TW201613907A - Antibacterial basic biaromatic derivatives with aminoalkoxy substitution - Google Patents
Antibacterial basic biaromatic derivatives with aminoalkoxy substitutionInfo
- Publication number
- TW201613907A TW201613907A TW104133759A TW104133759A TW201613907A TW 201613907 A TW201613907 A TW 201613907A TW 104133759 A TW104133759 A TW 104133759A TW 104133759 A TW104133759 A TW 104133759A TW 201613907 A TW201613907 A TW 201613907A
- Authority
- TW
- Taiwan
- Prior art keywords
- compounds
- aminoalkoxy
- substitution
- antibacterial
- gram
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14189026 | 2014-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW201613907A true TW201613907A (en) | 2016-04-16 |
Family
ID=51743312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW104133759A TW201613907A (en) | 2014-10-15 | 2015-10-14 | Antibacterial basic biaromatic derivatives with aminoalkoxy substitution |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9850256B2 (zh) |
| EP (1) | EP3207042B1 (zh) |
| JP (1) | JP2017531008A (zh) |
| KR (1) | KR20170066644A (zh) |
| CN (1) | CN106795171A (zh) |
| AR (1) | AR102256A1 (zh) |
| AU (1) | AU2015332747A1 (zh) |
| BR (1) | BR112017007438A2 (zh) |
| CA (1) | CA2963699A1 (zh) |
| ES (1) | ES2702214T3 (zh) |
| MX (1) | MX2017004891A (zh) |
| RU (1) | RU2017116617A (zh) |
| TW (1) | TW201613907A (zh) |
| WO (1) | WO2016059097A1 (zh) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA030067B1 (ru) | 2013-07-22 | 2018-06-29 | Идорсиа Фармасьютиклз Лтд | Производные 1-(пиперазин-1-ил)-2-([1,2,4]триазол-1-ил)этанона |
| SI3245203T1 (sl) * | 2015-01-15 | 2019-03-29 | Idorsia Pharmaceuticals Ltd | Derivati hiroksialkil-piperazina kot modulatorji receptorja CXCR3 |
| AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| AR108108A1 (es) * | 2016-04-14 | 2018-07-18 | Idorsia Pharmaceuticals Ltd | Derivados biaromáticos antibacterianos con sustitución de oxetan-3-iloxi |
| GB2550437B (en) * | 2016-05-20 | 2021-06-23 | Bugworks Res Inc | Heterocyclic compounds useful as anti-bacterial agents and method for production |
| TW201833120A (zh) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
| WO2018202524A1 (de) | 2017-05-04 | 2018-11-08 | Bayer Cropscience Aktiengesellschaft | 2-{[2-(phenyloxymethyl)pyridin-5-yl]oxy}-ethanamin-derivate und verwandte verbindungen als schädlingsbekämpfungsmittel z.b. für den pflanzenschutz |
| JP2019019124A (ja) * | 2017-07-19 | 2019-02-07 | 日本化薬株式会社 | ピラジン化合物 |
| CN117980303A (zh) * | 2021-09-20 | 2024-05-03 | 豪夫迈·罗氏有限公司 | 新化合物以及它们在治疗细菌感染中的用途 |
| CN117999261A (zh) * | 2021-09-20 | 2024-05-07 | 豪夫迈·罗氏有限公司 | 新化合物以及它们在治疗细菌感染中的用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19802239A1 (de) | 1998-01-22 | 1999-07-29 | Bayer Ag | Neue mit Bicyclen substituierte Oxazolidinone |
| TW200406413A (en) | 2002-06-26 | 2004-05-01 | Glaxo Group Ltd | Compounds |
| CL2008001003A1 (es) * | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| CL2008001002A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| CN105541769A (zh) | 2007-06-29 | 2016-05-04 | 奥克塞拉有限公司 | 用于治疗眼科疾病和紊乱的炔基苯基衍生化合物 |
| PL2245028T3 (pl) | 2007-12-18 | 2012-07-31 | Actelion Pharmaceuticals Ltd | Pochodne 5-aminocyklilometyloksazolidyn-2-onu |
| JP5349500B2 (ja) * | 2008-02-20 | 2013-11-20 | アクテリオン ファーマシューティカルズ リミテッド | アザトリシクリック抗菌性化合物 |
| CA2713187C (en) | 2008-02-22 | 2016-06-07 | Actelion Pharmaceuticals Ltd | Oxazolidinone derivatives |
| MX2011000968A (es) * | 2008-08-04 | 2011-03-02 | Actelion Pharmaceuticals Ltd | Derivados de alquilaminometiloxazolidinona triciclicos. |
| AR073774A1 (es) | 2008-10-07 | 2010-12-01 | Actelion Pharmaceuticals Ltd | Compuestos antibioticos oxazolidinona triciclicos |
| ES2628091T3 (es) | 2008-10-10 | 2017-08-01 | Idorsia Pharmaceuticals Ltd | Antibióticos de oxazolidinilo |
| EP2346862B1 (en) | 2008-10-10 | 2012-09-12 | Actelion Pharmaceuticals Ltd. | 2-benzothiophenyl-and 2-naphthyl-0xaz0lidin0nes and their azaisostere analogues as antibacterial agents |
| US8575364B2 (en) | 2008-10-30 | 2013-11-05 | Janssen Pharmaceutica Nv | Modulators of serotonin receptor |
| KR20140054057A (ko) * | 2011-08-11 | 2014-05-08 | 액테리온 파마슈티칼 리미티드 | 퀴나졸린-2,4-디온 유도체 |
| CA2854264A1 (en) | 2011-11-08 | 2013-05-16 | Actelion Pharmaceuticals Ltd | 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives |
| AU2014255326B2 (en) * | 2013-04-16 | 2018-09-13 | Idorsia Pharmaceuticals Ltd | Antibacterial biaromatic derivatives |
-
2015
- 2015-10-13 AR ARP150103308A patent/AR102256A1/es unknown
- 2015-10-14 AU AU2015332747A patent/AU2015332747A1/en not_active Abandoned
- 2015-10-14 CA CA2963699A patent/CA2963699A1/en not_active Abandoned
- 2015-10-14 CN CN201580055488.0A patent/CN106795171A/zh active Pending
- 2015-10-14 TW TW104133759A patent/TW201613907A/zh unknown
- 2015-10-14 JP JP2017520323A patent/JP2017531008A/ja not_active Ceased
- 2015-10-14 MX MX2017004891A patent/MX2017004891A/es unknown
- 2015-10-14 BR BR112017007438A patent/BR112017007438A2/pt not_active Application Discontinuation
- 2015-10-14 ES ES15778983T patent/ES2702214T3/es active Active
- 2015-10-14 EP EP15778983.5A patent/EP3207042B1/en not_active Not-in-force
- 2015-10-14 RU RU2017116617A patent/RU2017116617A/ru unknown
- 2015-10-14 WO PCT/EP2015/073751 patent/WO2016059097A1/en active Application Filing
- 2015-10-14 US US15/516,290 patent/US9850256B2/en not_active Expired - Fee Related
- 2015-10-14 KR KR1020177012871A patent/KR20170066644A/ko unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3207042A1 (en) | 2017-08-23 |
| EP3207042B1 (en) | 2018-10-03 |
| MX2017004891A (es) | 2017-12-07 |
| AU2015332747A1 (en) | 2017-06-01 |
| BR112017007438A2 (pt) | 2018-01-16 |
| ES2702214T3 (es) | 2019-02-27 |
| US20170305927A1 (en) | 2017-10-26 |
| CN106795171A (zh) | 2017-05-31 |
| JP2017531008A (ja) | 2017-10-19 |
| US9850256B2 (en) | 2017-12-26 |
| KR20170066644A (ko) | 2017-06-14 |
| RU2017116617A (ru) | 2018-11-15 |
| WO2016059097A1 (en) | 2016-04-21 |
| AR102256A1 (es) | 2017-02-15 |
| CA2963699A1 (en) | 2016-04-21 |
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