TW200732374A - High efficiency method of preparing polyalkylene oxide carboxylic acids - Google Patents

High efficiency method of preparing polyalkylene oxide carboxylic acids

Info

Publication number
TW200732374A
TW200732374A TW095148888A TW95148888A TW200732374A TW 200732374 A TW200732374 A TW 200732374A TW 095148888 A TW095148888 A TW 095148888A TW 95148888 A TW95148888 A TW 95148888A TW 200732374 A TW200732374 A TW 200732374A
Authority
TW
Taiwan
Prior art keywords
polyalkylene oxide
high efficiency
carboxylic acids
efficiency method
oxide carboxylic
Prior art date
Application number
TW095148888A
Other languages
English (en)
Chinese (zh)
Inventor
Hong Zhao
Anthony J Martinez
Original Assignee
Enzon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzon Pharmaceuticals Inc filed Critical Enzon Pharmaceuticals Inc
Publication of TW200732374A publication Critical patent/TW200732374A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/337—Polymers modified by chemical after-treatment with organic compounds containing other elements
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW095148888A 2006-01-10 2006-12-26 High efficiency method of preparing polyalkylene oxide carboxylic acids TW200732374A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/328,662 US7989554B2 (en) 2006-01-10 2006-01-10 Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid

Publications (1)

Publication Number Publication Date
TW200732374A true TW200732374A (en) 2007-09-01

Family

ID=38256821

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095148888A TW200732374A (en) 2006-01-10 2006-12-26 High efficiency method of preparing polyalkylene oxide carboxylic acids

Country Status (11)

Country Link
US (1) US7989554B2 (cg-RX-API-DMAC10.html)
EP (1) EP1976896B1 (cg-RX-API-DMAC10.html)
JP (1) JP5199125B2 (cg-RX-API-DMAC10.html)
KR (1) KR20080083064A (cg-RX-API-DMAC10.html)
CN (1) CN101356203A (cg-RX-API-DMAC10.html)
AT (1) ATE512994T1 (cg-RX-API-DMAC10.html)
AU (1) AU2006335041A1 (cg-RX-API-DMAC10.html)
CA (1) CA2636280A1 (cg-RX-API-DMAC10.html)
IL (1) IL192409A0 (cg-RX-API-DMAC10.html)
TW (1) TW200732374A (cg-RX-API-DMAC10.html)
WO (1) WO2007081596A2 (cg-RX-API-DMAC10.html)

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US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
US20090156629A1 (en) * 2006-06-09 2009-06-18 Enzon Pharmaceuticals, Inc. Indenoisoquinoline-releasable polymer conjugates
MX2009008549A (es) * 2007-02-09 2009-08-18 Enzon Pharmaceuticals Inc Tratamiento de canceres resistentes o refractarios con conjugados polimericos de brazos multiples de 7-etil-10-hidroxicamptotecina.
PL2147122T3 (pl) * 2007-04-20 2015-05-29 Leadiant Biosciences Ltd Enzymatyczna terapia przeciwnowotworowa
HUE027603T2 (en) * 2007-04-20 2016-10-28 Sigma-Tau Rare Disease Ltd Stable, recombinant adenosine deaminase
JP2010533202A (ja) * 2007-07-11 2010-10-21 エンゾン ファーマシューティカルズ，インコーポレーテッド 多置換芳香族部分を含むポリマー性薬剤送達システム
TW201010732A (en) * 2008-08-29 2010-03-16 Enzon Pharmaceuticals Inc Method of treating RAS associated cancer
US20100098654A1 (en) * 2008-10-21 2010-04-22 Fabio Pastorino Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
AU2015332533B2 (en) 2014-10-14 2018-08-30 Halozyme, Inc. Compositions of adenosine deaminase-2 (ADA2), variants thereof and methods of using same
WO2023061827A1 (en) * 2021-10-13 2023-04-20 Basf Se Compositions comprising polymers, polymers, and their use

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Also Published As

Publication number Publication date
JP2009523191A (ja) 2009-06-18
EP1976896B1 (en) 2011-06-15
US20070173615A1 (en) 2007-07-26
JP5199125B2 (ja) 2013-05-15
IL192409A0 (en) 2008-12-29
EP1976896A2 (en) 2008-10-08
WO2007081596A2 (en) 2007-07-19
EP1976896A4 (en) 2009-09-02
WO2007081596A3 (en) 2007-12-13
ATE512994T1 (de) 2011-07-15
AU2006335041A1 (en) 2007-07-19
CN101356203A (zh) 2009-01-28
KR20080083064A (ko) 2008-09-12
US7989554B2 (en) 2011-08-02
CA2636280A1 (en) 2007-07-19

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