TW201338789A - Method for preparing hair growth agent, and composition prepared by said method - Google Patents

Abstract

Provided are: a method for adjusting the optimal blend amount of 6-benzylaminopurine at which the hair growth effect of 6-benzylaminopurine can be exhibited; and a hair growth agent composition produced by the method. The present invention provides: a method for preparing a solution using a mixed solvent of water and ethanol in which the solvent ratio of water to ethanol is 65:35 to 10:90 (by weight) relative to an effective concentration of 0.2 to 1.0 wt% of 6-benzylaminopurine; and a hair growth agent composition prepared using a solution produced by the method. The hair growth agent composition can be used particularly as a hair tonic.

Description

Preparation method of hair growth agent and composition thereof

The present invention provides a preparation method and a composition thereof which can exert the optimum blending amount of the 6-Benzylaminopurine hair growth effect by using a mixed solvent of water and ethanol.

6-Benzylamine oxime is a functional material for hair raising that was first developed by the applicant in the world (refer to Patent Document 1).

However, although the 6-benzylamine oxime has excellent performance, it is a material which is very difficult to prepare for formulation because it is a poorly soluble material.

That is, when expressed by the Japanese Pharmacopoeia as a standard, 6-benzylamine oxime exhibits a solubility characteristic of "insoluble in methanol, ethanol, extremely insoluble in ethyl acetate, chloroform, and almost insoluble in water".

Generally, in the design of a solution system, the solvent that can be used from the viewpoint of safety and the like is actually limited to ethanol or water. According to the explanation of solubility in the above Japanese Pharmacopoeia, "insoluble" means "to dissolve 1g. The amount of solvent necessary for the solute is in the range of 100 mL to 1000 mL. "Almost insoluble" means "the amount of the solvent necessary to dissolve 1 g of the solute is 1000 mL or more". Therefore, the case of using only water is self-evident, and even in the case of using ethanol, it is apparent that the technical difficulty associated with the dissolution method is apparent when designing a transparent preparation in which 6-benzylamine is blended.

The actual test conducted by the applicant's team (using the Japanese Pharmacopoeia as the standard), using ethanol as the solvent, the dissolution of 6-benzylamine at room temperature Before and after the solution is 0.4% by weight, it is an obvious fact that water is below the detection limit.

On the other hand, in terms of the hair growth effect, the effect of the 6-benzylamine oxime in a blending amount of 0.1% by weight can be expected, but in addition to the solubility in the preparation for the release of 6-benzylamine oxime to the skin, the individual is When the difference is considered, the research of the applicant's team clearly indicates that the most appropriate blending amount for maintaining the hair growth effect of 6-benzylamine is at least 0.2% (refer to Non-Patent Document 1).

In order to provide an effective concentration related to the hair-raising effect of 6-benzylamine oxime, and to adopt an ethanol-based formula design in order to provide a transparent preparation, a commercial product of 6-benzylamine oxime blending has been developed so far. .

Therefore, in terms of manufacturing, because it is listed as a dangerous substance specified in the fire protection regulations (using more than 60% by weight of ethanol), it is necessary to invest in, for example, explosion-proof equipment, and it is also an unfavorable formula design. In addition, not only that, but also the consumer must be reminded of the preservation and use of the attention, there is also a sense of discomfort associated with the use of significant ethanol odor.

Of course, if the amount of ethanol used is reduced by taking countermeasures against this problem, the solubility of 6-benzylamine oxime which is hardly soluble in water is lowered in the preparation, which promotes precipitation at a low temperature and causes inability to be exerted. The problem of stable hair growth.

In order to solve these problems, the applicant's team tried to use a variety of additives (dissolving aids), although a certain degree of results were obtained, but the conditions for the critical range of the type and amount of the solvent were not found. Therefore, the method for preparing the effective amount of 6-benzylamine oxime is not sufficient, and the current situation has not yet been A fundamental solution is achieved (see patent documents 2 and 3).

Prior technical document Patent document

Patent Document 1: Patent No. 2636118

Patent Document 2: Special Kaiping No. 10-72321

Patent Document 3: WO2005/030152

Non-patent document

Non-Patent Document 1: San Francisco and Other FJ 20~26 1993

The first object of the present invention is to provide a method for preparing an alcohol to be used without using an additive and a composition thereof (transparent composition) while maintaining the necessary amount of the hair-raising effect of 6-benzylamine.

A second object of the present invention is to provide a method capable of avoiding the problem of using a dangerous substance and a composition thereof (a transparent composition having an ethanol content of 60% by weight or less).

The third object of the present invention is to improve the solubility of 6-benzylamine oxime by using a specific additive, and in particular to provide a solution preparation method which improves the weight ratio of water in a mixed solvent and is excellent in workability, and Composition.

For the first problem, in the mixed solvent system of water and ethanol, the solubility characteristics of 6-benzylamine oxime relative to the specific solvent ratio are clear. The method of providing a concentration which can easily prepare the hair-raising effect of 6-benzylamine oxime, and the composition obtained by the method (transparent composition) are obtained.

As described above, 6-benzylamine oxime can only dissolve in ethanol at about 0.4% by weight at room temperature, and although it has almost insoluble in water, the present invention can still be obtained in a mixed solvent system of ethanol and water. A surprising finding that 6-benzylamine oxime can be dissolved in excess of 1.0% by weight under certain conditions. When the amount of 6-benzylamine oxime is 0.2% by weight, even if water accounts for 65% by weight of the entire preparation, it can be dissolved, and if it is a mixed solvent of water and ethanol at a weight ratio of 30:70, it can be easily dissolved. 6-benzylamine oxime to the extent of weight percent. On the contrary, it is clear that if the ratio of ethanol is further increased, the amount of dissolution of 6-benzylamine oxime will gradually decrease (the critical range).

That is, according to the present invention, when the effective concentration of 6-benzylamine is 0.2 to 1.0% by weight, a mixed solvent of a ratio of water to ethanol (weight ratio) of 65:35 to 10:90 is used to prepare a solution. Method, and clarified hair growth composition using the solution.

In the second problem, in the mixed solvent system of water and ethanol, while maintaining the effective concentration of CTP, the method of providing a solution to the problem is achieved by setting the mixing ratio of water to a better range. That is, according to the present invention, it is possible to provide a mixed solvent of a solvent ratio of water to alcohol (weight ratio) of 60:40 to 10:90 for an effective concentration of 6-benzylamine oxime of 0.3 to 0.5% by weight. The method is provided with a clarified hair growth agent composition using the solution.

For the third problem, while increasing the solubility of 6-benzylamine oxime, it is also prepared by using a solution of a specific additive which can further reduce the amount of ethanol. In this way, it is easier to provide a so-called non-hazardous composition.

The applicant's team has confirmed the effectiveness of the polyvalent alcohol as an additive capable of increasing the solubility of 6-benzylamine oxime since the prior art, but its stoichiometric relationship, that is, for 6-benzylamine oxime The trend of polyvalent alcohols in the "solubility characteristics of a mixed solvent of water and ethanol" cannot be determined. Therefore, it is not possible to achieve the effectiveness of the hairdressing agent which does not damage the 6-benzylamine oxime, and it is impossible to achieve a specific blending amount of the polyvalent alcohol which should lower the ethanol blending ratio, and the high-definition formula design has its design. limit.

In view of the above problems, after confirming the trend of polyvalent alcohols, it was surprisingly found that not only the solubility of 6-benzylamine oxime but also the contribution ratio of water to ethanol is increased in the polyvalent alcohols. That is, a substance having an effect of maintaining the solubility of 6-benzylamine oxime even if the ratio of water is further increased is found.

Therefore, after continuing the double confirmation, it was found that the effect of reducing the amount of ethanol can be obtained by blending the substance having the same characteristics as the polyvalent alcohol in the optimum amount and blending the amount of 6-benzylamine which is necessary for the hair growth effect. As a result of the effect of increasing the amount of water used, it is possible to stably obtain a high degree of freedom modulation method in which the amount of ethanol used is 60% by weight or less, and the present invention has been completed.

That is, according to the present invention, when the effective concentration of 6-benzylamine oxime is 0.2 to 1.0% by weight, a solution is prepared by using a mixed solvent of water to ethanol in a solvent ratio (weight ratio) of 65:35 to 10:90. In addition, by adding a specific additive having a function of improving the solubility of 6-benzylamine and increasing the amount of water used, a non-hazard type of hair-care agent can be provided. Things.

Further, according to the present invention, in the case where the effective concentration of 6-benzylamine is 0.3 to 0.5% by weight, a solution is prepared by using a mixed solvent of water to alcohol in a solvent ratio (weight ratio) of 60:40 to 10:90. Further, by adding a solution adjustment method of a specific additive having a function of improving the solubility of 6-benzylamine and increasing the amount of water used, a non-hazard type hair growth agent composition can be provided.

The invention is:

<1> A method for preparing a solution, which comprises dissolving 6-benzylaminopurine in a mixed solvent of water and ethanol, and using a solvent ratio of water to ethanol (weight ratio) For a mixed solvent of 65:35 to 10:90, a solution of a concentration of 6-benzylamine oxime of 0.2 to 1.0% by weight is prepared.

<2> The method for preparing a solution according to the above <1>, which is a mixed solvent of a ratio of water to ethanol (weight ratio) of 60:40 to 40:60, and a concentration of 6-benzylamine oxime is adjusted to 0.3~ 0.5% by weight solution.

<3> The method for preparing a solution according to the above <1> or <2>, which further comprises an additive having a function of improving the solubility of 6-benzylamine and increasing the amount of water used.

<4> The method for preparing a solution according to the above <3>, wherein the additive is one or more selected from the group consisting of polyvalent alcohols, sugars or sugar alcohols, polyphenols, betaines, and organic acid salts. Compound.

(5) The method for preparing a hair growth solution according to the above <4>, wherein the additive is one or more selected from the group consisting of polyethylene glycol, glycerin, diglycerin, and c A compound of diol, dipropylene glycol, 1,3-butylene glycol, xylose, maltose, trehalose, sorbitol, xylitol, epigallocatechin, betaine, and sodium lactate.

<6> A transparent hair-care agent composition comprising a solution prepared by the preparation method according to any one of the above <1> to <5>.

<7> The hair growth agent composition according to the above <6>, wherein the hair growth agent composition is a non-hazardous type hair growth agent composition.

<8> A composition of a hair growth agent according to the above <6> or <7>, wherein one or more selected from the group consisting of c-AMP and its derivative, Fuss Compounds of Forskolin, carpentium chloride, pentaglyceride, and Minoxidil.

<9> A composition for a hair growth agent comprising the extract of plants, fungi, seaweeds, and microorganisms added to the composition of the hair growth agent according to any one of the above <6> to <8>.

<10> A hair conditioner comprising the hair growth agent composition according to any one of the items <6> to <9> above.

According to the present invention, it is possible to provide a hair dye preparation liquid which can be adjusted to a refreshing feeling of use and an ethanol-based solvent, and a hair-care agent composition which can provide a gentle and irritating odor and a pungent odor.

In addition, by utilizing the findings obtained in accordance with the present invention, The preparation as a whole can reduce the blending amount of ethanol to less than 60% by weight of the non-hazardous and transparent finishing agent composition.

Hereinafter, the present invention will be described.

Since the present invention provides a method and a composition for stably modulating an effective concentration solution capable of exhibiting a 6-benzylamine hair growth effect by using a mixed solvent of water and ethanol in a specific ratio, the feature is that no special additive other than the mixed solvent is used. .

6-Benzylamine oxime (molecular weight 225.26) is a crystalline white powder, and is called 6-benzyl adenine or cytoplasm (hereinafter sometimes referred to as "CTP"), and is known as an active ingredient for bristles. In the present invention, the sufficient amount of the hair-raising effect is 0.2 to 1.0% by weight, and from the viewpoint of the pharmacological effect (agent utilization rate) and the burden on the skin, it is preferably 0.3 to 0.5% by weight, and 0.5 weight is used. % is most suitable, and an appropriate solution can be prepared by using a mixed solvent of water or ethanol so that the effective concentration is within the above range.

In the present invention, when the amount of the 6-benzylamine oxime used is 0.2% by weight, the weight ratio of the water and the ethanol mixed solvent can be freely dissolved and prepared at 65:35 to 10:90, and the amount can be adjusted with respect to 1.0% by weight. In the range of 40:60 to 10:90, the composition is freely dissolved, and a composition of a hair dye which is arbitrarily prepared in this range (hereinafter referred to as "stock 1") can be produced.

Further, since the weight ratio of water to ethanol mixed solvent can be in the range of 60:40 to 10:90 with respect to the amount of use of 0.3% by weight, or from the viewpoint of ethanol odor and irritation, it is preferred. At 60:40~ It is freely soluble in the range of 50:50, and is preferably in the range of 50:50 to 10:90 for 0.5% by weight, or 50:50 to 40 from the viewpoint of ethanol odor and stimulation: A 60% range is freely dissolved, and a hair growth agent composition using a solution prepared arbitrarily within the range (hereinafter referred to as "stock solution 2") can be produced.

Method for producing hair dye composition

The stock solution 1 or the stock solution 2 is prepared in advance in the above ratio, and the desired hair dye composition can be provided by using the stock solution to dissolve the functional component for the purpose of use. In this case, regardless of whether the raw liquid 1 or the raw liquid 2 is used, the weight ratio of water and ethanol which is the most appropriate is known, and the raw liquid of another functional component or the like is the same as the weight ratio of the water and the ethanol. The ratio is pre-modulated, and the composition of the finishing agent prepared at the most appropriate concentration necessary can be easily produced. Further, in particular, among plant extracts and the like, there is an advantage that it is possible to produce a transparent and stable formulation which does not cause sediment or turbidity, such as a mixed solvent having a solvent type and a ratio.

In the present invention, a method for adjusting a solution of a non-hazardous hair-care agent composition can be easily produced by using a specific additive, and the additive specified in the present invention can not only simply increase the 6-benzylamine oxime. The amount of dissolution also has the effect of increasing the weight ratio of water in a mixed solvent of water and ethanol. Therefore, the composition can not only improve the stability of the 6-benzylamine oxime in the preparation, but also the degree of freedom in the amount of 6-benzylamine oxime used, and the invention of the sensibility of the alcohol-stimulated odor mitigation. .

Specific additives having the above properties may be selected from polyethylene glycol, Glycerin, diglycerin, propylene glycol, dipropylene glycol, and 1,3-butanediol, etc., from polyvalent alcohols, glucose, galactose, mannose, fructose, sorbose, ribose, arabinose, xylose, maltose, trehalose, Sugars or sugar alcohols such as sorbitol, xylitol, lactitol, maltitol and mannitol, catechins, epicatechins, gallocatechin, catechin gallate , polygallocate, gallic acid gallate, epicatechin gallate, epigallocatechin and epigallocatechin gallate, polyphenols, glycolic acid, Components having specific moisturizing functions such as organic acid salts such as serine, glycine, lysine, betaine, sodium lactate, and sodium DL-pyrrolidone, and compatible with water and ethanol mixed solvents A surfactant that forms a transparent phase. Surfactants are most preferred with a tendency to HLB of 14 to 18.

Among them, polyethylene glycol, glycerin, diglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, xylose, maltose, trehalose, sorbitol, xylitol, and epiphytic can be mentioned. Tea, betaine and sodium lactate.

In addition, it is preferable to use one or two or more kinds of liquids selected from the group consisting of an average molecular weight of 200, 300, and 400 to 600 from the viewpoint of the dissolution effect, but it is used in an appropriate combination in order to adjust the feeling of use. The above (1000, 1500, 4000 and 6000) are better. However, since the compatibility with a molecular weight of more than 20,000 and a molecular weight of 400 is not good, it is not suitable for the present invention.

The amount of the specific additive used varies depending on the amount of 6-benzylamine oxime used in the stock solution 1 or the stock solution 2, but when it is prepared in the range of 0.1 to 10% by weight, even if it is more than 1.5% by weight, 6- When benzylamine is used, It can be solubilized and can be made into a non-hazard type hair raising composition.

The composition of the hair-care agent prepared by the method of the present invention may contain various additives for use in a general hair-care agent or a scalp external preparation in accordance with the purpose within the range not impairing the effects of the present invention.

In the present invention, although the optimum concentration of the hair growth agent which is a 6-benzylamine oxime having a hair growth effect is prepared, other active ingredients having good solubility in the original liquid phase according to the preparation method can be used in combination. Specific examples thereof include c-AMP and its derivatives, Forskolin, carpentium chloride, pentadecyl glyceride, and Minoxidil, which are specifically directed to pentadecanoic acid. The glyceride has a problem that the stability (precipitation) in the presence of 6-benzylamine in the past is low at a low temperature. However, the preparation method of the present invention can improve the stability and provide a non-sticky property. The preparation of the sense of use. The stoichiometric relationship which is most effective in exerting the effects of the present invention is in the range of 0.01 to 0.2% by weight based on 1 part of the 6-benzylamine oxime.

The extract from plants, fungi, seaweeds, and microorganisms having hair growth activity may be appropriately selected and used, but the solvent of the extract is extracted, as described above, from the viewpoint of stability, using the present invention It is preferable that the predetermined stock solution is water or ethanol of the same composition.

Those who have hair growth activity from plants, fungi, seaweeds, and microorganisms, which are extracted from water or ethanol-based solvents, are suitable for use in the present invention, and are also capable of contributing to 6-benzyl. The enhancement and multiplication of the hair growth effect of the amine.

You can also cite almonds (almonds), indigo, nitrogen-fixing blue-green algae, and love slaves. 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Buergeri), Glycyrrhiza pallidiflora, Tamarix, catnip, scallions (wild leeks), beech, rice, stalk, long-striped sand, ground pepper, boxing, heterochromic carrageen, ramie, Ylang Ylang, Ylang Ylang, Iris, Iris Root, Leaf-shaped Iron Neck, Japanese Hokkaido Rock, Selaginella, Pinus sylvestris, Selaginella, Indica, Bodhi Tree; (Huito), Fennel, Netweed, Oolong Tea Extract, Cymbidium, Herbaceous Grass, Millettia laurentii, Voor, Cyanobacteria, Duckweed (Duckweed), Jing Sanling (three 棱), ebony root bark, Wuyu leaf, Lonicera japonica, turmeric extract, arnica, cephalopod, heart leaf dew grass, wuzi, sea genus seaweed, plucked mushroom, sphagnum moss, southern fan Algae, Asarum, Hard Algae, Red Seaweed, Algae, Algae, Reef, Seaweed, Red Algae, Malva, Small Fan, Feather, Borassus filabellifer, Hairy Seaweed , Prunella vulgaris, Duhuo / Heavy-toothed Angelica, Cat's Claw (Uncaria), Uwa Tea, Tree-shaped Spirulina, Hyssophyta, Sargasso, Brown Algae, Algae, Black Medicine, White-backed , sea fangs, licorice (Glycyrrhiza uralensis), acid algae, bearberry, shunbo, dragon claws; wild rosehip extract, kelp huge seaweed, hooked coriander, scallions, scallions, white scallions Emi (Artemisia dracunculus L. Alias: tarragon, sphaerocephala, scutellaria, scutellaria, long buckwheat (buckwheat, glutinous wheat), sylvestris sylvestris, sylvestris serrata, red leaf stalk, snail, snail Spirulina, Diptera, Diptera, Echinacea, Dioscorea, Diptera, Hydrange, Algae, Gloiocladia stipitata, Thin Snowweed, Edo Sakura, Brown Algae, Sessile Chlamydomonas, gorse, enoki mushroom, polygonatum, Cassia cassia (Cassia sylvestris), Shrimp sylvestris, Pleurotus eryngii, gentian, elderberry, eucalyptus (Canarium luzonicum), medlar (槐花), pea , brown algae kelp, Trillium; Astragalus, Astragalus, European asarum, Polygonatum, Phellodendron, Sakura, Aquilaria, Rhizoma Coptidis, Milk Thistle, Columbine, Bitterfish, Giant Algae, Large Stems, fan cactus, maple leaves (including buildings), woody (infrared), Japanese sand, Oshima cherry, big brown algae, cedar, seaweed, anti-self Algae, oats, seaweed algae, Taiwan sawtooth, plantain (Plantago, plantain), eucalyptus (scorpion), bridge cactus, carrageen, leaking Lu, Atractylodes, Lagerstroemia, Calendula, Giant Leaf Sargassum, Litmus sylvestris, Lushun Alder, Euonymus japonicus, Phyllostachys pubescens, Phyllostachys pubescens, G. sylvestris, P. sylvestris, P. sylvestris, Chinese Hawthorn, Algae, Barley Extract, Barley Fermentation Extract, Purple Beads (Zizhu), Dashan Sakura, Gang, Gangcao, Snake Bed (Cnidium), Bean Dregs, Algae Seaweed, Fan-shaped Algae, Net-ground Algae, Okinawa Dendrobium, Okamura, Okra, Inula (Covering), blue thorn head (Cangzhou stagnation, blue thorn head), Beixian Atractylodes, Zhenjiangli, Mianma striata, silver-white pleated umbrella, Oslo, Asian scorpion, small forsythia extract, Small forsythia, pink flower sesame, Xanthium (Xanthium), eucalyptus, bamboo leaf seaweed, ghost stone cauliflower, walnut, glutinous glutinous rice, medlar, Korean angelica, gastrodia elata (Tianma), Eurasian fragrant, golden ghost lily, tail Orchid, red stalk flower extract, wing stalk, scutellaria (cleft stalk), dragon bud (salted sauce), tuber stalk, Berries, watercress, Italian parsley, gold buttons, psoralen (Psoralea corylifolia L. ), celery, olives, Ou Rudula, wild horse ylang, citrus extract, polygala root; carnation, sun flower, rehmannia, catechu, shell-shaped red algae (P. Boudouresquei), mesophyll, horn net algae, wormwood, cocoa beans, Japanese sand vegetables, red algae seaweed (Acrocosium venulosum), persimmon leaf extract, ground ivy, mouth leaf vine, Huang Jing (Huang Jing), Asparagus algae, Laminaria longipedalis, money mint (Glechoma hederacea L. Subsp. Grandis Hara), Prunellae Spica, Kakocha, Nettle, and Chlorella It is a seaweed (Actabularia ryukyuensis), Umbrella, Eucalyptus, Abbott, Phyllostachys pubescens, kelp, cashew, scallop, wattson, cypress, cypress (cypress, cypress), peony, bitter Pi, Xia Ying, Xia Cao, Ge Xian Cao, Shui Long Cao, Diptera, Shell-shaped Algae, Wrinkled Perilla, Thick Leaf Kumbu, Mexican Ageratum, Pueraria, Caodou (Grassica), Brown algae, valerian, ylang-ylang, birch, sea gold sand (golden vine), broad-striped algae, alfalfa, birch, birch, birch, euphorbia, pepper (salt), pumpkin, jibe kapok, Cattail, Physalis angulata, German chamomile, valerian, kumquat, coleus, plant extract (Camotede Azafran), spirulina, chamomile, Japanese eucalyptus, monophyllum, Long bead, sea bream, Maackia amurensis, coriander, Garagara, C. serrata, Cones sable, Japanese mustard, Pinellia (seven summer), oatmeal, guarana (guarana) ), heart leaf, cloth, paulownia, cypress, papaya, kalkady, garcinia, cardamom, sacred (Cardo Santo), palm coconut, goat bean, red algae seaweed (Tichocarpus crinitus), money grass, carrot, red algae, corundum, basidiomycetes, water bitter, river moss, musk, tamarind, river willow, potentilla (potentilla, turfgrass), Yunzhi, long buckwheat (Dianhua), Artemisia annua (Artemisia annua), Artemisia argyi extract, cold cherry, sweet rosin, sweet glutinous rice (Ganzi), licorice, licorice Flavonoids, Manila agave, Cantharides, chills, small candle trees, coltsfoot flowers, Lysimachia (Lianqian), canna, geese, Han Fang, sweet leaves, Hanlan, sputum (Eclipta); Raspberry, Kiwi, Guihuang, Diaolou, Campanulaceae, Chrysanthemum, Chrysanthemum Kumbu, Ganmaju, Shantou Chicken, Convolvulus, Eucalyptus (Catalpa ovata G. Don), 枳 枳 (枳 )), Japanese plexus algae, Kishu mandarin, Taiwan ivy, Aloe vera, winter fragrant mint, tennis algae, yarrow grass, fox, cinnamon, orange (orange), quina, Cinchona tree, Quinoa, Wedge leaf hedgerow, Gelidium linoides, Purple leaf algae, Tamarix, Astragalus, Astragalus, Astragalus membranaceus, Wushou leaves, Peruvian apple cactus, cassava, Korean Vegetables, unripe fruit, fennel, kandiola, cucumber, bulbous nasturtium, nine-section calamus (nine calamus), polygonatum, oleander, almond, flag leaf cypress, corn mustard, jade leaf golden flower, tamarisk, soap Tree, Soap Bark, Loquat Bone Grass (Gold Sore Grass), Indus, Kirin, Eucheuma, Reed, Kumquat, Ginkgo (Ginkgo), Snapdragon, Golden Persimmon, Silver World Cactus, Pot marigold , Golden Thread, Golden Time, Ginkgo biloba, Golden Wu Fan Cactus, Loquat Leaf, Dragon Grass (Agrimonium), Osmanthus fragrans var. Aurantiacus), quince, silver orchid, golden edge orchid; guaco misto, astringent walnut (Cuachalalate), guava, bitter poplar, guaiac wood, gray ash gum, medlar extract , gooseberry, gooseberry, chestnut fruit, 鹄 兰, 枸杞, 枸杞 (Lycium chinense, L. Barbarum), Asparagus (asparagus), celandine (Chelidonium majus), bitter buckwheat (Bitter ginseng), eucalyptus, Artemisia annua (Artemisia annua), Hawthorn extract, plant (Kuteiteriba), palsy ( Pakcho), long buckwheat, 虞美人草, 芋根龙须菜, 古布阿苏, 鸡鸡椒,熊 Extract, Kumaseba, Violet, Verbena officinalis L. , V. Citronela), cumin extract, Kuranigeann, unicellular algae, Sophora flavescens extract, cranberry, chestnut, broadleaf grass, walnut, grapefruit extract, florets clematis, huzhang , Clover, Iron Holly (Save Bing), Blackwood, Black Cloud, Black Sugar Extract, Brown Algae, Algae, Algae, Algae, Algae, Black Fruit tea, two-column algae, black tea scorpion (Ribes nigrum, alias: black currant, black currants, black bean), black rice (black rice), long pine, algae, black hair, big leaf fishing樟 (black text), chlorella, oval small green algae, chlorella chlorella, chlorella (C. Vulgaris), Chlorella, mulberry extract, algae, mulberry leaf, water net algae, black-headed brown algae of the military fan, North American lone dish (small group fan, lone dish); Japanese catnip (Schizonepeta tenuifolia Briq. Var japonica Kitagawa)), cockscomb, soft sage, spatholobus, cassia twig (cinnabar), cockscomb (cockscomb, cockscomb), chicken inner gold, achyranthes root (Achyrantes root), cinnamon, gui (Kushigurusa), acid algae, aloe vera, under the moon beauty, laurel (laurel), moon peach, sycamore (syringa), cold rice vine (soil, mountain return), kenaf, turpentaceae seaweed, small kelp (Cutleria adspersa ), hair gun, geranium, hanging fruit, Pharbitis seed, gentian, burdock, medlar; safflower, aster (Astragalus sinicus L. ), mahogany, noble stone, camphor, rose flowers (rose flowers), perfume mint, mulberry, red Tea, Taiwan cypress, yeast, Japanese Pampas grass, Sakamoto (Sakamoto, Don Juan), sorghum, galangal (galangal), coriander, bezoar, Hu Huanglian (Hu Huanglian), Pterocarpus santalinus, coffee, Sudan cola fruit, bright cola fruit, ebony, cranberry (bilberry), dimpled Dalbergia, Hypericum, coconut palm, Moss-like chicken, Algae, Achyranthes, Astragalus, Wusong Raspberry (Raspberry), Piper angustifolium, Cosmos, Dongfeng Orchid, Fern Fern, Walnut Kernel, Cape and Vegetable, Dendrobium, Dwarf orientalis L. ), Hongyeza, Galla Chinensis, Cobauba, Cuban Balm, Wild Sakura, Xiaoping, Oxygen, Wupingkun, Burdock Extract, Great Burdock achene, Peony, Sesame, Beixuan Ginseng (Scrophularia sinensis), Coix seed, rice, rice bran, brown tongue, common mallow, horse mulberry, medlar, Korean glutinous rice, baggage willow, Leuca martinicensis, coleoptera, sweet Lemon, small crown flower, fenugreek, rosin (Colophony), African defensive, African huanghuali (Guibourtia demeusii), milk vine bark, medlar, kelp, kelp, Kunnfuyo, comfrey, jade leaf golden flower; Small flower stalk, Gleditsia japonica, Bupleurum, sisal, Qiongma, Caixin, slashed sand, sage, Phyllostachys pubescens, Phyllostachys pubescens, Rehmannia glutinosa First island peony, double cross net algae, green algae, sakura scorpion, Fuhua algae, cherry, pomegranate, sago coconut, fine bamboo (笹), 笹金, queen agave, 笹叶银兰, feathery seaweed ( Chondria lancifolia), Lily, Camellia, Alisma (沢 Diarrhea), sweet potato, taro, sugar cane, sugar beet, sakura, thick net algae, schisandra, jujube kernel (sour jujube kernel), safflower, black triangle, sapodilla, white persimmon, fairy peach, cactus, mandarin, soapweed, Brown algae seaweed (Kjellmania arasakii), spirulina, single ear cohosh (Cassie), Jurassic double tree, sand sap (sand thorn), crape myrtle, red stalk, stalk (mountain stalk), hickory ( Hawthorn), Shanwuyu, dragon fruit, dragon blood (croton), coral algae, hawthorn, three-leaf clover, mountain mushroom, hawthorn, Sanqishen, mountain summer, hawthorn (Hawthorn), mountain pepper, alfalfa Gardenia fruit, Shandou root (Mountain root), Shantala, sandalwood, mulberry seed (mulberry, mulberry), Cnicus benedictus, Shengbi Luo, mountain lentils; Xue Yazhi (emulsification) Wood fruit fat, shea butter, shiitake mushroom extract, rehmannia, seaweed (Contarinia okamurae), long sac water cloud, aster flower (Aster), spider orchid, brown algae (Stypopodium zonale), digitalis, red soft thorn algae Guest, Gentleman (Gentleman), Acanthopanax, Rhododendron chinense (Acacia), Earthworm, Purple Root, Black Fern, Perilla, Perilla Leaf , cedar, P. sinensis, weeping birch, weeping willow, red sandalwood, lemongrass, shrimp flower, 栝楼 (王瓜), licorice (Glycyrrhiza echinata), powder grass (Glycyrrhiza echinata), white flower paulownia, clematis Lingxian), East China, Drosophila, Clematis, Cinnamon, Cinnamon, Admiral, Ascomycetes (Ascomycetes), Zoysia, Kochia, Maackia tashiroi, Island Chrysanthemum, Red Algae Seaweed (Heterosiphonia pulchra), Litchi broccoli, Hongzhi mushroom, Zimulian (Xinyi: Frangipani), Lower wild grass, Sakamoto algae, Potato, brown Pleated umbrella, peony, Caesalpinia decapetala, musk, spirulina, ginseng (sand ginseng), jasmine, plantago seed, plantain, brazil pear, Ophiopogon japonicus, palm leaf, tree, Chongyang wood (Chongyang wood), beet, perennial star, shrink sand (Amomum, sand), earthworm, wine flower (alcohol flower), cone flower, palm, spring orchid, jujube bark (Zizyphus joazeiro) , ginger, dried ginger, Changshan, Iris, Cimicifuga, Ginger, Shanglu, Cardamom, Ligustrum lucidum, Myagropsis myagroides, White peony, White birch, A. platensis, Lamprothamnium succinctum R . D. W. ), Gracilaria bursa-pastoris, Japanese purple orchid (white and), Arab mustard, wild mushroom, white herb, Dahuatianjing, Xiuzhen mushroom, Caesalpinia bonduc, white clover (Clover) ), chicken bone grass (bone grass), fragrant root iris, white dandelion, white hibiscus, magnolia, red algae (Sornar), zebra (Microberlinia bisulcata), sinka (Shinnkonasakushirubura) , ginger grass, ginseng, white flower Ruixiang (Ruixiang, Ruixianghua, Shendinghua); sweet tea (sweet cold), basil (Ocimum basilicum L. Alias: Meguro, Basil, Sweet Basil, Mulimu, Arufaweaka, Watermelon, Pickling Extract, Shuiqian Temple Seaweed, Sorrel (Sorrel), Simuberi, Caesalpinia sappan, Cedar, questioning, linear algae, brown algae (Coccophora langsdorfii), wild amaranth, Meraceae (Milania humilifollia), stripe laver, canola, red algae algae (Acrosorium polyneurum), Myriogramme polyneura, Chamaebotrys boergesenii, Lenormandiopsis lorenzii, Sawgrass, Costaria costata, Red algae algae (Halarachnion latissimum ), Chai Huling (Xu Changqing), true red algae seaweed (Neoholmesia), lily of the valley, star apple, stevia, strawberry, spirulina, mint, purslane (purslane, purslane), alfalfa algae, candied dates Prune), Surigathinn, Brassica, Junhelan, Swartzia polyphylla; Aoki, Western artichoke, Western red pine, Asparagus, St. John's wort, European larch, often Ivy, Agrimonia eupatoria, western walnut, sharp thorn, European bilberry, Taraxacum officinale Weber, horse chestnut, western pear, western summer snow grass, western elderberry, western juniper, ocean Valerian, peppermint extract, leaf leaf algae, western rose, field flower, western wind butterfly, western wind butterfly, mistletoe, western mountain mint, western mustard, ceylon cinnamon, rat tail Grass, Clary Sage, Shi Wei, Miniature Calamus (Acorus gramineus, A. Gramineus var pusillus alias: Changyang, Shichangpu, Qiangpu), Chixiaodou, Heather, Cedar, Shijie, Cedron, hollyhock, Meiyuanzhi, ginseng, zebra (Microberlinia brazzavillensis), geranium, Water celery, celery, Chuanxiong, Qianjin, lyrics, Andrographis paniculata (through heart), Toad venom, Senntariumu, bitter, senna, immortal, immortal Human palm, big cockroach (big cockroach), invertebrate flower, thousand vibration, fairy wood; grass aconite, grass fruit, mulberry parasitic, Tibetan, atractylodes, sambucus, continued with the child (continued with the child), arborvitae leaves, vegetarian heart Lamei, Red-feathered algae, hard-haired horny moss, buckwheat, eucalyptus, dyed Yoshino cherry, Dioscorea opposita, Halothrix ambigua, Perilla herb, sorghum; black sweet cherry, Antarctic bull algae , anise (anise), rhubarb (Rhubarb), cockroach, radish (large root), soybean, soybean protein (thermophilic protease decomposition, thermolysin-like protease decomposition), jujube, orange, thyme, Dawencao, Continental Liu, Daunntorawasu, Chrysymenia wrightii, Gurley Blue Thorn (Southeast Blue Thorn), Sausage (Eclipta), Otsuka (Da戟), Kaolin Sakura, Iron Knife, Golden Retriever Dog (Dog Ridge), Tasha Seaweed, Rhodoptilum plumosum, Hollyhock, Hypnea variabilis, Silver Spot Thyme, Tangerine, Japanese Sansui, Sargassum Seaweed (Sargassum tosaense), Bean (Bean Bean), Tobacco, Brown Algae (Desmar) Estia tabacoides), algae, green algae (Valonia macrophysa), golden threaded tortoise, jade wisteria, Chaetomorpha moniligera, Japanese sargasso, onion, tuber nasturtium, Phytophthora, Luo Azialia elata Seem, Liaodong elm, broadleaf holly, Thalia (Scorpio peony), South American lupine, red algae (Palmaria palmata), red rosewood (Dalbergia cochinchinensis), broadleaf Dalbergia (Dalbergia latifolia), Luhan, edible cactus, Salvia, and thick Membrane, dandelion, kauri; European chestnut (Castanea sativa Miller. C. Vesca Gaertn. , C. Vulgaris Lam. ), cherry, Algae crassifolia, thatch, bamboo ginseng, chicory, chicory, seaweed, red spirulina, chlorella, tea, tea (Camellia sinensis), hard stalk, algae Nitella acuminata var. Capitulifera), tea, pearl grass (Chanca piedra (Phyllanthus niruri)), tulip, tuberose, diced, Korean Schisandra (Schisandra), 芜荑 (芜夷), Korean ginseng, Korean wild chrysanthemum, Korean poncho, gentian ( Gentian), Chokonosutei, Poria, Ding Lu, Schisandra, Red Seaweed (Reinboldiella schmitziana), Tangerine; Tongji, Yuezizi, Evening Primrose, Double-leaf Orchid, Red Algae Seaweed (Nemalion multifidum ), mushrooms (mushrooms), mountain corals, cyanobacteria, kudzu, beautiful varieties of Durian sea bream, carrageen, sawtooth, tea, thunder, roots, geranium (laccus), comfrey (duck) , ginseng, leaf bud, chopsticks, brown algae (Ecklonia stolonifera), Phyllostachys pubescens, sylvestris sylvestris, long bottle of jujube, scorpion spirulina, Polygonum, apricot (apricot), earth ginseng (four leaves ginseng), Roach, Taiwan Mountain Chrysanthemum, Tea Tree, Dichroa root, Sycamore, Caesalpinia coriaria, Thira, Dill, Thin Walnut, Watermelon, Duke Blueberry, Dew Raspberry, Terminalia Tree, pine, safflower, scorpionfish (Hydrocotyle sibthorpioids) e), Tiantai Wuyao, sweet tea, Gastrodia elata, Asparagus; Huateng vine, winter melon seed, winter carnation (Toukaninn), pepper, angelica, winter sunflower, angelica ginger, calendula, medicine, scaly fern, Japanese scorpion, Chinese big leaf tea, Cordyceps sinensis, Sichuan Intermittent (chuanchuan), salt marsh seaweed, soy milk, peach kernel, fish scale spruce, corn, holly, gentian, cassia, red color wood, big thief (wood thief), houttuynia, tooth Eucalyptus, Chondrus armatus, Gloiocladia spinulosa, Thorn, Dokoharututa, Hawthorn, Tugan (Tugan), Cocks, Wrinkled Laver, Palm M. sylvestris, rabbit scorpion, Japanese horse chestnut, Japanese ginseng, carrageen (for carrageen), Eucommia (eucommia), solo, black raspberry, ash tree (Qinpi), tomato, inulin (Inula helenium) ), tragacanth, sauerkraut, trichosanthes, medlar, bird's nest algae, tolu-scented gum, turkish platycodon, turfgrass, sorghum, scorpion, sapphire, geranium, mucus, black Bean; night fruit, sarcophagus, yam, red algae (Schimmelmannia plumosa), algae, red algae (Ne Ohypophyllum middendorfii), long kelp, brown algae (Sargassum segii), shovel (Rumex crispus), spirulina, Phytophthora, long pine, acacia (fake leaf), citron (fragrant), eggplant, leeks, rapeseed , Bean, Natto, natto (Bacillus natto culture metabolite), Japanese vine (Millettia japonica), summer mandarin, date, Namba rose (Sakura), mucosal algae, intermittent (intermittent), Napo (gro) ), true red algae, spray fish, mushroom, lychee, algae, lily, red raspberry, attached melon algae, Glycyrrhiza glabra, South Tianzhu, Fake tiger, ramie (castor), geranium (Gelidium subfastigiatum); iris, camphor, Picrasma ailanthoides, nutmeg, smooth algae, fleshy algae, red algae (Masudaphycus irregulare), fresh algae , Ryukyu sea octopus, seaweed (Acrothrix pacifica), Boswella carteriiBird wood, lactic acid bacteria, lactic acid fermented material, Bonerorchis joo-iokiana, leeks, skunks, scoparia, sacral bones (sambucus) ), two ear grass, carrot, garlic; scalloped algae, luminal algae, shallot, cat foot kelp, silver willow, espresso, algae, long leaf 藓, ramie, dodder, acacia, acacia, Acacia wood, Albizia, scoparia; Nanguo Xiaoyan (Dayu), Ten Sisters, Linghua (Linghua), Lingyan Yelian, Celosia, Yarrow, Serenoa repens, serrated horsetail Algae, saw palmetto, anterior hummus (pre-Hu), wild rose extract, kelp (Nobonori), peach kernel; birch, arbuscular algae, powdered algae, ochre cauliflower, pineapple, vermilion, fritillary (female) , F. chinensis, plants (Glycoxylon pra Ealtum), Lupin, Hawthorn, Lily, Drynaria Rhizome (Drynaria fortunei), Mineral (Bakugaishi), Wheat Moth, Malt Root, White Flower, Cannabis, Cabbage, Orchid (Dactylorhiza aristata), European White Fresh, white tea, white magnolia, Gai's black raspberry, geese red, lychee, sorghum, sorghum, stalk (Alchimilla vulgaris L.) ), 榛 (榛子), Dongpu, lotus (lian), red algae Polyneura japonica, Stenogramma interrupta, Caesalpinia globulorum, lacquer, parsley extract, bare barley, lotus leaf pleated umbrella, sweet potato, light bamboo (bamboo), knotweed, Imitation stone flower, patchouli, hand-flavored, mint, hairy, coix seed, coix seed, red algae seaweed (Kallymenia callophylloides), whole cryptophyta, anemarrhena (mother), banana, grape algae, alfalfa (蒺藜Seed, hedgehog), internal algae, dendritic algae, vanilla seed, Japanese broccoli, red algae (Pterosiphonia pennata), esculenta, Maackia floribunda, algae, papaya, hairy skin (Kochia scoparia), sea scorpion, squid, squid, kelp, kelp, Pajaro bobo, double kelp, sweet pepper, chicken thorn, Luoshen , Persimmon, Vitex rotundifolia, Aconite (Aconite), Rose extract, Wolfberry, Northern Sand Ginseng, Witch Hazel, Artemisia, Hamula, Balata , roses, mushrooms, lataka, ylang, cones, scallops (western) Jiazi), medicinal wall grass, white pearl tree, hedgehog, spring cold orchid, bitter gourd (bitter gourd, green bitter gourd), Japanese eucalyptus (skin, eucalyptus, eucalyptus), barbasco, rose grass, four Algae algae, spring gentian, violet, fat sea (fat sea), bread tree, Campanulaceae (Hannpennrei); Hiiokoshi, pecan, beet, hollyhock (Althaea officinalis), green pepper, brown algae Seaweed (Myagropsis yendoi), Shegan, Spirulina, Radix, Codonopsis (Dangshen), Zeng Algae, algae, Bianhua (Aster, Vine), Acacia, Dali, Leu, Bidens pilosa, Spirulina, Water chestnut (Lingshi), African thorn (Pygeum africanum), Sargassum, seaweed (Gloioderma japonica Okamura), Camellia, Pistachio, Ami fennel, Qinghai, Dendrobium (Dendrobium), Dye wood, Spirulina, Daisy (daisy), baby millet Flowers, garland orchids, Hinachiyodori, Schisandra, Japanese cypress, cypress, Luohanbai, Fucus, soft silk, Japanese worm, Bismuth, ramie, apricot Pleurotus sp. ), sunflower, Tibetan fennel, Tiankui (Tianhua), Typha (Typha), Black Beads, Mouse Ear, C. elegans, Vinca minor L. , Catharantus minor), broccoli, seaweed (Callophyllis rhynchocarpa Ruprecht), Japanese worm, squid, spirulina, spirulina, brazil mushroom (Agaricus blazei, Brazilian mushroom), nest orchid, vertical Alder, pepper, scorpionfish, lily, wild angelica (Angelisa dahurica alias: valerian), Atractylodes, cypress eucalyptus, white sandalwood, white medicinal herb, medlar, genus Guibourtia tessmannii, black chicken Bean seeds, sphagnum moss, seaweed (Pylayella littoralis), cercariae, lindenia, scutellaria, stellate polycylobacteria, seaweed (Cryptarachne polyglandulosa), lentils, flat pine algae, spirulina, whitish algae, Flat-lined algae, long-splintered spirulina, sclerophylla, sassafras, rooted parsley, pulsatilla (Pulsatilla), Meiyuanzhi, Bai'an algae, Calophyllis crispata Okamura, wide reef, Spirulina , broadleaf group, scorpion, eucalyptus, dwarf bearberry, folded umbrella, betel 榔 (large clothing, betel nut), betel nut, betel nut; Phyto COLLAGE, laver, Pu'er tea, Nanteng (Nanteng), incomplete bacteria (incomplete bacteria), Japanese winter, coltsfoot, bee Bucket, scorpion, thick-edged algae, overturned agave, kelp (Fukureshinori), erythroporex, kelp, sea spirulina, aconite (Aconite, Fuzi alias: bird pocket), fucoidan, thick Leaf fern, Japanese fresh algae, sea cucumber algae (Prionitis articulata), cynomolgus, mobile sargasso, chain-shaped pod algae, algae-free algae, Zeeland (bluegrass), sylvestris seaweed (Rhodomelaceae) , lentils pods, sassafras (Ting Sakura, sassafras), silver Bupleurum, lanceolate, sorrel, bitter orange, coriander, green seaweed, grape, grape leaf, spirulina, noodle algae, scutellaria Tree, Hongxi mushroom, small red cabbage, Daping, duckweed, Pradosian lactescens, Periandra dulcis, Brazilian ginseng, Caesalpinia echinata, Platymiscium trinitatis, Blackberry, plum, Fritschiella, capsule algae, blueberry Cranberry), dates, broom fork sp seaweed, Furuseria is a seaweed, mushroom, flowers month, psyllium, green beans (green beans); rice, red flowers, red bayberry, hazelnut, catechu (Acacia catechu Willd. ), lavender, loofah, petunia, white birch, phoenix, asparagus, schistosomiasis, seaweed, safflower, cystaea, sclerotium, Beniyanagikori, agave, pepper, Peppermint, Dioscorea opposita, Belladonna, Single-banded Algae, Raspberry, Peruvian Flavor, Bergamot, Avocado, South African Leaf (Vernonia amygdalina), Repellent Vernonia (Vernonia) Anthelmintica), Vernonia cinerea, Vernonia tomentosa, Vernonia noveboracense, Vernonia praealta, Barry platycodon, leaf fairy stick, water drunk driving, sedum, Henna; rosewood, boisenberry, coniferous algae, sphagnum, dandelion, gems, eucalyptus, impatiens (phoenix, acute, stalk), horseberry, yolk, red algae ( Schmitzia japonica), and Magnolia, windproof, spinach, physalis (Deng Rügen), Japanese Magnolia (Huangpu: Chuanpu), stalked sea bream (papaya), dandelion, Charophyta (Nitellopsis obtusa), double star algae, Green barley, fir algae, green algae (Enteromorpha crinita), linear duck feather algae, wild leek, eucalyptus (bitter chrysanthemum), fine leaf tulip chrysanthemum, atractylodes (celella), spray algae, sedum three ( Sedum chinensis, Phyllostachys pubescens, Echinacea root, thin red leeks, spirulina, Laminaria religiosa, Plocamium leptophyllum, linden, peony, hops, Poplar, Strychni Semen, glaze Borage (borage lettuce), Bordeaux leaf, group algae, false bauhinia, bilberry, bitter almond, Cistanche (Cistanche, Dendrobium), Gooseberry vine, true pleat detached umbrella, Dendrobium candidum, S. cerevisiae; Wood Chrysanthemum), Rose (Rosa maikwai H. Hara), rose flower, feather leaf Tiannanxing (Tiannanxing), Wuling (Maternal velvet), germ, ephedra (ephedra), maca, eucalyptus, macadamia, maackia chinensis, Wudang magnolia, medlar Dish (sea man grass), giant algae seaweed, whole leaf giant algae, giant algae, true kumbu, Japanese health Spear, intricate red algae, marsala. degree. West Alla (Masarannzu-ba. Do. Saara), two-winged beans, massil. Ground. Sideroxylon rugosum, hibiscus (wood scorpion), hornbeam, martini, pine, pine cone, Pouteria salicifolia, pine mushroom, pine, pine kelp, schisandra, goldfish, Lunar grass, jasmine, martini (Peruvian pepper tree), antler hawthorn, bean, Fuji cherry, dodder, holly leaf, horsetail, marjoram (wild peppermint), milk thistle, marigold, algae, seaweed (Neodilsea Tenuipes), broadleaf rosewood, Japanese carrageen, black spirulina, sacred rosewood (Pterocarpus marsupium), mulberry, medlar, verbascum (palm flower), horse chestnut, vine, mango, mangosteen, Camomile (German chamomile), witch hazel, chamomile, walnut, orange, ganoderma lucidum, rosemary; crescent moon, mandarin, Bupleurum (Bupleurum), ragweed (Agave), waterwheel, kelp , fruit, water plantain, Lobelia, Lobelia (half of lotus), several algae, lycopene (Kalli), red algae (Pikea yoshizakii), villi, three stone kelp, sleeping vegetables, Clover, Clover, Viburnum, Green, Fruit, Mint, Mini笹, mimosa, small flower peach, deep mountain willow, 蘘荷, mysterious fruit, miso, green algae, spirulina, myrrh, scorpion; Brosimum acutifolium, green wood (iron tree), 蜈蚣Algae, jasmine, hibiscus, eucalyptus, eucalyptus, eucalyptus, eucalyptus, genus, genus, genus, genus, genus, genus, genus, genus, genus, genus, genus, genus, genus, genus, genus, genus, genus Purple iris, purple dragon mustard, Japanese purple beads, scutellaria, Millettia pedula, purple corn, evergreen wisteria (Kunming spatholobus), purple hawthorn, seaweed (Chnospora implexa); thorn pear, wakame, small clam, white Mangosteen, Leonurus japonicus, night primrose, Australian tea tree, lemon balm, yellow vanilla wood rhinoceros, merbau, cantaloupe, cotton (cotton); dandelion, Mongolian artemisia, Mengzong bamboo, wood unicorn, big thief, Mutong, Mufangji, Mulian, Umbrella Asparagus, Cartilage, Pepper Tree (California), Seaweed, Goto, Whole Leaf Holly, Mokka, Brown Tree, Cohen, Wood, Wood , Chinese nut galls (Galla rhois), myrrh, Motuyurena, Chondria intertexta, red leaf raspberry, rhubarb, peach, peach leaf, mung bean sprout, black cherry, from Todoxy algae, jute (jute); chrysanthemum, balsamic grass, red sandalwood (Pterocarpus indicus), purple sapphire, puzzle (puzzle), motherwort, cornflower, one-way lotus, cornflower mint, night vine, Yakaba, Yaksha Gallic, Red Algae Seaweed (Yatabella hirsuta), long distance kinky藿 (Episcus), fragrant red bayberry, octagonal golden plate, Sterculia foetida, palm-shaped medlar, branching sargasso, mistletoe (willow), willow, spicy cockroach, cartilage, serrated horsetail Algae, Diptera, Hymenoptera, Trichosanthes, Huge, Zijinniu (Zijiniu), Guanzhong, Tianmingjing (Hefeng, Tianmingjing), Xiaosangshu, American Shanglu (Commercial Land) ), mountain cherry, mountain celery, scalloped algae, Japanese yam, Lespedeza bicolor, Maoshan Elm (Hawthorn), Mountain Grape, Mountain Peach, Mountain Willow, Mountain Artemisia, Fan-shaped Top Algae, Yalenzura; Red-algae Seaweed (aconthopeltis japonica), Eucalyptus, Euglena, Red Algae Seaweed ( Euthora cristata), cockscomb, saxifrage, snow willow, Japanese citron, thin leafed wood, yucca, stalked cartilage, sage, lily, spirulina; sheep's hooves, raspberries, wine grapes, European beech, Coix seed, brown algae seaweed (Striaria attenuata), Japanese powder algae, tetracystis seaweed, hydrangea, poncho, longhorned ponytail; Leiwan (leiwan), Laifuzi, lime, rye seeds, India Snake root, mangosteen (roam), raspberry, shrub plant (Rathania) (Hedgehog plant), soft purple pliers (Arnebia comfrey), groundnut (falling peanut), pepper, trumpet algae, real lavender, lavender, Orchid, Lansium domesticum, lantana, rambutan; lamp algae, lycopene, agarwood, longan meat (longan meat), unicorn asparagus, agave, gentian, thickened algae, Nanling silk flower, green tea, apple, gentian; Dr. tea Echinops (Echinops ritro L. , Xinjiang blue thorn head); Ganoderma lucidum, Regro, lettuce, seaweed (Lessonia sp), red currant, dragon fruit, salvia miltiorrhiza (red rooted sage (Salvia miltiorrhiza)), lemon, lemon grass, forsythia, jaundice ;Loasa urens, Lamei (Plum), Wax Coconut, Poplar, Rosewood, Rosemary, Chamomile, Royal Jelly, Laurel, Sumu, Lu Root (Aloe, Reed), Rosin, Rosemary (Rosmarinus); Artemisia absinthium L. Alias: bitter, arboreal, European AI), bud, wasabi, wasabi radish, cotton, cotton (Watafujiu), medlar (Mimeng), Cyanobacteria, phylum, and mantle.

The hair growth medium composition of the present invention contains a form acceptable for the pharmaceutical, quasi-drug, and cosmetic fields, and the dosage form is advantageous for the transparent formulation of the object of the present invention. Specifically, for example, a water-based or ethanol-based solution preparation, a solubilized preparation such as a gel or an essence using the stock solution of the present invention, whether it is liquid or not, and a spray preparation mixed preparation such as a gas gel.

When preparing the desired transparent preparation using the stock solution of the present invention, it is noted that it is not necessary to carry out the rapid addition of water or alcohol, and it is necessary to carry out slowly. In addition, the temperature of the solvent at the time of addition is noted in a manner that does not destroy the stability. At any time, when the concentration of 6-benzylamine oxime dissolved in the stock solution is high, it is necessary to sufficiently consider the precipitation which is likely to occur over time at a low temperature.

[Examples]

Hereinafter, the present invention will be specifically described by way of Examples, but the scope of the present invention is not limited to the examples described below. In the examples, the "dissolution concentration of CTP" means the maximum amount of 6-benzylamine oxime which is not precipitated and is dissolved stably in a transparent state.

In the table, the following abbreviations are sometimes used.

CTP: 6-benzylamine

PEG: polyethylene glycol: PG: Propylene glycol: di-PG: dipropylene glycol

1,3-BG: 1,3-butanediol

Solubility characteristics of 6-benzylamine oxime 25 ° C

Table 1 shows the dissolved concentration of CTP with respect to a mixed solvent of water and ethanol when no additive is used. The upper part of the table indicates the mixing ratio of water and ethanol in the mixed solvent.

Effect of specific additives on the solubility characteristics of 6-benzylamine oxime 25 ° C

Table 2-1 to Table 2-14 show the dissolved concentration of 6-benzylamine oxime in a mixed solvent of water and ethanol, and further, when the additive is used.

Formulation example

The component belonging to A was uniformly stirred to prepare a prepared stock solution in which 6-benzylamine oxime was dissolved. In the stock solution, ingredients which belong to B which are uniformly dissolved by each other are gradually added, and uniformly stirred to produce a transparent and stable conditioner.

The component belonging to A was uniformly stirred to prepare a prepared stock solution in which 6-benzylamine oxime was dissolved. In the stock solution, ingredients which belong to B which are uniformly dissolved by each other are gradually added, and uniformly stirred to produce a transparent and stable conditioner.

The component belonging to A was uniformly stirred to prepare a prepared stock solution in which 6-benzylamine oxime was dissolved. In the stock solution, ingredients which belong to B which are uniformly dissolved by each other are gradually added, and uniformly stirred to produce a transparent and stable conditioner.

The component belonging to A was uniformly stirred to prepare a prepared stock solution in which 6-benzylamine oxime was dissolved. In the stock solution, ingredients which belong to B which are uniformly dissolved by each other are gradually added, and uniformly stirred to produce a transparent and stable conditioner.

The component belonging to A was uniformly stirred to prepare a prepared stock solution in which 6-benzylamine oxime was dissolved. In the stock solution, ingredients which belong to B which are uniformly dissolved by each other are gradually added, and uniformly stirred to produce a transparent and stable conditioner.

After the components belonging to A are uniformly mixed and dissolved, they are placed in a gas-filled container, and B is pressurized and filled in the container according to a usual method to produce a gas gel.

After the components belonging to A are uniformly mixed and dissolved, they are placed in a gas-filled container, and B is pressurized and filled in the container according to a usual method to produce a gas gel.

[Industrial Applicability]

According to the preparation method of the solution of the present invention, a solution in which 6-benzylamine oxime is used as an active ingredient and which is irritating and tempered by ethanol is obtained, and is particularly suitable as a composition for a hair growth agent. Further, a non-hazardous transparent hair-developing agent composition having an ethanol blending amount as low as 60% by weight or less can be provided.

Claims (10)

A method for preparing a solution, which comprises a method of dissolving 6-benzylaminopurine in a mixed solvent of water and ethanol, and using a solvent ratio of water to ethanol (weight ratio) of 65 A mixed solvent of 35 to 10:90 is prepared to prepare a solution having a concentration of 6-benzylamine oxime of 0.2 to 1.0% by weight. For example, the method for preparing a solution according to claim 1 is to use a mixed solvent of a ratio of water to ethanol (weight ratio) of 60:40 to 40:60 to prepare a concentration of 6-benzylamine oxime of 0.3 to 0.5. % by weight solution. The preparation method of the solution of the first or second aspect of the patent application is further added with an additive having a function of improving the solubility of 6-benzylamine and increasing the amount of water used. The method for preparing a solution according to the third aspect of the invention, wherein the additive is one or more compounds selected from the group consisting of polyhydric alcohols, sugars or sugar alcohols, polyphenols, betaines, and organic acid salts. . The method for preparing a solution according to the fourth aspect of the invention, wherein the additive is one or more selected from the group consisting of polyethylene glycol, glycerin, diglycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, and wood. Compounds of sugar, maltose, trehalose, sorbitol, xylitol, epigallocatechin, betaine, and sodium lactate. A transparent hair-care agent composition comprising a solution prepared by a preparation method according to any one of claims 1 to 5. The hair growth agent composition of claim 6, wherein the hair growth agent composition is a non-hazardous type hair growth agent composition. A hair-care agent composition characterized by further comprising one or more selected from the group consisting of c-AMP and a derivative thereof, and forskolin (in the composition of the hair-care agent according to claim 6 or 7) Forskolin), carropium chloride, pentaglyceride, Minoxidil compounds. A composition of a hair-care agent, which is characterized in that one or more of the composition of the hair-care agent according to any one of claims 6 to 8 are selected from the group consisting of plants, fungi, seaweeds, and microorganisms. The composition of the extract. A hair conditioner comprising: a composition of a hair growth agent according to any one of claims 6 to 9 of the patent application.