TW202031243A - Hair Treatment Composition - Google Patents
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q5/00—Preparations for care of the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q5/12—Preparations containing hair conditioners
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Abstract
Description
本發明係關於一種毛髮處理組成物。The present invention relates to a hair treatment composition.
毛髮顏色係由黑色素所形成。黑色素中有褐色至黑色之真黑色素及黃色至紅色之棕黑素之2種。毛髮顏色係由毛髮中之真黑色素與棕黑素之存在比所決定。例如,於真黑色素較多而棕黑素較少之情形時,毛髮成為黑髮。於真黑色素較少而棕黑素較多之情形時,毛髮成為金髮或紅毛。若毛髮中包含之黑色素減少、或消失,則毛髮成為白髮或灰白發(例如,參照專利文獻1至3)。Hair color is formed by melanin. There are two types of melanin: brown to black eumelanin and yellow to red brown melanin. Hair color is determined by the ratio of eumelanin to pheomelanin in the hair. For example, when there is more eumelanin and less brown melanin, the hair becomes black. When there is less eumelanin and more brown melanin, the hair becomes blond or red. If the melanin contained in the hair decreases or disappears, the hair becomes gray hair or gray hair (for example, refer to
毛囊之隆突區域中存在色素幹細胞。色素幹細胞生成色素細胞(黑色素細胞)。色素細胞生成黑色素並供給至毛母細胞(角質形成細胞)。被供給黑色素之毛母細胞分裂,變成毛髮而長出。認為色素幹細胞會因年齡增加而減少或活性降低。認為色素幹細胞之減少及活性之降低係白髮或灰白髮之原因。 [先前技術文獻] [專利文獻]There are pigment stem cells in the bulge area of the hair follicle. Pigment stem cells produce pigment cells (melanocytes). Pigment cells produce melanin and supply it to hair mother cells (keratinocytes). Hair mother cells supplied with melanin divide into hair and grow out. It is believed that pigment stem cells will decrease or their activity will decrease due to age. It is believed that the decrease in pigment stem cells and the decrease in activity are the cause of gray hair or gray hair. [Prior Technical Literature] [Patent Literature]
[專利文獻1]日本專利第3289975號公報 [專利文獻2]日本專利第4971072號公報 [專利文獻3]日本專利第5850266號公報[Patent Document 1] Japanese Patent No. 3289975 [Patent Document 2] Japanese Patent No. 4971072 [Patent Document 3] Japanese Patent No. 5850266
[發明所欲解決之課題][The problem to be solved by the invention]
本發明之目的之一在於提供一種毛髮處理組成物,該毛髮處理組成物可有效率地增加毛髮之黑色素。 [解決課題之技術手段]One of the objectives of the present invention is to provide a hair treatment composition which can efficiently increase the melanin of hair. [Technical means to solve the problem]
根據本發明之態樣,提供一種毛髮處理組成物,其包含0.0005重量%以上之黑色素合成促進肽、0.00069重量%以上之毛髮再生肽、0.00001重量%以上之抗老化肽、0.01525重量%以上之幹細胞溶解物及0.00563重量%以上之消炎性植物萃取物。According to an aspect of the present invention, there is provided a hair treatment composition comprising more than 0.0005 wt% melanin synthesis promoting peptide, more than 0.00069 wt% hair regeneration peptide, more than 0.00001 wt% anti-aging peptide, and more than 0.01525 wt% stem cells Solubles and anti-inflammatory plant extracts of 0.00563% by weight or more.
於上述毛髮處理組成物中,黑色素合成促進肽可為棕櫚醯四肽-20或棕櫚醯四肽-20醯胺。In the aforementioned hair treatment composition, the melanin synthesis promoting peptide may be palmitoyltetrapeptide-20 or palmitoyltetrapeptide-20amide.
於上述毛髮處理組成物中,棕櫚醯四肽-20醯胺可包含於Greyverse(註冊商標)。In the aforementioned hair treatment composition, palmitoyltetrapeptide-20 amide may be contained in Greyverse (registered trademark).
於上述毛髮處理組成物中,毛髮再生肽可為乙醯四肽-3。In the above hair treatment composition, the hair regeneration peptide may be acetotetrapeptide-3.
於上述毛髮處理組成物中,毛髮再生肽可包含於Capixyl(註冊商標)。In the above hair treatment composition, the hair regrowth peptide may be contained in Capixyl (registered trademark).
於上述毛髮處理組成物中,抗老化肽可為三氟乙醯三肽-2。In the above hair treatment composition, the anti-aging peptide may be trifluoroacetyl tripeptide-2.
於上述毛髮處理組成物中,抗老化肽可包含於Progeline(註冊商標)。In the above hair treatment composition, the anti-aging peptide may be contained in Progeline (registered trademark).
於上述毛髮處理組成物中,幹細胞溶解物可包含蘋果幹細胞溶解物。In the above hair treatment composition, the stem cell lysate may include apple stem cell lysate.
於上述毛髮處理組成物中,可包含0.009重量%以上之蘋果幹細胞溶解物。In the above hair treatment composition, the apple stem cell lysate may be included in an amount of 0.009% by weight or more.
於上述毛髮處理組成物中,幹細胞溶解物可包含竹子幹細胞溶解物。In the above hair treatment composition, the stem cell lysate may include bamboo stem cell lysate.
於上述毛髮處理組成物中,可包含0.00625重量%以上之竹子幹細胞溶解物。In the above hair treatment composition, the bamboo stem cell lysate may be included in an amount of 0.00625% by weight or more.
於上述毛髮處理組成物中,消炎性植物萃取物可包含柳蘭萃取物。In the above-mentioned hair treatment composition, the anti-inflammatory plant extract may include a Liulan extract.
於上述毛髮處理組成物中,可包含0.005重量%以上之上述柳蘭萃取物。The above hair treatment composition may contain 0.005% by weight or more of the above willow orchid extract.
於上述毛髮處理組成物中,柳蘭萃取物可包含於Defenscalp(註冊商標)。In the aforementioned hair treatment composition, the Liulan extract may be contained in Defenscalp (registered trademark).
於上述毛髮處理組成物中,消炎性植物萃取物可包含紅三葉草之花萃取物。In the aforementioned hair treatment composition, the anti-inflammatory plant extract may include a flower extract of red clover.
於上述毛髮處理組成物中,可包含0.00063重量%以上之紅三葉草之花萃取物。In the above hair treatment composition, the red clover flower extract may be included in an amount of 0.00063% by weight or more.
於上述毛髮處理組成物中,紅三葉草之花萃取物可包含於Capixyl(註冊商標)。In the above hair treatment composition, the flower extract of red clover may be contained in Capixyl (registered trademark).
上述毛髮處理組成物可防止白髮或灰白髮。The above hair treatment composition can prevent gray hair or gray hair.
上述毛髮處理組成物可增加毛髮之黑色素。The above hair treatment composition can increase the melanin of the hair.
上述毛髮處理組成物可為洗髮精。The aforementioned hair treatment composition may be a shampoo.
上述毛髮處理組成物可為美容液。The aforementioned hair treatment composition may be a beauty liquid.
根據本發明之態樣,提供一種防止白髮或灰白髮之方法,該方法包括將上述毛髮處理組成物施用於頭皮。According to an aspect of the present invention, there is provided a method for preventing gray hair or gray hair, the method comprising applying the aforementioned hair treatment composition to the scalp.
根據本發明之態樣,提供一種毛髮之黑色素之增加方法,該方法包括將上述毛髮處理組成物施用於頭皮。According to an aspect of the present invention, there is provided a method for increasing the melanin of hair, the method comprising applying the hair treatment composition to the scalp.
根據本發明之態樣,提供一種毛髮處理組成物,其包含1.0重量%以上之Greyverse(註冊商標)、2.5重量%以上之Capixyl(註冊商標)、0.05重量%以上之Progeline(註冊商標)、0.009重量%以上之蘋果幹細胞溶解物、0.00625重量%以上之竹子幹細胞溶解物及0.1重量%以上之Defenscalp(註冊商標)。According to an aspect of the present invention, there is provided a hair treatment composition comprising 1.0% by weight or more of Greyverse (registered trademark), 2.5% by weight or more of Capixyl (registered trademark), 0.05% by weight or more of Progeline (registered trademark), 0.009 More than weight% of apple stem cell lysate, 0.00625 weight% or more of bamboo stem cell lysate, and 0.1 weight% or more of Defenscalp (registered trademark).
上述毛髮處理組成物可防止白髮或灰白髮。The above hair treatment composition can prevent gray hair or gray hair.
上述毛髮處理組成物可增加毛髮之黑色素。The above hair treatment composition can increase the melanin of the hair.
上述毛髮處理組成物可為洗髮精。The aforementioned hair treatment composition may be a shampoo.
上述毛髮處理組成物可為美容液。 [發明之效果]The aforementioned hair treatment composition may be a beauty liquid. [Effects of Invention]
根據本發明,可提供一種毛髮處理組成物,該毛髮處理組成物可有效率地增加毛髮之黑色素。According to the present invention, a hair treatment composition can be provided, which can efficiently increase the melanin of hair.
以下,對本發明之實施形態進行詳細說明。再者,以下所示之實施形態係例示用於使該發明之技術思想具體化之裝置或方法者,該發明之技術思想並未將構成材料之組合等限定於下述者。該發明之技術思想可於申請專利範圍內加入各種變更。Hereinafter, embodiments of the present invention will be described in detail. In addition, the embodiment shown below is an example of a device or method for embodying the technical idea of the invention, and the technical idea of the invention does not limit the combination of constituent materials and the like to the following. Various changes can be added to the technical idea of the invention within the scope of the patent application.
實施形態之毛髮處理組成物包含0.0005重量%以上之黑色素合成促進肽、0.00069重量%以上之毛髮再生肽、0.00001重量%以上之抗老化肽、0.01525重量%以上之幹細胞溶解物及0.00563重量%以上之消炎性植物萃取物。The hair treatment composition of the embodiment includes 0.0005 wt% or more of melanin synthesis promoting peptide, 0.00069 wt% or more of hair regeneration peptide, 0.00001 wt% or more of anti-aging peptide, 0.01525 wt% or more of dry cell lysate, and 0.00563 wt% or more. Anti-inflammatory plant extracts.
實施形態之毛髮處理組成物中之黑色素合成促進肽之濃度可為0.0005重量%以上、0.00065重量%以上、或0.0008重量%以上。又,黑色素合成促進肽之濃度亦可為0.0025重量%以下、0.002重量%以下、或0.0015重量%以下。黑色素合成促進肽促進黑色素之合成。黑色素合成促進肽例如與黑皮質素1受體(MC1-R)結合。又,黑色素合成促進肽可降低導致白髮或灰白髮之黑色素之氧化壓力。例如,黑色素合成促進肽可使作為長壽蛋白質之去乙醯化酶(SIRT)活化,使作為抗氧化酶之酪胺酸激酶相關蛋白質(TRP)-2活化。The concentration of the melanin synthesis promoting peptide in the hair treatment composition of the embodiment may be 0.0005% by weight or more, 0.00065% by weight or more, or 0.0008% by weight or more. In addition, the concentration of the melanin synthesis promoting peptide may be 0.0025% by weight or less, 0.002% by weight or less, or 0.0015% by weight or less. Melanin synthesis promoting peptide promotes the synthesis of melanin. The melanin synthesis promoting peptide binds to
作為黑色素合成促進肽之例子,可列舉:棕櫚醯四肽-20、棕櫚醯四肽-20醯胺及乙醯六肽-1。棕櫚醯四肽-20係棕櫚酸與由精胺酸、組胺酸、苯丙胺酸及色胺酸所構成之合成四肽的反應產物。棕櫚醯四肽-20係α-促黑素細胞激素(MSH)之仿生肽。棕櫚醯四肽-20醯胺可包含於Greyverse(註冊商標、AH&NS)。Examples of melanin synthesis promoting peptides include palmitoyl tetrapeptide-20, palmitoyl tetrapeptide-20 amide, and acethexapeptide-1. Palmitoyl tetrapeptide-20 is a reaction product of palmitic acid and a synthetic tetrapeptide composed of arginine, histidine, phenylalanine and tryptophan. Palmitoyl Tetrapeptide-20 is a biomimetic peptide of α-melanocyte-stimulating hormone (MSH). Palmitoyl tetrapeptide-20 amide can be included in Greyverse (registered trademark, AH&NS).
實施形態之毛髮處理組成物中之Greyverse(註冊商標、AH&NS)之濃度可為1.0重量%以上、1.25重量%以上、或1.5重量%以上。又,Greyverse(註冊商標、AH&NS)之濃度亦可為6.0重量%以下、5.5重量%以下、或5.0重量%以下。The concentration of Greyverse (registered trademark, AH&NS) in the hair treatment composition of the embodiment may be 1.0% by weight or more, 1.25% by weight or more, or 1.5% by weight or more. In addition, the concentration of Greyverse (registered trademark, AH&NS) may be 6.0% by weight or less, 5.5% by weight or less, or 5.0% by weight or less.
實施形態之毛髮處理組成物中之毛髮再生肽之濃度可為0.00069重量%以上、0.0009重量%以上、或0.0011重量%以上。又,毛髮再生肽之濃度亦可為0.00345重量%以下、0.00276重量%以下、或0.00207重量%以下。毛髮再生肽可為保護毛囊及毛根之肽。又,毛髮再生肽可具有抑制導致白髮或灰白髮之炎症的消炎作用。毛髮再生肽可為抑制5α還原酶、抑制雄性激素之肽。The concentration of the hair regenerative peptide in the hair treatment composition of the embodiment may be 0.00069% by weight or more, 0.0009% by weight or more, or 0.0011% by weight or more. In addition, the concentration of the hair regenerative peptide may be 0.00345% by weight or less, 0.00276% by weight or less, or 0.00207% by weight or less. Hair regeneration peptides can be peptides that protect hair follicles and hair roots. In addition, the hair regenerative peptide can have an anti-inflammatory effect that inhibits inflammation that causes gray hair or gray hair. The hair regeneration peptide can be a peptide that inhibits 5α reductase and inhibits male hormones.
作為毛髮再生肽之例子,可列舉乙醯四肽-3及三肽-1銅。乙醯四肽-3係使包含離胺酸、甘胺酸、組胺酸及離胺酸之合成四肽乙醯化而獲得。乙醯四肽-3可包含於Capixyl(註冊商標、AH&NS)。As examples of hair regeneration peptides, acetotetrapeptide-3 and tripeptide-1 copper can be cited. Acetyltetrapeptide-3 is obtained by acetylating synthetic tetrapeptides including lysine, glycine, histidine and lysine. Acetatetetrapeptide-3 can be contained in Capixyl (registered trademark, AH&NS).
實施形態之毛髮處理組成物中之Capixyl(註冊商標、AH&NS)之濃度可為2.5重量%以上、3.125重量%以上、或3.75重量%以上。又,Capixyl(註冊商標、AH&NS)之濃度亦可為15.0重量%以下、13.75重量%以下、或12.5重量%以下。The concentration of Capixyl (registered trademark, AH&NS) in the hair treatment composition of the embodiment may be 2.5% by weight or more, 3.125% by weight or more, or 3.75% by weight or more. In addition, the concentration of Capixyl (registered trademark, AH&NS) may be 15.0% by weight or less, 13.75% by weight or less, or 12.5% by weight or less.
實施形態之毛髮處理組成物中之抗老化肽之濃度可為0.00001重量%以上、0.00001重量%以上、或0.00002重量%以上。又,抗老化肽之濃度亦可為0.00005重量%以下、0.00004重量%以下、或0.00003重量%以下。抗老化肽例如提高毛囊細胞及毛乳頭細胞對壓力激素之耐受性。抗老化肽可具有抑制導致白髮或灰白髮之炎症的功能。由於存在毛髮再生肽與抗老化肽,而有抑制嗜中性球彈性蛋白酶、相對於壓力激素而保護毛囊之傾向。The concentration of the anti-aging peptide in the hair treatment composition of the embodiment can be 0.00001% by weight or more, 0.00001% by weight or more, or 0.00002% by weight or more. In addition, the concentration of the anti-aging peptide may be 0.00005% by weight or less, 0.00004% by weight or less, or 0.00003% by weight or less. Anti-aging peptides, for example, increase the tolerance of hair follicle cells and dermal papilla cells to stress hormones. Anti-aging peptides may have the function of inhibiting inflammation that causes gray hair or gray hair. Due to the presence of hair regenerative peptides and anti-aging peptides, it has a tendency to inhibit neutrophil elastase and protect hair follicles from stress hormones.
作為抗老化肽之例子,可列舉三氟乙醯三肽-2。三氟乙醯三肽-2可由包含纈胺酸、酪胺酸及纈胺酸之三肽-2與三氟乙酸獲得。三氟乙醯三肽-2可包含於Progeline(註冊商標、AH&NS)。As an example of the anti-aging peptide, trifluoroacetyl tripeptide-2 can be cited. Trifluoroacetate tripeptide-2 can be obtained from tripeptide-2 containing valine, tyrosine and valine and trifluoroacetic acid. Trifluoroacetyl tripeptide-2 can be included in Progeline (registered trademark, AH&NS).
實施形態之毛髮處理組成物中之Progeline(註冊商標、AH&NS)之濃度可為0.05重量%以上、0.0625重量%以上、或0.075重量%以上。又,Progeline(註冊商標、AH&NS)之濃度可為0.3重量%以下、0.275重量%以下、或0.25重量%以下。The concentration of Progeline (registered trademark, AH&NS) in the hair treatment composition of the embodiment may be 0.05% by weight or more, 0.0625% by weight or more, or 0.075% by weight or more. In addition, the concentration of Progeline (registered trademark, AH&NS) may be 0.3% by weight or less, 0.275% by weight or less, or 0.25% by weight or less.
實施形態之毛髮處理組成物中之幹細胞溶解物之濃度可為0.01525%重量以上、0.01976重量%以上、或0.02432重量%以上。又,幹細胞溶解物之濃度亦可為0.076重量%以下、0.061重量%以下、或0.0456重量%以下。幹細胞溶解物可為幹細胞之萃取物。幹細胞溶解物至少包含幹細胞之細胞質成分之溶解物。幹細胞溶解物除幹細胞之細胞質成分之溶解物以外,亦可包含幹細胞之細胞壁成分之溶解物。The concentration of the stem cell lysate in the hair treatment composition of the embodiment can be 0.01525% by weight or more, 0.0176% by weight or more, or 0.02432% by weight or more. In addition, the concentration of the dry cell lysate may be 0.076% by weight or less, 0.061% by weight or less, or 0.0456% by weight or less. The stem cell lysate may be an extract of stem cells. The stem cell lysate contains at least the lysate of the cytoplasmic component of stem cells. In addition to the lysate of the cytoplasmic components of stem cells, the stem cell lysate may also include the lysate of the cell wall components of stem cells.
幹細胞溶解物可包含蘋果幹細胞溶解物。蘋果幹細胞溶解物可為蘋果幹細胞之萃取物。蘋果幹細胞具有於毛根中維持黑色素之效果。蘋果幹細胞溶解物至少包含蘋果幹細胞之細胞質成分之溶解物。蘋果幹細胞溶解物除蘋果幹細胞之細胞質成分之溶解物以外,亦可包含蘋果幹細胞之細胞壁成分之溶解物。蘋果幹細胞溶解物例如保護頭皮、保護毛囊、使隆突幹細胞活化。由於存在毛髮再生肽與蘋果幹細胞溶解物,而有毛根保護作用與膠原蛋白17產生促進作用提高之傾向。蘋果幹細胞溶解物之製造方法為任意,例如,可藉由對蘋果幹細胞施加高壓,而獲得蘋果幹細胞溶解物。蘋果幹細胞溶解物可包含於包含卵磷脂、甘油、三仙膠及苯氧基乙醇之溶劑中。The stem cell lysate may include apple stem cell lysate. The apple stem cell lysate can be an extract of apple stem cells. Apple stem cells have the effect of maintaining melanin in the hair roots. The apple stem cell lysate contains at least the lysate of the cytoplasmic components of apple stem cells. In addition to the lysate of the cytoplasmic components of apple stem cells, the lysate of apple stem cells may also include the lysate of the cell wall components of apple stem cells. Apple stem cell lysate protects the scalp, protects hair follicles, and activates bulge stem cells. Due to the presence of hair regeneration peptides and apple stem cell lysates, there is a tendency to increase the protective effect of hair roots and the promotion of collagen 17 production. The method for producing the apple stem cell lysate is arbitrary. For example, the apple stem cell lysate can be obtained by applying high pressure to the apple stem cells. The lysate of apple stem cells can be contained in a solvent containing lecithin, glycerin, sanxian gum and phenoxyethanol.
實施形態之毛髮處理組成物中之蘋果幹細胞溶解物之濃度可為0.009%重量以上、0.0117重量%以上、或0.0144重量%以上。又,蘋果幹細胞溶解物之濃度亦可為0.045重量%以下、0.036重量%以下、或0.027重量%以下。作為蘋果幹細胞溶解物,例如可使用PhytoCellTec Malus Domestica(註冊商標、AH&NS)。The concentration of the lysate of apple stem cells in the hair treatment composition of the embodiment may be 0.009% by weight or more, 0.0117% by weight or more, or 0.0144% by weight or more. In addition, the concentration of the lysate of apple stem cells may be 0.045% by weight or less, 0.036% by weight or less, or 0.027% by weight or less. As an apple stem cell lysate, for example, PhytoCellTec Malus Domestica (registered trademark, AH&NS) can be used.
幹細胞溶解物可包含竹子幹細胞溶解物。竹子幹細胞溶解物可為竹子幹細胞之萃取物。作為竹子幹細胞,可使用孟宗竹生長點幹細胞。竹子幹細胞溶解物至少包含竹子幹細胞之細胞質成分之溶解物。竹子幹細胞溶解物除竹子幹細胞之細胞質成分之溶解物以外,亦可包含竹子幹細胞之細胞壁成分之溶解物。竹子幹細胞溶解物之製造方法為任意,例如,可萃取竹子幹細胞之細胞質之水溶物。The stem cell lysate may include bamboo stem cell lysate. The bamboo stem cell lysate can be an extract of bamboo stem cells. As bamboo stem cells, Mengzong bamboo growth point stem cells can be used. The bamboo stem cell lysate contains at least the lysate of the cytoplasmic components of bamboo stem cells. In addition to the lysate of the cytoplasmic components of the bamboo stem cells, the bamboo stem cell lysate may also include the lysate of the cell wall components of the bamboo stem cells. The method of manufacturing bamboo stem cell lysate is arbitrary, for example, the cytoplasmic water solubles of bamboo stem cells can be extracted.
實施形態之毛髮處理組成物中之竹子幹細胞溶解物之濃度可為0.00625重量%以上、0.00813重量%以上、或0.01重量%以上。又,竹子幹細胞溶解物之濃度可為0.03125重量%以下、0.025重量%以下、或0.01875重量%以下。竹子幹細胞溶解物例如具有抗糖化作用,促進膠原蛋白之產生,衍生角蛋白。再者,存在若頭皮糖化,則頭皮變硬之傾向。由於存在竹子幹細胞溶解物、毛髮再生肽及蘋果幹細胞溶解物,而有抗糖化作用與角蛋白衍生作用提高之傾向。竹子幹細胞溶解物例如可自AH&NS獲得。The concentration of the bamboo stem cell lysate in the hair treatment composition of the embodiment may be 0.00625% by weight or more, 0.00813% by weight or more, or 0.01% by weight or more. In addition, the concentration of the bamboo stem cell lysate may be 0.03125 wt% or less, 0.025 wt% or less, or 0.01875 wt% or less. The bamboo stem cell lysate has anti-glycation effect, promotes the production of collagen, and derives keratin. Furthermore, if the scalp is glycated, the scalp tends to become hard. Due to the presence of bamboo stem cell lysate, hair regeneration peptide and apple stem cell lysate, there is a tendency to increase anti-glycation and keratin-derived effects. The bamboo stem cell lysate can be obtained from AH&NS, for example.
實施形態之毛髮處理組成物中之消炎性植物萃取物之濃度可為0.00563重量%以上、0.00732重量%以上、或0.00901重量%以上。又,消炎性植物萃取物之濃度亦可為0.02815重量%以下、0.02252重量%以下、或0.01689重量%以下。消炎性植物萃取物可具有保護毛根之作用。由於存在毛髮再生肽與消炎性植物萃取物,而有消炎作用與毛根保護作用提高之傾向。The concentration of the anti-inflammatory plant extract in the hair treatment composition of the embodiment can be 0.00563% by weight or more, 0.00732% by weight or more, or 0.00901% by weight or more. In addition, the concentration of the anti-inflammatory plant extract may be 0.02815% by weight or less, 0.02252% by weight or less, or 0.01689% by weight or less. Anti-inflammatory plant extracts can protect hair roots. Due to the presence of hair regenerative peptides and anti-inflammatory plant extracts, there is a tendency for anti-inflammatory effects and hair root protection to increase.
作為消炎性植物萃取物之例子,可列舉柳蘭萃取物。柳蘭萃取物可為柳蘭之花之萃取物、柳蘭之葉之萃取物及柳蘭之莖之萃取物、以及該等之混合物。柳蘭萃取物將作為頭皮固有菌之馬拉色菌 (Malassezia)之量維持於適度之狀態,保護毛根。柳蘭萃取物含有下述化學式所示之月見草素B(Oenothein B)作為有效成分。 [化1] As an example of anti-inflammatory plant extracts, Liulan extract can be cited. The Liulan extract may be the flower extract of Liulan, the leaf extract of Liulan and the stem extract of Liulan, and mixtures of these. Willow orchid extract maintains the proper amount of Malassezia, which is a native bacteria of the scalp, to protect the hair roots. Willow orchid extract contains Oenothein B (Oenothein B) shown in the following chemical formula as an active ingredient. [化1]
實施形態之毛髮處理組成物中之柳蘭萃取物之濃度可為0.005重量%以上、0.0065重量%以上、或0.008重量%以上。又,實施形態之毛髮處理組成物中之柳蘭萃取物之濃度亦可為0.025重量%以下、0.02重量%以下、或0.015重量%以下。柳蘭萃取物可包含於Defenscalp(註冊商標、AH&NS)。The concentration of the Liulan extract in the hair treatment composition of the embodiment may be 0.005% by weight or more, 0.0065% by weight or more, or 0.008% by weight or more. In addition, the concentration of the Liulan extract in the hair treatment composition of the embodiment may be 0.025% by weight or less, 0.02% by weight or less, or 0.015% by weight or less. Willow orchid extract can be contained in Defenscalp (registered trademark, AH&NS).
實施形態之毛髮處理組成物中之Defenscalp(註冊商標、AH&NS)之濃度可為0.1%重量以上、0.125重量%以上、或0.15重量%以上。又,Defenscalp(註冊商標、AH&NS)之濃度亦可為0.6重量%以下、0.55重量%以下、或0.5重量%以下。The concentration of Defenscalp (registered trademark, AH&NS) in the hair treatment composition of the embodiment may be 0.1% by weight or more, 0.125% by weight or more, or 0.15% by weight or more. In addition, the concentration of Defenscalp (registered trademark, AH&NS) may be 0.6% by weight or less, 0.55% by weight or less, or 0.5% by weight or less.
又,作為消炎性植物萃取物之例子,可列舉紅三葉草之花萃取物及鰐梨油脂肪酸丁酯。較佳為於實施形態之毛髮處理組成物中,與毛髮再生肽一同調配有紅三葉草之花萃取物或鰐梨油脂肪酸丁酯。紅三葉草具有抑制可對毛乳頭細胞造成傷害之介白素8的效果。又,紅三葉草包含下述化學式所示之鷹嘴豆芽素A(Biochanin A)。
[化2] In addition, as examples of anti-inflammatory plant extracts, red clover flower extracts and avocado oil fatty acid butyl ester can be cited. Preferably, in the hair treatment composition of the embodiment, a red clover flower extract or avocado oil fatty acid butyl ester is formulated together with the hair regeneration peptide. Red clover has the effect of inhibiting
實施形態之毛髮處理組成物中之紅三葉草之花萃取物之濃度可為0.00063重量%以上、0.00082重量%以上、或0.001重量%以上。又,紅三葉草之花萃取物之濃度亦可為0.00315重量%以下、0.00232重量%以下、0.00189重量%以下。紅三葉草之花萃取物可包含於Capixyl(註冊商標、AH&NS)或Miniporyl(註冊商標、AH&NS)。The concentration of the red clover flower extract in the hair treatment composition of the embodiment may be 0.00063% by weight or more, 0.00082% by weight or more, or 0.001% by weight or more. In addition, the concentration of the flower extract of red clover may be 0.00315% by weight or less, 0.00232% by weight or less, and 0.00189% by weight or less. The flower extract of red clover can be contained in Capixyl (registered trademark, AH&NS) or Miniporyl (registered trademark, AH&NS).
實施形態之毛髮處理組成物可為洗髮精、美容液、護髮素、凝膠、頭髮護理劑、髮乳、酊劑、噴霧劑、慕絲、洗淨組成物、潤髮乳、養髮露、髮膏劑及泡沫等。實施形態之毛髮處理組成物例如每天應用於頭皮1次以上。The hair treatment composition of the embodiment can be shampoo, beauty lotion, hair conditioner, gel, hair care agent, hair cream, tincture, spray, mousse, cleansing composition, hair conditioner, hair care lotion , Hair cream and foam, etc. The hair treatment composition of the embodiment is applied to the scalp more than once a day, for example.
實施形態之毛髮處理組成物例如可包含:水、C1-C4-烷醇等水溶性有機溶劑;油;脂肪性物質;蠟;C6-C30單羧酸與一元、二元或三元醇之酯;飽和之非環式及環式烴;脂肪酸;脂肪族醇;聚矽氧油;界面活性成分;消泡劑;噴射劑;消泡劑;乳化劑;發泡劑;及助溶劑。界面活性成分可為陰離子性、陽離子性、兩性及中性。乳化劑可為陰離子性、陽離子性、兩性及中性。The hair treatment composition of the embodiment may include, for example, water, C1-C4-alkanol and other water-soluble organic solvents; oils; fatty substances; waxes; esters of C6-C30 monocarboxylic acids and mono-, di-, or tri-alcohols ; Saturated acyclic and cyclic hydrocarbons; fatty acids; aliphatic alcohols; silicone oils; surface active ingredients; defoamers; propellants; defoamers; emulsifiers; foaming agents; and co-solvents. The interface active ingredients can be anionic, cationic, amphoteric and neutral. The emulsifier can be anionic, cationic, amphoteric and neutral.
實施形態之毛髮處理組成物例如可包含水溶性或水分散性之毛髮聚合物。作為毛髮聚合物之例子,可列舉造型聚合物及調整聚合物。更具體而言,作為毛髮聚合物之例子,可列舉:乙酸乙烯酯與丁烯酸之共聚物、甲基乙烯基醚與馬來酸酐之共聚物、丙烯酸或甲基丙烯酸與其他單體之共聚物、聚胺酯、N-乙烯基吡咯啶酮及聚矽氧聚合物。The hair treatment composition of the embodiment may include, for example, a water-soluble or water-dispersible hair polymer. Examples of hair polymers include modeling polymers and conditioning polymers. More specifically, examples of hair polymers include: copolymers of vinyl acetate and crotonic acid, copolymers of methyl vinyl ether and maleic anhydride, copolymers of acrylic acid or methacrylic acid and other monomers Polyurethane, polyurethane, N-vinylpyrrolidone and silicone polymer.
實施形態之毛髮處理組成物例如可包含聚二甲基矽氧烷等水不溶性聚矽氧。實施形態之毛髮處理組成物例如可包含脂肪醯胺等蠟。The hair treatment composition of the embodiment may include, for example, water-insoluble polysiloxane such as polydimethylsiloxane. The hair treatment composition of the embodiment may contain wax such as fatty amide, for example.
實施形態之毛髮處理組成物例如可包含抗氧化劑。上述柳蘭萃取物及紅三葉草之花萃取物亦可作為抗氧化劑而發揮功能。作為其他抗氧化劑之例,可列舉:血色素、維生素C及維生素E。The hair treatment composition of the embodiment may contain an antioxidant, for example. The above-mentioned Liulan extract and red clover flower extract can also function as antioxidants. Examples of other antioxidants include hemoglobin, vitamin C, and vitamin E.
實施形態之毛髮處理組成物例如可包含保存劑、抗氧化劑、芳香油、脂質再脂肪化劑、活性成分及護理成分。例如,實施形態之毛髮處理組成物可包含泛醇、膠原蛋白、維生素類、蛋白質水解物、α及β羥基碳酸、穩定劑、pH調整劑、乳白劑、著色劑、染料、凝膠形成劑、鹽、保濕劑、錯合劑、黏度調節劑及遮光劑。The hair treatment composition of the embodiment may include, for example, a preservative, an antioxidant, an aromatic oil, a lipid re-fatification agent, an active ingredient, and a care ingredient. For example, the hair treatment composition of the embodiment may include panthenol, collagen, vitamins, protein hydrolysates, α and β hydroxycarbonic acid, stabilizers, pH adjusters, opacifiers, colorants, dyes, gel forming agents, Salt, humectant, complexing agent, viscosity regulator and sunscreen.
實施形態之毛髮處理組成物例如可包含聚烷基矽氧烷、聚芳基矽氧烷、聚芳烷基矽氧烷、聚矽氧樹脂、聚醚矽氧烷、二甲聚矽氧烷共聚醇(CTFA)及胺基官能化聚矽氧化合物。The hair treatment composition of the embodiment may include, for example, polyalkylsiloxane, polyarylsiloxane, polyaralkylsiloxane, polysiloxane resin, polyethersiloxane, and dimethylpolysiloxane copolymer. Alcohol (CTFA) and amine functionalized polysiloxane compound.
於實施形態之毛髮處理組成物包含噴射劑之情形時,實施形態之毛髮處理組成物例如可包含丙烷/丁烷、戊烷、二甲醚、1,1-二氟乙烷(HFC-152a)、二氧化碳、氮氣及壓縮空氣之混合物。When the hair treatment composition of the embodiment includes a propellant, the hair treatment composition of the embodiment may include, for example, propane/butane, pentane, dimethyl ether, 1,1-difluoroethane (HFC-152a) , Carbon dioxide, nitrogen and compressed air mixture.
於實施形態之毛髮處理組成物包含非離子性乳化劑之情形時,實施形態之毛髮處理組成物例如可包含月桂醇聚醚-4等月桂醇聚醚、鯨蠟醇聚醚-1等鯨蠟醇聚醚、聚乙二醇鯨蠟醚、鯨蠟硬脂醇聚醚-25等鯨蠟硬脂醇聚醚、聚二醇脂肪酸甘油酯、羥化卵磷脂、脂肪酸之乳醯酯及烷基多糖苷。When the hair treatment composition of the embodiment includes a nonionic emulsifier, the hair treatment composition of the embodiment may include, for example, laureth-4 such as laureth-4, ceteth-1, etc. Alcohol, polyethylene glycol cetyl ether, ceteareth-25 and other cetearyl alcohol polyethers, polyglycol fatty acid glycerides, hydroxylated lecithin, lactic acid esters and alkyl groups of fatty acids Polyglycoside.
於實施形態之毛髮處理組成物包含非離子性界面活性劑之情形時,實施形態之毛髮處理組成物例如可包含具有6至20個碳原子之直鏈或支鏈烷基鏈之脂肪族醇或烷酚與環氧乙烷及/或環氧丙烷之反應產物。When the hair treatment composition of the embodiment includes a nonionic surfactant, the hair treatment composition of the embodiment may include, for example, aliphatic alcohol or a linear or branched alkyl chain having 6 to 20 carbon atoms. The reaction product of alkylphenol and ethylene oxide and/or propylene oxide.
實施形態之毛髮處理組成物例如可包含烷基氧化胺、單-或二烷基烷醇醯胺、聚乙二醇之脂肪酸酯、烷基多糖苷及山梨醇酐酯。The hair treatment composition of the embodiment may include, for example, alkyl amine oxide, mono- or dialkyl alkanol amide, fatty acid ester of polyethylene glycol, alkyl polyglycoside, and sorbitan ester.
於實施形態之毛髮處理組成物包含陽離子性乳化劑及/或陽離子性界面活性劑之情形時,實施形態之毛髮處理組成物例如可包含經四級化之銨化合物。實施形態之毛髮處理組成物例如可包含氯化或溴化鯨蠟基三甲基銨、氯化硬脂基苄基二甲基銨、氯化二硬脂基二甲基銨、硬脂醯胺丙基二甲基胺、羥乙基鯨蠟基二甲基磷酸銨、聚(氧基-1,2-乙烷二基)、及(十八烷基氮基)三-2,1-(乙烷二基)三-(羥基)-磷酸酯。實施形態之毛髮處理組成物例如可包含瓜爾膠羥丙基三甲基氯化銨等陽離子性瓜爾膠衍生物。When the hair treatment composition of the embodiment includes a cationic emulsifier and/or a cationic surfactant, the hair treatment composition of the embodiment may include, for example, a quaternized ammonium compound. The hair treatment composition of the embodiment may include, for example, cetyl trimethyl ammonium chloride or bromide, stearyl benzyl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, and stearyl amine Propyl dimethyl amine, hydroxyethyl cetyl dimethyl ammonium phosphate, poly(oxy-1,2-ethanediyl), and (octadecyl nitrogen) tri-2,1-( Ethane diyl) tris-(hydroxy)-phosphate. The hair treatment composition of the embodiment may include, for example, a cationic guar derivative such as guar hydroxypropyltrimethylammonium chloride.
於實施形態之毛髮處理組成物包含陰離子性乳化劑及/或陰離子性界面活性劑之情形時,實施形態之毛髮處理組成物例如可包含烷基硫酸鹽、烷基醚硫酸鹽、烷基磺酸鹽、烷基芳基磺酸鹽、烷基琥珀酸鹽、烷基磺基琥珀酸鹽、N-烷基肌胺酸鹽、醯基牛磺酸鹽、醯基羥乙基磺酸鹽、烷基磷酸鹽、烷基醚磷酸鹽、烷基醚羧酸鹽及α-烯烴磺酸鹽。When the hair treatment composition of the embodiment includes an anionic emulsifier and/or an anionic surfactant, the hair treatment composition of the embodiment may include, for example, alkyl sulfate, alkyl ether sulfate, and alkyl sulfonic acid. Salt, alkyl aryl sulfonate, alkyl succinate, alkyl sulfosuccinate, N-alkyl sarcosine, acylotaurate, acylate isethionate, alkane Alkyl phosphate, alkyl ether phosphate, alkyl ether carboxylate, and α-olefin sulfonate.
於實施形態之毛髮處理組成物包含陰離子性界面活性劑之情形時,實施形態之毛髮處理組成物例如可包含月桂基硫酸鈉、月桂基硫酸銨、月桂醚硫酸鈉、月桂醚硫酸銨、月桂醯肌胺酸鈉、油基琥珀酸鈉、月桂基磺基琥珀酸銨、十二烷基苯磺酸鈉及三乙醇醯胺癸基苯磺酸鹽。When the hair treatment composition of the embodiment includes an anionic surfactant, the hair treatment composition of the embodiment may include, for example, sodium lauryl sulfate, ammonium lauryl sulfate, sodium laureth sulfate, ammonium laureth sulfate, and laurel Sodium sarcosine, sodium oleyl succinate, ammonium lauryl sulfosuccinate, sodium dodecyl benzene sulfonate and triethanolamide decyl benzene sulfonate.
於實施形態之毛髮處理組成物包含兩性界面活性劑之情形時,實施形態之毛髮處理組成物例如可包含烷基甜菜鹼、烷基醯胺丙基甜菜鹼、烷基磺基甜菜鹼、烷基甘胺酸鹽、烷基羧基甘胺酸鹽、烷基兩性乙酸鹽或丙酸鹽、以及烷基兩性二乙酸鹽或二丙酸鹽。When the hair treatment composition of the embodiment includes an amphoteric surfactant, the hair treatment composition of the embodiment may include, for example, alkyl betaine, alkyl amidopropyl betaine, alkyl sulfobetaine, and alkyl sulfobetaine. Glycine, alkylcarboxyglycine, alkyl amphoteric acetate or propionate, and alkyl amphoteric diacetate or dipropionate.
實施形態之毛髮處理組成物可增加毛髮之黑色素,防止白髮或灰白髮。實施形態之毛髮處理組成物可使毛髮顏色恢復至變成白髮或灰白髮前之顏色。The hair treatment composition of the embodiment can increase the melanin of the hair and prevent gray hair or gray hair. The hair treatment composition of the embodiment can restore the hair color to the color before turning white or gray hair.
藉由將實施形態之毛髮處理組成物應用於頭皮,黑色素合成促進肽於毛囊中會促進黑色素之合成,但並不受理論約束。即便促進黑色素之合成,若不長出粗壯之毛髮,亦無法使白髮或灰白髮有效地恢復為包含黑色素之毛髮。對此,毛髮再生肽及幹細胞溶解物促進包含黑色素之毛髮變粗壯而長出。進而,抗老化肽提高毛囊細胞及毛乳頭細胞對壓力激素之耐受性,消炎性植物萃取物抑制毛囊中之炎症,藉此可使白髮或灰白髮有效地恢復為包含黑色素之毛髮。By applying the hair treatment composition of the embodiment to the scalp, the melanin synthesis promoting peptide in the hair follicle can promote the synthesis of melanin, but is not bound by theory. Even if the synthesis of melanin is promoted, if thick hair is not grown, gray or gray hair cannot be effectively restored to hair containing melanin. In this regard, hair regenerative peptides and stem cell lysates promote thickening and growth of hair containing melanin. Furthermore, anti-aging peptides increase the tolerance of hair follicle cells and dermal papilla cells to stress hormones, and anti-inflammatory plant extracts inhibit inflammation in hair follicles, thereby effectively returning gray or gray hair to hair containing melanin.
如上所述,藉由實施形態記載了本發明,但不應理解為作為所揭示之一部分之記載及圖式限定該發明。對於該行業者而言,應可自此揭示內容明白各種代替實施形態、實施例及運用技術。應當理解,本發明包含此處未記載之各種實施形態等。As described above, the present invention has been described in the embodiments, but it should not be understood that the description and drawings as part of the disclosure limit the invention. For those in the industry, it should be possible to understand various alternative embodiments, examples, and operating technologies from the disclosure content. It should be understood that the present invention includes various embodiments that are not described herein.
(實施例)(Example)
準備實施例之香精(美容液),其包含0.001重量%之棕櫚醯四肽-20、0.00138重量%之乙醯四肽-3、0.00125重量%之紅三葉草花萃取物、0.00002重量%之三氟乙醯三肽-2、0.018重量%之蘋果果實培養幹細胞萃取物、0.0125重量%之孟宗竹生長點幹細胞溶解質及0.01重量%之柳蘭花/葉/莖萃取物。Prepare the fragrance (beauty lotion) of the example, which contains 0.001% by weight of palmitoyl tetrapeptide-20, 0.00138% by weight of acetyltetrapeptide-3, 0.00125% by weight of red clover flower extract, and 0.00002% by weight of trifluoride Acetyl tripeptide-2, 0.018% by weight of apple fruit cultured stem cell extract, 0.0125% by weight of Mengzong bamboo growing point stem cell lysate, and 0.01% by weight of willow flower/leaf/stem extract.
棕櫚醯四肽-20包含於Greyverse(註冊商標)。實施例之香精中之Greyverse(註冊商標)之含量為2.0重量%。乙醯四肽-3及紅三葉草花萃取物包含於Capixyl(註冊商標)。實施例之香精中之Capixyl(註冊商標)之含量為5.0重量%。三氟乙醯三肽-2包含於Progeline(註冊商標)。實施例之香精中之Progeline(註冊商標)之含量為0.1重量%。蘋果果實培養幹細胞萃取物及孟宗竹生長點幹細胞溶解質購買自AH&NS。柳蘭花/葉/莖萃取物包含於Defenscalp(註冊商標)。實施例之香精中之Defenscalp(註冊商標)之含量為0.2重量%。Palmitoyl Tetrapeptide-20 is included in Greyverse (registered trademark). The content of Greyverse (registered trademark) in the flavors of the examples is 2.0% by weight. Acetotetrapeptide-3 and red clover flower extract are contained in Capixyl (registered trademark). The content of Capixyl (registered trademark) in the flavors of the examples is 5.0% by weight. Trifluoroacetate tripeptide-2 is included in Progeline (registered trademark). The content of Progeline (registered trademark) in the flavors of the examples is 0.1% by weight. Apple fruit culture stem cell extract and Mengzong bamboo growing point stem cell lysate were purchased from AH&NS. Willow flower/leaf/stem extract is contained in Defenscalp (registered trademark). The content of Defenscalp (registered trademark) in the flavors of the examples is 0.2% by weight.
選擇20歲至69歲之成人20名(平均年齡為43歲)作為受驗者。受驗者開始使用實施例之香精前,醫師及毛髮診斷師觀察受驗者之頭頂部及側頭部之白髮。又,醫師及毛髮診斷師使用顯微鏡,觀察受驗者之側頭部(耳輪頂部之髮際線)之毛髮根部之毛髮顏色。Twenty adults (average age 43) between 20 and 69 years old are selected as subjects. Before the subject starts to use the fragrance of the embodiment, the doctor and the hair diagnostician observe the white hair on the top and side of the subject's head. In addition, doctors and hair diagnosticians use microscopes to observe the hair color at the roots of the subject's head (the hairline at the top of the helix).
其後,受驗者3個月期間每天使用1次包含抗氧化劑之洗髮精進行洗髮,將實施例之香精應用於整個頭皮。該期間,受驗者被禁止使用其他洗髮精、頭髮化妝料、白髮染劑及染髮劑等。開始使用實施例之香精後,醫師及毛髮診斷師於第1個月、第2個月及第3個月觀察受驗者之毛髮。再者,開始使用實施例之香精2個月後,1名受驗者由於個人原因不再進行試驗。Thereafter, the subjects used shampoo containing antioxidants once a day for 3 months to wash their hair, and applied the fragrance of the example to the entire scalp. During this period, the subjects were prohibited from using other shampoos, hair cosmetics, white hair dyes and hair dyes. After starting to use the fragrance of the embodiment, the doctor and the hair diagnostician observe the subject's hair in the first month, the second month, and the third month. Furthermore, two months after starting to use the fragrance of the example, one subject did not conduct the test due to personal reasons.
將由醫師及毛髮診斷師觀察所得之受驗者之白髮量之改善度比率之推移示於圖1及表1。再者,於白髮量減少之情形時,評價為改善。對於頭頂部之白髮量,與使用前相比,開始使用1個月後,「不變」為20名中8名(40%)、「稍微改善」為20名中5名(25%)、「改善」為20名中7名(35%)。對於頭頂部之白髮量,與使用前相比,開始使用2個月後,「不變」為20名中5名(25%)、「稍微改善」為20名中10名(50%)、「改善」為20名中5名(25%)。對於頭頂部之白髮量,與使用前相比,開始使用3個月後,「稍微改善」為19名中8名(42%)、「改善」為19名中11名(58%)。
[表1]
表示實施例之醫師及毛髮診斷師所評價之白髮量之改善度比率之推移的表
對於側頭部之白髮量,與使用前相比,開始使用1個月後,「不變」為20名中8名(40%)、「稍微改善」為20名中5名(25%)、「改善」為20名中7名(35%)。對於側頭部之白髮量,與使用前相比,開始使用2個月後,「不變」為20名中1名(5%)、「稍微改善」為20名中16名(80%)、「改善」為20名中3名(15%)。對於側頭部之白髮量,與使用前相比,開始使用3個月後,「稍微改善」為19名中10名(53%)、「改善」為19名中9名(47%)。Regarding the amount of gray hair on the side of the head, compared with before use, one month after the start of use, "unchanged" was 8 out of 20 (40%), and "slightly improved" was 5 out of 20 (25%) ), "Improved" is 7 out of 20 (35%). Regarding the amount of gray hair on the lateral head, compared with before use, 2 months after the start of use, "unchanged" was 1 out of 20 (5%), and "slightly improved" was 16 out of 20 (80%) ), "improvement" is 3 out of 20 (15%). Regarding the amount of gray hair on the side of the head, compared with before use, after 3 months of use, "slightly improved" was 10 out of 19 (53%), and "improved" was 9 out of 19 (47%). .
將由醫師及毛髮診斷師觀察所得之受驗者之白髮顏色之改善度比率之推移示於圖2及表2。再者,於白髮上帶有顏色之情形時,評價為改善。對於頭頂部之白髮顏色,與使用前相比,開始使用1個月後,「不變」為20名中8名(40%)、「稍微改善」為20名中7名(35%)、「改善」為20名中5名(25%)。對於頭頂部之白髮顏色,與使用前相比,開始使用2個月後,「不變」為20名中2名(10%)、「稍微改善」為20名中15名(75%)、「改善」為20名中3名(15%)。對於頭頂部之白髮顏色,與使用前相比,開始使用3個月後,「稍微改善」為19名中10名(53%)、「改善」為19名中9名(47%)。
[表2]
表示實施例之醫師及毛髮診斷師所評價之白髮顏色之改善度比率之推移的表
對於側頭部之白髮顏色,與使用前相比,開始使用1個月後,「不變」為20名中8名(40%)、「稍微改善」為20名中9名(45%)、「改善」為20名中3名(15%)。對於側頭部之白髮顏色,與使用前相比,開始使用2個月後,「不變」為20名中1名(5%)、「稍微改善」為20名中17名(85%)、「改善」為20名中2名(10%)。對於側頭部之白髮顏色,與使用前相比,開始使用3個月後,「稍微改善」為19名中13名(68%)、「改善」為19名中6名(32%)。Regarding the white hair color on the side of the head, compared with before use, after 1 month of use, "unchanged" was 8 of 20 (40%), and "slightly improved" was 9 of 20 (45%) ), "improvement" is 3 out of 20 (15%). Regarding the white hair color on the side of the head, compared with before use, after 2 months of use, "unchanged" was 1 in 20 (5%), and "slightly improved" was 17 in 20 (85%) ), "improvement" is 2 out of 20 (10%). Regarding the white hair color on the side of the head, compared with before use, after 3 months of use, "slightly improved" was 13 out of 19 (68%), and "improved" was 6 out of 19 (32%). .
將由醫師及毛髮診斷師觀察所得之受驗者之白髮根部之改善度比率之推移示於圖3及表3。再者,於白髮根部變灰之情形時,評價為改善。對於頭頂部之白髮根部之狀態,與使用前相比,開始使用1個月後,「不變」為20名中8名(40%)、「稍微改善」為20名中5名(25%)、「改善」為20名中7名(35%)。對於頭頂部之白髮根部之狀態,與使用前相比,開始使用2個月後,「不變」為20名中3名(15%)、「稍微改善」為20名中14名(70%)、「改善」為20名中3名(15%)。對於頭頂部之白髮根部之狀態,與使用前相比,開始使用3個月後,「稍微改善」為19名中10名(53%)、「改善」為19名中9名(47%)。
[表3]
表示實施例之醫師及毛髮診斷師所評價之白髮根部之改善度比率之推移的表
對於側頭部之白髮根部之狀態,與使用前相比,開始使用1個月後,「不變」為20名中9名(45%)、「稍微改善」為20名中5名(25%)、「改善」為20名中6名(30%)。對於側頭部之白髮根部之狀態,與使用前相比,開始使用2個月後,「不變」為20名中1名(5%)、「稍微改善」為20名中11名(55%)、「改善」為20名中8名(40%)。對於側頭部之白髮根部之狀態,與使用前相比,開始使用3個月後,「稍微改善」為19名中8名(42%)、「改善」為19名中11名(58%)。Regarding the condition of the white hair roots on the side head, compared with before use, after 1 month of use, "unchanged" was 9 out of 20 (45%), and "slightly improved" was 5 out of 20 ( 25%), "improvement" is 6 out of 20 (30%). Regarding the condition of the white hair roots on the side head, compared with before use, after 2 months of use, "unchanged" was 1 in 20 (5%), and "slightly improved" was 11 in 20 ( 55%), "Improved" is 8 out of 20 (40%). Regarding the condition of the white hair roots on the side head, compared with before use, after 3 months of use, "slightly improved" was 8 out of 19 (42%), and "improved" was 11 out of 19 (58 %).
關於擔心白髮之情況,對受驗者進行使用視覺類比量表(VAS)之問卷調查。於VAS中,將擔心白髮時之評價值設為0、不擔心白髮時之評價值設為10。結果,如圖4及表4所示,表明開始使用實施例之香精後,不再擔心白髮。又,關於VAS之變化率(%),於大於105%之情形時,意指改善,於小於95%之情形時,意指惡化。如圖5所示,表明開始使用實施例之香精後,擔心白髮之情況有所改善。
[表4]
表示實施例之利用問卷調查所得之受驗者擔心白髮之情況之推移的表
([擔心(0)不擔心(10)]白髮)
關於白髮量,對受驗者進行使用VAS之問卷調查。於VAS中,將白髮量增加時之評價值設為0、白髮量減少時之評價值設為10。結果,如圖6及表5所示,表明開始使用實施例之香精後,白髮量減少。又,如圖7所示,表明開始使用實施例之香精後,白髮量有所改善。
[表5]
表示實施例之利用問卷調查所得之受驗者之白髮量之推移的表
(白髮量[增加(0)減少(10)])
關於白髮顏色,對受驗者進行使用VAS之問卷調查。於VAS中,將白髮顏色變淺時之評價值設為0、白髮顏色變深時之評價值設為10。結果,如圖8及表6所示,表明開始使用實施例之香精後,白髮顏色變深。又,如圖9所示,表明開始使用實施例之香精後,白髮顏色有所改善。
[表6]
表示實施例之利用問卷調查所得之受驗者之白髮顏色之推移的表
(白髮顏色[變淺(0)變深(10)])
關於白髮範圍,對受驗者進行使用VAS之問卷調查。於VAS中,將白髮範圍增加時之評價值設為0、白髮範圍減少時之評價值設為10。結果,如圖10及表7所示,表明開始使用實施例之香精後,白髮範圍減少。又,如圖11所示,表明開始使用實施例之香精後,白髮範圍有所改善。
[表7]
表示實施例之利用問卷調查所得之受驗者之白髮範圍之推移的表
(白髮範圍[增加(0)減少(10)])
關於白髮顯眼情況,對受驗者進行使用VAS之問卷調查。於VAS中,將白髮變得顯眼時之評價值設為0、白髮不再顯眼時之評價值設為10。結果,如圖12及表8所示,表明開始使用實施例之香精後,白髮不再顯眼。又,如圖13所示,表明開始使用實施例之香精後,白髮顯眼情況有所改善。
[表8]
表示實施例之利用問卷調查所得之受驗者之白髮顯眼情況之推移的表
(白髮[變得顯眼(0)不再顯眼(10)])
醫師對受驗者確認受驗部位之頭皮發癢及頭皮異常。結果,如表9所示,未確認到頭皮狀態。
[表9]
表示實施例之醫師及毛髮診斷師對受驗者之診斷結果的表
(比較例) 準備比較例之香精(美容液),其包含0.001重量%之棕櫚醯四肽-20,但不含乙醯四肽-3、紅三葉草花萃取物、三氟乙醯三肽-2、蘋果果實培養幹細胞萃取物、孟宗竹生長點幹細胞溶解質及柳蘭花/葉/莖萃取物,且其他組成與實施例之香精相同。(Comparative example) Prepare the fragrance (beauty lotion) of the comparative example, which contains 0.001% by weight of palmitoyltetrapeptide-20, but does not contain acetotetrapeptide-3, red clover flower extract, trifluoroacetyl tripeptide-2, and apple fruit Cultivation stem cell extract, Mengzong bamboo growing point stem cell lysate and Willow flower/leaf/stem extract, and other compositions are the same as the flavor of the embodiment.
選擇20歲至69歲之成人20名(平均年齡為44歲)作為受驗者。受驗者開始使用比較例之香精前,醫師及毛髮診斷師觀察受驗者之頭頂部及側頭部之白髮。又,醫師及毛髮診斷師使用顯微鏡,觀察受驗者之側頭部(耳輪頂部之髮際線)之毛髮根部之毛髮顏色。Twenty adults (average age 44) between 20 and 69 years old are selected as subjects. Before the subject started using the fragrance of the comparative example, the doctor and the hair diagnostician observed the gray hair on the top and side of the subject's head. In addition, doctors and hair diagnosticians use microscopes to observe the hair color at the roots of the subject's head (the hairline at the top of the helix).
其後,受驗者(1名受驗者由於個人原因不再進行試驗)3個月期間每天使用1次包含抗氧化劑之洗髮精進行洗髮,將比較例之香精應用於整個頭皮。該期間,受驗者被禁止使用其他洗髮精、頭髮化妝料、白髮染劑及染髮劑等。開始使用比較例之香精後,醫師及毛髮診斷師於第1個月、第2個月及第3個月觀察受驗者之毛髮。Thereafter, the subjects (one subject did not conduct the test due to personal reasons) used shampoo containing antioxidants once a day for 3 months to wash their hair, and applied the fragrance of the comparative example to the entire scalp. During this period, the subjects were prohibited from using other shampoos, hair cosmetics, white hair dyes and hair dyes. After starting to use the fragrance of the comparative example, the doctor and the hair diagnostician observed the subject's hair in the first month, the second month, and the third month.
將由醫師及毛髮診斷師觀察所得之受驗者之白髮量之改善度比率之推移示於圖14及表10。觀察基準與實施例相同。對於頭頂部之白髮量,與使用前相比,開始使用1個月後,「不變」為19名中6名(31%)、「稍微改善」為19名中10名(53%)、「改善」為19名中3名(16%)。對於頭頂部之白髮量,與使用前相比,開始使用2個月後,「不變」為19名中6名(32%)、「稍微改善」為19名中12名(63%)、「改善」為19名中1名(5%)。對於頭頂部之白髮量,與使用前相比,開始使用3個月後,「稍微改善」為19名中13名(68%)、「改善」為19名中6名(32%)。
[表10]
表示比較例之醫師及毛髮診斷師所評價之白髮量之改善度比率之推移的表
因此,使用比較例之香精之情形與使用實施例之香精之情形相比,頭頂部之白髮量之改善程度較低。Therefore, in the case of using the fragrance of the comparative example, compared with the case of using the fragrance of the example, the degree of improvement in the amount of gray hair on the top of the head is lower.
對於側頭部之白髮量,與使用前相比,開始使用1個月後,「不變」為19名中7名(37%)、「稍微改善」為19名中11名(58%)、「改善」為19名中1名(5%)。對於側頭部之白髮量,與使用前相比,開始使用2個月後,「不變」為19名中3名(16%)、「稍微改善」為19名中15名(79%)、「改善」為19名中1名(5%)。對於側頭部之白髮量,與使用前相比,開始使用3個月後,「稍微改善」為19名中16名(84%)、「改善」為19名中3名(16%)。Regarding the amount of gray hair on the lateral head, compared with before use, after 1 month of use, "unchanged" was 7 of 19 (37%), and "slightly improved" was 11 of 19 (58%) ), "improvement" is 1 out of 19 (5%). Regarding the amount of gray hair on the side head, compared with before use, after 2 months of use, "unchanged" was 3 out of 19 (16%), and "slightly improved" was 15 out of 19 (79%) ), "improvement" is 1 out of 19 (5%). Regarding the amount of gray hair on the side of the head, compared with before use, after 3 months of use, "slightly improved" was 16 out of 19 (84%), and "improved" was 3 out of 19 (16%). .
因此,使用比較例之香精之情形與使用實施例之香精之情形相比,側頭部之白髮量之改善程度較低。Therefore, in the case of using the fragrance of the comparative example, compared with the case of using the fragrance of the example, the degree of improvement in the amount of gray hair on the side head is lower.
將由醫師及毛髮診斷師觀察所得之受驗者之白髮顏色之改善度比率之推移示於圖15及表11。觀察基準與實施例相同。對於頭頂部之白髮顏色,與使用前相比,開始使用1個月後,「不變」為19名中8名(42%)、「稍微改善」為19名中9名(47%)、「改善」為19名中2名(11%)。對於頭頂部之白髮顏色,與使用前相比,開始使用2個月後,「不變」為19名中5名(26%)、「稍微改善」為19名中12名(63%)、「改善」為19名中2名(11%)。對於頭頂部之白髮顏色,與使用前相比,開始使用3個月後,「稍微改善」為19名中12名(63%)、「改善」為19名中7名(37%)。
[表11]
表示比較例之醫師及毛髮診斷師所評價之白髮顏色之改善度比率之推移的表
因此,使用比較例之香精之情形與使用實施例之香精之情形相比,頭頂部之白髮顏色之改善程度較低。Therefore, in the case of using the fragrance of the comparative example, compared with the case of using the fragrance of the example, the degree of improvement of the white hair color on the top of the head is lower.
對於側頭部之白髮顏色,與使用前相比,開始使用1個月後,「不變」為19名中8名(42%)、「稍微改善」為19名中11名(58%)。對於側頭部之白髮顏色,與使用前相比,開始使用2個月後,「不變」為19名中4名(21%)、「稍微改善」為19名中15名(79%)。對於側頭部之白髮顏色,與使用前相比,開始使用3個月後,「不變」為19名中1名(5%)、「稍微改善」為19名中14名(74%)、「改善」為19名中4名(21%)。Regarding the white hair color on the side of the head, compared with before use, after 1 month of use, "unchanged" was 8 of 19 (42%), and "slightly improved" was 11 of 19 (58%) ). Regarding the white hair color on the side of the head, compared with before use, after 2 months of use, "unchanged" was 4 of 19 (21%), and "slightly improved" was 15 of 19 (79%) ). Regarding the white hair color on the side of the head, compared with before use, after 3 months of use, "unchanged" was 1 of 19 (5%), and "slightly improved" was 14 of 19 (74%) ), "Improved" is 4 out of 19 (21%).
因此,使用比較例之香精之情形與使用實施例之香精之情形相比,側頭部之白髮顏色之改善程度較低。Therefore, in the case of using the fragrance of the comparative example, the degree of improvement in the white hair color of the side head is lower than the case of using the fragrance of the example.
將由醫師及毛髮診斷師觀察所得之受驗者之白髮根部之改善度比率之推移示於圖16及表12。觀察基準與實施例相同。對於頭頂部之白髮根部之狀態,與使用前相比,開始使用1個月後,「不變」為19名中8名(42%)、「稍微改善」為19名中11名(58%)。對於頭頂部之白髮根部之狀態,與使用前相比,開始使用2個月後,「不變」為19名中8名(42%)、「稍微改善」為19名中11名(58%)。對於頭頂部之白髮根部之狀態,與使用前相比,開始使用3個月後,「不變」為19名中1名(5%)、「稍微改善」為19名中13名(69%)、「改善」為19名中5名(26%)。
[表12]
表示比較例之醫師及毛髮診斷師所評價之白髮根部之改善度比率之推移的表
因此,使用比較例之香精之情形與使用實施例之香精之情形相比,頭頂部之白髮根部之改善程度較低。Therefore, in the case of using the fragrance of the comparative example, the degree of improvement of the white hair root on the top of the head is lower than that of the fragrance of the example.
對於側頭部之白髮根部之狀態,與使用前相比,開始使用1個月後,「不變」為19名中8名(42%)、「稍微改善」為19名中9名(47%)、「改善」為19名中2名(11%)。對於側頭部之白髮根部之狀態,與使用前相比,開始使用2個月後,「不變」為19名中3名(16%)、「稍微改善」為19名中10名(53%)、「改善」為19名中6名(31%)。對於側頭部之白髮根部之狀態,與使用前相比,開始使用3個月後,「稍微改善」為19名中10名(53%)、「改善」為19名中9名(47%)。Regarding the condition of the white hair roots on the side head, compared with before use, one month after the start of use, "unchanged" was 8 of 19 (42%), and "slightly improved" was 9 of 19 ( 47%), "Improved" is 2 out of 19 (11%). Regarding the condition of the white hair roots on the lateral head, compared with before use, after 2 months of use, "unchanged" was 3 out of 19 (16%), and "slightly improved" was 10 out of 19 ( 53%), "Improved" is 6 out of 19 (31%). Regarding the condition of the white hair roots on the lateral head, compared with before use, after 3 months of use, "slightly improved" was 10 out of 19 (53%), and "improved" was 9 out of 19 (47 %).
因此,使用比較例之香精之情形與使用實施例之香精之情形相比,側頭部之白髮根部之改善程度較低。Therefore, in the case of using the fragrance of the comparative example, compared with the case of using the fragrance of the example, the degree of improvement of the white hair roots on the side head is lower.
無no
圖1係表示實施例之醫師及毛髮診斷師所評價之白髮量之改善度比率之推移的圖。 圖2係表示實施例之醫師及毛髮診斷師所評價之白髮顏色之改善度比率之推移的圖。 圖3係表示實施例之醫師及毛髮診斷師所評價之白髮根部之改善度比率之推移的圖。 圖4係表示實施例之利用問卷調查所得之受驗者擔心白髮之情況之推移的圖。 圖5係表示實施例之利用問卷調查所得之受驗者擔心白髮之情況之VAS變化率之推移的圖。 圖6係表示實施例之利用問卷調查所得之受驗者之白髮量之推移的圖。 圖7係表示實施例之利用問卷調查所得之受驗者之白髮量之VAS變化率之推移的圖。 圖8係表示實施例之利用問卷調查所得之受驗者之白髮顏色之推移的圖。 圖9係表示實施例之利用問卷調查所得之受驗者之白髮顏色之VAS變化率之推移的圖。 圖10係表示實施例之利用問卷調查所得之受驗者之白髮範圍之推移的圖。 圖11係表示實施例之利用問卷調查所得之受驗者之白髮範圍之VAS變化率之推移的圖。 圖12係表示實施例之利用問卷調查所得之受驗者之白髮顯眼情況之推移的圖。 圖13係表示實施例之利用問卷調查所得之受驗者之白髮顯眼情況之VAS變化率之推移的圖。 圖14係表示比較例之醫師及毛髮診斷師所評價之白髮量之改善度比率之推移的圖。 圖15係表示比較例之醫師及毛髮診斷師所評價之白髮顏色之改善度比率之推移的圖。 圖16係表示比較例之醫師及毛髮診斷師所評價之白髮根部之改善度比率之推移的圖。Fig. 1 is a graph showing the transition of the rate of improvement in the amount of gray hair evaluated by the physician and the hair diagnostician of the embodiment. Fig. 2 is a graph showing the transition of the gray hair color improvement rate evaluated by the physician and the hair diagnostician of the embodiment. Fig. 3 is a graph showing the transition of the rate of improvement of the gray hair roots evaluated by the physicians and hair diagnosticians of the examples. FIG. 4 is a diagram showing the transition of the subject's worry about gray hair obtained by the questionnaire survey of the embodiment. Fig. 5 is a graph showing the transition of the VAS change rate when the subject is worried about gray hair obtained by the questionnaire survey of the embodiment. Fig. 6 is a graph showing the transition of the amount of gray hair of the subject obtained by the questionnaire survey of the embodiment. Fig. 7 is a graph showing the transition of the VAS change rate of the gray hair amount of the subject obtained by the questionnaire survey of the embodiment. Fig. 8 is a diagram showing the transition of the white hair color of the subject obtained by the questionnaire survey of the embodiment. Fig. 9 is a graph showing the transition of the VAS change rate of the white hair color of the subject obtained by the questionnaire survey of the embodiment. Fig. 10 is a diagram showing the transition of the gray hair range of the subject obtained by the questionnaire survey of the embodiment. FIG. 11 is a graph showing the transition of the VAS change rate of the gray hair range of the subject obtained by the questionnaire survey of the embodiment. Fig. 12 is a diagram showing the transition of the conspicuous white hair of the subject obtained by the questionnaire survey of the embodiment. FIG. 13 is a graph showing the transition of the VAS change rate of the subject's gray hair conspicuously obtained by the questionnaire survey of the embodiment. Fig. 14 is a graph showing the transition of the percentage of improvement in the amount of gray hair evaluated by a physician and a hair diagnostician in a comparative example. Fig. 15 is a graph showing the transition of the degree of improvement of the gray hair color evaluated by the physician and the hair diagnostician of the comparative example. Fig. 16 is a graph showing the transition of the improvement rate of the gray hair roots evaluated by the physician and the hair diagnostician of the comparative example.
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