CA3056571C - N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives - Google Patents

N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives Download PDF

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Publication number
CA3056571C
CA3056571C CA3056571A CA3056571A CA3056571C CA 3056571 C CA3056571 C CA 3056571C CA 3056571 A CA3056571 A CA 3056571A CA 3056571 A CA3056571 A CA 3056571A CA 3056571 C CA3056571 C CA 3056571C
Authority
CA
Canada
Prior art keywords
compound
chloro
methoxypiperidin
thiadiazol
imidazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3056571A
Other languages
English (en)
French (fr)
Other versions
CA3056571A1 (en
Inventor
Manoj Kumar Khera
Naresh Chintaman Dumbre
Pasha Khan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of CA3056571A1 publication Critical patent/CA3056571A1/en
Application granted granted Critical
Publication of CA3056571C publication Critical patent/CA3056571C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3056571A 2017-03-14 2018-03-13 N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives Active CA3056571C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201711008754 2017-03-14
IN201711008754 2017-03-14
PCT/JP2018/010670 WO2018169092A1 (en) 2017-03-14 2018-03-13 N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives

Publications (2)

Publication Number Publication Date
CA3056571A1 CA3056571A1 (en) 2018-09-20
CA3056571C true CA3056571C (en) 2021-11-23

Family

ID=62002340

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3056571A Active CA3056571C (en) 2017-03-14 2018-03-13 N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives

Country Status (6)

Country Link
US (1) US10752647B2 (https=)
EP (1) EP3596071A1 (https=)
JP (1) JP2020511457A (https=)
CA (1) CA3056571C (https=)
TW (1) TW201840322A (https=)
WO (1) WO2018169092A1 (https=)

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200526626A (en) 2003-09-13 2005-08-16 Astrazeneca Ab Chemical compounds
WO2006087544A2 (en) 2005-02-18 2006-08-24 Astrazeneca Ab Pyrrole derivatives as dna gyrase and topoisomerase inhibitors
NZ561613A (en) 2005-02-18 2010-12-24 Astrazeneca Ab Antibacterial piperidine derivatives
CN101163674A (zh) 2005-02-18 2008-04-16 阿斯利康(瑞典)有限公司 作为dna促旋酶和拓扑异构酶抑制剂的吡咯衍生物
US20080269214A1 (en) 2005-03-04 2008-10-30 Astrazeneca Ab Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors
CN101171250A (zh) 2005-03-04 2008-04-30 阿斯利康(瑞典)有限公司 具有抗菌活性的氮杂环丁烷和吡咯的三环衍生物
JP2009520785A (ja) 2005-12-23 2009-05-28 アストラゼネカ アクチボラグ 抗菌性のピロロピリジン、ピロロピリミジン、及びピロロアゼピン
WO2008020229A2 (en) 2006-08-17 2008-02-21 Astrazeneca Ab Antibacterial pyrrolecarboxamides
WO2008020227A2 (en) 2006-08-17 2008-02-21 Astrazeneca Ab Antibacterial pyrrolecarboxamides
TW200819437A (en) 2006-08-17 2008-05-01 Astrazeneca Ab Chemical compounds
TW200906412A (en) 2007-06-12 2009-02-16 Astrazeneca Ab Piperidine compounds and uses thereof
TWI498115B (zh) 2007-12-27 2015-09-01 Daiichi Sankyo Co Ltd 咪唑羰基化合物
US20120108565A1 (en) 2008-07-30 2012-05-03 Lalima Sharma Pyrrole carboxylic acid derivatives as antibacterial agents
TW201026694A (en) 2008-12-12 2010-07-16 Astrazeneca Ab Compound 468
TW201026695A (en) 2008-12-12 2010-07-16 Astrazeneca Ab Piperidine compounds and uses thereof-596
JP2011026305A (ja) * 2009-06-24 2011-02-10 Daiichi Sankyo Co Ltd イミダゾールカルボニル化合物を含有する医薬組成物
CN103261200B (zh) * 2010-09-13 2016-03-30 阿迪维纳斯疗法有限公司 作为a2b腺苷受体拮抗剂的前药的嘌呤化合物、它们的制备方法及医药用途
WO2014057415A2 (en) 2012-10-10 2014-04-17 Vitas Pharma Research Pvt Ltd Inhibitors of dna gyrase for the treatment of bacterial infections
KR20180054650A (ko) 2015-09-30 2018-05-24 다이이찌 산쿄 가부시키가이샤 히드록시알킬 티아디아졸 유도체

Also Published As

Publication number Publication date
EP3596071A1 (en) 2020-01-22
CA3056571A1 (en) 2018-09-20
TW201840322A (zh) 2018-11-16
US20200040019A1 (en) 2020-02-06
WO2018169092A1 (en) 2018-09-20
US10752647B2 (en) 2020-08-25
JP2020511457A (ja) 2020-04-16

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