TW202016530A - 使用光子計數光偵測器以偵測壽命之系統及方法 - Google Patents
使用光子計數光偵測器以偵測壽命之系統及方法 Download PDFInfo
- Publication number
- TW202016530A TW202016530A TW108131144A TW108131144A TW202016530A TW 202016530 A TW202016530 A TW 202016530A TW 108131144 A TW108131144 A TW 108131144A TW 108131144 A TW108131144 A TW 108131144A TW 202016530 A TW202016530 A TW 202016530A
- Authority
- TW
- Taiwan
- Prior art keywords
- array
- light
- photodetector
- sample well
- sample
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 72
- 238000001514 detection method Methods 0.000 claims abstract description 242
- 230000003287 optical effect Effects 0.000 claims description 109
- 230000005284 excitation Effects 0.000 claims description 74
- 125000003729 nucleotide group Chemical group 0.000 claims description 68
- 239000002773 nucleotide Substances 0.000 claims description 54
- 108020004707 nucleic acids Proteins 0.000 claims description 48
- 102000039446 nucleic acids Human genes 0.000 claims description 48
- 150000007523 nucleic acids Chemical class 0.000 claims description 48
- 230000004044 response Effects 0.000 claims description 29
- 238000003860 storage Methods 0.000 claims description 24
- 230000000295 complement effect Effects 0.000 claims description 13
- 238000013519 translation Methods 0.000 claims description 6
- 230000009471 action Effects 0.000 description 22
- 238000003491 array Methods 0.000 description 15
- 238000009826 distribution Methods 0.000 description 14
- 238000010586 diagram Methods 0.000 description 13
- 230000033001 locomotion Effects 0.000 description 10
- 230000008569 process Effects 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 9
- 239000000758 substrate Substances 0.000 description 9
- 230000006870 function Effects 0.000 description 8
- 230000001678 irradiating effect Effects 0.000 description 8
- 238000003384 imaging method Methods 0.000 description 7
- 230000008901 benefit Effects 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 238000012163 sequencing technique Methods 0.000 description 6
- 108020004414 DNA Proteins 0.000 description 5
- 238000010168 coupling process Methods 0.000 description 5
- 230000003595 spectral effect Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 4
- 230000008878 coupling Effects 0.000 description 4
- 238000005859 coupling reaction Methods 0.000 description 4
- 238000010348 incorporation Methods 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 230000005540 biological transmission Effects 0.000 description 3
- 239000002800 charge carrier Substances 0.000 description 3
- 238000004590 computer program Methods 0.000 description 3
- 238000004624 confocal microscopy Methods 0.000 description 3
- 230000005281 excited state Effects 0.000 description 3
- 238000005286 illumination Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 230000002123 temporal effect Effects 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000005304 joining Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000007493 shaping process Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 229930024421 Adenine Natural products 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 229940104302 cytosine Drugs 0.000 description 1
- 230000023077 detection of light stimulus Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000005283 ground state Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 238000004557 single molecule detection Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
- H10F30/00—Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors
- H10F30/20—Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors the devices having potential barriers, e.g. phototransistors
- H10F30/21—Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors the devices having potential barriers, e.g. phototransistors the devices being sensitive to infrared, visible or ultraviolet radiation
- H10F30/22—Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors the devices having potential barriers, e.g. phototransistors the devices being sensitive to infrared, visible or ultraviolet radiation the devices having only one potential barrier, e.g. photodiodes
- H10F30/225—Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors the devices having potential barriers, e.g. phototransistors the devices being sensitive to infrared, visible or ultraviolet radiation the devices having only one potential barrier, e.g. photodiodes the potential barrier working in avalanche mode, e.g. avalanche photodiodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
- G01N2021/641—Phosphorimetry, gated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6484—Optical fibres
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
- H10F77/00—Constructional details of devices covered by this subclass
- H10F77/95—Circuit arrangements
- H10F77/953—Circuit arrangements for devices having potential barriers
- H10F77/957—Circuit arrangements for devices having potential barriers for position-sensitive photodetectors, e.g. lateral-effect photodiodes or quadrant photodiodes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Optical Measuring Cells (AREA)
- Photometry And Measurement Of Optical Pulse Characteristics (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862724167P | 2018-08-29 | 2018-08-29 | |
| US62/724,167 | 2018-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202016530A true TW202016530A (zh) | 2020-05-01 |
Family
ID=67953862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW108131144A TW202016530A (zh) | 2018-08-29 | 2019-08-29 | 使用光子計數光偵測器以偵測壽命之系統及方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20200072752A1 (https=) |
| EP (1) | EP3844486A1 (https=) |
| JP (1) | JP2021535385A (https=) |
| KR (1) | KR20210046061A (https=) |
| CN (1) | CN112930476A (https=) |
| AU (1) | AU2019330042A1 (https=) |
| BR (1) | BR112021003146A2 (https=) |
| CA (1) | CA3109816A1 (https=) |
| MX (1) | MX2021002414A (https=) |
| TW (1) | TW202016530A (https=) |
| WO (1) | WO2020047262A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102585730B1 (ko) | 2014-08-08 | 2023-10-10 | 퀀텀-에스아이 인코포레이티드 | 수신된 광자들의 시간 비닝을 위한 집적 디바이스 |
| JP2019512090A (ja) | 2016-02-17 | 2019-05-09 | テッセラクト ヘルス インコーポレイテッドＴｅｓｓｅｒａｃｔ Ｈｅａｌｔｈ，Ｉｎｃ． | 寿命イメージングおよび検出用途のためのセンサおよびデバイス |
| KR102560427B1 (ko) | 2016-12-22 | 2023-07-28 | 퀀텀-에스아이 인코포레이티드 | 직접 비닝 픽셀을 갖는 집적 광검출기 |
| WO2019246328A1 (en) | 2018-06-22 | 2019-12-26 | Quantum-Si Incorporated | Integrated photodetector with charge storage bin of varied detection time |
| TW202145595A (zh) | 2020-01-14 | 2021-12-01 | 美商寬騰矽公司 | 用於壽命及光譜特性分析之感應器 |
| JP7763763B2 (ja) | 2020-01-14 | 2025-11-04 | クアンタム－エスアイ インコーポレイテッド | 寿命特性評価のための集積センサ |
| TW202147591A (zh) | 2020-03-02 | 2021-12-16 | 美商寬騰矽公司 | 用於多維信號分析之整合感應器 |
| EP4133524A2 (en) | 2020-04-08 | 2023-02-15 | Quantum-si Incorporated | Integrated sensor with reduced skew |
| CN114015560B (zh) * | 2021-10-20 | 2024-07-05 | 深圳市中科先见医疗科技有限公司 | 一种分子检测芯片 |
| US11927814B2 (en) * | 2022-01-05 | 2024-03-12 | Scidatek Inc. | Semiconductor photodetector array sensor integrated with optical-waveguide-based devices |
| WO2023137051A2 (en) | 2022-01-12 | 2023-07-20 | Quantum-Si Incorporated | Integrated sensor |
| CN116148232B (zh) * | 2023-02-23 | 2026-04-17 | 华东师范大学 | 一种全谱荧光寿命快速测量装置 |
| DE102024136606B3 (de) | 2024-12-09 | 2026-03-05 | Quantum Technologies Gmbh | NV-Zentren basierende Wirbelstromkamera |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1123469A (ja) * | 1997-06-30 | 1999-01-29 | Suzuki Motor Corp | 蛍光免疫測定装置 |
| DE19748211A1 (de) * | 1997-10-31 | 1999-05-06 | Zeiss Carl Fa | Optisches Array-System und Reader für Mikrotiterplatten |
| US20060019265A1 (en) * | 2004-04-30 | 2006-01-26 | Kimberly-Clark Worldwide, Inc. | Transmission-based luminescent detection systems |
| CN105917003A (zh) * | 2013-11-17 | 2016-08-31 | 宽腾矽公司 | 用于生物和化学试样的快速分析的有源像素集成装置 |
| US10174363B2 (en) * | 2015-05-20 | 2019-01-08 | Quantum-Si Incorporated | Methods for nucleic acid sequencing |
| KR102585730B1 (ko) * | 2014-08-08 | 2023-10-10 | 퀀텀-에스아이 인코포레이티드 | 수신된 광자들의 시간 비닝을 위한 집적 디바이스 |
| MX384725B (es) * | 2014-08-08 | 2025-03-14 | Quantum Si Inc | Dispositivo integrado con fuente de luz externa para el sondeo, detección y análisis de moléculas. |
| CN106796175B (zh) * | 2014-08-08 | 2021-01-05 | 宽腾矽公司 | 用于探测、检测和分析分子的光学系统和检测芯片 |
| CA2986237A1 (en) * | 2015-05-20 | 2016-11-24 | Quantum-Si Incorporated | Method of determining the sequence of a nucleic acid using time resolved luminescence |
| US10246742B2 (en) * | 2015-05-20 | 2019-04-02 | Quantum-Si Incorporated | Pulsed laser and bioanalytic system |
| CN108463714B (zh) * | 2016-01-13 | 2021-02-05 | 马克斯-普朗克科学促进学会 | 用于测量电子激发态的平均寿命的发射寿命测量方法和设备 |
| MX2018014856A (es) * | 2016-06-01 | 2019-03-07 | Quantum Si Inc | Llamador de pulso y llamador de base. |
-
2019
- 2019-08-29 CA CA3109816A patent/CA3109816A1/en active Pending
- 2019-08-29 TW TW108131144A patent/TW202016530A/zh unknown
- 2019-08-29 JP JP2021510670A patent/JP2021535385A/ja active Pending
- 2019-08-29 BR BR112021003146-4A patent/BR112021003146A2/pt not_active IP Right Cessation
- 2019-08-29 AU AU2019330042A patent/AU2019330042A1/en not_active Abandoned
- 2019-08-29 US US16/554,751 patent/US20200072752A1/en not_active Abandoned
- 2019-08-29 WO PCT/US2019/048824 patent/WO2020047262A1/en not_active Ceased
- 2019-08-29 CN CN201980071659.7A patent/CN112930476A/zh active Pending
- 2019-08-29 KR KR1020217008826A patent/KR20210046061A/ko not_active Ceased
- 2019-08-29 EP EP19768949.0A patent/EP3844486A1/en not_active Withdrawn
- 2019-08-29 MX MX2021002414A patent/MX2021002414A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3844486A1 (en) | 2021-07-07 |
| BR112021003146A2 (pt) | 2021-05-11 |
| US20200072752A1 (en) | 2020-03-05 |
| CN112930476A (zh) | 2021-06-08 |
| JP2021535385A (ja) | 2021-12-16 |
| WO2020047262A1 (en) | 2020-03-05 |
| AU2019330042A1 (en) | 2021-03-11 |
| KR20210046061A (ko) | 2021-04-27 |
| MX2021002414A (es) | 2021-04-28 |
| CA3109816A1 (en) | 2020-03-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW202016530A (zh) | 使用光子計數光偵測器以偵測壽命之系統及方法 | |
| US20230258862A1 (en) | Optical coupler and waveguide system | |
| US20220113469A1 (en) | Optical rejection photonic structures | |
| US20230341621A1 (en) | Optical waveguides and couplers for delivering light to an array of photonic elements | |
| US8834797B2 (en) | Scanning system and method for imaging and sequencing | |
| JP7763763B2 (ja) | 寿命特性評価のための集積センサ | |
| US12203855B2 (en) | Sensor for lifetime plus spectral characterization | |
| JP2021535385A5 (https=) | ||
| US12169142B2 (en) | Integrated circuit with sequentially-coupled charge storage and associated techniques | |
| US12188868B2 (en) | Waveguide excitation uniformity | |
| US20240003811A1 (en) | Integrated sensor for multi-dimensional signal analysis | |
| WO2007144864A1 (en) | Solid-state fluorescent analyser | |
| US20220186305A1 (en) | Integrated circuit with improved charge transfer efficiency and associated techniques | |
| JP2021501894A (ja) | 超解像蛍光顕微鏡及び蛍光寿命測定のためのデバイス及び方法 | |
| JPWO2020047262A5 (https=) | ||
| US20240280488A1 (en) | Methods and device for detecting single photons from a sample comprising at least one emitter |