TW200640886A - Crystalline forms of linezolid intermediate - Google Patents
Crystalline forms of linezolid intermediateInfo
- Publication number
- TW200640886A TW200640886A TW095106393A TW95106393A TW200640886A TW 200640886 A TW200640886 A TW 200640886A TW 095106393 A TW095106393 A TW 095106393A TW 95106393 A TW95106393 A TW 95106393A TW 200640886 A TW200640886 A TW 200640886A
- Authority
- TW
- Taiwan
- Prior art keywords
- crystalline forms
- linezolid intermediate
- linezolid
- morpholmyl
- oxazolidinyl
- Prior art date
Links
- TYZROVQLWOKYKF-ZDUSSCGKSA-N linezolid Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCOCC1 TYZROVQLWOKYKF-ZDUSSCGKSA-N 0.000 title abstract 2
- 229960003907 linezolid Drugs 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65664605P | 2005-02-24 | 2005-02-24 | |
| US65677805P | 2005-02-24 | 2005-02-24 | |
| US69082205P | 2005-06-14 | 2005-06-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200640886A true TW200640886A (en) | 2006-12-01 |
Family
ID=36498839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095106393A TW200640886A (en) | 2005-02-24 | 2006-02-24 | Crystalline forms of linezolid intermediate |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US7291614B2 (zh) |
| EP (3) | EP1866295A2 (zh) |
| JP (2) | JP2008530028A (zh) |
| CA (2) | CA2602073A1 (zh) |
| IL (3) | IL183379A0 (zh) |
| MX (3) | MX2007010141A (zh) |
| TW (1) | TW200640886A (zh) |
| WO (3) | WO2006091731A2 (zh) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011114210A2 (en) | 2010-03-15 | 2011-09-22 | Jubilant Life Sciences Limited | Processes for the preparation of linezolid |
| SG185103A1 (en) | 2010-04-30 | 2012-12-28 | Univ Indiana Res & Tech Corp | Processes for preparing linezolid |
| EP2603506A1 (en) | 2010-08-11 | 2013-06-19 | Synthon BV | Process for making linezolid |
| CN103140487A (zh) | 2010-08-11 | 2013-06-05 | 斯索恩有限公司 | 制备利奈唑胺的方法 |
| WO2012094622A2 (en) * | 2011-01-07 | 2012-07-12 | The Regents Of The University Of California | Amination of aryl alcohol derivatives |
| US20150025236A1 (en) | 2012-01-24 | 2015-01-22 | Jubilant Life Sciences Limited | Process for the preparation of stable crystalline form-i of linezolid, substantially free of residual solvent |
| ES2603252T3 (es) | 2012-11-09 | 2017-02-24 | Synthon Bv | Proceso para preparar linezolid |
| US9586913B2 (en) | 2013-04-25 | 2017-03-07 | Symed Labs Limited | Processes for the preparation of linezolid using novel intermediates |
| MX2021001169A (es) | 2013-11-15 | 2023-02-10 | Akebia Therapeutics Inc | Formas sólidas de ácido {[5-(3-clorofenil)-3-hidroxipiridin-2-carb onil]amino}acético, composiciones, y usos de las mismas. |
| CN109265407B (zh) * | 2018-10-23 | 2020-05-29 | 扬子江药业集团北京海燕药业有限公司 | 一种双利奈唑胺的合成方法 |
| CN109444294B (zh) * | 2018-12-27 | 2021-06-22 | 苏州莱奥生物技术有限公司 | 一种分离利奈唑胺和其手性异构体的高效液相色谱方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
| US4801600A (en) * | 1987-10-09 | 1989-01-31 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
| US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| EP0610265B1 (en) * | 1991-11-01 | 1996-12-27 | PHARMACIA & UPJOHN COMPANY | Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents |
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| MY115155A (en) | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| US5688792A (en) | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
| EP0748801B1 (en) * | 1994-03-02 | 2001-12-19 | Daicel Chemical Industries, Ltd. | 2-isoxazoline derivative and process for producing the same, and process for producing related derivatives from the same |
| JP3831954B2 (ja) * | 1995-05-19 | 2006-10-11 | ダイソー株式会社 | ４−ヒドロキシ−２−ピロリドンの製法 |
| GB9812413D0 (en) | 1998-06-10 | 1998-08-05 | Glaxo Group Ltd | Compound and its use |
| DE19827282A1 (de) * | 1998-06-19 | 1999-12-23 | Bayer Ag | Verfahren zur Herstellung von cycloaliphatischen Aminen |
| AR027261A1 (es) | 2000-02-02 | 2003-03-19 | Upjohn Co | Linezolid forma cristalina ii |
| US6444813B2 (en) | 2000-02-02 | 2002-09-03 | Pharmacia & Upjohn Company | Linezolid-crystal form II |
| US6514529B2 (en) * | 2000-03-22 | 2003-02-04 | Pharmacia & Upjohn Company | Oxazolidinone tablet formulation |
| YU52403A (sh) * | 2000-12-26 | 2006-03-03 | Dr.Reddy's Research Foundation | Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže |
| CN1300116C (zh) * | 2001-04-16 | 2007-02-14 | 卫材株式会社 | 1h－吲唑化合物 |
| AU2001100437A4 (en) | 2001-10-03 | 2001-11-01 | Pfizer Limited | Reference standards for determining the purity or stability of amlodipine maleate and processes therefor |
| AU2003224345A1 (en) * | 2002-04-30 | 2003-11-17 | Orchid Chemicals & Pharmaceuticals | Antibacterial agents |
| AU2002339721A1 (en) | 2002-09-20 | 2004-04-08 | Lupin Limited | Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents |
| DE09163348T1 (de) | 2003-10-16 | 2010-01-07 | Symed Labs Ltd., Hyderabad | Kristalline Form von Linezolid |
| EP1745028A2 (en) * | 2004-06-29 | 2007-01-24 | Teva Pharmaceutical Industries Ltd | Solid forms of linezolid and processes for preparation thereof |
-
2006
- 2006-02-23 JP JP2007554359A patent/JP2008530028A/ja active Pending
- 2006-02-23 US US11/361,457 patent/US7291614B2/en not_active Expired - Fee Related
- 2006-02-23 CA CA002602073A patent/CA2602073A1/en not_active Abandoned
- 2006-02-23 EP EP06735895A patent/EP1866295A2/en not_active Withdrawn
- 2006-02-23 MX MX2007010141A patent/MX2007010141A/es not_active Application Discontinuation
- 2006-02-23 WO PCT/US2006/006414 patent/WO2006091731A2/en active Application Filing
- 2006-02-24 US US11/362,312 patent/US20060258655A1/en not_active Abandoned
- 2006-02-24 MX MX2007010143A patent/MX2007010143A/es not_active Application Discontinuation
- 2006-02-24 JP JP2007555389A patent/JP2008530144A/ja active Pending
- 2006-02-24 WO PCT/US2006/006655 patent/WO2006091848A2/en active Application Filing
- 2006-02-24 TW TW095106393A patent/TW200640886A/zh unknown
- 2006-02-24 EP EP06721050A patent/EP1861383A2/en not_active Withdrawn
- 2006-02-24 CA CA002588876A patent/CA2588876A1/en not_active Abandoned
- 2006-02-24 MX MX2007010136A patent/MX2007010136A/es not_active Application Discontinuation
- 2006-02-24 WO PCT/US2006/006529 patent/WO2006091777A1/en active Application Filing
- 2006-02-24 EP EP06735977A patent/EP1853571A1/en not_active Withdrawn
- 2006-02-24 US US11/361,509 patent/US20060252932A1/en not_active Abandoned
-
2007
- 2007-05-24 IL IL183379A patent/IL183379A0/en unknown
- 2007-05-24 IL IL183380A patent/IL183380A0/en unknown
- 2007-06-19 IL IL184038A patent/IL184038A0/en unknown
- 2007-10-23 US US11/977,344 patent/US20080045707A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20080045707A1 (en) | 2008-02-21 |
| MX2007010143A (es) | 2007-09-27 |
| EP1853571A1 (en) | 2007-11-14 |
| EP1866295A2 (en) | 2007-12-19 |
| IL183379A0 (en) | 2007-09-20 |
| US20070021417A1 (en) | 2007-01-25 |
| US7291614B2 (en) | 2007-11-06 |
| WO2006091731A2 (en) | 2006-08-31 |
| EP1861383A2 (en) | 2007-12-05 |
| US20060258655A1 (en) | 2006-11-16 |
| WO2006091848A3 (en) | 2006-12-28 |
| WO2006091777A1 (en) | 2006-08-31 |
| MX2007010136A (es) | 2007-09-27 |
| CA2602073A1 (en) | 2006-08-31 |
| US20060252932A1 (en) | 2006-11-09 |
| WO2006091848A2 (en) | 2006-08-31 |
| JP2008530028A (ja) | 2008-08-07 |
| WO2006091848A9 (en) | 2006-11-09 |
| JP2008530144A (ja) | 2008-08-07 |
| IL184038A0 (en) | 2007-10-31 |
| WO2006091731A3 (en) | 2006-10-19 |
| IL183380A0 (en) | 2007-09-20 |
| CA2588876A1 (en) | 2006-08-31 |
| MX2007010141A (es) | 2007-09-27 |
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