TW200716517A - Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles - Google Patents

Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles

Info

Publication number
TW200716517A
TW200716517A TW095115054A TW95115054A TW200716517A TW 200716517 A TW200716517 A TW 200716517A TW 095115054 A TW095115054 A TW 095115054A TW 95115054 A TW95115054 A TW 95115054A TW 200716517 A TW200716517 A TW 200716517A
Authority
TW
Taiwan
Prior art keywords
oxindoles
preparing
compounds
thio
disubstituted
Prior art date
Application number
TW095115054A
Other languages
English (en)
Inventor
Bogdan Kazimierz Wilk
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of TW200716517A publication Critical patent/TW200716517A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/35—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW095115054A 2005-04-29 2006-04-27 Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles TW200716517A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67638105P 2005-04-29 2005-04-29

Publications (1)

Publication Number Publication Date
TW200716517A true TW200716517A (en) 2007-05-01

Family

ID=36937284

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095115054A TW200716517A (en) 2005-04-29 2006-04-27 Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles

Country Status (12)

Country Link
US (1) US7595338B2 (zh)
EP (1) EP1877377A2 (zh)
JP (1) JP2008540337A (zh)
CN (1) CN101166722A (zh)
AU (1) AU2006242542A1 (zh)
BR (1) BRPI0608221A2 (zh)
CA (1) CA2603818A1 (zh)
GT (1) GT200600179A (zh)
MX (1) MX2007013450A (zh)
PE (1) PE20061370A1 (zh)
TW (1) TW200716517A (zh)
WO (1) WO2006118955A2 (zh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR056968A1 (es) * 2005-04-11 2007-11-07 Xenon Pharmaceuticals Inc Compuestos espiro-oxindol y composiciones farmacéuticas
MY145694A (en) * 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
PE20070220A1 (es) * 2005-07-29 2007-03-19 Wyeth Corp Proceso para la sintesis de moduladores del receptor de progesterona
JP2010506853A (ja) * 2006-10-12 2010-03-04 ゼノン・ファーマシューティカルズ・インコーポレイテッド 疼痛などのナトリウムチャネル媒介性の疾患の処置のための、スピロ（［３，２−フロ］ピリジン−３，３’−インドール）−２’（１’ｈ）−オン誘導体および関連化合物
MX2009003874A (es) * 2006-10-12 2009-04-22 Xenon Pharmaceuticals Inc Derivados de espiro-oxindol triciclicos y sus usos como agentes terapeuticos.
US8466188B2 (en) * 2006-10-12 2013-06-18 Xenon Pharmaceuticals Inc. Use of spiro-oxindole compounds as therapeutic agents
US20080312306A1 (en) * 2007-06-15 2008-12-18 Wyeth Polymorphs, solvates, and hydrate of 5-(4'-fluoro-2'-oxo-1',2'-dihydrospiro[cyclopropane-1,3'-indol]-5'-yl)-1-methyl-1h-pyrrole-2-carbonitrile
US20080319204A1 (en) * 2007-06-25 2008-12-25 Wyeth Process for the synthesis of progesterone receptor modulators
EP2234491A4 (en) * 2007-12-20 2010-12-22 Teva Womens Health Inc DOSAGE SCHEMES AND PHARMACEUTICAL COMPOSITIONS AND PACKAGING FOR EMERGENCY CONTRACEPTION
NZ592275A (en) * 2008-10-17 2013-04-26 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their use as therapeutic agents
CA2741024A1 (en) * 2008-10-17 2010-04-22 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
EA201101619A1 (ru) 2009-05-15 2012-05-30 Новартис Аг Производные 5-пиридин-3-ил-1,3-дигидроиндол-2-она и их применение в качестве модуляторов альдостеронсинтазы и/или cyp11b1
EA201101621A1 (ru) 2009-05-15 2012-05-30 Новартис Аг Производные бензоксазолона в качестве ингибиторов альдостеронсинтазы
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
BR112012008993A2 (pt) * 2009-10-14 2015-09-22 Xenon Pharmaceuticals Inc métodos sintéticos para compostos espiro-oxindole
WO2011047173A2 (en) * 2009-10-14 2011-04-21 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
NZ601667A (en) 2010-02-26 2014-10-31 Xenon Pharmaceuticals Inc Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
RU2013114350A (ru) * 2010-09-16 2014-10-27 Ф.Хоффманн-Ля Рош Аг Новый способ
US8933248B2 (en) 2012-06-21 2015-01-13 Council Of Scientific & Industrial Research 3-substituted-3-hydroxy oxindole derivatives and process for preparation thereof
CN103936649B (zh) * 2014-03-29 2016-05-04 贵州大学 3-(2-丙烯酸酯)-3-硫代氧化吲哚化合物及其制备方法
CN107428678B (zh) 2015-01-22 2021-01-01 赛诺菲-安万特德国有限公司 用于制备2-[4-(环丙烷羰基)苯基]-2-甲基-丙腈的方法
WO2016127068A1 (en) 2015-02-05 2016-08-11 Teva Pharmaceuticals International Gmbh Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound
RU2601749C1 (ru) * 2015-09-08 2016-11-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный технический университет" (ВолгГТУ) Способ получения 4'-фторспиро[циклопропан-1,3'-индол]-2'(1'н)-она
WO2019099760A1 (en) * 2017-11-16 2019-05-23 University Of Houston System Aryl-substituted acetamide and pyrrolidin-2-one derivatives and their use for the treatment of seizures

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732278A (en) 1970-12-02 1973-05-08 Us Navy Ethyl(4-trifluoromethyl-2,3,5,6-tetra-fluorophenyl)cyanoacetate
DE2965291D1 (en) 1978-10-27 1983-06-01 Ici Plc Halogenated esters of cyclopropane acids, their preparation, compositions and use as pesticides
DE3015587A1 (de) 1980-04-23 1981-10-29 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von acylcyaniden
FR2482955A1 (fr) 1980-05-23 1981-11-27 Roussel Uclaf Nouveaux derives de l'acide cyclopropane carboxylique, leur procede de preparation et leur application a la lutte contre les parasites
US4783547A (en) 1986-04-18 1988-11-08 Ici Americas Inc. Polyfluoroaromatic nitriles
US4866185A (en) 1986-04-18 1989-09-12 Ici Americas Inc. Difunctional polyfluoroaromatic derivatives and a process of preparing the same
US4965394A (en) 1986-04-18 1990-10-23 Ici Americas Inc. Difunctional polyfluoroaromatic derivatives and a process of preparing the same
DE3630732A1 (de) 1986-09-10 1988-03-17 Bayer Ag 2-cyano-2-alkoximino-acetamide
US5288732A (en) 1986-09-10 1994-02-22 Bayer Aktiengesellschaft 2-cyano-2-alkoximino-acetamides
US5231109A (en) 1986-09-10 1993-07-27 Bayer Aktiengesellschaft 2-cyano-2-alkoximino-acetamides
FR2610624B1 (fr) 1987-02-06 1989-06-09 Roussel Uclaf Nouveaux esters d'acides cyclopropanecarboxyliques apparentes a l'acide pyrethrique, leur procede de preparation et leur application a la lutte contre les parasites
DE3735821A1 (de) 1987-10-22 1989-05-03 Peroxid Chemie Gmbh Verfahren zur polymerisation von ethylen unter erhoehtem druck
DE3909213A1 (de) 1989-03-21 1990-10-11 Bayer Ag Halogenbenzolderivate
GB9125791D0 (en) 1991-12-04 1992-02-05 Schering Agrochemicals Ltd Herbicides
AU5118893A (en) 1992-10-13 1994-05-09 Nippon Soda Co., Ltd. Oxazole and thiazole derivatives
US5545769A (en) 1994-09-29 1996-08-13 E. I. Du Pont De Nemours And Company Process for the manufacture of selected halogenated hydrocarbons containing fluorine and hydrogen and compositions provided therein
DK0805148T3 (da) 1994-12-19 2005-01-24 Nippon Soda Co Benzamidoximderivat, fremgangsmåde til fremstilling heraf og anvendelse af baktericid i landbrug og gartneri
FR2734564B1 (fr) 1995-05-24 1997-07-04 Rhone Poulenc Chimie Procede d'hydroxyalkylation d'un ether aromatique
KR100517576B1 (ko) 1995-08-01 2005-12-21 이.아이,듀우판드네모아앤드캄파니 할로카본의제조방법,선택된화합물및hf함유공비조성물
DE19529089A1 (de) 1995-08-08 1997-02-13 Bayer Ag Mercapto-triazolyl-nitrile
FR2739098B1 (fr) 1995-09-25 1997-11-28 Rhone Poulenc Chimie Procede d'acylation d'un compose aromatique
FR2745285B1 (fr) 1996-02-28 1998-04-10 Rhone Poulenc Chimie Nouveau catalyseur de c-alkylation d'un compose aromatique et son utilisation
FR2745287B1 (fr) 1996-02-28 1998-04-10 Rhone Poulenc Chimie Nouvelle composition catalytique et sa mise en oeuvre dans un procede d'acylation d'un compose aromatique
US6005118A (en) 1996-05-03 1999-12-21 Caron; Stephane Methods of preparing 4-cyano-4 (substituted indazole) cyclohexane-carboxylic acids useful as PDE4 inhibitors
US6040487A (en) 1996-07-31 2000-03-21 E. I. Du Pont De Nemours And Company Process for the manufacture of halocarbons
IT1284926B1 (it) 1996-10-08 1998-05-28 Isagro Spa Composizioni fungicide e loro utilizzo per il controllo di funghi fitopatogeni
DE19835943A1 (de) 1998-08-08 2000-02-10 Bayer Ag Substituierte Triazinone
US6303782B1 (en) 1999-04-20 2001-10-16 Pfizer Inc Process for preparing benzylnitriles
DE10038639A1 (de) 2000-07-28 2002-02-21 Schering Ag Nichtsteroidale Entzündungshemmer
DE60107603T2 (de) 2000-09-19 2005-10-06 Sumitomo Chemical Co. Ltd. Pyrimidinverbindungen und deren verwendung als pestizide
US7276526B2 (en) 2001-07-13 2007-10-02 Bristol-Myers Squibb Pharma Company Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands
US6482983B1 (en) 2001-07-31 2002-11-19 Millennium Specialty Chemicals Process for obtaining N-monosubstituted amides
AR039208A1 (es) 2002-04-03 2005-02-09 Syngenta Participations Ag Compuestos de fenil- y piridilalquinos, composicion herbicida que los contiene, procedimiento de preparacion de aquellos y procedimiento para combatir el crecimiento de plantas indeseadas
US6977131B2 (en) 2002-05-30 2005-12-20 Kodak Polychrome Graphics Llc Selected polymeric sulfonate acid generators and their use in processes for imaging radiation-sensitive elements
US7517899B2 (en) * 2004-03-30 2009-04-14 Wyeth Phenylaminopropanol derivatives and methods of their use
TW200602293A (en) 2004-04-05 2006-01-16 Merck & Co Inc Process for the preparation of enantiomerically enriched beta amino acid derivatives

Also Published As

Publication number Publication date
CN101166722A (zh) 2008-04-23
BRPI0608221A2 (pt) 2009-11-24
WO2006118955A2 (en) 2006-11-09
GT200600179A (es) 2006-11-22
US20060247441A1 (en) 2006-11-02
AU2006242542A1 (en) 2006-11-09
JP2008540337A (ja) 2008-11-20
MX2007013450A (es) 2008-01-21
EP1877377A2 (en) 2008-01-16
US7595338B2 (en) 2009-09-29
PE20061370A1 (es) 2007-01-08
CA2603818A1 (en) 2006-11-09
WO2006118955A3 (en) 2007-01-11

Similar Documents

Publication Publication Date Title
TW200716517A (en) Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles
ZA200802007B (en) 1,3-disubstituted indole derivatives for use as PPAR modulators
ZA200800512B (en) Substituted tetrahydro-1H-pyrido[4,3,B]indoles as serotonin receptor agonists and antagonists
EP1863810A4 (en) NEW TETRAHYDRO-1H-PYRIDO [4,3-B] INDOLDERIVATE AS CB1 'RECEPTOR LIGANDS
MY143367A (en) Substituted indole derivatives for pharmaceutical compositions for treating respiratory diseases
MX2012003539A (es) Derivados de indol como moduladores de los canales de calcio activados por la liberacion de calcio (crac).
WO2011008312A3 (en) Indole and indoline derivatives and methods of use thereof
SI1888541T1 (sl) Benzo(d)izoksazol-3-il-aminske spojine in njihova uporaba kot ligandi vaniloidnega receptorja
HK1078075A1 (en) Process for preparing indolinone derivatives
ATE502921T1 (de) Substituierte indole
IL199187A0 (en) Indole derivatives as s1p1 receptor agonists
MY152992A (en) Octahydro-pyrrolo[3,4-b]pyrrole derivatives
NZ552137A (en) New 4-benzylidene-piperidin derivatives
IL191763A0 (en) Pyrrolo [2,3-b]pyridine derivatives as h3 receptor modulators
WO2009071689A3 (de) 5-halogen-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen
EA201070804A1 (ru) (аза)индольное производное, замещенное по положению 5, содержащая его фармацевтическая композиция, промежуточные соединения и способ их получения
PL1831191T3 (pl) Pochodne chromanu i ich zastosowanie jako ligandów receptorów 5-HT
IL183965A0 (en) Novel process for the preparation of substituted indoles
WO2011084434A3 (en) Aza-ring fused indole and indoline derivatives
HUP0401523A3 (en) Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them
WO2005033112A3 (en) Substituted indole derivatives
WO2009056707A3 (fr) Dérivés de l'ind0l-2-0ne disubstitues en 3, leur preparation et leur application en thérapeutique
IN2012DN03844A (zh)
SI1893589T1 (sl) Substituirani N-benzo(d)izoksazol-3-il-aminski derivati kot inhibitorji mGluR5, serotonin-(5-HT) in noradrenalinskih receptorjev in njihova uporaba za pripravo zdravil
EP2121601B8 (fr) Nouveaux derives indoliques, leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens