AU2016363719B2 - 1,3,4-thiadiazole compounds and their use in treating cancer - Google Patents
1,3,4-thiadiazole compounds and their use in treating cancer Download PDFInfo
- Publication number
- AU2016363719B2 AU2016363719B2 AU2016363719A AU2016363719A AU2016363719B2 AU 2016363719 B2 AU2016363719 B2 AU 2016363719B2 AU 2016363719 A AU2016363719 A AU 2016363719A AU 2016363719 A AU2016363719 A AU 2016363719A AU 2016363719 B2 AU2016363719 B2 AU 2016363719B2
- Authority
- AU
- Australia
- Prior art keywords
- methoxy
- pyrrolidin
- amino
- acetamide
- thiadiazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- PZPJTLFIXFGBRD-UKRRQHHQSA-N C[C@@H](C(Nc1nnc(N[C@H](CC2)CN2c2ccc(C)nn2)[s]1)=O)c(cc1OC)ccc1F Chemical compound C[C@@H](C(Nc1nnc(N[C@H](CC2)CN2c2ccc(C)nn2)[s]1)=O)c(cc1OC)ccc1F PZPJTLFIXFGBRD-UKRRQHHQSA-N 0.000 description 1
- JSMGQCCZONCCBM-MRVPVSSYSA-N Cc(cc1)nnc1N(CC1)C[C@@H]1Nc1nnc(N)[s]1 Chemical compound Cc(cc1)nnc1N(CC1)C[C@@H]1Nc1nnc(N)[s]1 JSMGQCCZONCCBM-MRVPVSSYSA-N 0.000 description 1
- IPQZUSSGKYCXIB-RHSMWYFYSA-N Cc(cc1)nnc1N(CC1)C[C@@H]1Nc1nnc(NC([C@@H](c2cccc(OC(F)F)c2)OC)=O)[s]1 Chemical compound Cc(cc1)nnc1N(CC1)C[C@@H]1Nc1nnc(NC([C@@H](c2cccc(OC(F)F)c2)OC)=O)[s]1 IPQZUSSGKYCXIB-RHSMWYFYSA-N 0.000 description 1
- PHHFVHIMNXTSKE-MRVPVSSYSA-N Cc1cc(N(CC2)C[C@@H]2Nc2nnc(N)[s]2)nnc1 Chemical compound Cc1cc(N(CC2)C[C@@H]2Nc2nnc(N)[s]2)nnc1 PHHFVHIMNXTSKE-MRVPVSSYSA-N 0.000 description 1
- MAVOVIAMLBQGEA-CRAIPNDOSA-N Cc1cc(N(CC2)C[C@@H]2Nc2nnc(NC([C@@H](c(cc3)ccc3OC)OC)=O)[s]2)nnc1 Chemical compound Cc1cc(N(CC2)C[C@@H]2Nc2nnc(NC([C@@H](c(cc3)ccc3OC)OC)=O)[s]2)nnc1 MAVOVIAMLBQGEA-CRAIPNDOSA-N 0.000 description 1
- NKPBNEQDGYAJFW-NVXWUHKLSA-N Cc1cnnc(N(CC2)C[C@@H]2Nc2nnc(NC([C@@H](c(cc3)ccc3F)OC)=O)[s]2)c1 Chemical compound Cc1cnnc(N(CC2)C[C@@H]2Nc2nnc(NC([C@@H](c(cc3)ccc3F)OC)=O)[s]2)c1 NKPBNEQDGYAJFW-NVXWUHKLSA-N 0.000 description 1
- MAVOVIAMLBQGEA-QAPCUYQASA-N Cc1cnnc(N(CC2)C[C@@H]2Nc2nnc(NC([C@H](c(cc3)ccc3OC)OC)=O)[s]2)c1 Chemical compound Cc1cnnc(N(CC2)C[C@@H]2Nc2nnc(NC([C@H](c(cc3)ccc3OC)OC)=O)[s]2)c1 MAVOVIAMLBQGEA-QAPCUYQASA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562260787P | 2015-11-30 | 2015-11-30 | |
| US62/260787 | 2015-11-30 | ||
| PCT/EP2016/079251 WO2017093300A1 (en) | 2015-11-30 | 2016-11-30 | 1,3,4-thiadiazole compounds and their use in treating cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2016363719A1 AU2016363719A1 (en) | 2018-07-05 |
| AU2016363719A8 AU2016363719A8 (en) | 2018-07-12 |
| AU2016363719B2 true AU2016363719B2 (en) | 2019-11-14 |
Family
ID=57421876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016363719A Ceased AU2016363719B2 (en) | 2015-11-30 | 2016-11-30 | 1,3,4-thiadiazole compounds and their use in treating cancer |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US9938265B2 (enExample) |
| EP (1) | EP3383871B1 (enExample) |
| JP (1) | JP6873132B2 (enExample) |
| KR (1) | KR20180083412A (enExample) |
| CN (1) | CN108349967B (enExample) |
| AR (1) | AR106876A1 (enExample) |
| AU (1) | AU2016363719B2 (enExample) |
| BR (1) | BR112018010812A2 (enExample) |
| CA (1) | CA3005516C (enExample) |
| CL (1) | CL2018001408A1 (enExample) |
| CO (1) | CO2018006929A2 (enExample) |
| DK (1) | DK3383871T3 (enExample) |
| DO (1) | DOP2018000134A (enExample) |
| EA (1) | EA201891240A1 (enExample) |
| ES (1) | ES2759940T3 (enExample) |
| IL (1) | IL258644A (enExample) |
| MX (1) | MX2018006528A (enExample) |
| NI (1) | NI201800065A (enExample) |
| PE (1) | PE20181450A1 (enExample) |
| PH (1) | PH12018501132A1 (enExample) |
| SG (1) | SG11201803813UA (enExample) |
| SV (1) | SV2018005701A (enExample) |
| TN (1) | TN2018000126A1 (enExample) |
| TW (1) | TW201730188A (enExample) |
| WO (1) | WO2017093300A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201520959D0 (en) | 2015-11-27 | 2016-01-13 | Astrazeneca Ab And Cancer Res Technology Ltd | Bis-pyridazine compounds and their use in treating cancer |
| TW201731511A (zh) * | 2015-11-30 | 2017-09-16 | 阿斯特捷利康公司 | １，３，４-噻二唑化合物及其在治療癌症中之用途 |
| US10323028B2 (en) * | 2015-11-30 | 2019-06-18 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
| ES2939506T3 (es) | 2018-10-16 | 2023-04-24 | Medshine Discovery Inc | Derivado de tiadiazol y usos del mismo como inhibidor de GLS1 para el tratamiento de cáncer |
| WO2025196446A1 (en) * | 2024-03-22 | 2025-09-25 | Sitryx Therapeutics Limited | Thiadiazoles as glutaminase 1 inhibitors |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015181539A1 (en) * | 2014-05-30 | 2015-12-03 | Astrazeneca Ab | 1, 3, 4-thiadiazole compounds and their use in treating cancer |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2295068T3 (es) * | 1999-11-24 | 2008-04-16 | MERCK & CO., INC. | Gamma-hidroxi-2-(fluoroalquilaminocarbonil)-1-piperazinpentanamidas como inhibidores de la proteasa del vih. |
| US6451828B1 (en) * | 2000-08-10 | 2002-09-17 | Elan Pharmaceuticals, Inc. | Selective inhibition of glutaminase by bis-thiadiazoles |
| AR044688A1 (es) * | 2003-06-12 | 2005-09-21 | Euro Celtique Sa | Agentes terapeuticos utiles para el tratamiento del dolor |
| WO2006053342A2 (en) * | 2004-11-12 | 2006-05-18 | Osi Pharmaceuticals, Inc. | Integrin antagonists useful as anticancer agents |
| MX2011011094A (es) * | 2009-04-20 | 2011-11-04 | Hoffmann La Roche | Derivados de prolina como inhibidores de catepsina. |
| CN108785305B (zh) * | 2011-11-21 | 2021-10-29 | 卡利泰拉生物科技公司 | 谷氨酰胺酶的杂环抑制剂 |
| HUE056078T2 (hu) * | 2012-11-16 | 2022-01-28 | Calithera Biosciences Inc | Heterociklusos glutamináz inhibitorok |
| WO2014079011A1 (en) | 2012-11-22 | 2014-05-30 | Agios Pharmaceuticals, Inc. | Heterocyclic compounds for inhibiting glutaminase and their methods of use |
| KR20160100407A (ko) * | 2014-01-06 | 2016-08-23 | 리젠 파마슈티컬스 소시에떼 아노님 | 신규한 글루타미나제의 저해제 |
| WO2015138902A1 (en) * | 2014-03-14 | 2015-09-17 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors |
| TW201731511A (zh) | 2015-11-30 | 2017-09-16 | 阿斯特捷利康公司 | １，３，４-噻二唑化合物及其在治療癌症中之用途 |
| US10323028B2 (en) | 2015-11-30 | 2019-06-18 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
-
2016
- 2016-11-29 US US15/363,018 patent/US9938265B2/en active Active
- 2016-11-29 TW TW105139312A patent/TW201730188A/zh unknown
- 2016-11-30 MX MX2018006528A patent/MX2018006528A/es unknown
- 2016-11-30 BR BR112018010812A patent/BR112018010812A2/pt not_active Application Discontinuation
- 2016-11-30 EA EA201891240A patent/EA201891240A1/ru unknown
- 2016-11-30 AR ARP160103665A patent/AR106876A1/es unknown
- 2016-11-30 JP JP2018526717A patent/JP6873132B2/ja active Active
- 2016-11-30 CN CN201680067261.2A patent/CN108349967B/zh active Active
- 2016-11-30 KR KR1020187017164A patent/KR20180083412A/ko not_active Withdrawn
- 2016-11-30 SG SG11201803813UA patent/SG11201803813UA/en unknown
- 2016-11-30 PE PE2018001021A patent/PE20181450A1/es unknown
- 2016-11-30 CA CA3005516A patent/CA3005516C/en active Active
- 2016-11-30 WO PCT/EP2016/079251 patent/WO2017093300A1/en not_active Ceased
- 2016-11-30 AU AU2016363719A patent/AU2016363719B2/en not_active Ceased
- 2016-11-30 DK DK16802102.0T patent/DK3383871T3/da active
- 2016-11-30 TN TNP/2018/000126A patent/TN2018000126A1/en unknown
- 2016-11-30 ES ES16802102T patent/ES2759940T3/es active Active
- 2016-11-30 EP EP16802102.0A patent/EP3383871B1/en active Active
-
2018
- 2018-04-11 IL IL258644A patent/IL258644A/en unknown
- 2018-05-24 CL CL2018001408A patent/CL2018001408A1/es unknown
- 2018-05-29 SV SV2018005701A patent/SV2018005701A/es unknown
- 2018-05-29 PH PH12018501132A patent/PH12018501132A1/en unknown
- 2018-05-29 NI NI201800065A patent/NI201800065A/es unknown
- 2018-05-29 DO DO2018000134A patent/DOP2018000134A/es unknown
- 2018-06-29 CO CONC2018/0006929A patent/CO2018006929A2/es unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015181539A1 (en) * | 2014-05-30 | 2015-12-03 | Astrazeneca Ab | 1, 3, 4-thiadiazole compounds and their use in treating cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| CO2018006929A2 (es) | 2018-10-10 |
| ES2759940T3 (es) | 2020-05-12 |
| NI201800065A (es) | 2018-10-18 |
| MX2018006528A (es) | 2019-05-15 |
| EP3383871B1 (en) | 2019-09-11 |
| US9938265B2 (en) | 2018-04-10 |
| WO2017093300A1 (en) | 2017-06-08 |
| SV2018005701A (es) | 2018-11-27 |
| AU2016363719A1 (en) | 2018-07-05 |
| DOP2018000134A (es) | 2018-06-30 |
| DK3383871T3 (da) | 2019-12-16 |
| AR106876A1 (es) | 2018-02-28 |
| JP2019501134A (ja) | 2019-01-17 |
| IL258644A (en) | 2018-06-28 |
| JP6873132B2 (ja) | 2021-05-19 |
| EP3383871A1 (en) | 2018-10-10 |
| CN108349967B (zh) | 2022-02-15 |
| AU2016363719A8 (en) | 2018-07-12 |
| TN2018000126A1 (en) | 2019-10-04 |
| CN108349967A (zh) | 2018-07-31 |
| KR20180083412A (ko) | 2018-07-20 |
| TW201730188A (zh) | 2017-09-01 |
| US20170152254A1 (en) | 2017-06-01 |
| EA201891240A1 (ru) | 2018-11-30 |
| PH12018501132A1 (en) | 2019-01-21 |
| ES2759940T8 (es) | 2020-05-20 |
| PE20181450A1 (es) | 2018-09-12 |
| CA3005516A1 (en) | 2017-06-08 |
| CA3005516C (en) | 2024-04-16 |
| CL2018001408A1 (es) | 2018-10-12 |
| BR112018010812A2 (pt) | 2018-11-27 |
| SG11201803813UA (en) | 2018-06-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10294221B2 (en) | 1, 3, 4-thiadiazole compounds and their use in treating cancer | |
| US11753405B2 (en) | 1,3,4-thiadiazole compounds and their use in treating cancer | |
| AU2016361834B2 (en) | 1,3,4-thiadiazole compounds and their use in treating cancer | |
| CA3005516C (en) | 1,3,4-thiadiazole compounds and their use in treating cancer | |
| US10577354B2 (en) | Bis-pyridazine compounds and their use in treating cancer | |
| HK1260702A1 (en) | 1,3,4-thiadiazole compounds and their use in treating cancer | |
| HK1260702B (en) | 1,3,4-thiadiazole compounds and their use in treating cancer | |
| HK1260707B (en) | 1,3,4-thiadiazole compounds and their use in treating cancer | |
| HK1260707A1 (en) | 1,3,4-thiadiazole compounds and their use in treating cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TH | Corrigenda |
Free format text: IN VOL 32 , NO 25 , PAGE(S) 3591 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME ASTRAZENECA AB; CANCER RESEARCH TECHNOLOGY LIMITED, APPLICATION NO. 2016363719, UNDER INID (72) CORRECT THE CO-INVENTOR TO WOOD, JAMES MATTHEW |
|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |