TW202021591A - B細胞惡性腫瘤之治療 - Google Patents

B細胞惡性腫瘤之治療 Download PDF

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Publication number
TW202021591A
TW202021591A TW108128967A TW108128967A TW202021591A TW 202021591 A TW202021591 A TW 202021591A TW 108128967 A TW108128967 A TW 108128967A TW 108128967 A TW108128967 A TW 108128967A TW 202021591 A TW202021591 A TW 202021591A
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TW
Taiwan
Prior art keywords
compound
enantiomers
alkyl
mixtures
formula
Prior art date
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TW108128967A
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English (en)
Chinese (zh)
Inventor
丹尼爾 P 戈德
Original Assignee
美商梅製藥公司
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Application filed by 美商梅製藥公司 filed Critical 美商梅製藥公司
Publication of TW202021591A publication Critical patent/TW202021591A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
TW108128967A 2018-08-14 2019-08-14 B細胞惡性腫瘤之治療 TW202021591A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862718929P 2018-08-14 2018-08-14
US62/718,929 2018-08-14
US201862775797P 2018-12-05 2018-12-05
US62/775,797 2018-12-05
US201962836511P 2019-04-19 2019-04-19
US62/836,511 2019-04-19

Publications (1)

Publication Number Publication Date
TW202021591A true TW202021591A (zh) 2020-06-16

Family

ID=69525845

Family Applications (1)

Application Number Title Priority Date Filing Date
TW108128967A TW202021591A (zh) 2018-08-14 2019-08-14 B細胞惡性腫瘤之治療

Country Status (14)

Country Link
US (1) US20210299134A1 (enExample)
EP (1) EP3836935A4 (enExample)
JP (1) JP2021534115A (enExample)
KR (1) KR20210043635A (enExample)
CN (1) CN112888441A (enExample)
AU (1) AU2019321432A1 (enExample)
BR (1) BR112021002760A2 (enExample)
CA (1) CA3109184A1 (enExample)
IL (1) IL280726A (enExample)
MA (1) MA53236A (enExample)
MX (1) MX2021001606A (enExample)
SG (1) SG11202101450VA (enExample)
TW (1) TW202021591A (enExample)
WO (1) WO2020036999A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107501241B (zh) 2011-03-28 2020-10-13 梅制药公司 化合物、含有其的药物组合物以及它们在治疗增生性疾病中的用途
EP3630118A4 (en) 2017-05-23 2021-03-31 MEI Pharma, Inc. COMBINATION THERAPY
MX2020001727A (es) 2017-08-14 2020-03-20 Mei Pharma Inc Terapia de combinacion.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014500275A (ja) * 2010-12-06 2014-01-09 フォリカ,インコーポレイテッド 禿頭症を治療するため、および毛髪の成長を促進するための方法
CN107501241B (zh) * 2011-03-28 2020-10-13 梅制药公司 化合物、含有其的药物组合物以及它们在治疗增生性疾病中的用途
CA2979671C (en) * 2014-09-23 2020-03-10 Genentech, Inc. Methods of using anti-cd79b immunoconjugates
WO2017007658A1 (en) * 2015-07-07 2017-01-12 Rigel Pharmaceuticals, Inc. A combination for immune mediated cancer treatment
WO2017035234A1 (en) * 2015-08-24 2017-03-02 Epizyme, Inc. Method for treating cancer
US11365252B2 (en) * 2016-07-20 2022-06-21 University Of Utah Research Foundation CD229 CAR T cells and methods of use thereof
CN109982687A (zh) * 2016-09-19 2019-07-05 梅制药公司 联合疗法
WO2018060833A1 (en) * 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
WO2018082444A1 (zh) * 2016-11-02 2018-05-11 叶宝欢 吡唑并嘧啶化合物作为pi3k抑制剂及其应用
MX2020001727A (es) * 2017-08-14 2020-03-20 Mei Pharma Inc Terapia de combinacion.

Also Published As

Publication number Publication date
JP2021534115A (ja) 2021-12-09
CA3109184A1 (en) 2020-02-20
IL280726A (en) 2021-03-25
SG11202101450VA (en) 2021-03-30
EP3836935A1 (en) 2021-06-23
US20210299134A1 (en) 2021-09-30
EP3836935A4 (en) 2022-09-14
MX2021001606A (es) 2021-04-19
KR20210043635A (ko) 2021-04-21
BR112021002760A2 (pt) 2021-05-11
CN112888441A (zh) 2021-06-01
WO2020036999A1 (en) 2020-02-20
MA53236A (fr) 2021-06-23
AU2019321432A1 (en) 2021-03-25

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