KR20230086819A - Composition for disinfection - Google Patents

Abstract

The present invention belongs to a disinfectant used for sterilization of fingers, etc., by blending chondroitin sulfate or chondroitin sulfate as a moisturizing agent, improving moisturizing properties, preventing roughness of hands that cause invasion and infection of bacteria or viruses, An object of the present invention is to provide a composition for disinfection in which chondroitin sulfate or chondroitin sulfate is uniformly present in the composition, wherein 20 to 60% by weight of lower alcohol having 1 to 3 carbon atoms, 40 to 65% by weight of water, chondroitin sulfate or chondroitin It can be solved by a disinfecting composition containing 0.006 to 1% by weight of sulfate and a disinfecting composition containing an oil and fat component, a thickener and a surfactant, and having a viscosity of 50 to 300 Pa·s at 25°C.

Description

Composition for disinfection {COMPOSITION FOR DISINFECTION}

The present invention belongs to a disinfectant used for sterilization of fingers and the like, and relates to a disinfectant composition having excellent moisturizing properties and properties.

Conventionally, it is generally known that lower alcohols having 1 to 3 carbon atoms, such as ethanol and isopropyl alcohol, have a disinfecting action against bacteria and viruses by destroying bacterial cell membranes or viral envelopes or coagulating proteins such as enzymes. Disinfectants formulated with lower alcohol are widely used. However, in general, in disinfectants containing lower alcohol such as ethanol and isopropyl alcohol, when used to disinfect fingers, for example, there is a problem of causing roughness of the user's hands. The roughness of the hands refers to a state in which the stratum corneum and the sebaceous film are removed and the stratum corneum falls off, and the skin barrier function is lost. From this point of view, there is a demand for an antiseptic having excellent moisturizing properties that can prevent roughness of hands, that is, loss of skin barrier function, even when a lower alcohol is incorporated.

For example, Patent Document 1 discloses a disinfectant containing a carboxyvinyl polymer, a fatty acid ester such as a natural polysaccharide, and a lower alcohol, and the blending ratio of the lower alcohol is 20 to 50% by weight. By blending carboxyvinyl polymer, which is a viscous agent, so-called clumping occurs in which the polymer component precipitates (resinizes) on the finger due to the salts of the finger when rubbed on the finger. To prevent this, natural polysaccharide or a derivative thereof is blended It is characterized by having

Japanese Unexamined Patent Publication No. 10-130173

However, in the composition described in the examples of Patent Document 1, there was a problem that moisturizing properties were not sufficient.

Further, in the invention described in Patent Document 1, it is proposed to use sodium chondroitin sulfate as a natural polysaccharide, but when chondroitin sodium sulfate is actually blended, the problem is that it cannot be uniformly present in the composition, such as not dissolving due to the balance of other components in the composition. there was

Therefore, in the present invention, it belongs to a disinfectant used for sterilization of fingers, etc., and by blending chondroitin sulfate or chondroitin sulfate as a moisturizing agent, the moisturizing property is improved, and roughness of the hand, which is the cause of invasion and infection of bacteria or viruses, is prevented. It is an object of the present invention to provide a disinfectant composition in which chondroitin sulfate or chondroitin sulfate is uniformly present in the composition.

[1] That is, the present invention is a disinfectant composition characterized in that it contains 20 to 60% by weight of lower alcohol having 1 to 3 carbon atoms, 40 to 65% by weight of water, and 0.006 to 1% by weight of chondroitin sulfate or chondroitin sulfate. am.

[2] The composition for disinfection according to [1] above, which contains an oil and fat component, a thickener, and a surfactant, and has a viscosity of 50 to 300 Pa·s at 25°C.

[3] The disinfectant composition according to [1] or [2] above, wherein the thickener is at least one selected from carboxyvinyl polymer and cellulose derivative.

[4] The disinfectant composition according to [1] or [2] above, wherein the surfactant contains a polyoxyethylene alkyl ether and a fatty acid ester of a polyhydric alcohol.

[5] In addition, the above [1] or the above characterized in that it contains at least one disinfectant component selected from benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, povidone iodine, isopropylmethylphenol, and chloroxylenol. It is the composition for disinfection described in [2].

According to the present invention, it belongs to a disinfectant used for sterilization of fingers, etc., and by blending chondroitin sulfate or chondroitin sulfate as a moisturizing agent, the moisturizing property is improved, and roughness of the hand that causes invasion and infection of bacteria or viruses is prevented. While doing so, chondroitin sulfate or chondroitin sulfate may be uniformly present in the composition.

Hereinafter, embodiments relating to the composition for disinfection of the present invention will be described in detail. In addition, when there is a notation indicating a range in the description, the upper limit and the lower limit are included.

The lower alcohol having 1 to 3 carbon atoms in the present invention is an alcohol having 1 to 3 carbon atoms such as methanol, ethanol and isopropyl alcohol. By using the lower alcohol, bacteria or viruses are killed by destruction of cell membranes of bacteria or envelopes of viruses or coagulation of proteins such as enzymes, and adverse effects on the human body, such as diseases caused by the bacteria or viruses, can be prevented.

It is preferable that it is 20 to 60 weight% as a content rate in the composition for disinfection of a C1-C3 lower alcohol. When the content ratio exceeds 60% by weight, chondroitin sulfate or chondroitin sulfate cannot be uniformly dissolved or dispersed. In addition, if the content ratio is less than 20% by weight, bacteria and viruses cannot be sufficiently disinfected, and other bactericidal components and the like must be added in order to express the desired effect.

Chondroitin sulfate or chondroitin sulfate in the present invention is a compound in which sulfuric acid is bound to a sugar chain having a disaccharide composed of D-gluconic acid and N-acetyl-D-galactosamine as a constituent unit, or hydrogen of the sulfuric acid is sodium, potassium, etc. It is a salt substituted with and is formulated as a moisturizing agent. By blending chondroitin sulfate or chondroitin sulfate, the moisturizing properties of the composition for disinfection, particularly the moisturizing properties over time, are improved.

The content of chondroitin sulfate or chondroitin sulfate in the composition for disinfection is preferably 0.006 to 1% by weight. When the content ratio is within the above range, it can be uniformly dissolved or dispersed in the disinfectant composition, and also, the moisturizing properties are continued to prevent roughness of the user's hands.

The fats and oils in the present invention are liquid or solid fats and oils at room temperature of 20°C to 25°C. Can be mixed as needed. By emulsifying the fats and oils, when the composition for disinfection is used, the oils and fats spread on the skin of the fingers and the like to prevent volatilization of moisture from the skin, thereby preventing roughness of the hands. Both natural and synthetic oils and fats can be used, and either plant-derived or animal-derived oils can be used as natural products.

Examples of the fats and oils include hydrocarbons such as liquid paraffin, light liquid paraffin, and squalane, isopropyl palmitate, octyl palmitate, isopropyl myristate, isononanoate, and carbon atoms of 8 to 22 carbon atoms. Medium-chain fatty acid triglycerides composed of fatty acids, ester oils such as tri(caprylic capric acid) glyceryl, myristyl alcohol (carbon number 14), cetanol (carbon number 16), stearyl alcohol (carbon number 18), cetostearyl alcohol (a mixture of 16 and 18 carbon atoms), behenyl alcohol (22 carbon atoms), isostearyl alcohol (18 carbon atoms), 2-hexyldecanol (16 carbon atoms), 2-octyldodecanol (20 carbon atoms), etc. Alcohols, aliphatic alcohols such as unsaturated monohydric alcohols such as oleyl alcohol (carbon number 18), soybean oil, safflower oil, grapeseed oil, rosehip oil, sunflower oil, evening primrose oil, cottonseed oil, sesame oil, wheat germ oil, almond oil and the like are preferred, and non-drying oils include olive oil, sandalwood oil, camellia oil, castor oil, peanut oil, avocado oil, macadamia nut oil, hazelnut oil, meadow foam oil, jojoba oil, and the like, and essential oils include eucalyptus oil and peppermint oil. , Roman chamomile oil and the like (vegetable oil) are preferred. The fats and oils may be used alone or in combination of two or more.

As a content ratio in the composition for disinfection of oil and fat, it is preferable that it is 0.5 to 20 weight%, and it is more preferable that it is 1.0 to 10 weight%. If the content ratio is within the above range, it is possible to prevent roughness of the user's hand when used.

The thickener in the present invention is a component that increases the viscosity of the disinfectant composition. Can be mixed as needed. By using a thickener, the viscosity of the disinfectant composition can be increased to a predetermined viscosity.

As the thickener, for example, cross-linked polyacrylic acid, carboxyvinyl polymer, carboxymethyl cellulose, hydroxyethyl cellulose, cellulose derivatives such as hydroxypropyl cellulose, xanthan gum, guar gum, gum arabic, sodium alginate, propylene alginate Glycol, ethyl cellulose, sodium polyacrylate, cyclodextrin and the like are preferred, and among these, carboxyvinyl polymer and carboxymethyl cellulose are more preferred. The thickener may be used alone or in combination of two or more.

The content of the thickener in the composition for disinfection is preferably 0.1 to 10% by weight, more preferably 0.2 to 7% by weight. If the content ratio is in the above range, it can be adjusted to a desired viscosity suitable for use.

The surfactant in the present invention is a component for stabilizing the creamy properties by uniformly mixing the disinfectant composition. Can be mixed as needed. By using a surfactant, it is possible to prevent separation of lower alcohol having 1 to 3 carbon atoms, which is a component of the disinfectant composition.

Examples of the surfactant include cationic surfactants, anionic surfactants, amphoteric surfactants, and nonionic surfactants. Cationic surfactants are surfactants that become cations when dissociated in water, and are preferably, for example, alkyltrimethylammonium salts, alkyldimethylammonium salts, and alkylbenzyldimethylammonium salts. Among them, the alkyl group preferably has 12 to 22 carbon atoms, and the counter anion is preferably a chloride ion, hydroxide ion, or bromide ion.

The anionic surfactant is a surfactant that becomes an anion when dissociated in water. For example, fatty acid salts, monoalkyl sulfates, alkyl polyoxyethylene sulfates, alkylbenzene sulfonates, monoalkyl phosphates, and the like are preferable. Among them, the alkyl group preferably has 12 to 22 carbon atoms, and the counter cation is preferably a sodium ion, potassium ion, calcium ion, or magnesium ion.

And, the amphoteric surfactant is a surfactant that has both an anionic site and a cationic site in the molecule and becomes amphoteric between cations, anions, and cations and anions depending on the pH of the solution, for example, alkyldimethylamine. oxides, alkylcarboxybetaines and the like are preferred. Among these, the alkyl group preferably has 12 to 22 carbon atoms.

The nonionic surfactant is an active agent having a hydrophilic site in which the hydrophilic part is not ionized, and examples thereof include polyoxyethylene alkyl ethers such as polyoxyethylene cetyl ether and polyoxyethylene stearyl ether, glycerin fatty acid esters, and sorbitan fatty acids. Polyhydric alcohol fatty acid esters such as esters and sucrose fatty acid esters, fatty acid esters of polyoxyethylene-added polyhydric alcohols, fatty acid diethanolamides, and the like are preferred. Among the nonionic surfactants, those having an HLB of 3 to 17 calculated from Griffin's formula are more preferable. In the above nonionic surfactants, those having a polyoxyethylene backbone can appropriately change the number of added moles of oxyethylene. If the HLB is a nonionic surfactant within the above range, the storage stability of the composition for disinfection is excellent, and, specifically, it is possible to maintain a creamy state without separation or the like even after elapse of time. In addition, although the said surfactant can be used alone or in combination of 2 or more types, it is preferable to combine HLB 3-6 surfactant and HLB 12-17 surfactant.

In addition, water is blended in the composition for disinfection of the present invention. As water, water of the Japanese Pharmacopoeia standard is preferable, for example, constant water such as tap water, well water, etc., and constant water by any of distillation, ion exchange treatment with an ion exchange membrane, ultrafiltration treatment with an ultrafiltration membrane, or a combination thereof. Purified water treated with, and sterilized purified water obtained by sterilizing the purified water by heating or the like are preferred. In addition, the blending ratio of the water is the remainder excluding ethanol, chondroitin sulfate or chondroitin sulfate used in the present invention, and when a thickener, surfactant, etc. are blended, it is the remainder excluding the above, preferably 40 to 65% by weight , preferably 42 to 63% by weight.

In addition, a disinfectant component may be incorporated into the disinfectant composition of the present invention, if necessary. Disinfection components are formulated to disinfect germs or viruses that cannot be sufficiently disinfected with lower alcohols having 1 to 3 carbon atoms. As the disinfecting component, for example, benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, povidone iodine, isopropylmethylphenol, chloroxylenol and the like are preferable, and benzethonium chloride is more preferable. In addition, the above disinfection components may be used alone or in combination of two or more.

In the disinfectant composition of the present invention, since the viscosity can be improved by blending a thickener, the viscosity of the disinfectant composition of the present invention is determined by the Brookfield rotational viscometer type B described in JIS K7117-1 (manufactured by Toki Sangyo Co., Ltd., trade name In measurement using "TVB-10M"), it is preferably 50 to 300 Pa·s under 25°C conditions, and more preferably 100 to 250 Pa·s. If the viscosity of the disinfectant composition is within this range, even if it adheres to the skin of a finger or the like, it does not immediately flow down and is easy to spread even when spreading.

In the composition for disinfection of the present invention, a moisturizer other than chondroitin sulfate or chondroitin sulfate may be further incorporated. Examples of other humectants include polyhydric alcohols such as glycerin, polyglycerin, propylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, polyethylene glycol, maltitol, and sorbitol. , sodium hyaluronate, urea, sodium lactate, trimethylglycine and the like are preferred.

Antioxidants such as tocopherol, vitamin C, and BHT, pH adjusters, buffers, flavorings, pigments, and the like may be added to the disinfectant composition of the present invention, if necessary, in addition to the above components.

Example

[Example 1]

A composition for disinfection was prepared by mixing 30 parts by weight of ethanol, 1 part by weight of sodium chondroitin sulfate, and 100 parts by weight of the composition with the remainder water, and mixing well.

[Example 2]

A disinfectant composition was prepared in the same manner as in Example 1, except that 50 parts by weight of ethanol was used.

[Example 3]

A composition for disinfection was prepared in the same manner as in Example 1, except that 0.01 part by weight of sodium chondroitin sulfate was used.

[Comparative Example 1]

A disinfectant composition was prepared in the same manner as in Example 1, except that ethanol was used in 10 parts by weight.

[Comparative Example 2]

A disinfectant composition was prepared in the same manner as in Example 1, except that ethanol was used in 70 parts by weight.

[Comparative Example 3]

* A disinfectant composition was prepared in the same manner as in Example 1, except that chondroitin sodium sulfate was not mixed.

[Appearance appearance]

In visually evaluating the properties of the disinfectant composition immediately after production, as an evaluation criterion, a state in which chondroitin sulfate is uniformly dissolved is evaluated as "A", and chondroitin sodium sulfate is not dissolved or chondroitin sodium sulfate A state in which cloudiness occurred was evaluated as "C" evaluation, "A" evaluation was evaluated as preferable, and "C" evaluation was evaluated as undesirable.

[moisturizing properties]

In evaluating the moisture retention of the prepared disinfectant composition, as an evaluation standard, five professional panelists performed sensory evaluation on a five-point scale of 1 to 5 for the feeling of moisture after use, and obtained an average score based on the following evaluation criteria. and classified, and the "A" evaluation was preferable, and the "B" evaluation and the "C" evaluation were evaluated as undesirable.

A: An average score of 4.0 or higher

B: Average score of 2.0 or more and less than 4.0

C: average less than 2.0

*[Sterilization effect]

In evaluating the bactericidal effect of the prepared disinfectant composition, the sample and the bacterial solution were directly contacted and then spread on a flat medium to evaluate the number of bacteria. As an evaluation criterion, an efficacy of 99.99% or more of the ratio of the number of bacteria killed by contact with the disinfectant composition to the controlled number of bacteria was evaluated as "A", and an efficacy of less than 99.99% was evaluated as "C", and " It was evaluated that the "A" evaluation was preferable and the "C" evaluation was undesirable.

For Examples 1 to 3 and Comparative Examples 1 to 3, Table 1 shows the results of external appearance, moisturizing properties, and bactericidal efficacy.

As shown in Table 1, in the composition containing ethanol and water, when chondroitin sodium sulfate is incorporated, the moisturizing properties are good. In the case of the degree, the bactericidal effect was not desirable. From the above results, it can be seen that as a disinfectant composition, the mixing ratio of ethanol, water, and chondroitin sodium sulfate needs to be within a predetermined range in order to exhibit a desirable sterilization effect while having good properties in which sodium chondroitin sulfate is uniformly dissolved. there was.

[Example 4]

30 parts by weight of ethanol, sodium chondroitin sulfate (1.0 part by weight) as a moisturizer, 0.4 part by weight of carboxyvinyl polymer (manufactured by Wako Pure Chemical Industries, Ltd., trade name: "Hibiswaco 103") as a thickener, polyoxyethylene cetyl as a nonionic surfactant Ether (manufactured by Nikko Chemicals, Inc., trade name: "NIKKOL BC-15", HLB: 15.5) 2 parts by weight, glycerin monostearate as a nonionic surfactant (manufactured by Nikko Chemicals, trade name: "NIKKOL MGS-AMV" , HLB: 4.0) 2 parts by weight, liquid paraffin (manufactured by Chuo Kasei Co., Ltd., trade name: "Liquid Paraffin 350S") as 1 part by weight, isopropyl myristate as oil and fat 1 part by weight, oil and fat 0.5 parts by weight of stearyl alcohol, 0.5 parts by weight of glycerin as a humectant, 0.2 parts by weight of dimethylpolysiloxane (trade name: "Q7-9120SILICONE FLUID350CST" manufactured by Toray Dow Corning Co., Ltd.), and 0.05 part by weight of benzethonium chloride as a disinfectant component , 0.072 parts by weight of sodium hydroxide, the balance was adjusted to 100 parts by weight of water, and mixed well to prepare a composition for disinfection.

[Example 5]

A disinfectant composition was prepared in the same manner as in Example 4, except that 50 parts by weight of ethanol was used in Example 4. And as a result of measuring the viscosity similarly to Example 4, it was 80 Pa.s.

[Example 6]

A disinfectant composition was prepared in the same manner as in Example 4, except that 0.5 parts by weight of sodium chondroitin sulfate was used. And as a result of measuring the viscosity in the same way as in Example 4, it was 95 Pa·s.

[Example 7]

A disinfectant composition was prepared in the same manner as in Example 4, except that 0.1 part by weight of sodium chondroitin sulfate was used. And as a result of measuring the viscosity in the same way as in Example 4, it was 101 Pa·s.

[Example 8]

A disinfectant composition was prepared in the same manner as in Example 4, except that 0.01 part by weight of chondroitin sulfate was used in Example 4. And as a result of measuring the viscosity in the same way as in Example 4, it was 95 Pa·s.

[Comparative Example 4]

A disinfectant composition was prepared in the same manner as in Example 4, except that 0.01 part by weight of sodium hyaluronate was used instead of sodium chondroitin sulfate. And as a result of measuring the viscosity in the same way as in Example 4, it was 128 Pa·s.

[Comparative Example 5]

A disinfectant composition was prepared in the same manner as in Example 4, except that 0.05 parts by weight of carboxyvinyl polymer and 0.09 parts by weight of sodium hydroxide were used without mixing sodium chondroitin sulfate. And as a result of measuring the viscosity in the same way as in Example 4, it was 211 Pa·s.

[Comparative Example 6]

A disinfectant composition was prepared in the same manner as in Example 4 except that 40 parts by weight of ethanol, 0.05 parts by weight of carboxyvinyl polymer, and 0.09 parts by weight of sodium hydroxide were used without mixing chondroitin sodium sulfate. And as a result of measuring the viscosity in the same way as in Example 4, it was 183 Pa·s.

[Comparative Example 7]

A disinfectant composition was prepared in the same manner as in Example 4, except that ethanol was used in 70 parts by weight. And, after production, separation, cloudiness, etc. occurred, and the viscosity could not be measured similarly to Example 4.

[Comparative Example 8]

A disinfectant composition was prepared in the same manner as in Example 4, except that 0.005 parts by weight of chondroitin sulfate was used in Example 4. And as a result of measuring the viscosity in the same way as in Example 4, it was 10 5 Pa·s.

[Comparative Example 9]

A disinfectant composition was prepared in the same manner as in Example 4, except that 10 parts by weight of ethanol was used in Example 4. And as a result of measuring the viscosity in the same way as in Example 4, it was 185 Pa·s.

[Appearance appearance]

In visually evaluating the properties of the disinfectant composition immediately after preparation, as an evaluation criterion, a state in which sodium chondroitin sulfate is uniformly dissolved, creamy, and no separation is observed is evaluated as "A", and cloudy but chondroitin A state in which sodium sulfate is dissolved and no separation is observed is evaluated as "B", and a state in which the separation is not uniform is evaluated as "C", and "A" evaluation and "B" evaluation are preferable, and "C" evaluation is preferable. rated as not.

[moisturizing properties]

In evaluating the moisturizing properties of the disinfectant composition prepared, 5 professional panelists performed a sensory evaluation of 5 stages of 1 to 5 for the moisturizing feeling after use, and the average score was obtained and classified based on the following evaluation criteria, " It was evaluated that "A" evaluation was preferable, and "B" evaluation and "C" evaluation were not preferable.

A: An average score of 4.0 or higher

B: Average score of 2.0 or more and less than 4.0

C: average less than 2.0

[Sterilization effect]

In evaluating the bactericidal effect of the prepared disinfectant composition, the sample and the bacterial solution were directly contacted, then smeared and cultured on a plate medium, and the number of bacteria was evaluated. As an evaluation criterion, an efficacy of 99.99% or more of the ratio of the number of bacteria killed by contact with the disinfectant composition to the controlled number of bacteria was evaluated as "A", and an efficacy of less than 99.99% was evaluated as "C", and " It was evaluated that the "A" evaluation was preferable and the "C" evaluation was undesirable.

For Examples 4 to 8 and Comparative Examples 4 to 9, Table 2 shows the results of viscosity, appearance, moisture retention, and bactericidal effect.

From Table 2, by using ethanol, chondroitin sodium sulfate, and water in a predetermined content ratio in a formulation system such as ethanol, chondroitin sulfate, thickener, surfactant, and water, stable creamy properties can be maintained during the preparation of a disinfectant composition, and moisturizing It was found that the sterilization and bactericidal effect were also good. In this way, by containing an oil-fat component, a thickener and a surfactant, and setting the viscosity within a predetermined range, the lower alcohol having 1 to 3 carbon atoms is blended in a high ratio, the emulsion stability is excellent, and roughness of the hand can be prevented during use. A semi-solid, high-viscosity emulsion composition for disinfection with good moisture retention can be formed.

[Comparative Example 10]

A disinfectant composition containing 78 parts by weight of ethanol, 0.4 parts by weight of carboxyvinyl polymer, 0.072 parts by weight of sodium hydroxide, and the balance of water was prepared.

[Comparative Example 11]

A disinfectant composition containing 54 parts by weight of ethanol, 0.4 parts by weight of carboxyvinyl polymer, 0.072 parts by weight of sodium hydroxide, and the balance of water was prepared.

About the composition for disinfection of Example 8 and Comparative Examples 10-11, the amount of water evaporation was measured. That is, the amount of transdermal water evaporation when the disinfectant composition was applied once and 10 consecutive times in an environment of a temperature of about 25° C. and a humidity of 30 to 40% was measured 5 minutes and 10 minutes after application once, 10 times in a row. 5, 10, 20, and 30 minutes after application were measured using a Tewameter TM300 (manufactured by Courage + Khazaka). Then, the amount of change was calculated from the difference between the amount of transepidermal water evaporation after the lapse of time and the amount of transepidermal water evaporation before application, and the skin barrier properties of the skin were evaluated. The amount of change, which is the difference between the amount of transepidermal water evaporated before application and the amount of transepidermal water evaporated 10 minutes after 10 minutes after the first application and 10 consecutive applications, was calculated, and a negative change was evaluated as good. The results are shown in Table 3.

From Table 3, in the disinfectant composition in Example 8, after 1 application and after 10 applications, the amount of transdermal water loss after 10 minutes is smaller than the amount of transepidermal water loss before application, and the amount of transdermal water loss after 10 minutes It was found that the amount of change from the initial transdermal water evaporation amount was a negative number, and water evaporation was suppressed, and the skin barrier properties were superior to those of Comparative Examples 10 to 11. In addition, by having excellent skin barrier properties, invasion and infection of bacteria or viruses from the skin can be prevented.

Claims (1)

A disinfectant composition comprising 30 to 50% by weight of ethanol, 40 to 65% by weight of water, and 0.01 to 1% by weight of sodium chondroitin sulfate as a moisturizing agent.