TW201606304A - 測定治療反應之方法 - Google Patents

測定治療反應之方法 Download PDF

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Publication number
TW201606304A
TW201606304A TW103130859A TW103130859A TW201606304A TW 201606304 A TW201606304 A TW 201606304A TW 103130859 A TW103130859 A TW 103130859A TW 103130859 A TW103130859 A TW 103130859A TW 201606304 A TW201606304 A TW 201606304A
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TW
Taiwan
Prior art keywords
metadoxine
mice
erk
ratio
subject
Prior art date
Application number
TW103130859A
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English (en)
Chinese (zh)
Inventor
亞隆 達尼里
強納森 魯賓
喬安娜 舒曼
Original Assignee
亞克柏拉有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/038,258 external-priority patent/US20150073023A1/en
Application filed by 亞克柏拉有限公司 filed Critical 亞克柏拉有限公司
Publication of TW201606304A publication Critical patent/TW201606304A/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415Pyridoxine, i.e. Vitamin B6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
TW103130859A 2013-09-09 2014-09-05 測定治療反應之方法 TW201606304A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361875384P 2013-09-09 2013-09-09
US14/038,258 US20150073023A1 (en) 2013-09-09 2013-09-26 Method Of Treating Fragile X Syndrome And Related Disorders
US201461991351P 2014-05-09 2014-05-09

Publications (1)

Publication Number Publication Date
TW201606304A true TW201606304A (zh) 2016-02-16

Family

ID=52629036

Family Applications (2)

Application Number Title Priority Date Filing Date
TW103130859A TW201606304A (zh) 2013-09-09 2014-09-05 測定治療反應之方法
TW103130856A TW201605443A (zh) 2013-09-09 2014-09-05 治療x染色體脆折症及相關病症的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW103130856A TW201605443A (zh) 2013-09-09 2014-09-05 治療x染色體脆折症及相關病症的方法

Country Status (12)

Country Link
EP (2) EP3044589A1 (cg-RX-API-DMAC7.html)
JP (2) JP2016530291A (cg-RX-API-DMAC7.html)
KR (2) KR20160078956A (cg-RX-API-DMAC7.html)
CN (2) CN105917225A (cg-RX-API-DMAC7.html)
AU (2) AU2014316779A1 (cg-RX-API-DMAC7.html)
CA (2) CA2923421A1 (cg-RX-API-DMAC7.html)
EA (2) EA201690559A1 (cg-RX-API-DMAC7.html)
IL (2) IL244343A0 (cg-RX-API-DMAC7.html)
MX (2) MX2016003006A (cg-RX-API-DMAC7.html)
SG (2) SG11201601830PA (cg-RX-API-DMAC7.html)
TW (2) TW201606304A (cg-RX-API-DMAC7.html)
WO (2) WO2015033224A2 (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3239161A1 (en) * 2013-07-31 2017-11-01 UDC Ireland Limited Luminescent diazabenzimidazole carbene metal complexes
US20150073023A1 (en) 2013-09-09 2015-03-12 Alcobra Ltd. Method Of Treating Fragile X Syndrome And Related Disorders
CN108538365A (zh) * 2017-03-24 2018-09-14 华东师范大学 一种基于数据分析技术的自闭症社交能力评估系统
CN112055587A (zh) * 2018-04-13 2020-12-08 Healx有限公司 脆性x综合征的治疗
KR20190121569A (ko) * 2018-04-18 2019-10-28 건국대학교 글로컬산학협력단 아그마틴 및 이의 약학적으로 허용 가능한 염을 포함하는 취약 x 증후군 예방 또는 치료용 약학조성물
JP7387179B2 (ja) * 2018-06-07 2023-11-28 オービッド・セラピューティクス・インコーポレイテッド 発達障害の処置における(s)-3-アミノ-4-(ジフルオロメチレニル)シクロペンタ-1-エン-1-カルボン酸および関連化合物、(1s,3s)-3-アミノ-4-(ジフルオロメチリデン)シクロペンタン-1-カルボン酸ならびにビガバトリンの使用
WO2021141426A1 (ko) * 2020-01-08 2021-07-15 건국대학교 글로컬산학협력단 리수리드 화합물을 유효성분으로 포함하는 취약 x 증후군 또는 관련 발달 장애 치료용 조성물
CN115397414A (zh) * 2020-02-07 2022-11-25 株式会社纽若梵提 包含利美尼定的用于治疗脆性x染色体综合征的组合物
CA3183065A1 (en) * 2020-06-29 2022-01-06 James GRIESSER Treatment of fragile x syndrome with cannabidiol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1131856B (it) 1980-06-30 1986-06-25 Baldacci Lab Spa Composizione farmaceutica per il trattamento di intossicazioni alcooliche
US20020155170A1 (en) * 2000-11-30 2002-10-24 Walsh William John Nutrient supplements and methods for treating autism and for preventing the onset of autism
IL187159A0 (en) 2007-07-03 2009-02-11 Gur Megiddo Use of metadoxine in relief of alcohol intoxication
BRPI1015231A2 (pt) * 2009-06-25 2018-02-20 Alcobra Ltd método para tratamento, suavização de sintomas, alívio, melhoria e prevenção de uma doença, distúrbio ou condição cognitiva

Also Published As

Publication number Publication date
IL244453A0 (en) 2016-04-21
AU2014316779A1 (en) 2016-03-17
SG11201601605YA (en) 2016-04-28
CN105517546A (zh) 2016-04-20
JP2016530536A (ja) 2016-09-29
IL244343A0 (en) 2016-04-21
EP3043792A2 (en) 2016-07-20
JP2016530291A (ja) 2016-09-29
MX2016003002A (es) 2016-09-08
KR20160078956A (ko) 2016-07-05
TW201605443A (zh) 2016-02-16
CN105917225A (zh) 2016-08-31
WO2015033224A3 (en) 2015-07-02
WO2015035402A1 (en) 2015-03-12
MX2016003006A (es) 2016-06-10
AU2014315026A1 (en) 2016-03-24
CA2922901A1 (en) 2015-03-12
EP3044589A1 (en) 2016-07-20
WO2015033224A2 (en) 2015-03-12
KR20160086818A (ko) 2016-07-20
EA201690557A1 (ru) 2016-07-29
SG11201601830PA (en) 2016-04-28
EA201690559A1 (ru) 2016-08-31
CA2923421A1 (en) 2015-03-12

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