TW200716102A - Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors - Google Patents

Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors

Info

Publication number
TW200716102A
TW200716102A TW095118365A TW95118365A TW200716102A TW 200716102 A TW200716102 A TW 200716102A TW 095118365 A TW095118365 A TW 095118365A TW 95118365 A TW95118365 A TW 95118365A TW 200716102 A TW200716102 A TW 200716102A
Authority
TW
Taiwan
Prior art keywords
class
penems
alkylidene
bicyclic
lactam antibiotics
Prior art date
Application number
TW095118365A
Other languages
English (en)
Inventor
Tarek Suhayl Mansour
Aranapakam Mudumbai Venkatesan
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of TW200716102A publication Critical patent/TW200716102A/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW095118365A 2005-06-01 2006-05-24 Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors TW200716102A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68634705P 2005-06-01 2005-06-01

Publications (1)

Publication Number Publication Date
TW200716102A true TW200716102A (en) 2007-05-01

Family

ID=36992759

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095118365A TW200716102A (en) 2005-06-01 2006-05-24 Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors

Country Status (17)

Country Link
US (1) US20060276445A1 (zh)
EP (1) EP1885357A1 (zh)
JP (1) JP2008545747A (zh)
KR (1) KR20080016676A (zh)
CN (1) CN101217955A (zh)
AR (1) AR058795A1 (zh)
AU (1) AU2006252604A1 (zh)
BR (1) BRPI0610957A2 (zh)
CA (1) CA2609428A1 (zh)
GT (1) GT200600236A (zh)
IL (1) IL187694A0 (zh)
MX (1) MX2007015172A (zh)
NO (1) NO20076076L (zh)
PE (1) PE20070080A1 (zh)
RU (1) RU2007145594A (zh)
TW (1) TW200716102A (zh)
WO (1) WO2006130588A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
US20090018332A1 (en) * 2007-06-28 2009-01-15 Wyeth Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors
EP2266581B1 (en) * 2008-03-18 2015-09-23 Dikovskiy, Aleksander Vladimirovich Pharmaceutical composition of antibiotics and prebiotics for preventing and treating dysbiosis during antibacterial therapy
CN102020659B (zh) * 2009-09-11 2013-07-03 中国中化股份有限公司 一种甲缩醛青霉烯中间体的制备方法
JP6263606B2 (ja) 2013-05-02 2018-01-17 ファイザー・インク Ｐｄｅ１０阻害剤としてのイミダゾ−トリアジン誘導体
CN103435617B (zh) * 2013-08-22 2016-04-27 南京华安药业有限公司 一种6,7-二氢-5H-吡咯并[1,2-a]咪唑-2-甲醛的合成方法
KR102148587B1 (ko) 2016-02-23 2020-08-26 화이자 인코포레이티드 6,7-디히드로-5H-피라졸로[5,1-b][1,3]옥사진-2-카르복스아미드 화합물
BR112019003158B1 (pt) 2016-08-15 2022-10-25 Bayer Cropscience Aktiengesellschaft Derivados de heterociclo bicíclico condensado, seu uso, formulação agroquímica, e método para controlar pragas animais
CN114990241A (zh) * 2022-06-07 2022-09-02 天津金匙医学科技有限公司 用于预测鲍曼不动杆菌对抗生素药敏表型的特征基因组合、试剂盒及测序方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8518416D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
GB9222700D0 (en) * 1992-10-29 1992-12-09 Smithkline Beecham Plc Chemical compounds
GB9326248D0 (en) * 1993-12-23 1994-02-23 Smithkline Beecham Plc Pharmaceutical formulations
PL179415B1 (pl) * 1994-04-25 2000-09-29 Smithkline Beecham Plc Preparat farmaceutyczny do leczenia zakazen bakteryjnych i sposób wytwarzania preparatu farmaceutycznego do leczenia zakazen bakteryjnych PL PL
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AU2003223786A1 (en) * 2002-05-09 2003-11-11 Cytokinetics, Inc. Compounds, methods and compositions
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
CN101232881A (zh) * 2005-07-27 2008-07-30 惠氏公司 双环6-亚烷基-青霉烯B-内酰胺酶抑制剂与β-内酰胺抗生素的组合：广谱抗生素

Also Published As

Publication number Publication date
WO2006130588A1 (en) 2006-12-07
GT200600236A (es) 2007-03-29
PE20070080A1 (es) 2007-01-24
RU2007145594A (ru) 2009-07-20
CA2609428A1 (en) 2006-12-07
AR058795A1 (es) 2008-02-27
CN101217955A (zh) 2008-07-09
JP2008545747A (ja) 2008-12-18
AU2006252604A1 (en) 2006-12-07
EP1885357A1 (en) 2008-02-13
KR20080016676A (ko) 2008-02-21
US20060276445A1 (en) 2006-12-07
IL187694A0 (en) 2008-11-03
BRPI0610957A2 (pt) 2010-08-03
NO20076076L (no) 2008-02-27
MX2007015172A (es) 2008-02-19

Similar Documents

Publication Publication Date Title
TW200716102A (en) Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716104A (en) Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
UA101966C2 (en) Beta-lactamase inhibitors
TN2010000203A1 (en) Beta-lactamase inhibitors
WO2007129176A3 (en) Improvements in therapy for treating resistant bacterial infections
WO2007097940A3 (en) Reca inhibitors with antibiotic activity, compositions and methods of use
WO2008039420A3 (en) Novel inhibitors of beta-lactamase
WO2005004799A3 (en) β-LACTAMASE INHIBITORS AND METHODS OF USE THEREOF
WO2008127275A3 (en) Pyrrolinone compounds as inhibitors of bacterial peptidyl trna hydrolase and uses thereof
GEP20094679B (en) Dipeptidyl peptidase inhibitors
UA100007C2 (ru) Гетероциклические ингибиторы мек, их применение и фармацевтическая композиция, которая их содержит
AU2003286776A1 (en) Novel inhibitors of dipeptidyl peptidase iv
WO2007115821A3 (en) Organic compounds
WO2006072612A3 (en) Triazolophthalazines as pde2- inhibitors
ZA200701137B (en) Triazolophthalazines
AU2003901008A0 (en) Composition for the treatment and prevention of bacterial infections
EP4272831A3 (en) Diazabicyclooctanones as inhibitors of serine beta-lactamases
NZ706734A (en) Pharmaceutical compositions useful for the treatment or control of bacterial infections
AU2002353768A1 (en) 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors.
AU2003301903A1 (en) Isoxazoline derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme
WO2009023160A8 (en) Novel inhibitors of bacterial sortase enzymes and methods of using the same
TW200727897A (en) Bicyclic 6-alkylidene-penem β-lactamase inhibitors and β-lactam antibiotic combination: a broad spectrum antibiotic
WO2004048393A3 (en) NOVEL INHIBITORS OF β-LACTAMASE
TW200738235A (en) Tricyclic 6-alkylidene-penem β-lactamase inhibitors and β-lactam antibiotic combination: a broad spectrum antibiotic
GB0415160D0 (en) Inhibitors of bacterial infection