TW201836619A - Disinfectant composition - Google Patents

Abstract

To provide a disinfectant composition belonging to the category of disinfectants to be used for sterilizing fingers, etc., said disinfectant composition containing chondroitin sulfate or a chondroitin sulfate salt as a moisturizing agent and thus having an improved moisturizing effect, being capable of preventing chapped hand skin causing bacterial or viral invasion and infection, and ensuring the uniform dispersion of the chondroitin sulfate or chondroitin sulfate salt in the composition. A disinfectant composition characterized by comprising 20-60 wt% of a lower alcohol having 1-3 carbon atoms, 40-65 wt% of water and 0.006-1 wt% of chondroitin sulfate or a chondroitin sulfate salt; a disinfectant composition comprising an oily component, a thickener and a surfactant and having a viscosity of 50-300 Pa.s at 25 DEG C; etc.

Description

Disinfecting composition

The present invention relates to a disinfecting composition which is excellent in moisturizing properties and properties, and is a disinfectant which is used for disinfection of a finger or the like.

Conventionally, a lower alcohol having 1 to 3 carbon atoms such as ethanol or isopropyl alcohol is generally known to be sterilized by bacteria or viruses by the destruction of a bacterial cell membrane or a membrane other than a virus, or a protein such as an enzyme. A disinfectant that blends the lower alcohols. However, in general, a disinfectant which incorporates a lower alcohol such as ethanol or isopropyl alcohol, for example, when used for disinfecting a finger, causes problems such as roughness of a user's hand. Rough hand refers to a state in which the stratum corneum and the sebaceous membrane are removed and the stratum corneum is insufficient, and the skin is isolated from the function of the skin. This state can be said to be easily infected by invading bacteria or viruses from the isolated defect portion. From this point of view, it is still desired to prevent the hand roughness, that is, the disinfectant which is excellent in moisture retention of the defect of the skin barrier function even if the lower alcohol is blended.

For example, Patent Document 1 discloses a disinfectant containing a carboxyvinyl polymer, a natural polysaccharide, or the like, a fatty acid ester, and a lower alcohol, and the blending ratio of the lower alcohol is 20 to 50% by weight. In order to prevent this, the carboxyvinyl polymer blended with the adhesive will cause the polymer component to precipitate on the finger (resinized) due to the salt of the finger when rubbed by the finger. A natural polysaccharide or a derivative thereof is blended as a feature. [Prior Technical Literature] [Patent Literature]

[Patent Document 1] Japanese Patent Laid-Open No. Hei 10-130173

[Questions to be solved by the invention]

However, the composition described in the examples of Patent Document 1 has a problem that the moisture retention property is not sufficient.

Further, in the invention described in Patent Document 1, although sodium chondroitin sulfate is used as a natural polysaccharide, when sodium chondroitin sulfate is actually blended, it may not be uniformly dissolved due to the balance of other components of the composition. The problem in the composition.

Therefore, in the present invention, a disinfectant which is used for sterilization of a finger or the like is provided, and by mixing chondroitin sulfate or chondroitin sulfate as a moisturizing agent, moisturizing property is enhanced, and invasion of bacteria or virus is prevented and infection is caused. The cause of the hand is rough, and the purpose is to make the composition for disinfection in which the chondroitin sulfate or chondroitin sulfate is uniformly present in the composition. [Means to solve the problem]

[1] That is, the present invention is a disinfecting composition characterized by containing 20 to 60% by weight of a lower alcohol having 1 to 3 carbon atoms, 40 to 65% by weight of water, chondroitin sulfuric acid or chondroitin sulfate 0.006 to ～ 1% by weight.

[2] The composition for disinfection according to the above [1], which comprises a fat or oil component, a tackifier, and a surfactant, and has a viscosity at 25 ° C of 50 to 300 Pa·s.

[3] The disinfecting composition according to the above [1], wherein the tackifier is at least one selected from the group consisting of a carboxyvinyl polymer and a cellulose derivative.

[4] The disinfecting composition according to any one of the above [1], wherein the surfactant comprises a polyoxyethylene alkyl ether and a fatty acid ester of a polyhydric alcohol.

[5] The disinfecting composition according to any one of the above [1], wherein the composition for disinfection is selected from benzethonium chloride or benzalkonium chloride. And a disinfecting component of at least one of chlorhexidine gluconate, povidone iodine, isopropylmethylphenol, and chloroxylenol. [Effects of the Invention]

According to the present invention, it is a disinfectant which is used for sterilization of a finger or the like, and can be used as a moisturizing agent by blending chondroitin sulfate or chondroitin sulfate to enhance moisturization while preventing invasion of bacteria or viruses and becoming a cause of infection. Rough, while allowing chondroitin sulfate or chondroitin sulfate to be uniformly present in the composition.

Hereinafter, embodiments of the disinfecting composition of the present invention will be described in detail. In addition, when there is a sign indicating the range in the description, the upper limit and the lower limit are included.

The lower alcohol having 1 to 3 carbon atoms of the present invention is an alcohol having 1 to 3 carbon atoms such as methanol, ethanol or isopropyl alcohol. By using the lower alcohol, the bacteria or the virus can be killed by the destruction of the membrane of the bacteria or the membrane of the virus or the coagulation of proteins such as enzymes, thereby preventing the adverse effects on the human body caused by the diseases caused by the bacteria or viruses. .

The content ratio of the disinfecting composition of the lower alcohol having 1 to 3 carbon atoms is preferably 20 to 60% by weight. When the content exceeds 60% by weight, chondroitin sulfate or chondroitin sulfate cannot be uniformly dissolved or dispersed. Moreover, when the content ratio is less than 20% by weight, the bacteria or the virus cannot be sufficiently disinfected, and it is necessary to add another sterilizing component or the like in order to express the desired effect.

The chondroitin sulfate or chondroitin sulfate of the present invention is a compound of a sugar chain-bonded sulfuric acid which comprises a sugar composed of D-gluconic acid and N-ethinyl-D-galactosamine as a constituent unit or A salt whose hydrogen sulfate is replaced by sodium, potassium or the like is blended as a humectant. By blending chondroitin sulfate or chondroitin sulfate, the moisturizing property of the composition for disinfection, especially the moisturizing property at the elapsed time, is improved.

The content ratio of the composition for disinfection of chondroitin sulfate or chondroitin sulfate is preferably 0.006 to 1% by weight. When the content ratio is in the above range, the composition for disinfection can be uniformly dissolved or dispersed, and the moisturizing property can be maintained, and the hand of the user can be prevented from being rough.

The fat or oil of the present invention is a liquid or solid fat at a normal temperature of 20 ° C to 25 ° C. Blending can be carried out if necessary. When the composition for disinfection is used by emulsification of fats and oils, it is possible to prevent moisture from volatilizing from the skin by diffusing the oil to the skin of a finger or the like, thereby preventing hand roughness and the like. As the fats and oils, natural products and synthetic materials can be used, and as the natural product, any of the oils derived from plants and animals can be used.

As the fat and oil component, for example, a hydrocarbon such as flowing paraffin, light flowing paraffin, or squalane, isopropyl palmitate, octyl palmitate, isopropyl myristate, isodecyl isononanoate, and carbon number 8 are preferable. - a fatty acid such as a medium chain fatty acid triglyceride or a tris(decyl/decanoic acid) glyceryl group, a myristyl alcohol (carbon number 14), and a cetyl alcohol (carbon number 16). , stearyl alcohol (carbon number 18), cetearyl alcohol (mixture of carbon numbers 16 and 18), behenyl alcohol (carbon number 22), isostearyl alcohol (carbon number 18), a saturated monohydric alcohol such as 2-hexyl decyl alcohol (carbon number 16) or 2-octyldodecanol (carbon number 20), or an unsaturated monohydric alcohol such as oleyl alcohol (carbon number 18) Alcohol, soybean oil, safflower oil, grape seed oil, rosehip oil, sunflower oil, evening primrose seed oil, cottonseed oil, sesame oil, wheat germ oil, almond oil, etc., as a non-drying oil, preferably olive oil, camellia oil , camellia oil, castor oil, peanut oil, avocado oil, macadamia nut oil, hazelnut oil, meadowfoam oil, jojoba oil, etc., as essential oils, preferably eucalyptus oil, peppermint oil, Roman chamomile Etc. (vegetable oil). These oils and fats may be used alone or in combination of two or more.

The content of the composition for disinfection in the oil and fat is preferably 0.5 to 20% by weight, more preferably 1.0 to 10% by weight. When the content ratio is in the above range, it is possible to prevent the user's hand from being rough during use.

The tackifier of the present invention is a component which increases the viscosity of the composition for disinfection. Blending can be carried out if necessary. By using a tackifier, the viscosity of the disinfecting composition can be increased to a viscosity as specified.

As the tackifier, for example, a carboxyvinyl polymer of a crosslinked polyacrylic acid or a cellulose derivative such as carboxymethylcellulose, hydroxyethylcellulose or hydroxypropylcellulose, xanthan gum or melon is preferred. Glycol gum, gum arabic, sodium alginate, propylene glycol alginate, ethyl cellulose, sodium polyacrylate, cyclodextrin, etc., among which, a carboxyvinyl polymer or a carboxymethyl cellulose is more preferred. These tackifiers may be used alone or in combination of two or more.

The content of the composition for disinfection in the tackifier is preferably from 0.1 to 10% by weight, more preferably from 0.2 to 7% by weight. When the content ratio is in the above range, it can be adjusted to suit the desired viscosity.

The surfactant in the present invention is a component which uniformly mixes the disinfecting composition and stabilizes the creamy property. Blending can be carried out if necessary. By using a surfactant, it is possible to prevent the lower alcohol or the like having a carbon number of 1 to 3 from being separated from the components of the disinfecting composition.

Examples of the surfactant include a cationic surfactant, an anionic surfactant, an amphoteric surfactant, and a nonionic surfactant. The cationic surfactant is a surfactant which becomes a cation when dissociated in water, and is preferably, for example, an alkyltrimethylammonium salt, an alkyldimethylammonium salt, an alkylbenzyldimethylammonium salt or the like. Among them, the alkyl group is preferably a carbon number of 12 to 22, and as the counter anion, a chloride ion, a hydroxide ion, a bromide ion or the like is preferable.

Further, the anionic surfactant is an anionic surfactant when dissociated in water, and is preferably, for example, a fatty acid salt, a monoalkyl sulfate, an alkyl polyoxyethylene sulfate, an alkylbenzenesulfonate, or a monoalkyl phosphate. Salt and so on. The alkyl group is preferably a carbon number of 12 to 22, and as a counter cation, a sodium ion, a potassium ion, a calcium ion, a magnesium ion or the like is preferable.

Further, the amphoteric surfactant has both an anionic portion and a cationic portion in the molecule, and the pH of the solution becomes a cationic, an anionic, and a cationic and anionic surfactant, for example, an alkyl group. Base amine oxide, alkyl carboxyl betaine, and the like. The alkyl group is preferably a carbon number of 12 to 22.

Further, the nonionic surfactant is an active agent having a hydrophilic portion which is not ionized in the hydrophilic portion, and is preferably a polyoxyethylene alkyl ether such as polyoxyethylene cetyl ether or polyoxyethylene stearyl ether. A polyhydric alcohol fatty acid ester such as a glycerin fatty acid ester or a sorbitan fatty acid ester or a sucrose fatty acid ester, a fatty acid ester of a polyoxyethylene addition polyhydric alcohol, or a fatty acid diethanolamine. Among the above nonionic surfactants, the HLB calculated by the formula of Griffin is preferably from 3 to 17. When the nonionic surfactant has a polyoxyethylene skeleton, the addition molar number of oxyethylene can be appropriately changed. When the HLB is a nonionic surfactant in the above range, the composition for disinfection is excellent in storage stability, and specifically, it can maintain a creamy state even if it does not separate over time. Further, these surfactants may be used alone or in combination of two or more. However, it is preferred to combine the surfactants of HLB 3 to 6 and the surfactants of HLB 12 to 17.

Further, the disinfecting composition of the present invention is blended with water. The water is preferably water of the Japanese Pharmacopoeia standard, for example, normal water such as tap water or well water, and is any one of distillation, ion exchange treatment by an ion exchange membrane, and ultrafiltration treatment by an ultrafiltration membrane. Alternatively, the purified water of the normal water is treated by the combination of the above, and it is preferably a sterilized purified water obtained by sterilizing purified water by heating or the like. Further, the blending ratio of the above water is to remove the residual of the ethanol, chondroitin sulfate or chondroitin sulfate used in the present invention, and when the tackifier, the surfactant, etc. are blended, the residue is removed, preferably. It is 40 to 65 wt%, more preferably 42 to 63 wt%.

Further, the disinfecting composition of the present invention may be blended with a disinfecting component if necessary. The disinfecting component is blended in order to sterilize bacteria or viruses which are not sufficiently sterilized by the lower alcohols having 1 to 3 carbon atoms. As the disinfecting component, for example, benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, pravone iodine, isopropylmethylphenol, chloroxylenol, etc., more preferably benzethon chloride Ammonium. Further, these disinfecting components may be used alone or in combination of two or more.

In the disinfecting composition of the present invention, when the viscosity is increased by blending the tackifier, the viscosity of the disinfecting composition of the present invention is Brookfield-shaped rotational viscometer type B as described in JIS K7117-1. (Measured by Toki Sangyo Co., Ltd., product name "TVB-10M"), it is preferably 50 to 300 Pa·s at 25 ° C, more preferably 100 to 250 Pa·s. When the viscosity of the composition for disinfection is in this range, even if it adheres to the skin of a finger or the like, it does not fall off instantaneously, and it is easy to smear when applied.

The sterilizing composition of the present invention may further incorporate a humectant other than chondroitin sulfate or chondroitin sulfate. As other humectants, for example, glycerin, polyglycerin, propylene glycol, 1,3-butanediol, 1,2-pentanediol, 1,2-hexanediol, polyethylene glycol, maltitol, sorbose are preferred. Polyol such as alcohol, sodium hyaluronate, urea, sodium lactate, trimethylglycine, and the like.

In addition to the above components, the disinfecting composition of the present invention may be blended with an antioxidant such as tocopherol, vitamin C or BHT, a pH adjuster, a buffer, a perfume, a coloring matter or the like, if necessary. [Examples]

[Example 1] A composition for 30 parts by weight of ethanol, 1 part by weight of sodium chondroitin sulfate, and 100 parts by weight of water was adjusted, and thoroughly mixed to prepare a composition for disinfection.

[Example 2] A disinfecting composition was produced in the same manner as in Example 1 except that the amount of ethanol was changed to 50 parts by weight.

[Example 3] A disinfecting composition was prepared in the same manner as in Example 1 except that the sodium chondroitin sulfate was set to 0.01 part by weight.

[Comparative Example 1] A disinfecting composition was produced in the same manner as in Example 1 except that the amount of ethanol was changed to 10 parts by weight.

[Comparative Example 2] A disinfecting composition was produced in the same manner as in Example 1 except that the amount of ethanol was changed to 70 parts by weight.

[Comparative Example 3] A disinfecting composition was prepared in the same manner as in Example 1 except that the chondroitin sulfate sodium was not blended.

[Appearance property] When the properties of the composition for disinfection to be produced were evaluated by visual observation, the state in which the sodium chondroitin sulfate was uniformly dissolved was evaluated as "○", and the sodium chondroitin sulfate was not dissolved or produced by sulfuric acid. The state of durness caused by chondroitin sodium was evaluated as "x", "○" was evaluated as better, and "x" was evaluated as poor.

[Moisturizing property] When evaluating the moisture retention of the disinfectant composition to be produced, the five-stage functional evaluation of the moisturizing sensation from 1 to 5 points after the use of the special-purpose inspector is performed as the evaluation standard. The average point is to distinguish between the following evaluation criteria. It is better to conduct a "〇" assessment, and the "△" assessment and the "×" assessment are poor assessments. ○: The average point is 4.0 or more. △: The average point is 2.0 or more and less than 4.0 ×: The average point is less than 2.0.

[Bactericidal effect] When evaluating the bactericidal efficacy of the produced disinfectant composition, the sample and the bacterial liquid were directly contacted, and then applied to a plate medium to evaluate the number of bacteria. As a basis for the evaluation, the number of bacteria killed by contact with the disinfecting composition was 99.99% or more, and the effect was evaluated as "○", and the effect of less than 99.99% was evaluated as "". ×”, “○” is evaluated as better, and “×” is evaluated as poor.

The results of the appearance properties, moisture retention, and sterilization efficacy of Examples 1 to 3 and Comparative Examples 1 to 3 are shown in Table 1.

As shown in Table 1, when the composition of ethanol and water is blended, when the chondroitin sulfate sodium is blended, although the moisturizing property is good, when the blending amount of ethanol is 70 parts by weight, the sodium chondroitin sulfate cannot be dissolved, and the ethanol is mixed. When the amount is about 10 parts by weight, the sterilization effect is not good. As a result of the above, it has been found that as a composition for disinfection, in order to exhibit not only a good trait of uniformly dissolving sodium chondroitin sulfate but also a good bactericidal effect, it is necessary to mix the ratio of ethanol, water and sodium chondroitin sulfate. The specified range.

[Example 4] Adjusting 30 parts by weight of ethanol and a humectant sodium chondroitin sulfate (1.0 part by weight, a carboxyvinyl polymer of a tackifier (manufactured by Wako Pure Chemical Industries, Ltd., trade name: "HIVISWAKO103") 0.4 2 parts by weight of a polyoxyethylene cetyl ether (manufactured by Nikko Chemical Co., Ltd., trade name: "NIKKOL BC-15", HLB: 15.5), a nonionic surfactant, and a nonionic surfactant Stearic acid glycerin (manufactured by Nikko Chemical Co., Ltd., trade name: "NIKKOL MGS-AMV", HLB: 4.0) 2 parts by weight, and liquid paraffin (manufactured by Central Chemicals Co., Ltd., trade name: "mobile paraffin 350S" 1) 1 part by weight, 1 part by weight of isopropyl myristate, 0.5 parts by weight of stearyl alcohol, 0.5 parts by weight of humectant, and dimethyl polyoxane (Dolly Dow Corning) Co., Ltd. product name: "Q7-9120SILICONE FLUID350CST") 0.2 parts by weight, 0.05 parts by weight of benzethonium chloride as a disinfecting component, 0.072 parts by weight of sodium hydroxide, and 100 parts by weight of water remaining, thoroughly mixed For disinfection As it was.

[Example 5] A disinfecting composition was produced in the same manner as in Example 4 except that the amount of the ethanol in Example 4 was 50 parts by weight. Further, when the viscosity was measured in the same manner as in Example 4, it was 80 Pa·s.

[Example 6] A disinfecting composition was prepared in the same manner as in Example 4 except that the sodium chondroitin sulfate of Example 4 was set to 0.5 part by weight. Further, when the viscosity was measured in the same manner as in Example 4, it was 95 Pa·s.

[Example 7] A disinfecting composition was prepared in the same manner as in Example 4 except that the sodium chondroitin sulfate of Example 4 was made 0.1 part by weight. Further, when the viscosity was measured in the same manner as in Example 4, it was 101 Pa·s.

[Example 8] A disinfecting composition was prepared in the same manner as in Example 4 except that the sodium chondroitin sulfate of Example 4 was set to 0.01 part by weight. Further, when the viscosity was measured in the same manner as in Example 4, it was 95 Pa·s.

[Comparative Example 4] A disinfecting composition was prepared in the same manner as in Example 4 except that sodium chondroitin sulfate of Example 4 was replaced with 0.01 parts by weight of sodium hyaluronate. Further, when the viscosity was measured in the same manner as in Example 4, it was 128 Pa·s.

[Comparative Example 5] The same procedure as in Example 4 was carried out except that the sodium chondroitin sulfate of Example 4 was not blended, the carboxyvinyl polymer was 0.05 parts by weight, and the sodium hydroxide was determined to be 0.09 parts by weight. Make a disinfectant composition. Further, when the viscosity was measured in the same manner as in Example 4, it was 211 Pa·s.

[Comparative Example 6] Except that the amount of the ethanol in Example 4 was 40 parts by weight, the sodium chondroitin sulfate was not blended, and the carboxyvinyl polymer was set to 0.05 part by weight to 0.09 part by weight. Example 4 was carried out in the same manner to prepare a disinfecting composition. Further, when the viscosity was measured in the same manner as in Example 4, it was 183 Pa·s.

[Comparative Example 7] A disinfecting composition was produced in the same manner as in Example 4 except that the amount of the ethanol in Example 4 was 70 parts by weight. Further, after the production, separation or white turbidity was observed, and the viscosity could not be measured in the same manner as in Example 4.

[Comparative Example 8] A disinfecting composition was prepared in the same manner as in Example 4 except that the sodium chondroitin sulfate of Example 4 was made 0.005 parts by weight. Further, when the viscosity was measured in the same manner as in Example 4, it was 105 Pa·s.

[Comparative Example 9] A disinfecting composition was produced in the same manner as in Example 4 except that the amount of the ethanol in Example 4 was 10 parts by weight. Further, when the viscosity was measured in the same manner as in Example 4, it was 185 Pa·s.

[Appearance property] When the properties of the composition for disinfection to be produced were visually evaluated, the chondroitin sulfate sodium was uniformly dissolved as a criterion for evaluation, and the state in which the cream was separated was not evaluated as "○", although There was ambiguity but dissolved chondroitin sulfate sodium, and no separation was observed as "△". The state in which the separation was not uniform was evaluated as "X", and the "○" evaluation and "△" evaluation were preferable. The "X" assessment is not good.

[Moisturizing property] When evaluating the moisturizing property of the prepared disinfectant composition, five members of the specialized inspector were evaluated for the five-stage functionality of the moisturizing feeling after use from 1 to 5, and the average point was determined. For the following assessment criteria, the "〇" assessment is preferred, and the "△" assessment and the "×" assessment are poor assessments. ○: The average point is 4.0 or more. △: The average point is 2.0 or more and less than 4.0 ×: The average point is less than 2.0.

[Bactericidal effect] When the bactericidal efficacy of the produced disinfectant composition is evaluated, the sample and the bacterial liquid are directly contacted, and then applied to a plate medium for cultivation, and the number of bacteria is evaluated. As a basis for the evaluation, the number of bacteria killed by contact with the disinfecting composition was 99.99% or more, and the effect was evaluated as "○", and the effect of less than 99.99% was evaluated as "". ×”, “○” is evaluated as better, and “×” is evaluated as poor.

The results regarding the viscosity, the appearance property, the moisture retention property, and the sterilization efficacy are shown in Table 2 for Examples 4 to 8 and Comparative Examples 4 to 9.

From Table 2, it is known that a blending system of ethanol, sodium chondroitin sulfate, a tackifier, a surfactant, water, etc., is made into a disinfecting composition by using ethanol, chondroitin sulfate, and water as specified contents. The product is stable during the production, and can maintain the cream-like properties, and has good moisturizing and bactericidal effects. In this way, by containing the oil and fat component, the tackifier, and the surfactant, and the viscosity is within the specified range, even if the lower alcohol having 1 to 3 carbon atoms is blended at a high ratio, the emulsion stability can be excellent and further used. It also prevents the hand-roughness of the semi-solid shape with good moisture retention and high-viscosity emulsified composition for disinfection.

[Comparative Example 10] A disinfecting composition was prepared by preparing 78 parts by weight of ethanol, 0.4 parts by weight of a carboxyvinyl polymer, and 0.072 of sodium hydroxide.

[Comparative Example 11] A disinfecting composition was prepared by preparing 54 parts by weight of ethanol, 0.4 parts by weight of a carboxyvinyl polymer, and 0.072 of sodium hydroxide.

The disinfection compositions of Example 8 and Comparative Examples 10 to 11 were measured for the amount of water evapotranspiration. That is, the transdermal moisture evapotranspiration amount of the disinfecting composition at a temperature of about 25 ° C and a humidity of 30 to 40% in one application and 10 consecutive application, after one application After 5 minutes and 10 minutes, the coating was applied 10 times, and after 5, 10, 20, and 30 minutes, it was measured using Tewameter TM300 (Courage+Khazaka Co., Ltd.). Then, the amount of change was calculated from the difference between the transepidermal water evapotranspiration after the passage and the percutaneous water evapotranspiration amount before application, and the skin barrier property of the skin was evaluated. The amount of change in the difference in the amount of percutaneous water evapotranspiration before coating was calculated from the amount of percutaneous water evapotranspiration after 10 minutes from the first application and the ten consecutive coatings, and the amount of change was negative. The assessment is good. The results of these are shown in Table 3.

From Table 3, it is understood that in the disinfecting composition of Example 8, after one application and after 10 coatings, the transdermal moisture evapotranspiration after 10 minutes is smaller than the percutaneous moisture evapotranspiration before coating. The amount of change in the transdermal moisture evapotranspiration after 10 minutes and the initial transdermal water evapotranspiration amount was negative, and the evapotranspiration of the water was suppressed, and the skin barrier properties were superior to those of Comparative Examples 10 to 11. Moreover, by being excellent in skin barrier properties, invasion and infection of bacteria or viruses from the skin can be prevented.

Claims (5)

A disinfecting composition comprising 20 to 60% by weight of a lower alcohol having 1 to 3 carbon atoms, 40 to 65% by weight of water, and 0.006 to 1% by weight of chondroitin sulfate or chondroitin sulfate. The disinfecting composition according to claim 1, which comprises a fat or oil component, a tackifier and a surfactant, and has a viscosity at 25 ° C of 50 to 300 Pa·s. The disinfecting composition according to claim 1 or claim 2, wherein the tackifier is at least one selected from the group consisting of a carboxyvinyl polymer and a cellulose derivative. The composition for disinfection according to claim 1 or claim 2, wherein the surfactant comprises a polyoxyethylene alkyl ether and a fatty acid ester of a polyhydric alcohol. The disinfectant composition of claim 1 or claim 2, which comprises a benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, puerone iodine, isopropylmethyl At least one disinfecting component of phenol or chloroxylenol.