TW200733956A - Toluidine blue O drug substance and composition comprising the same for in vivo staining and chemotherapeutic treatment of dysplastic tissues - Google Patents

Toluidine blue O drug substance and composition comprising the same for in vivo staining and chemotherapeutic treatment of dysplastic tissues

Info

Publication number
TW200733956A
TW200733956A TW096101848A TW96101848A TW200733956A TW 200733956 A TW200733956 A TW 200733956A TW 096101848 A TW096101848 A TW 096101848A TW 96101848 A TW96101848 A TW 96101848A TW 200733956 A TW200733956 A TW 200733956A
Authority
TW
Taiwan
Prior art keywords
composition
toluidine blue
same
chemotherapeutic treatment
drug substance
Prior art date
Application number
TW096101848A
Other languages
English (en)
Chinese (zh)
Inventor
Karl Okolotowicz
Original Assignee
Zila Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zila Biotechnology Inc filed Critical Zila Biotechnology Inc
Publication of TW200733956A publication Critical patent/TW200733956A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B21/00—Thiazine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Oncology (AREA)
  • Optics & Photonics (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
TW096101848A 2002-06-04 2002-07-22 Toluidine blue O drug substance and composition comprising the same for in vivo staining and chemotherapeutic treatment of dysplastic tissues TW200733956A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2002/017720 WO2003103569A2 (en) 2002-06-04 2002-06-04 Toluidine blue o drug substance and use thereof for in vivo staining and chemotherapeutic treatment of dysplastic tissues

Publications (1)

Publication Number Publication Date
TW200733956A true TW200733956A (en) 2007-09-16

Family

ID=29731309

Family Applications (1)

Application Number Title Priority Date Filing Date
TW096101848A TW200733956A (en) 2002-06-04 2002-07-22 Toluidine blue O drug substance and composition comprising the same for in vivo staining and chemotherapeutic treatment of dysplastic tissues

Country Status (9)

Country Link
EP (1) EP1534346A4 (ja)
JP (1) JP2005535605A (ja)
CN (1) CN1302815C (ja)
AU (1) AU2002312319A1 (ja)
BR (1) BRPI0215775A2 (ja)
IL (1) IL165516A0 (ja)
MX (1) MXPA04012031A (ja)
TW (1) TW200733956A (ja)
WO (1) WO2003103569A2 (ja)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH071257B2 (ja) * 1985-09-09 1995-01-11 エスエス製薬株式会社 混合ビタミン剤中の水溶性ビタミン類の同時定量法
JPS6410171A (en) * 1987-07-03 1989-01-13 Shimadzu Corp Analysis of amino acid
JP3549880B2 (ja) * 1991-10-31 2004-08-04 ジラ・インコーポレーテッド 生物学的染料組成物、調製方法および上皮癌描写への使用方法
US6194573B1 (en) * 1997-11-13 2001-02-27 Zila, Inc. Process for manufacture of in vivo stain composition
US6086852A (en) * 1997-11-13 2000-07-11 Zila, Inc. In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue
AU5357498A (en) * 1997-11-13 1999-06-07 Zila, Inc. (in vivo) stain composition, process of manufacture, and methods of use to identify dysplastic tissue
AU2000237154A1 (en) * 2000-02-28 2001-09-12 Zila, Inc. Method for detecting and killing epithelial cancer cells
JP4424838B2 (ja) * 2000-08-31 2010-03-03 株式会社トクヤマ 四級アンモニウム塩の分析方法

Also Published As

Publication number Publication date
CN1627961A (zh) 2005-06-15
IL165516A0 (en) 2006-01-15
EP1534346A2 (en) 2005-06-01
WO2003103569A2 (en) 2003-12-18
BRPI0215775A2 (pt) 2016-07-05
EP1534346A4 (en) 2007-07-25
MXPA04012031A (es) 2005-03-07
CN1302815C (zh) 2007-03-07
WO2003103569A3 (en) 2004-05-21
JP2005535605A (ja) 2005-11-24
AU2002312319A1 (en) 2003-12-22

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