TW201834710A - 以整合素抑制劑治療胃腸道疾病 - Google Patents

以整合素抑制劑治療胃腸道疾病 Download PDF

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Publication number
TW201834710A
TW201834710A TW106144036A TW106144036A TW201834710A TW 201834710 A TW201834710 A TW 201834710A TW 106144036 A TW106144036 A TW 106144036A TW 106144036 A TW106144036 A TW 106144036A TW 201834710 A TW201834710 A TW 201834710A
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Taiwan
Prior art keywords
integrin inhibitor
individual
reservoir
ingestible device
disease
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TW106144036A
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English (en)
Chinese (zh)
Inventor
哈利 斯坦黎
莎瑞特 席恩
蜜雪兒 羅倫斯 瓊斯
克里斯多福 勞倫 威爾
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美商寶珍那提公司
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Publication of TW201834710A publication Critical patent/TW201834710A/zh

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TW106144036A 2016-12-14 2017-12-14 以整合素抑制劑治療胃腸道疾病 TW201834710A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201662434369P 2016-12-14 2016-12-14
US62/434,369 2016-12-14
US201762478863P 2017-03-30 2017-03-30
US62/478,863 2017-03-30
US201762545220P 2017-08-14 2017-08-14
US62/545,220 2017-08-14
US201762583804P 2017-11-09 2017-11-09
US62/583,804 2017-11-09

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KR (1) KR20190095936A (enExample)
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BR (1) BR112019012071A2 (enExample)
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US20200390426A1 (en) * 2017-12-22 2020-12-17 Aobiome Llc Devices and methods for microbiome sampling
WO2019246455A1 (en) * 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an integrin inhibitor
WO2020070818A1 (ja) * 2018-10-03 2020-04-09 オリンパス株式会社 内視鏡装置及び観察時間計測方法
EP3956358A4 (en) * 2019-04-17 2023-01-25 Millennium Pharmaceuticals, Inc. COMBINATION THERAPY WITH ALPHA4BETA7 INHIBITOR AND IL-23 INHIBITOR
CN115666704B (zh) * 2019-12-13 2025-09-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置
JP7444991B2 (ja) * 2019-12-16 2024-03-06 イーライ リリー アンド カンパニー 消化器サンプリングのためのカプセル
CN117729881A (zh) * 2021-03-05 2024-03-19 光疗胶囊医学有限公司 用于胃肠位置估计的装置和方法
US20220326255A1 (en) * 2021-04-01 2022-10-13 Medibeacon Inc. Methods of monitoring mucosal healing
JP7699774B2 (ja) * 2021-09-07 2025-06-30 公立大学法人名古屋市立大学 間質性膀胱炎・膀胱痛症候群の予防又は治療用医薬組成物
CN114659995B (zh) * 2022-05-24 2022-08-23 广东省农业科学院动物科学研究所 一种基于显微高光谱的鱼类诱食剂效果评价方法及系统
CN114907468B (zh) * 2022-06-10 2023-05-23 东莞理工学院 一种仿刺参整合素多克隆抗体、抗原蛋白及其制备方法
CN116027048A (zh) * 2023-02-06 2023-04-28 山东中鸿特检生物科技有限公司 一种细胞因子风暴综合征诊断试剂盒及其应用
AU2024282654A1 (en) 2023-05-30 2025-12-04 Paragon Therapeutics, Inc. Alpha4beta7 integrin antibody compositions and methods of use
WO2025050006A1 (en) * 2023-09-01 2025-03-06 Biora Therapeutics, Inc. Ingestible drug delivery device

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4190328A (en) 1978-12-01 1980-02-26 Levine Robert A Process for detection of blood-borne parasites
DE2928477C3 (de) * 1979-07-14 1982-04-15 Battelle-Institut E.V., 6000 Frankfurt Vorrichtung zur Freisetzung von Substanzen an definierten Orten des Verdauungstraktes
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US4904582A (en) 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
JP2681061B2 (ja) 1988-06-08 1997-11-19 ロンドン・ダイアグノスティック・インコーポレーテッド 検出可能なシグナルのセンシタイザー誘導発生を利用したアッセイ
US6251581B1 (en) 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
US5314805A (en) 1991-10-28 1994-05-24 Molecular Probes, Inc. Dual-fluorescence cell viability assay using ethidium homodimer and calcein AM
US5596090A (en) 1992-07-24 1997-01-21 The United States Of America As Represented By The Secretary Of The Navy Antisense oligonucleotides directed against human VCAM-1 RNA
EP0656946B2 (en) 1992-08-21 2010-03-31 Vrije Universiteit Brussel Immunoglobulins devoid of light chains
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
US5763602A (en) 1996-10-01 1998-06-09 Li; Ying-Syi Methods of syntheses of phthalocyanine compounds
US5919792A (en) 1996-10-30 1999-07-06 Merck & Co., Inc. Integrin antagonists
AU6780398A (en) 1997-03-28 1998-10-22 Du Pont Merck Pharmaceutical Company, The Heterocyclic integrin inhibitor prodrugs
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
PT1007033E (pt) 1997-08-28 2008-07-22 Novartis Ag Antagonistas do antigénio-1 da função de linfócitos
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AU2679899A (en) 1998-02-18 1999-09-06 Dade Behring Inc. Chemiluminescent compositions for use in detection of multiple analytes
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
BR0007663A (pt) 1999-01-22 2002-05-07 Elan Pharm Inc Derivados de acila para uso no tratamento de doenças relacionadas com o vla-4
US8636648B2 (en) * 1999-03-01 2014-01-28 West View Research, Llc Endoscopic smart probe
US6331530B1 (en) 1999-07-13 2001-12-18 The Trustees Of Columbia University In The City Of New York Hydrophilic carrier for photosensitizers that cleaves when they catalyze the formation of singlet oxygen
US6703248B1 (en) 1999-12-15 2004-03-09 Dade Behring Marburg Gmbh Particles for diagnostic and therapeutic use
ES2341843T3 (es) 2000-02-03 2010-06-29 EISAI R&D MANAGEMENT CO., LTD. Inhibidores de la expresion de integrina.
US7074408B2 (en) 2000-02-25 2006-07-11 Immunex Corporation Use of integrin antagonists to inhibit angiogenesis
WO2001068586A2 (en) 2000-03-14 2001-09-20 Novartis Ag α4β1 AND α4β7 INTEGRIN INHIBITORS
US6794506B2 (en) 2000-07-21 2004-09-21 Elan Pharmaceuticals, Inc. 3-(heteroaryl) alanine derivatives-inhibitors of leukocyte adhesion mediated by VLA-4
DE10040105A1 (de) 2000-08-17 2002-02-28 Merck Patent Gmbh Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften
CA2435205A1 (en) * 2001-01-22 2002-08-01 V-Target Technologies Ltd. Ingestible device
US7160258B2 (en) * 2001-06-26 2007-01-09 Entrack, Inc. Capsule and method for treating or diagnosing the intestinal tract
DE10204789A1 (de) 2002-02-06 2003-08-14 Merck Patent Gmbh Inhibitoren des Integrins alpha¶v¶beta6
KR20040108655A (ko) 2002-03-05 2004-12-24 아클라라 바이오사이언시스 인코퍼레이티드 막-결합된 민감제를 사용하는 복합 분석법
EP2336185A1 (en) 2002-03-13 2011-06-22 Biogen Idec Inc. Anti- alpha v beta 6 antibodies
CA2491355A1 (en) 2002-07-05 2004-01-15 Temrel Limited Controlled release compositions comprising coated pellets having non-uniform coating thicknesses
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
RU2334506C2 (ru) * 2003-01-29 2008-09-27 И-Пилл Фарма Лтд. Активная доставка лекарственного средства в желудочно-кишечном тракте
DE10305784A1 (de) 2003-02-12 2004-08-26 Merck Patent Gmbh Verfahren zur Herstellug bicyclischer aromatischer Aminosäuren sowie deren Zwischenprodukte
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
US7402398B2 (en) 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
CN1874789A (zh) 2003-09-23 2006-12-06 光科学公司 用于光动力疗法的缀合物
DE602004014795D1 (de) 2003-10-01 2008-08-14 Merck Patent Gmbh Alfavbeta3 und alfavbeta6 integrin antagonisten als antifibrotische mittel
WO2005035495A2 (en) 2003-10-08 2005-04-21 Nicholas Piramal India Limited Fibrinogen receptor antagonists and their use
ATE551339T1 (de) 2003-11-05 2012-04-15 Sarcode Bioscience Inc Modulatoren der zellulären adhäsion
BRPI0509271A (pt) 2004-03-26 2007-09-04 Lek Pharmaceuticals formas de dosagens farmacêuticas gastrorresistentes compreendendo ácido n-(2-(2-ftalimidaetóxi)-acetil-l-alanil-d-glutámico(lk-4 23)
AU2005277567A1 (en) 2004-08-16 2006-03-02 Medimmune, Llc Integrin antagonists with enhanced antibody dependent cell-mediated cytotoxicity activity
DK176145B1 (da) 2004-09-23 2006-10-02 Guldmann V As Kobling
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
DE102004059613A1 (de) * 2004-12-10 2006-06-14 Liedtke, Rainer K., Dr. Zusammensetzung und Methode einer topischen Therapie von Neurodermitis
EP1841490A2 (en) * 2005-01-18 2007-10-10 Koninklijke Philips Electronics N.V. Electronically controlled capsule
ITMI20050328A1 (it) 2005-03-03 2006-09-04 Univ Degli Studi Milano Composti peptidomimetrici e preparazione di derivati biologicamente attivi
WO2007054128A1 (en) 2005-11-14 2007-05-18 Dominion Pharmakine S.L. Novel inhibitors of the lfa-1/icam-1 interaction, and uses thereof
GB0507918D0 (en) 2005-04-19 2005-05-25 Novartis Ag Organic compounds
US8030328B2 (en) 2005-05-20 2011-10-04 Elan Pharmaceuticals, Inc. Imidazolone phenylalanine derivatives
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
TWI323734B (en) 2005-08-19 2010-04-21 Abbott Lab Dual variable domain immunoglobulin and uses thereof
GB0520378D0 (en) 2005-10-06 2005-11-16 Novartis Ag Organic compounds
US7928113B2 (en) 2005-11-14 2011-04-19 University Of Southern California Integrin-binding small molecules
WO2007069635A1 (ja) 2005-12-13 2007-06-21 Daiichi Sankyo Company, Limited Ｖｌａ－４阻害薬
MY151045A (en) 2006-02-27 2014-03-31 Elan Pharm Inc Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4
MY159375A (en) 2006-03-21 2016-12-30 Genentech Inc Combinatorial therapy
EP2021373A4 (en) 2006-05-31 2010-06-02 Hanwa Chemical Corp MONOCLONAL ANTIBODY VCAM-1 SPECIFIC
JP2009541018A (ja) * 2006-06-23 2009-11-26 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 薬剤投与システム
CA2658612C (en) 2006-08-03 2015-11-17 Astrazeneca Ab Antibodies directed to .alpha.v.beta.6 and uses thereof
EP2125076B1 (en) * 2007-02-26 2012-06-20 Duocure, Inc. Spray administration of compositions including active agents such as peptides to the gastrointestinal tract
EP2380564B1 (en) * 2007-04-04 2014-10-22 Sigmoid Pharma Limited An oral pharmaceutical composition
KR101559596B1 (ko) 2007-07-17 2015-10-12 메르크 파텐트 게엠베하 조작 항-알파 ｖ-인테그린 잡종 항체
WO2009076434A1 (en) 2007-12-12 2009-06-18 Molecular Insight Pharmaceuticals, Inc. Inhibitors of integrin vla-4
WO2011004395A1 (en) 2009-07-06 2011-01-13 Intas Biopharmaceuticals Limited Microemulsion formulation for biologicals
JP6030956B2 (ja) * 2009-08-05 2016-11-24 テル ハショマー メディカル リサーチ インフラストラクチャー アンド サーヴィシーズ リミテッド 胃腸管の異常の診断に使える情報を提供する方法と機器
EP2491057A4 (en) 2009-10-23 2013-05-29 Hanwha Chemical Corp HUMAN RECOMBINANT MONOCLONAL ANTIBODY WITH SPECIFIC BINDING TO VCAM-1 AND INHIBITION OF ADHESION AND TRANSMIGRATION BETWEEN LEUKOYZTS AND ENDOTHELIAL CELLS
ITFI20100019A1 (it) 2010-02-12 2011-08-13 Univ Firenze Inibitori peptidomimetici di integrine basati sull'1,2,3-triazolo per la diagnosi e terapia dei tumori.
US8853149B2 (en) 2010-03-19 2014-10-07 H. Lee Moffitt Cancer Center And Research Institute, Inc. Integrin interaction inhibitors for the treatment of cancer
EP2563405A1 (en) 2010-04-30 2013-03-06 Elan Pharmaceuticals Inc. Selective integrin inhibitors
US9415004B2 (en) * 2010-12-23 2016-08-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8907081B2 (en) 2011-05-27 2014-12-09 Sharp Laboratories Of America, Inc. Long wavelength absorbing porphyrin photosensitizers for dye-sensitized solar cells
RU2597425C2 (ru) 2011-08-17 2016-09-10 Пирамаль Имэджинг Са Соединения для связывания со специфическим для тромбоцитов гликопротеином iib/iiia и их применение для визуализации тромбов
FR2979346B1 (fr) 2011-08-23 2013-09-27 Univ Joseph Fourier Nanocorps anti-vcam-1
WO2013113326A1 (en) 2012-01-31 2013-08-08 Curevac Gmbh Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
FR2986432B1 (fr) 2012-02-06 2014-03-14 Univ Lille Ii Droit & Sante Proteines 28kda gst provenant de schistosomes pour leur utilisation dans le traitement des maladies inflammatoires auto-immunes engendrant une reponse de type th1 et/ou th17
GB201207155D0 (en) 2012-04-24 2012-06-06 Isis Innovation Antibodies
US20140349944A1 (en) 2013-05-23 2014-11-27 Musc Foundation For Research Development Chaperone-based integrin inhibitors for the treatment of cancer and inflammatory diseases
RU2015155552A (ru) 2013-05-24 2017-06-27 Нестек С.А. Путеспецифические способы прогнозирования диагноза синдрома раздраженного кишечника
US10472376B2 (en) * 2013-07-03 2019-11-12 Takeda Pharmaceutical Company Limited Amide compound
WO2015059569A1 (en) * 2013-09-26 2015-04-30 Medimetrics Personalized Drug Delivery, B.V. Delivery capsule with threshold release
US20160249793A1 (en) * 2013-12-27 2016-09-01 Kang-Huai Wang Capsule Camera Device with Multi-Spectral Light Sources
ES2923641T3 (es) 2013-12-30 2022-09-29 Epimab Biotherapeutics Inc Inmunoglobulina con Fabs en tándem y usos de la misma
GB201400442D0 (en) * 2014-01-10 2014-02-26 Sigmoid Pharma Ltd Compositions for use in the treatment of ulcerative colitis
US10219748B2 (en) 2014-01-22 2019-03-05 Nutech Ventures Gastrointestinal sensor implantation system
WO2015131078A1 (en) * 2014-02-27 2015-09-03 Biogen Ma Inc. Method of assessing risk of pml
DE102014004843A1 (de) 2014-04-02 2015-10-08 Schaltbau Gmbh Gleichstromschütz mit zusätzlicher Schalttauglichkeit für Wechselstromlasten und Polung entgegen der Vorzugsstromrichtung
CA2955666A1 (en) 2014-08-13 2016-02-18 Cedars-Sinai Medical Center Anti-methanogenic compositions and uses thereof
AU2015319850B2 (en) * 2014-09-25 2019-09-26 Bt Bidco, Inc. Electromechanical pill device with localization capabilities
US9714288B2 (en) 2014-09-30 2017-07-25 The Regents Of The University Of California Antisense compounds and uses thereof
WO2016099792A1 (en) * 2014-11-19 2016-06-23 Nano Pharmaceutical Laboratories Llc Wireless communications system integrating electronics into orally ingestible products for controlled release of active ingredients
CN104473611B (zh) 2015-01-19 2018-01-30 吉林大学 具有超声波定位功能的胶囊内窥镜系统
KR20170122776A (ko) 2015-03-06 2017-11-06 신세틱 바이오로직스, 인코퍼레이티드 마이크로바이옴 보호를 위한 안전하고 유효한 베타-락타마제 투약
WO2023091991A1 (en) 2021-11-17 2023-05-25 H2 Clipper, Inc. Improved system, method and apparatus for airship manufacture using robotics

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