TW201730188A - 1,3,4-噻二唑化合物及其在治療癌症中之用途 - Google Patents
1,3,4-噻二唑化合物及其在治療癌症中之用途 Download PDFInfo
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- TW201730188A TW201730188A TW105139312A TW105139312A TW201730188A TW 201730188 A TW201730188 A TW 201730188A TW 105139312 A TW105139312 A TW 105139312A TW 105139312 A TW105139312 A TW 105139312A TW 201730188 A TW201730188 A TW 201730188A
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- Prior art keywords
- methoxy
- pyrrolidin
- amino
- thiadiazol
- compound
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Medicinal Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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Applications Claiming Priority (1)
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| US201562260787P | 2015-11-30 | 2015-11-30 |
Publications (1)
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| TW201730188A true TW201730188A (zh) | 2017-09-01 |
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| TW105139312A TW201730188A (zh) | 2015-11-30 | 2016-11-29 | 1,3,4-噻二唑化合物及其在治療癌症中之用途 |
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| WO (1) | WO2017093300A1 (enExample) |
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| GB201520959D0 (en) | 2015-11-27 | 2016-01-13 | Astrazeneca Ab And Cancer Res Technology Ltd | Bis-pyridazine compounds and their use in treating cancer |
| US10040789B2 (en) * | 2015-11-30 | 2018-08-07 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
| US10323028B2 (en) * | 2015-11-30 | 2019-06-18 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
| CN112888686B (zh) * | 2018-10-16 | 2022-04-19 | 南京明德新药研发有限公司 | 噻二唑衍生物及其作为gls1抑制剂的应用 |
| WO2025196446A1 (en) * | 2024-03-22 | 2025-09-25 | Sitryx Therapeutics Limited | Thiadiazoles as glutaminase 1 inhibitors |
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| AU777824B2 (en) * | 1999-11-24 | 2004-11-04 | Merck Sharp & Dohme Corp. | Gamma-hydroxy-2-(fluoroalkylaminocarbonyl)-1- piperazinepentanamides as HIV protease inhibitors |
| US6451828B1 (en) * | 2000-08-10 | 2002-09-17 | Elan Pharmaceuticals, Inc. | Selective inhibition of glutaminase by bis-thiadiazoles |
| TWI287010B (en) * | 2003-06-12 | 2007-09-21 | Euro Celtique Sa | Therapeutic agents useful for treating pain |
| WO2006053342A2 (en) * | 2004-11-12 | 2006-05-18 | Osi Pharmaceuticals, Inc. | Integrin antagonists useful as anticancer agents |
| PL2421826T3 (pl) * | 2009-04-20 | 2014-03-31 | Hoffmann La Roche | Pochodne proliny jako inhibitory katepsyn |
| RS59705B1 (sr) | 2011-11-21 | 2020-01-31 | Calithera Biosciences Inc | Heterociklični inhibitori glutaminaze |
| JP6275153B2 (ja) * | 2012-11-16 | 2018-02-07 | キャリセラ バイオサイエンシーズ， インコーポレイテッド | ヘテロ環式グルタミナーゼ阻害剤 |
| US9029531B2 (en) | 2012-11-22 | 2015-05-12 | Agios Pharmaceuticals, Inc. | Compounds and their methods of use |
| EP3092235A2 (en) * | 2014-01-06 | 2016-11-16 | Rhizen Pharmaceuticals S.A. | Novel inhibitors of glutaminase |
| WO2015138902A1 (en) * | 2014-03-14 | 2015-09-17 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors |
| GB201409624D0 (en) | 2014-05-30 | 2014-07-16 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
| US10040789B2 (en) | 2015-11-30 | 2018-08-07 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
| US10323028B2 (en) * | 2015-11-30 | 2019-06-18 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
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| CA3005516A1 (en) | 2017-06-08 |
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| EP3383871A1 (en) | 2018-10-10 |
| DK3383871T3 (da) | 2019-12-16 |
| ES2759940T8 (es) | 2020-05-20 |
| EP3383871B1 (en) | 2019-09-11 |
| EA201891240A1 (ru) | 2018-11-30 |
| SV2018005701A (es) | 2018-11-27 |
| CN108349967A (zh) | 2018-07-31 |
| IL258644A (en) | 2018-06-28 |
| MX2018006528A (es) | 2019-05-15 |
| AU2016363719B2 (en) | 2019-11-14 |
| KR20180083412A (ko) | 2018-07-20 |
| ES2759940T3 (es) | 2020-05-12 |
| JP2019501134A (ja) | 2019-01-17 |
| BR112018010812A2 (pt) | 2018-11-27 |
| US9938265B2 (en) | 2018-04-10 |
| WO2017093300A1 (en) | 2017-06-08 |
| AU2016363719A1 (en) | 2018-07-05 |
| CN108349967B (zh) | 2022-02-15 |
| CL2018001408A1 (es) | 2018-10-12 |
| TN2018000126A1 (en) | 2019-10-04 |
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