TW200733965A - Salts, prodrugs and formulations of 1-[5-(4-amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxy-phenyl]-3-(2,4-dichloro-phenyl)-urea - Google Patents
Salts, prodrugs and formulations of 1-[5-(4-amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxy-phenyl]-3-(2,4-dichloro-phenyl)-ureaInfo
- Publication number
- TW200733965A TW200733965A TW095145947A TW95145947A TW200733965A TW 200733965 A TW200733965 A TW 200733965A TW 095145947 A TW095145947 A TW 095145947A TW 95145947 A TW95145947 A TW 95145947A TW 200733965 A TW200733965 A TW 200733965A
- Authority
- TW
- Taiwan
- Prior art keywords
- phenyl
- pyrrolo
- prodrugs
- dichloro
- pyrimidine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74907005P | 2005-12-09 | 2005-12-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200733965A true TW200733965A (en) | 2007-09-16 |
Family
ID=38123252
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW095145947A TW200733965A (en) | 2005-12-09 | 2006-12-08 | Salts, prodrugs and formulations of 1-[5-(4-amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxy-phenyl]-3-(2,4-dichloro-phenyl)-urea |
Country Status (8)
Country | Link |
---|---|
AR (1) | AR058293A1 (es) |
DO (1) | DOP2006000271A (es) |
GT (1) | GT200600496A (es) |
NL (1) | NL2000337A1 (es) |
PE (1) | PE20071037A1 (es) |
TW (1) | TW200733965A (es) |
UY (1) | UY29991A1 (es) |
WO (1) | WO2007066189A2 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090143423A1 (en) * | 2007-10-19 | 2009-06-04 | Abbott Gmbh & Co. Kg | Solid dispersion product containing n-aryl urea-based compound |
BRPI0818340A2 (pt) * | 2007-10-19 | 2015-04-22 | Abbott Gmbh & Co Kg | Produto de dispersão sólida de fármacos baseados em n-aril uréia |
DK2358720T3 (en) * | 2008-10-16 | 2016-06-06 | Univ California | Heteroarylkinaseinhibitorer fused-ring |
CN102892768A (zh) | 2009-12-30 | 2013-01-23 | 艾科尔公司 | 被取代的吡咯并氨基嘧啶化合物 |
EP2585048B1 (en) * | 2010-06-23 | 2018-04-11 | CymaBay Therapeutics, Inc. | Compositions of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
CA2846496C (en) | 2011-09-02 | 2020-07-14 | The Regents Of The University Of California | Substituted pyrazolo[3,4-d]pyrimidines and uses thereof |
US20140004192A1 (en) * | 2012-04-13 | 2014-01-02 | Ziopharm Oncology, Inc. | Pharmaceutical formulations of indibulin and uses thereof |
CA2876689C (en) | 2012-06-13 | 2022-04-26 | Incyte Corporation | Substituted tricyclic compounds as fgfr inhibitors |
US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
MX2015003874A (es) | 2012-09-26 | 2015-12-16 | Univ California | Modulacion de ire1. |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
HUE036571T2 (hu) | 2013-04-19 | 2018-07-30 | Incyte Holdings Corp | Biciklusos heterociklusok mint FGFR inhibitorok |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
EP3259269B9 (en) | 2015-02-20 | 2020-03-04 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
CN107722012B (zh) * | 2016-08-11 | 2020-05-29 | 斯福瑞(南通)制药有限公司 | 制备4-氯-7H-吡咯并[2,3-d]嘧啶的方法 |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
CR20200590A (es) | 2018-05-04 | 2021-04-26 | Incyte Corp | Formas sólidas de un inhibidor de fgfr y procesos para prepararlas |
US11174257B2 (en) | 2018-05-04 | 2021-11-16 | Incyte Corporation | Salts of an FGFR inhibitor |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
KR20220100879A (ko) | 2019-10-14 | 2022-07-18 | 인사이트 코포레이션 | Fgfr 저해제로서의 이환식 헤테로사이클 |
WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
CA3162010A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Derivatives of an fgfr inhibitor |
WO2021113479A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
AR126102A1 (es) | 2021-06-09 | 2023-09-13 | Incyte Corp | Heterociclos tricíclicos como inhibidores de fgfr |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69837903T2 (de) * | 1997-08-11 | 2008-02-14 | Pfizer Products Inc., Groton | Feste pharmazeutische Dispersionen mit erhöhter Bioverfügbarkeit |
UA80171C2 (en) * | 2002-12-19 | 2007-08-27 | Pfizer Prod Inc | Pyrrolopyrimidine derivatives |
-
2006
- 2006-11-24 WO PCT/IB2006/003416 patent/WO2007066189A2/en active Application Filing
- 2006-11-27 NL NL2000337A patent/NL2000337A1/nl active Search and Examination
- 2006-12-05 DO DO2006000271A patent/DOP2006000271A/es unknown
- 2006-12-06 PE PE2006001565A patent/PE20071037A1/es not_active Application Discontinuation
- 2006-12-06 UY UY29991A patent/UY29991A1/es not_active Application Discontinuation
- 2006-12-07 AR ARP060105422A patent/AR058293A1/es unknown
- 2006-12-07 GT GT200600496A patent/GT200600496A/es unknown
- 2006-12-08 TW TW095145947A patent/TW200733965A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
GT200600496A (es) | 2007-07-17 |
AR058293A1 (es) | 2008-01-30 |
WO2007066189A3 (en) | 2008-08-14 |
DOP2006000271A (es) | 2007-08-15 |
UY29991A1 (es) | 2007-07-31 |
NL2000337A1 (nl) | 2007-06-12 |
WO2007066189A2 (en) | 2007-06-14 |
PE20071037A1 (es) | 2007-11-19 |
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