TW201325592A

TW201325592A - 用於治療癌症之磷脂醯肌醇－３激酶抑制劑

用於治療癌症之磷脂醯肌醇－３激酶抑制劑 Download PDF

Info

Publication number: TW201325592A
Authority: TW; Taiwan
Prior art keywords: nhc; group; phenyl; compound; amino
Prior art date: 2011-09-14

Application number

TW101133789A

Other languages

English (en)

Chinese (zh)

Inventor

Arthur Decillis

Joanne Lager

Gary Thomas Emmons

Soto Rodrigo Ruiz

Original Assignee

Exelixis Inc

Sanofi Sa

Priority date

2011-09-14

Filing date

2012-09-14

Publication date

2013-07-01

2012-09-14 Application filed by Exelixis Inc, Sanofi Sa filed Critical Exelixis Inc

2013-07-01 Publication of TW201325592A publication Critical patent/TW201325592A/zh

Links

206010028980 Neoplasm Diseases 0.000 title claims description 82
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201000011510 cancer Diseases 0.000 title claims description 25
239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 241
238000000034 method Methods 0.000 claims abstract description 121
HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 claims abstract description 87
229960003881 letrozole Drugs 0.000 claims abstract description 85
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206010014759 Endometrial neoplasm Diseases 0.000 claims abstract description 40
-1 quinoxaline-2-yl Chemical group 0.000 claims description 367
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208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 51
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DTXOCJGLLMAFBX-UHFFFAOYSA-N oxo-[[1-[2-[[4-(oxoazaniumylmethylidene)pyridin-1-yl]methoxy]ethoxymethyl]pyridin-4-ylidene]methyl]azanium;dichloride Chemical compound [Cl-].[Cl-].C1=CC(=C[NH+]=O)C=CN1COCCOCN1C=CC(=C[NH+]=O)C=C1 DTXOCJGLLMAFBX-UHFFFAOYSA-N 0.000 claims description 30
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OSDBJMYIUDLIRI-UHFFFAOYSA-N oxo-[[1-[[4-[[4-(oxoazaniumylmethylidene)pyridin-1-yl]methoxy]cyclohexyl]oxymethyl]pyridin-4-ylidene]methyl]azanium;dichloride Chemical compound [Cl-].[Cl-].C1=CC(=C[NH+]=O)C=CN1COC1CCC(OCN2C=CC(=C[NH+]=O)C=C2)CC1 OSDBJMYIUDLIRI-UHFFFAOYSA-N 0.000 claims description 25
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