EA201891240A1 - 1,3,4-тиадиазольные соединения и их применение в лечении рака - Google Patents
1,3,4-тиадиазольные соединения и их применение в лечении ракаInfo
- Publication number
- EA201891240A1 EA201891240A1 EA201891240A EA201891240A EA201891240A1 EA 201891240 A1 EA201891240 A1 EA 201891240A1 EA 201891240 A EA201891240 A EA 201891240A EA 201891240 A EA201891240 A EA 201891240A EA 201891240 A1 EA201891240 A1 EA 201891240A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- tiadiazolic
- cancer
- compounds
- treatment
- application
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Соединение формулы (I) или его фармацевтически приемлемая соль, где Q может представлять собой 5-метилпиридазин-3-ил, 5-хлорпиридазин-3-ил, 6-метилпиридазин-3-ил или 6-фторпиридазин-3-ил; R может представлять собой водород, фтор или метокси; Rможет представлять собой водород, метокси, дифторметокси или трифторметокси и Rможет представлять собой метил или этил. Соединение формулы (I) может ингибировать глутаминазу, например GLS1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562260787P | 2015-11-30 | 2015-11-30 | |
PCT/EP2016/079251 WO2017093300A1 (en) | 2015-11-30 | 2016-11-30 | 1,3,4-thiadiazole compounds and their use in treating cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201891240A1 true EA201891240A1 (ru) | 2018-11-30 |
Family
ID=57421876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201891240A EA201891240A1 (ru) | 2015-11-30 | 2016-11-30 | 1,3,4-тиадиазольные соединения и их применение в лечении рака |
Country Status (25)
Country | Link |
---|---|
US (1) | US9938265B2 (ru) |
EP (1) | EP3383871B1 (ru) |
JP (1) | JP6873132B2 (ru) |
KR (1) | KR20180083412A (ru) |
CN (1) | CN108349967B (ru) |
AR (1) | AR106876A1 (ru) |
AU (1) | AU2016363719B2 (ru) |
BR (1) | BR112018010812A2 (ru) |
CA (1) | CA3005516C (ru) |
CL (1) | CL2018001408A1 (ru) |
CO (1) | CO2018006929A2 (ru) |
DK (1) | DK3383871T3 (ru) |
DO (1) | DOP2018000134A (ru) |
EA (1) | EA201891240A1 (ru) |
ES (1) | ES2759940T3 (ru) |
IL (1) | IL258644A (ru) |
MX (1) | MX2018006528A (ru) |
NI (1) | NI201800065A (ru) |
PE (1) | PE20181450A1 (ru) |
PH (1) | PH12018501132A1 (ru) |
SG (1) | SG11201803813UA (ru) |
SV (1) | SV2018005701A (ru) |
TN (1) | TN2018000126A1 (ru) |
TW (1) | TW201730188A (ru) |
WO (1) | WO2017093300A1 (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201520959D0 (en) | 2015-11-27 | 2016-01-13 | Astrazeneca Ab And Cancer Res Technology Ltd | Bis-pyridazine compounds and their use in treating cancer |
US10323028B2 (en) * | 2015-11-30 | 2019-06-18 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
ES2939506T3 (es) * | 2018-10-16 | 2023-04-24 | Medshine Discovery Inc | Derivado de tiadiazol y usos del mismo como inhibidor de GLS1 para el tratamiento de cáncer |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6642237B1 (en) * | 1999-11-24 | 2003-11-04 | Merck & Co., Inc. | Gamma-hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamides and uses thereof |
US6451828B1 (en) * | 2000-08-10 | 2002-09-17 | Elan Pharmaceuticals, Inc. | Selective inhibition of glutaminase by bis-thiadiazoles |
MY142655A (en) * | 2003-06-12 | 2010-12-15 | Euro Celtique Sa | Therapeutic agents useful for treating pain |
US8003806B2 (en) * | 2004-11-12 | 2011-08-23 | OSI Pharmaceuticals, LLC | Integrin antagonists useful as anticancer agents |
SI2421826T1 (sl) * | 2009-04-20 | 2014-02-28 | F. Hoffmann-La Roche Ag | Derivati prolina kot inhibitorji katepsina |
EP2782570B1 (en) * | 2011-11-21 | 2019-09-18 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
PT2920168T (pt) * | 2012-11-16 | 2021-10-18 | Calithera Biosciences Inc | Inibidores heterocíclicos de glutaminase |
US9029531B2 (en) | 2012-11-22 | 2015-05-12 | Agios Pharmaceuticals, Inc. | Compounds and their methods of use |
EP3092236B1 (en) * | 2014-01-06 | 2020-08-26 | Rhizen Pharmaceuticals S.A. | Novel glutaminase inhibitors |
WO2015138902A1 (en) * | 2014-03-14 | 2015-09-17 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors |
GB201409624D0 (en) | 2014-05-30 | 2014-07-16 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
TW201731511A (zh) | 2015-11-30 | 2017-09-16 | 阿斯特捷利康公司 | 1,3,4-噻二唑化合物及其在治療癌症中之用途 |
US10323028B2 (en) | 2015-11-30 | 2019-06-18 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
-
2016
- 2016-11-29 US US15/363,018 patent/US9938265B2/en active Active
- 2016-11-29 TW TW105139312A patent/TW201730188A/zh unknown
- 2016-11-30 ES ES16802102T patent/ES2759940T3/es active Active
- 2016-11-30 KR KR1020187017164A patent/KR20180083412A/ko unknown
- 2016-11-30 JP JP2018526717A patent/JP6873132B2/ja active Active
- 2016-11-30 TN TNP/2018/000126A patent/TN2018000126A1/en unknown
- 2016-11-30 DK DK16802102.0T patent/DK3383871T3/da active
- 2016-11-30 AR ARP160103665A patent/AR106876A1/es unknown
- 2016-11-30 EP EP16802102.0A patent/EP3383871B1/en active Active
- 2016-11-30 AU AU2016363719A patent/AU2016363719B2/en active Active
- 2016-11-30 MX MX2018006528A patent/MX2018006528A/es unknown
- 2016-11-30 CN CN201680067261.2A patent/CN108349967B/zh active Active
- 2016-11-30 CA CA3005516A patent/CA3005516C/en active Active
- 2016-11-30 BR BR112018010812A patent/BR112018010812A2/pt not_active Application Discontinuation
- 2016-11-30 EA EA201891240A patent/EA201891240A1/ru unknown
- 2016-11-30 PE PE2018001021A patent/PE20181450A1/es unknown
- 2016-11-30 SG SG11201803813UA patent/SG11201803813UA/en unknown
- 2016-11-30 WO PCT/EP2016/079251 patent/WO2017093300A1/en active Application Filing
-
2018
- 2018-04-11 IL IL258644A patent/IL258644A/en unknown
- 2018-05-24 CL CL2018001408A patent/CL2018001408A1/es unknown
- 2018-05-29 SV SV2018005701A patent/SV2018005701A/es unknown
- 2018-05-29 PH PH12018501132A patent/PH12018501132A1/en unknown
- 2018-05-29 NI NI201800065A patent/NI201800065A/es unknown
- 2018-05-29 DO DO2018000134A patent/DOP2018000134A/es unknown
- 2018-06-29 CO CONC2018/0006929A patent/CO2018006929A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
TN2018000126A1 (en) | 2019-10-04 |
IL258644A (en) | 2018-06-28 |
JP2019501134A (ja) | 2019-01-17 |
NI201800065A (es) | 2018-10-18 |
AR106876A1 (es) | 2018-02-28 |
ES2759940T3 (es) | 2020-05-12 |
SV2018005701A (es) | 2018-11-27 |
ES2759940T8 (es) | 2020-05-20 |
AU2016363719A8 (en) | 2018-07-12 |
EP3383871B1 (en) | 2019-09-11 |
US9938265B2 (en) | 2018-04-10 |
WO2017093300A1 (en) | 2017-06-08 |
CA3005516C (en) | 2024-04-16 |
EP3383871A1 (en) | 2018-10-10 |
AU2016363719A1 (en) | 2018-07-05 |
TW201730188A (zh) | 2017-09-01 |
CA3005516A1 (en) | 2017-06-08 |
CL2018001408A1 (es) | 2018-10-12 |
PE20181450A1 (es) | 2018-09-12 |
KR20180083412A (ko) | 2018-07-20 |
CO2018006929A2 (es) | 2018-10-10 |
SG11201803813UA (en) | 2018-06-28 |
PH12018501132A1 (en) | 2019-01-21 |
CN108349967A (zh) | 2018-07-31 |
DOP2018000134A (es) | 2018-06-30 |
US20170152254A1 (en) | 2017-06-01 |
AU2016363719B2 (en) | 2019-11-14 |
MX2018006528A (es) | 2019-05-15 |
BR112018010812A2 (pt) | 2018-11-27 |
CN108349967B (zh) | 2022-02-15 |
JP6873132B2 (ja) | 2021-05-19 |
DK3383871T3 (da) | 2019-12-16 |
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