TW201102379A - 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of CCR2 - Google Patents

4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of CCR2 Download PDF

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Publication number
TW201102379A
TW201102379A TW099111900A TW99111900A TW201102379A TW 201102379 A TW201102379 A TW 201102379A TW 099111900 A TW099111900 A TW 099111900A TW 99111900 A TW99111900 A TW 99111900A TW 201102379 A TW201102379 A TW 201102379A
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group
alkyl
compound
disease
formula
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TW099111900A
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Chinese (zh)
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xu-qing Zhang
Heather Rae Hufnagel
Zhihua Sui
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Janssen Pharmaceutica Nv
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
TW099111900A 2009-04-17 2010-04-16 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of CCR2 TW201102379A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17022509P 2009-04-17 2009-04-17

Publications (1)

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TW201102379A true TW201102379A (en) 2011-01-16

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ID=42169493

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TW099111900A TW201102379A (en) 2009-04-17 2010-04-16 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of CCR2

Country Status (14)

Country Link
US (1) US8324186B2 (OSRAM)
EP (1) EP2419418B1 (OSRAM)
JP (1) JP5685581B2 (OSRAM)
KR (1) KR20120006051A (OSRAM)
CN (1) CN102459226B (OSRAM)
AR (1) AR076329A1 (OSRAM)
AU (1) AU2010236336B2 (OSRAM)
BR (1) BRPI1016205A2 (OSRAM)
CA (1) CA2758929A1 (OSRAM)
ES (1) ES2541607T3 (OSRAM)
MX (1) MX2011010963A (OSRAM)
NZ (1) NZ595433A (OSRAM)
TW (1) TW201102379A (OSRAM)
WO (1) WO2010121036A1 (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2555004T3 (es) 2008-12-10 2015-12-28 Janssen Pharmaceutica N.V. Antagonistas 4-azetidinil-1-heteroaril ciclohexanol de CCR2
CN102459225B (zh) * 2009-04-16 2014-08-20 詹森药业有限公司 Ccr2的4-氮杂环丁烷基-1-杂芳基-环己烷拮抗剂
EP2419419B1 (en) * 2009-04-17 2014-12-03 Janssen Pharmaceutica NV 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2
CN102459226B (zh) 2009-04-17 2014-09-17 詹森药业有限公司 Ccr2的4-氮杂环丁烷基-1-杂原子连接的-环己烷拮抗剂
TW201211027A (en) * 2010-06-09 2012-03-16 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of CCR2
CA2801934A1 (en) 2010-06-17 2011-12-22 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of ccr2
EP2771484A1 (en) 2011-10-28 2014-09-03 Galderma Research & Development New leukocyte infiltrate markers for rosacea and uses thereof
US10150728B2 (en) 2013-10-17 2018-12-11 Shionogi & Co., Ltd. Alkylene derivatives
US20230174633A1 (en) * 2020-03-30 2023-06-08 Memorial Sloan Kettering Cancer Center Methods and compositions for modulating lipid storage in adipose tissue

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US6037354A (en) 1997-06-18 2000-03-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
CA2293408A1 (en) 1997-06-18 1998-12-23 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
WO2001010439A1 (en) 1999-08-04 2001-02-15 Teijin Limited Cyclic amine ccr3 antagonists
WO2001034598A1 (en) 1999-11-08 2001-05-17 Wyeth [(indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders
US6245799B1 (en) 1999-11-08 2001-06-12 American Home Products Corp [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders
JP2004523534A (ja) 2000-12-20 2004-08-05 ブリストル−マイヤーズ　スクイブ　カンパニー ケモカイン受容体活性調節剤としての環状誘導体
BRPI0316732B8 (pt) * 2002-11-27 2021-05-25 Incyte Corp composto derivado de 3-aminopirrolidina e sua composição farmacêutica
UA87449C2 (ru) * 2002-11-27 2009-07-27 Инсайт Корпорейшн Производные 3-аминопиролидина как модуляторы рецепторов хемокина
GB0417801D0 (en) * 2004-08-10 2004-09-15 Novartis Ag Organic compounds
KR20070063562A (ko) 2004-09-28 2007-06-19 얀센 파마슈티카 엔.브이. 치환 디피페리딘 ｃｃｒ２ 길항제
UY29219A1 (es) * 2004-11-22 2006-04-28 Incyte Corp Sales de la n-(2- (((3r)-1-(trans-4-hidroxi-4-(6-metoxipiridin-3-il)-cilohexil) pirrolidin-3-il)amino)-2-oxoetil)-3- (trifluorometil) benzamida
GB0513747D0 (en) 2005-07-06 2005-08-10 Merck Sharp & Dohme Therapeutic compounds
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
WO2007130712A1 (en) 2006-01-31 2007-11-15 Janssen Pharmaceutica, Nv Substituted dipiperidine as ccr2 antagonists for the treatment of inflammatory diseases
AU2008335135A1 (en) * 2007-12-11 2009-06-18 Cytopathfinder, Inc. Carboxamide compounds and their use as chemokine receptor agonists
ES2555004T3 (es) 2008-12-10 2015-12-28 Janssen Pharmaceutica N.V. Antagonistas 4-azetidinil-1-heteroaril ciclohexanol de CCR2
CN102459225B (zh) 2009-04-16 2014-08-20 詹森药业有限公司 Ccr2的4-氮杂环丁烷基-1-杂芳基-环己烷拮抗剂
EP2419419B1 (en) 2009-04-17 2014-12-03 Janssen Pharmaceutica NV 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2
CN102459226B (zh) 2009-04-17 2014-09-17 詹森药业有限公司 Ccr2的4-氮杂环丁烷基-1-杂原子连接的-环己烷拮抗剂

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Publication number Publication date
WO2010121036A1 (en) 2010-10-21
EP2419418B1 (en) 2015-04-15
CN102459226A (zh) 2012-05-16
EP2419418A1 (en) 2012-02-22
CA2758929A1 (en) 2010-10-21
MX2011010963A (es) 2011-11-02
JP2012524110A (ja) 2012-10-11
AU2010236336A1 (en) 2011-11-03
JP5685581B2 (ja) 2015-03-18
CN102459226B (zh) 2014-09-17
BRPI1016205A2 (pt) 2016-04-19
AU2010236336B2 (en) 2015-01-15
NZ595433A (en) 2013-12-20
US20100267668A1 (en) 2010-10-21
KR20120006051A (ko) 2012-01-17
US8324186B2 (en) 2012-12-04
AR076329A1 (es) 2011-06-01
ES2541607T3 (es) 2015-07-22

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