BR112021003146A2 - sistema e métodos para detectar o tempo de vida ao usar fotodetectores de contagem de fótons - Google Patents
sistema e métodos para detectar o tempo de vida ao usar fotodetectores de contagem de fótons Download PDFInfo
- Publication number
- BR112021003146A2 BR112021003146A2 BR112021003146-4A BR112021003146A BR112021003146A2 BR 112021003146 A2 BR112021003146 A2 BR 112021003146A2 BR 112021003146 A BR112021003146 A BR 112021003146A BR 112021003146 A2 BR112021003146 A2 BR 112021003146A2
- Authority
- BR
- Brazil
- Prior art keywords
- array
- photodetectors
- photodetector
- sample
- arrangement
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
- H10F30/00—Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors
- H10F30/20—Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors the devices having potential barriers, e.g. phototransistors
- H10F30/21—Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors the devices having potential barriers, e.g. phototransistors the devices being sensitive to infrared, visible or ultraviolet radiation
- H10F30/22—Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors the devices having potential barriers, e.g. phototransistors the devices being sensitive to infrared, visible or ultraviolet radiation the devices having only one potential barrier, e.g. photodiodes
- H10F30/225—Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors the devices having potential barriers, e.g. phototransistors the devices being sensitive to infrared, visible or ultraviolet radiation the devices having only one potential barrier, e.g. photodiodes the potential barrier working in avalanche mode, e.g. avalanche photodiodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
- G01N2021/641—Phosphorimetry, gated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6484—Optical fibres
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
- H10F77/00—Constructional details of devices covered by this subclass
- H10F77/95—Circuit arrangements
- H10F77/953—Circuit arrangements for devices having potential barriers
- H10F77/957—Circuit arrangements for devices having potential barriers for position-sensitive photodetectors, e.g. lateral-effect photodiodes or quadrant photodiodes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Optical Measuring Cells (AREA)
- Photometry And Measurement Of Optical Pulse Characteristics (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862724167P | 2018-08-29 | 2018-08-29 | |
| US62/724,167 | 2018-08-29 | ||
| PCT/US2019/048824 WO2020047262A1 (en) | 2018-08-29 | 2019-08-29 | System and methods for detecting lifetime using photon counting photodetectors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021003146A2 true BR112021003146A2 (pt) | 2021-05-11 |
Family
ID=67953862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021003146-4A BR112021003146A2 (pt) | 2018-08-29 | 2019-08-29 | sistema e métodos para detectar o tempo de vida ao usar fotodetectores de contagem de fótons |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20200072752A1 (https=) |
| EP (1) | EP3844486A1 (https=) |
| JP (1) | JP2021535385A (https=) |
| KR (1) | KR20210046061A (https=) |
| CN (1) | CN112930476A (https=) |
| AU (1) | AU2019330042A1 (https=) |
| BR (1) | BR112021003146A2 (https=) |
| CA (1) | CA3109816A1 (https=) |
| MX (1) | MX2021002414A (https=) |
| TW (1) | TW202016530A (https=) |
| WO (1) | WO2020047262A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3471402B1 (en) | 2014-08-08 | 2023-05-31 | Quantum-Si Incorporated | Integrated device for temporal binning of received photons |
| KR20180111999A (ko) | 2016-02-17 | 2018-10-11 | 테서렉트 헬스, 인코포레이티드 | 수명 촬상 및 검출 응용을 위한 센서 및 디바이스 |
| CA3047826A1 (en) | 2016-12-22 | 2018-06-28 | Quantum-Si Incorporated | Integrated photodetector with direct binning pixel |
| CN119364214A (zh) | 2018-06-22 | 2025-01-24 | 宽腾矽公司 | 具有不同检测时间的电荷存储仓的集成光电检测器 |
| WO2021146473A1 (en) | 2020-01-14 | 2021-07-22 | Quantum-Si Incorporated | Integrated sensor for lifetime characterization |
| AU2021208557A1 (en) | 2020-01-14 | 2022-09-01 | Quantum-Si Incorporated | Sensor for lifetime plus spectral characterization |
| TW202147591A (zh) | 2020-03-02 | 2021-12-16 | 美商寬騰矽公司 | 用於多維信號分析之整合感應器 |
| KR20220165754A (ko) | 2020-04-08 | 2022-12-15 | 퀀텀-에스아이 인코포레이티드 | 스큐가 감소된 통합 센서 |
| CN114015560B (zh) * | 2021-10-20 | 2024-07-05 | 深圳市中科先见医疗科技有限公司 | 一种分子检测芯片 |
| US11927814B2 (en) * | 2022-01-05 | 2024-03-12 | Scidatek Inc. | Semiconductor photodetector array sensor integrated with optical-waveguide-based devices |
| WO2023137051A2 (en) | 2022-01-12 | 2023-07-20 | Quantum-Si Incorporated | Integrated sensor |
| CN116148232B (zh) * | 2023-02-23 | 2026-04-17 | 华东师范大学 | 一种全谱荧光寿命快速测量装置 |
| DE102024136606B3 (de) | 2024-12-09 | 2026-03-05 | Quantum Technologies Gmbh | NV-Zentren basierende Wirbelstromkamera |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1123469A (ja) * | 1997-06-30 | 1999-01-29 | Suzuki Motor Corp | 蛍光免疫測定装置 |
| DE19748211A1 (de) * | 1997-10-31 | 1999-05-06 | Zeiss Carl Fa | Optisches Array-System und Reader für Mikrotiterplatten |
| US20060019265A1 (en) * | 2004-04-30 | 2006-01-26 | Kimberly-Clark Worldwide, Inc. | Transmission-based luminescent detection systems |
| WO2015074001A1 (en) * | 2013-11-17 | 2015-05-21 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting and analyzing molecules |
| CA2957543A1 (en) * | 2014-08-08 | 2016-02-11 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting and analyzing molecules |
| US10174363B2 (en) * | 2015-05-20 | 2019-01-08 | Quantum-Si Incorporated | Methods for nucleic acid sequencing |
| EP3471402B1 (en) * | 2014-08-08 | 2023-05-31 | Quantum-Si Incorporated | Integrated device for temporal binning of received photons |
| EP4421188A3 (en) * | 2014-08-08 | 2024-10-23 | Quantum-Si Incorporated | Integrated device with external light source for probing, detecting, and analyzing molecules |
| WO2016187580A1 (en) * | 2015-05-20 | 2016-11-24 | Quantum-Si Incorporated | Method of determining the sequence of a nuclear acid using time resolved luminescence |
| US10246742B2 (en) * | 2015-05-20 | 2019-04-02 | Quantum-Si Incorporated | Pulsed laser and bioanalytic system |
| JP6637605B2 (ja) * | 2016-01-13 | 2020-01-29 | マックス−プランク−ゲゼルシャフト ツール フォーデルング デル ヴィッセンシャフテン エー.ヴェー. | 電子励起状態の平均寿命時間を測定するための発光寿命時間測定方法及び装置 |
| TWI755400B (zh) * | 2016-06-01 | 2022-02-21 | 美商寬騰矽公司 | 脈衝命名器及基質命名器、識別核苷酸之方法、校準定序儀器之方法、識別發生核苷酸併入事件之時間的方法、非暫時性電腦可讀儲存媒體、及定序儀器 |
-
2019
- 2019-08-29 AU AU2019330042A patent/AU2019330042A1/en not_active Abandoned
- 2019-08-29 JP JP2021510670A patent/JP2021535385A/ja active Pending
- 2019-08-29 WO PCT/US2019/048824 patent/WO2020047262A1/en not_active Ceased
- 2019-08-29 EP EP19768949.0A patent/EP3844486A1/en not_active Withdrawn
- 2019-08-29 MX MX2021002414A patent/MX2021002414A/es unknown
- 2019-08-29 CA CA3109816A patent/CA3109816A1/en active Pending
- 2019-08-29 BR BR112021003146-4A patent/BR112021003146A2/pt not_active IP Right Cessation
- 2019-08-29 KR KR1020217008826A patent/KR20210046061A/ko not_active Ceased
- 2019-08-29 US US16/554,751 patent/US20200072752A1/en not_active Abandoned
- 2019-08-29 TW TW108131144A patent/TW202016530A/zh unknown
- 2019-08-29 CN CN201980071659.7A patent/CN112930476A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2021002414A (es) | 2021-04-28 |
| CA3109816A1 (en) | 2020-03-05 |
| JP2021535385A (ja) | 2021-12-16 |
| EP3844486A1 (en) | 2021-07-07 |
| KR20210046061A (ko) | 2021-04-27 |
| CN112930476A (zh) | 2021-06-08 |
| TW202016530A (zh) | 2020-05-01 |
| WO2020047262A1 (en) | 2020-03-05 |
| US20200072752A1 (en) | 2020-03-05 |
| AU2019330042A1 (en) | 2021-03-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112021003146A2 (pt) | sistema e métodos para detectar o tempo de vida ao usar fotodetectores de contagem de fótons | |
| US20230258862A1 (en) | Optical coupler and waveguide system | |
| US20230341621A1 (en) | Optical waveguides and couplers for delivering light to an array of photonic elements | |
| JP5802653B2 (ja) | 光分析装置、光分析方法並びに光分析用コンピュータプログラム | |
| US20240096924A1 (en) | Integrated sensor for lifetime characterization | |
| JP2021535385A5 (https=) | ||
| US12203855B2 (en) | Sensor for lifetime plus spectral characterization | |
| EP1726940A1 (en) | Light measurement apparatus and light measurement method | |
| US12514005B2 (en) | Integrated sensor | |
| JP2023511550A (ja) | 集積システムにおける励起光生成用パルスレーザー光源 | |
| US20240003811A1 (en) | Integrated sensor for multi-dimensional signal analysis | |
| US20250267967A1 (en) | Backside illuminated structures with parallel charge transfer | |
| JP2006518067A (ja) | コインのテスト方法及びテスト装置 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2790 DE 25-06-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |