxamide as wild-type C-KIT kinase inhibitors for the treatment of erectile dysfunction
WO2025256609A1 (en) * 2024-06-13 2025-12-18 Third Harmonic Bio, Inc. Crystalline forms of a selective c-kit kinase inhibitor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013033167A1 (en) * 2011-09-01 2013-03-07 Irm Llc Compounds and compositions as c-kit kinase inhibitors
WO2013033203A1 (en) * 2011-09-01 2013-03-07 Irm Llc Compounds and compositions as c-kit kinase inhibitors
WO2013033070A1 (en) * 2011-09-01 2013-03-07 Irm Llc COMPOUNDS AND COMPOSITIONS AS c-KIT KINASE INHIBITORS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201490537A1 (ru) * 2011-09-01 2014-07-30 АйАрЭм ЭлЭлСи СОЕДИНЕНИЯ И КОМПОЗИЦИИ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗЫ C-Kit

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013033167A1 (en) * 2011-09-01 2013-03-07 Irm Llc Compounds and compositions as c-kit kinase inhibitors
WO2013033203A1 (en) * 2011-09-01 2013-03-07 Irm Llc Compounds and compositions as c-kit kinase inhibitors
WO2013033070A1 (en) * 2011-09-01 2013-03-07 Irm Llc COMPOUNDS AND COMPOSITIONS AS c-KIT KINASE INHIBITORS

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025146196A1 (zh) * 2024-01-04 2025-07-10 上海翰森生物医药科技有限公司 多环类衍生物抑制剂、其制备方法和应用

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JP2022533340A (ja) 2022-07-22
BR112021022685A2 (pt) 2022-03-29
KR20220007650A (ko) 2022-01-18
WO2020228746A1 (en) 2020-11-19
SG11202112281UA (en) 2021-12-30
IL287877A (en) 2022-01-01
MX2021013814A (es) 2022-02-10
EP3969453A4 (en) 2023-01-18
AU2020274564A1 (en) 2021-12-09
EP3969453A1 (en) 2022-03-23
MA55976A (fr) 2022-03-23
US20220194936A1 (en) 2022-06-23
TW202108581A (zh) 2021-03-01
CA3139552A1 (en) 2020-11-19

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Application publication date: 20220225