TW201625611A - 作為磷脂肌醇－３－激酶抑制劑之吲口巾衍生物 - Google Patents

作為磷脂肌醇－３－激酶抑制劑之吲口巾衍生物 Download PDF

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TW201625611A
TW201625611A TW104119395A TW104119395A TW201625611A TW 201625611 A TW201625611 A TW 201625611A TW 104119395 A TW104119395 A TW 104119395A TW 104119395 A TW104119395 A TW 104119395A TW 201625611 A TW201625611 A TW 201625611A
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amino
pyrimidin
pyrazolo
ethyl
methyl
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TW104119395A
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Chinese (zh)
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麥特歐 比亞傑堤
亞歷山卓 阿世達
安娜 瑪麗亞 卡佩利
馬蒂爾德 瓜拉
米契爾 芮汀尼
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吉斯藥品公司
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Veterinary Medicine (AREA)
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  • Neurology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
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  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
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  • Obesity (AREA)
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TW104119395A 2014-06-17 2015-06-16 作為磷脂肌醇－３－激酶抑制劑之吲口巾衍生物 TW201625611A (zh)

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EP14172764 2014-06-17

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US (1) US9527869B2 (Direct)
EP (1) EP3157920B1 (Direct)
JP (1) JP6730200B2 (Direct)
KR (1) KR102420322B1 (Direct)
CN (1) CN106661019B (Direct)
AR (1) AR100879A1 (Direct)
AU (1) AU2015276264B2 (Direct)
BR (1) BR112016028845B1 (Direct)
CA (1) CA2952287C (Direct)
CL (1) CL2016003214A1 (Direct)
EA (1) EA031409B1 (Direct)
ES (1) ES2750791T3 (Direct)
GE (2) GEAP201814349A (Direct)
IL (1) IL249554A0 (Direct)
MX (1) MX373129B (Direct)
PE (1) PE20170303A1 (Direct)
PH (1) PH12016502291A1 (Direct)
PL (1) PL3157920T3 (Direct)
SG (1) SG11201610473QA (Direct)
TN (1) TN2016000555A1 (Direct)
TW (1) TW201625611A (Direct)
WO (1) WO2015193263A1 (Direct)
ZA (1) ZA201608637B (Direct)

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KR102280614B1 (ko) 2013-03-15 2021-07-21 글로벌 블러드 테라퓨틱스, 인크. 헤모글로빈 조정을 위한 화합물 및 이의 용도
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
KR101815193B1 (ko) * 2015-12-29 2018-01-30 (주)스파크바이오파마 PPARγ 인산화 저해제 및 이를 포함하는 약학적 조성물
WO2017123991A1 (en) * 2016-01-15 2017-07-20 The Brigham And Women's Hospital, Inc. Pyridazine derivatives as eaat2 activators
US10189844B2 (en) * 2016-02-04 2019-01-29 Chiesi Farmaceutici S.P.A. Pyrazole derivatives as phosphoinositide 3-kinases inhibitors
WO2018166493A1 (zh) 2017-03-16 2018-09-20 江苏恒瑞医药股份有限公司 杂芳基并[4，3-c]嘧啶-5-胺类衍生物、其制备方法及其在医药上的应用
CN108129480A (zh) * 2018-03-11 2018-06-08 赵艳阳 一种含芳杂环亚甲基吲嗪衍生物的制备方法
WO2019236625A1 (en) * 2018-06-04 2019-12-12 Ohio State Innovation Foundation Eaat2 activators and methods of using thereof
KR20210149077A (ko) 2019-04-04 2021-12-08 키에시 파르마슈티시 엣스. 피. 에이. 포스포이노시타이드 3-키나아제 억제제로서 아이소크로멘 유도체
CN110156785B (zh) * 2019-04-15 2020-08-28 浙江大学 吲唑类化合物及其制备方法和应用
AU2020299632A1 (en) * 2019-07-03 2022-02-17 Sanford Burnham Prebys Medical Discovery Institute Inhibitors of low molecular weight protein tyrosine phosphatase (LMPTP) and uses thereof
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