CN112930476A - 使用光子计数光电检测器以检测寿命的系统及方法 - Google Patents

使用光子计数光电检测器以检测寿命的系统及方法 Download PDF

Info

Publication number
CN112930476A
CN112930476A CN201980071659.7A CN201980071659A CN112930476A CN 112930476 A CN112930476 A CN 112930476A CN 201980071659 A CN201980071659 A CN 201980071659A CN 112930476 A CN112930476 A CN 112930476A
Authority
CN
China
Prior art keywords
array
photodetectors
photodetector
sample wells
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980071659.7A
Other languages
English (en)
Chinese (zh)
Inventor
班杰明·西普里亚尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quantum Si Inc
Original Assignee
Quantum Si Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantum Si Inc filed Critical Quantum Si Inc
Publication of CN112930476A publication Critical patent/CN112930476A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
    • H10F30/00—Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors
    • H10F30/20—Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors the devices having potential barriers, e.g. phototransistors
    • H10F30/21—Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors the devices having potential barriers, e.g. phototransistors the devices being sensitive to infrared, visible or ultraviolet radiation
    • H10F30/22—Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors the devices having potential barriers, e.g. phototransistors the devices being sensitive to infrared, visible or ultraviolet radiation the devices having only one potential barrier, e.g. photodiodes
    • H10F30/225—Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors the devices having potential barriers, e.g. phototransistors the devices being sensitive to infrared, visible or ultraviolet radiation the devices having only one potential barrier, e.g. photodiodes the potential barrier working in avalanche mode, e.g. avalanche photodiodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G01N2021/641—Phosphorimetry, gated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
    • H10F77/00—Constructional details of devices covered by this subclass
    • H10F77/95—Circuit arrangements
    • H10F77/953—Circuit arrangements for devices having potential barriers
    • H10F77/957—Circuit arrangements for devices having potential barriers for position-sensitive photodetectors, e.g. lateral-effect photodiodes or quadrant photodiodes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
  • Photometry And Measurement Of Optical Pulse Characteristics (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CN201980071659.7A 2018-08-29 2019-08-29 使用光子计数光电检测器以检测寿命的系统及方法 Pending CN112930476A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862724167P 2018-08-29 2018-08-29
US62/724,167 2018-08-29
PCT/US2019/048824 WO2020047262A1 (en) 2018-08-29 2019-08-29 System and methods for detecting lifetime using photon counting photodetectors

Publications (1)

Publication Number Publication Date
CN112930476A true CN112930476A (zh) 2021-06-08

Family

ID=67953862

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980071659.7A Pending CN112930476A (zh) 2018-08-29 2019-08-29 使用光子计数光电检测器以检测寿命的系统及方法

Country Status (11)

Country Link
US (1) US20200072752A1 (https=)
EP (1) EP3844486A1 (https=)
JP (1) JP2021535385A (https=)
KR (1) KR20210046061A (https=)
CN (1) CN112930476A (https=)
AU (1) AU2019330042A1 (https=)
BR (1) BR112021003146A2 (https=)
CA (1) CA3109816A1 (https=)
MX (1) MX2021002414A (https=)
TW (1) TW202016530A (https=)
WO (1) WO2020047262A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023066311A1 (zh) * 2021-10-20 2023-04-27 深圳市中科先见医疗科技有限公司 一种单分子/单细胞检测芯片
CN116148232A (zh) * 2023-02-23 2023-05-23 华东师范大学 一种全谱荧光寿命快速测量装置

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102585730B1 (ko) 2014-08-08 2023-10-10 퀀텀-에스아이 인코포레이티드 수신된 광자들의 시간 비닝을 위한 집적 디바이스
JP2019512090A (ja) 2016-02-17 2019-05-09 テッセラクト ヘルス インコーポレイテッドＴｅｓｓｅｒａｃｔ Ｈｅａｌｔｈ，Ｉｎｃ． 寿命イメージングおよび検出用途のためのセンサおよびデバイス
KR102560427B1 (ko) 2016-12-22 2023-07-28 퀀텀-에스아이 인코포레이티드 직접 비닝 픽셀을 갖는 집적 광검출기
WO2019246328A1 (en) 2018-06-22 2019-12-26 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
TW202145595A (zh) 2020-01-14 2021-12-01 美商寬騰矽公司 用於壽命及光譜特性分析之感應器
JP7763763B2 (ja) 2020-01-14 2025-11-04 クアンタム－エスアイ インコーポレイテッド 寿命特性評価のための集積センサ
TW202147591A (zh) 2020-03-02 2021-12-16 美商寬騰矽公司 用於多維信號分析之整合感應器
EP4133524A2 (en) 2020-04-08 2023-02-15 Quantum-si Incorporated Integrated sensor with reduced skew
US11927814B2 (en) * 2022-01-05 2024-03-12 Scidatek Inc. Semiconductor photodetector array sensor integrated with optical-waveguide-based devices
WO2023137051A2 (en) 2022-01-12 2023-07-20 Quantum-Si Incorporated Integrated sensor
DE102024136606B3 (de) 2024-12-09 2026-03-05 Quantum Technologies Gmbh NV-Zentren basierende Wirbelstromkamera

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060019265A1 (en) * 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
US20150141268A1 (en) * 2013-11-17 2015-05-21 Quantum-Si Incorporated Active-source-pixel, integrated device for rapid analysis of biological and chemical specimens
US20160041095A1 (en) * 2014-08-08 2016-02-11 Quantum-Si Incorporated Optical system and assay chip for probing, detecting and analyzing molecule
US20160084761A1 (en) * 2014-08-08 2016-03-24 Quantum-Si Incorporated Integrated device with external light source for probing detecting and analyzing molecules
US20160344156A1 (en) * 2015-05-20 2016-11-24 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US20170107562A1 (en) * 2015-05-20 2017-04-20 Quantum-Si Incorporated Methods for nucleic acid sequencing
CN108463714A (zh) * 2016-01-13 2018-08-28 马克斯-普朗克科学促进学会 用于测量电子激发态的平均寿命的发射寿命测量方法和设备

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1123469A (ja) * 1997-06-30 1999-01-29 Suzuki Motor Corp 蛍光免疫測定装置
DE19748211A1 (de) * 1997-10-31 1999-05-06 Zeiss Carl Fa Optisches Array-System und Reader für Mikrotiterplatten
KR102585730B1 (ko) * 2014-08-08 2023-10-10 퀀텀-에스아이 인코포레이티드 수신된 광자들의 시간 비닝을 위한 집적 디바이스
CA2986237A1 (en) * 2015-05-20 2016-11-24 Quantum-Si Incorporated Method of determining the sequence of a nucleic acid using time resolved luminescence
MX2018014856A (es) * 2016-06-01 2019-03-07 Quantum Si Inc Llamador de pulso y llamador de base.

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060019265A1 (en) * 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
US20150141268A1 (en) * 2013-11-17 2015-05-21 Quantum-Si Incorporated Active-source-pixel, integrated device for rapid analysis of biological and chemical specimens
US20150141267A1 (en) * 2013-11-17 2015-05-21 Quantum-Si Incorporated Integrated device with external light source for probing detecting and analyzing molecules
US20160041095A1 (en) * 2014-08-08 2016-02-11 Quantum-Si Incorporated Optical system and assay chip for probing, detecting and analyzing molecule
US20160084761A1 (en) * 2014-08-08 2016-03-24 Quantum-Si Incorporated Integrated device with external light source for probing detecting and analyzing molecules
US20160344156A1 (en) * 2015-05-20 2016-11-24 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US20170107562A1 (en) * 2015-05-20 2017-04-20 Quantum-Si Incorporated Methods for nucleic acid sequencing
CN108463714A (zh) * 2016-01-13 2018-08-28 马克斯-普朗克科学促进学会 用于测量电子激发态的平均寿命的发射寿命测量方法和设备

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023066311A1 (zh) * 2021-10-20 2023-04-27 深圳市中科先见医疗科技有限公司 一种单分子/单细胞检测芯片
CN116148232A (zh) * 2023-02-23 2023-05-23 华东师范大学 一种全谱荧光寿命快速测量装置
CN116148232B (zh) * 2023-02-23 2026-04-17 华东师范大学 一种全谱荧光寿命快速测量装置

Also Published As

Publication number Publication date
TW202016530A (zh) 2020-05-01
EP3844486A1 (en) 2021-07-07
BR112021003146A2 (pt) 2021-05-11
US20200072752A1 (en) 2020-03-05
JP2021535385A (ja) 2021-12-16
WO2020047262A1 (en) 2020-03-05
AU2019330042A1 (en) 2021-03-11
KR20210046061A (ko) 2021-04-27
MX2021002414A (es) 2021-04-28
CA3109816A1 (en) 2020-03-05

Similar Documents

Publication Publication Date Title
CN112930476A (zh) 使用光子计数光电检测器以检测寿命的系统及方法
US20230258862A1 (en) Optical coupler and waveguide system
US20220113469A1 (en) Optical rejection photonic structures
US12300711B2 (en) Integrated sensor for lifetime characterization
US20230341621A1 (en) Optical waveguides and couplers for delivering light to an array of photonic elements
US12203855B2 (en) Sensor for lifetime plus spectral characterization
EP3305170B1 (en) Fluorescence lifetime sensor module and method of determining a fluorescence lifetime using a sensor module
US20220128402A1 (en) Integrated circuit with sequentially-coupled charge storage and associated techniques
US12514005B2 (en) Integrated sensor
US12297496B2 (en) Integrated circuit with improved charge transfer efficiency and associated techniques
US20240003811A1 (en) Integrated sensor for multi-dimensional signal analysis
US20250267967A1 (en) Backside illuminated structures with parallel charge transfer
US20240280488A1 (en) Methods and device for detecting single photons from a sample comprising at least one emitter
EP3896431A1 (en) Device and method for time-resolving hyperspectral imaging spectroscopy

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20210608

WD01 Invention patent application deemed withdrawn after publication