TW201840322A - 羥烷基噻二唑衍生物之n-膦醯基氧基甲基前驅藥 - Google Patents

羥烷基噻二唑衍生物之n-膦醯基氧基甲基前驅藥 Download PDF

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Publication number
TW201840322A
TW201840322A TW107108384A TW107108384A TW201840322A TW 201840322 A TW201840322 A TW 201840322A TW 107108384 A TW107108384 A TW 107108384A TW 107108384 A TW107108384 A TW 107108384A TW 201840322 A TW201840322 A TW 201840322A
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TW
Taiwan
Prior art keywords
compound
ethyl
chloro
methoxypiperidin
imidazol
Prior art date
Application number
TW107108384A
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English (en)
Chinese (zh)
Inventor
馬龍古馬 凱拉
那瑞區吉它曼 都布雷
巴價 汗
Original Assignee
日商第一三共股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 日商第一三共股份有限公司 filed Critical 日商第一三共股份有限公司
Publication of TW201840322A publication Critical patent/TW201840322A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW107108384A 2017-03-14 2018-03-13 羥烷基噻二唑衍生物之n-膦醯基氧基甲基前驅藥 TW201840322A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201711008754 2017-03-14
IN201711008754 2017-03-14

Publications (1)

Publication Number Publication Date
TW201840322A true TW201840322A (zh) 2018-11-16

Family

ID=62002340

Family Applications (1)

Application Number Title Priority Date Filing Date
TW107108384A TW201840322A (zh) 2017-03-14 2018-03-13 羥烷基噻二唑衍生物之n-膦醯基氧基甲基前驅藥

Country Status (6)

Country Link
US (1) US10752647B2 (https=)
EP (1) EP3596071A1 (https=)
JP (1) JP2020511457A (https=)
CA (1) CA3056571C (https=)
TW (1) TW201840322A (https=)
WO (1) WO2018169092A1 (https=)

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200526626A (en) 2003-09-13 2005-08-16 Astrazeneca Ab Chemical compounds
WO2006087544A2 (en) 2005-02-18 2006-08-24 Astrazeneca Ab Pyrrole derivatives as dna gyrase and topoisomerase inhibitors
NZ561613A (en) 2005-02-18 2010-12-24 Astrazeneca Ab Antibacterial piperidine derivatives
CN101163674A (zh) 2005-02-18 2008-04-16 阿斯利康(瑞典)有限公司 作为dna促旋酶和拓扑异构酶抑制剂的吡咯衍生物
US20080269214A1 (en) 2005-03-04 2008-10-30 Astrazeneca Ab Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors
CN101171250A (zh) 2005-03-04 2008-04-30 阿斯利康(瑞典)有限公司 具有抗菌活性的氮杂环丁烷和吡咯的三环衍生物
JP2009520785A (ja) 2005-12-23 2009-05-28 アストラゼネカ アクチボラグ 抗菌性のピロロピリジン、ピロロピリミジン、及びピロロアゼピン
WO2008020229A2 (en) 2006-08-17 2008-02-21 Astrazeneca Ab Antibacterial pyrrolecarboxamides
WO2008020227A2 (en) 2006-08-17 2008-02-21 Astrazeneca Ab Antibacterial pyrrolecarboxamides
TW200819437A (en) 2006-08-17 2008-05-01 Astrazeneca Ab Chemical compounds
TW200906412A (en) 2007-06-12 2009-02-16 Astrazeneca Ab Piperidine compounds and uses thereof
TWI498115B (zh) 2007-12-27 2015-09-01 Daiichi Sankyo Co Ltd 咪唑羰基化合物
US20120108565A1 (en) 2008-07-30 2012-05-03 Lalima Sharma Pyrrole carboxylic acid derivatives as antibacterial agents
TW201026694A (en) 2008-12-12 2010-07-16 Astrazeneca Ab Compound 468
TW201026695A (en) 2008-12-12 2010-07-16 Astrazeneca Ab Piperidine compounds and uses thereof-596
JP2011026305A (ja) * 2009-06-24 2011-02-10 Daiichi Sankyo Co Ltd イミダゾールカルボニル化合物を含有する医薬組成物
CN103261200B (zh) * 2010-09-13 2016-03-30 阿迪维纳斯疗法有限公司 作为a2b腺苷受体拮抗剂的前药的嘌呤化合物、它们的制备方法及医药用途
WO2014057415A2 (en) 2012-10-10 2014-04-17 Vitas Pharma Research Pvt Ltd Inhibitors of dna gyrase for the treatment of bacterial infections
KR20180054650A (ko) 2015-09-30 2018-05-24 다이이찌 산쿄 가부시키가이샤 히드록시알킬 티아디아졸 유도체

Also Published As

Publication number Publication date
EP3596071A1 (en) 2020-01-22
CA3056571A1 (en) 2018-09-20
CA3056571C (en) 2021-11-23
US20200040019A1 (en) 2020-02-06
WO2018169092A1 (en) 2018-09-20
US10752647B2 (en) 2020-08-25
JP2020511457A (ja) 2020-04-16

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