JP4713385B2 - Liquid skin preparation - Google Patents

Description

  TECHNICAL FIELD The present invention relates to a liquid skin external preparation, and more specifically, to a liquid skin external preparation that stably blends N-acetyl-L-hydroxyproline, reduces the feeling of tension during use, and is excellent in skin flexibility after use. Is.

  In recent years, skin aging such as wrinkles and sagging of skin caused by aging, exposure to ultraviolet rays, tension, and reduced elasticity has been a problem. In order to prevent or improve this skin aging, cell activators such as vitamin A, soybean extract, seaweed extract and the like are added. However, in the component having these cell activators, the anti-aging effect may not be sufficient, or the desired medicinal effect may not be obtained due to degradation such as decomposition in cosmetics. The improvement was desired.

From recent research, N-acetyl-L-hydroxyproline has been found as an effective substance for skin moisturization and aging, as a substance that promotes collagen synthesis in fibroblasts and improves the water retention function of the epidermis. . (See Patent Document 2)
JP-A-10-182411 (pages 1 to 9) International Publication No. WO00 / 51561 Pamphlet (Pages 1 to 39)

  N-acetyl-L-hydroxyproline is a strongly acidic substance, and it is necessary to neutralize with an appropriate basic substance when blended in a skin external preparation. However, when an alkali metal hydroxide such as sodium hydroxide or potassium hydroxide, which is a general neutralizing agent, is used, there is a feeling of firmness of the skin during use due to the N-acetyl-L-hydroxyproline metal salt. There was a case. Moreover, the softness | flexibility of the skin after apply | coating to skin was not enough. In order to make up for such drawbacks, studies have been made to improve oiliness and softness after use by blending oil and water-soluble polymers. However, in a low-viscosity liquid external preparation for skin that cannot contain an oil or a water-soluble polymer, no means for solving these drawbacks has been found.

  Accordingly, as a result of intensive studies to solve the above problems, the present inventors have found that 2-amino-2-methyl-1-propanol and / or 2-amino-2 as a neutralizing agent for N-acetyl-L-hydroxyproline. -By using methyl-1,3-propanediol, in a low-viscosity liquid external preparation for skin, it was found that there was no feeling of skin firmness after use and the flexibility of the back skin was excellent, and the present invention was completed. .

  That is, the present invention relates to component (a) N-acetyl-L-hydroxyproline and component (b) 2-amino-2-methyl-1-propanol and / or 2-amino-2-methyl-1,3-propanediol. It is a liquid skin external preparation characterized by mix | blending. Moreover, the compounding quantity of a component (a) is 0.1-5 mass%, and the compounding quantity of a component (b) is 0.05-3 mass%, Furthermore, the component (a ) And component (b) in a blending mass ratio (a) / (b) of 1 to 20, and a liquid skin preparation, further comprising an oil content of 0.5% or less. It is a liquid skin external preparation.

  According to the present invention, in a low-viscosity liquid skin external preparation containing N-acetyl-L-hydroxyproline and not containing a large amount of oil or water-soluble polymer, the skin feeling during use is reduced, and the skin The flexibility can be improved.

Hereinafter, the configuration of the present invention will be described in detail.
The component (a) N-acetyl-L-hydroxyproline used in the present invention is blended for the purpose of moisturizing and preventing aging. N-acetyl-L-hydroxyproline is an N-acetyl derivative of hydroxyproline, which is an amino acid widely present in nature as one of the constituent amino acids of collagen and elastin, and is a production method described in International Publication No. 00/51561 Etc. can be manufactured.

  Although the compounding quantity of the component (a) in the liquid skin external preparation of this invention is not specifically limited, 0.01-10 mass% (it abbreviates below as%) is preferable, More preferably, it is 0.1-5. %. Within this range, the moisturizing and antiaging effects are excellent, and good stability over time is obtained, which is preferable.

  The component (b) 2-amino-2-methyl-1-propanol and / or 2-amino-2-methyl-1,3-propanediol used in the present invention is a partially neutralized or completely neutralized component (a). It mixes for the purpose of neutralization, and is a component that reduces the feeling of skin tightness when using the external preparation for skin containing component (a), improves the softness of the skin, and is added stably.

The blending amount of the component (b) in the liquid skin external preparation of the present invention is preferably 0.01 to 10%, more preferably 0.05 to 1%. When it is in this range, it is preferable because the feeling of skin tightness can be reduced and the flexibility of the skin can be improved.

  In the liquid external preparation of the present invention, the blending mass ratio (a) / (b) of the component (a) and the component (b) from the viewpoint of reducing the feeling of skin tightness due to the component (a) and improving the flexibility of the skin. ) Is preferably 1-20, more preferably 1-10. If it is this range, the feeling of tightness of the skin can be reduced and the flexibility of the skin can be improved, which is preferable.

  The liquid skin external preparation of the present invention may contain an oil component, but the oil content is preferably 0.5% or less, more preferably 0.3% or less. By setting the blending amount of the oil component to 0.5% or less, the viscosity of the external preparation for skin can be kept low, so that the spreading at the time of use is good. Oils that can be blended in the present invention are natural oils, synthetic oils, semisolids, liquids, etc., as long as they are used in normal cosmetics. Regardless, hydrocarbons, waxes, fatty acids, higher alcohols, ester oils, silicone oils, fluorinated oils, and the like can be used. For example, hydrocarbons such as liquid paraffin, squalane, petrolatum, synthetic ester oils such as cetyl tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, olive oil, castor oil, jojoba oil, mink oil, macadamian Oils derived from plants and animals such as nut oil, apricot oil, persic oil, safflower oil, sunflower oil, avocado oil, medhome oil, camellia oil, almond oil, sesame oil, sesame oil, borage oil, shea fat, beeswax, Examples include carnauba wax, candelilla wax, and gay wax.

  The liquid skin external preparation of the present invention may contain a water-soluble polymer, but the amount is preferably 0.05% or less. By setting the amount of the water-soluble polymer to 0.05% or less, the viscosity of the external preparation for skin can be kept low, and the spreading at the time of use becomes good. Water-soluble polymers that can be blended in the present invention include plant polymers such as carrageenan, pectin, agar, locust bean gum, sugar polymers such as xanthan gum and hyaluronic acid, animal polymers such as gelatin, starch And starch polymers such as cellulose, cellulose polymers such as methylcellulose, carboxymethylcellulose and hydroxypropylcellulose, alginic acid polymers such as sodium alginate, acrylate polymers such as carboxyvinyl polymer and alkyl-modified carboxyvinyl polymer, etc. It is done.

In the liquid external preparation for use in the present invention, a surfactant can be blended according to the blending amount of oil, and the blending amount is preferably 1.0%. By setting the amount of the surfactant to 1.0% or less, it is possible to obtain a fresh feeling of use without a feeling of firmness of the skin. The surfactant that can be blended in the present invention is not particularly limited, such as an anionic surfactant, a nonionic surfactant, and an amphoteric surfactant, but a nonionic surfactant is preferable from the viewpoint of irritation to the skin. Specifically, glycerin fatty acid ester and its alkylene glycol adduct, polyglycerin fatty acid ester and its alkylene glycol adduct, propylene glycol fatty acid ester and its alkylene glycol adduct, sorbitan fatty acid ester and its alkylene glycol adduct, sorbitol Fatty acid ester and its alkylene glycol adduct, polyalkylene glycol fatty acid ester, sucrose fatty acid ester, polyoxyalkylene alkyl ether, glycerin alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene hydrogenated castor oil, lanolin alkylene glycol adduct , Polyoxyalkylene alkyl co-modified silicone, polyether-modified silicone and the like, Mashiku polyoxyalkylene alkyl ethers, glycerol alkyl ethers, polyoxyethylene alkyl phenyl ethers, polyoxyethylene hardened castor oil, the present invention should not be construed as being these any limitation.

  The liquid skin external preparation of the present invention includes, in addition to the above essential components, a neutralizing agent other than the component (b), an antioxidant, a pH adjuster, a fragrance, an antibacterial agent, an antiseptic, a cosmetic ingredient, and the like. It can mix | blend in the range which does not impair the effect of.

  The liquid skin external preparation in the present invention refers to one having a viscosity at 25 ° C. of 1 to 2000 mPa · s as measured by a Brookfield rotary viscometer. When the viscosity is in this range, it is possible to obtain a fresh feeling of use without a feeling of firmness of the skin.

  The dosage form of the liquid skin external preparation of the present invention is not particularly limited, and can be applied to any aqueous dosage form of water type, solubilization type, and oil-in-water emulsification.

  Applications of the liquid skin external preparation of the present invention can be exemplified by lotions, cosmetic liquids, body lotions, emulsions, packs, cleansing materials, makeup skin external preparations, aerosols, etc. Examples thereof include a method, a method of impregnating a nonwoven fabric, and the like.

  EXAMPLES Next, although an Example is given and this invention is further demonstrated, this invention is not limited at all by this.

Invention products 1 to 7 and comparative products 1 to 4: lotion lotions having the compositions shown in Tables 1 and 2 were prepared by the following production method. Table 1 and Table 2 show the results of the following evaluation methods for the obtained skin lotion (1) no skin tightness when used and (2) skin softness after use.

(Production method)
A: Components (1) to (5) are uniformly dissolved.
B: Components (6) to (16) are uniformly dissolved.
C: A was added to B to obtain a skin lotion.

[Softness of skin, lack of tension; evaluation method]
The cosmetics professional evaluation panel of 20 people used the above-mentioned lotions of the invention and comparative products. (1) No skin tension when used, (2) Skin softness after use Based on the evaluation criteria, a five-step evaluation was performed, and further, the determination criteria shown below were determined from the average score of all the panels.

[Evaluation criteria]
5 points: Very good 4 points: Good 3 points: Normal 2 points: Bad 1 point: Very bad [Criteria]
◎: Average point 4.5 points or more ○: Average point 3.5 points or more and less than 4.5 points △: Average point 2.5 points or more and less than 3.5 points ×: Average point less than 2.5 points

As is apparent from the results of Tables 1 and 2, the present invention products 1 to 7 according to the present invention are (1) no skin tightness when used compared to the comparative products, (2) after use. The skin lotion was excellent in skin softness. Moreover, the viscosity value in 25 degreeC of all invention products was 1000-1200 mPa * s. On the other hand, in Comparative Examples 1 to 3 in which the component (b) is not blended and the component (a) is neutralized using another basic substance, both the softness of the skin and the tightness of the skin are good. It wasn't.

Lotion (Ingredient) (%)
1. Polyoxyethylene (60) hydrogenated castor oil 0.3
2. Sorbitan sesquioleate 0.1
3. Tetra-2-ethylhexanoic acid pentaerythrit 0.3
4). Ethanol 10.0
5. Perfume appropriate amount 6. 6. Purified water remaining amount Citric acid 0.1
8). Sodium citrate 0.1
9. N-acetyl-L-hydroxyproline (Note 1) 2.0
10.2-Amino-2-methyl-1,3-propanediol 0.6
11. Potassium hydroxide 0.04
12 Edetate disodium 0.1
13. Glycerin 10.0
(Note 1): Kyowa Hakko

(Manufacturing method)
A: Components (1) to (5) are uniformly dissolved.
B: Components (6) to (13) are uniformly dissolved.
C: A was added to B to obtain a skin lotion.

The lotion of Example 2 had a viscosity value of 1200 mPa · s at 25 ° C., (1) no skin tension when used, and (2) a lotion excellent in skin softness after use. .

Liquid serum (ingredient) (%)
1. Monooleic acid polyoxyethylene (20) sorbitan 0.2
2. Sorbitan sesquioleate 0.1
3. Glyceryl trioctanoate 0.2
4). Jojoba oil 0.2
5. Squalane 0.1
6). 6. Purified water remaining amount Edetate disodium 0.1
8). Methylparaben 0.2
9. Phenoxyethanol 0.5
10. Glycerin 5.0
11. Sodium lactate 0.5
12 N-acetyl-L-hydroxyproline (Note 1) 1.0
13. 2-Amino-2-methyl-1-propanol 0.3
14 Xanthan gum 0.05
15. Purified water 10.0
16. Ethanol 3.0
17. Perfume appropriate amount (Note 1): manufactured by Kyowa Hakko

(Manufacturing method)
A: The component (14) is swollen with the component (15) heated to 70 ° C.
B: Components (1) to (5) are mixed and dissolved at 70 ° C.
C: Components (6) to (13) are heated and dissolved at 70 ° C., then added to B and emulsified.
D: After cooling C to room temperature, components (16), (17) and A were added to obtain a cosmetic liquid.

  The liquid cosmetic liquid of Example 3 has a viscosity value at 25 ° C. of 1500 mPa · s, (1) no liquid tightness when used, and (2) excellent liquid cosmetic liquid after use. there were.

Claims (4)

The following components (a), (b);
(A) N-acetyl-L-hydroxyproline (b) 2-amino-2-methyl-1-propanol and / or 2-amino-2-methyl-1,3-propanediol are blended. Liquid skin preparation.   The liquid skin external preparation according to claim 1, wherein the amount of component (a) is 0.1 to 5% by mass and the amount of component (b) is 0.05 to 3% by mass.   The liquid skin external preparation according to claim 1 or 2, wherein the blending mass ratio (a) / (b) of the component (a) and the component (b) is 1 to 20.   The liquid skin external preparation according to any one of claims 1 to 3, wherein the oil content is 0.5 mass% or less.