TW200637834A - Method of purifying macrolides - Google Patents
Method of purifying macrolidesInfo
- Publication number
- TW200637834A TW200637834A TW094145958A TW94145958A TW200637834A TW 200637834 A TW200637834 A TW 200637834A TW 094145958 A TW094145958 A TW 094145958A TW 94145958 A TW94145958 A TW 94145958A TW 200637834 A TW200637834 A TW 200637834A
- Authority
- TW
- Taiwan
- Prior art keywords
- macrolide
- purifying
- eluent
- bed
- collected
- Prior art date
Links
- 239000003120 macrolide antibiotic agent Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 229940041033 macrolides Drugs 0.000 title 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 239000003480 eluent Substances 0.000 abstract 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 2
- 235000019441 ethanol Nutrition 0.000 abstract 1
- 229960004592 isopropanol Drugs 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/282—Porous sorbents
- B01J20/285—Porous sorbents based on polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
- B01D15/426—Specific type of solvent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/22—Eight-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/18—Eight-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63862804P | 2004-12-22 | 2004-12-22 | |
| US63881504P | 2004-12-23 | 2004-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200637834A true TW200637834A (en) | 2006-11-01 |
Family
ID=36128612
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094145958A TW200637834A (en) | 2004-12-22 | 2005-12-22 | Method of purifying macrolides |
| TW094145959A TW200637835A (en) | 2004-12-22 | 2005-12-22 | Method of purifying tacrolimus |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094145959A TW200637835A (en) | 2004-12-22 | 2005-12-22 | Method of purifying tacrolimus |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20060142565A1 (https=) |
| EP (2) | EP1828204A1 (https=) |
| JP (2) | JP2007523201A (https=) |
| CA (2) | CA2586700A1 (https=) |
| IL (2) | IL183241A0 (https=) |
| MX (2) | MX2007005867A (https=) |
| TW (2) | TW200637834A (https=) |
| WO (2) | WO2006069333A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008059516A2 (en) * | 2006-08-21 | 2008-05-22 | Concord Biotech Limited | Process for purification of macrolides |
| WO2008065887A1 (en) * | 2006-11-27 | 2008-06-05 | Terumo Kabushiki Kaisha | Process for producing o-alkylated rapamycin derivative, and o-alkylated rapamycin derivative |
| KR101003042B1 (ko) * | 2008-03-17 | 2010-12-21 | 종근당바이오 주식회사 | 고순도 타크로리무스의 정제 방법 |
| GB201020032D0 (en) * | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| KR101344012B1 (ko) | 2012-04-09 | 2013-12-23 | 인하대학교 산학협력단 | 모사이동층 크로마토그래피를 이용하여 타크로리무스와 아스코마이신의 혼합액으로부터 타크로리무스를 분리하는 방법 |
| CN103554133B (zh) * | 2013-10-31 | 2015-06-24 | 国药集团川抗制药有限公司 | 一种制备高纯度他克莫司的工艺 |
| CN105301159B (zh) * | 2015-10-29 | 2017-01-18 | 无锡福祈制药有限公司 | 一种西罗莫司的高效液相色谱分析方法 |
| CN117402175A (zh) * | 2023-10-18 | 2024-01-16 | 国药集团川抗制药有限公司 | 一种他克莫司的结晶方法及其应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3244592A (en) * | 1962-06-09 | 1966-04-05 | Arai Tadashi | Ascomycin and process for its production |
| US3993749A (en) * | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
| US4160861A (en) * | 1977-10-03 | 1979-07-10 | Merck & Co., Inc. | Method for the separation of antibiotic macrolides |
| US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| US5182207A (en) * | 1984-09-14 | 1993-01-26 | American Cyanamid Company | Strains of streptomyces thermoarchaensis |
| US4874843A (en) * | 1987-12-03 | 1989-10-17 | Eli Lilly And Company | Chromatographic purification process |
| JP2639737B2 (ja) * | 1990-01-23 | 1997-08-13 | 寳酒造株式会社 | 新規ｒ１０６類化合物 |
| US5116756A (en) * | 1991-01-28 | 1992-05-26 | Merck & Co., Inc. | Process for producing FK-506 |
| US5194378A (en) * | 1991-01-28 | 1993-03-16 | Merck & Co., Inc. | Process for producing fk-506 |
| US5091389A (en) * | 1991-04-23 | 1992-02-25 | Merck & Co., Inc. | Lipophilic macrolide useful as an immunosuppressant |
| US5227295A (en) * | 1991-11-08 | 1993-07-13 | Dowelanco | Process for isolating A83543 and its components |
| WO1993018042A1 (en) * | 1992-03-02 | 1993-09-16 | Pfizer Inc. | Desosamino derivatives of macrolides as immunosuppressants and antifungal agents |
| US5612316A (en) * | 1992-03-02 | 1997-03-18 | Pfizer Inc. | Fluorosugar derivatives of macrolides |
| US5264355A (en) * | 1992-07-02 | 1993-11-23 | Merck & Co., Inc. | Methlating enzyme from streptomyces MA6858 |
| UA41884C2 (uk) * | 1993-11-05 | 2001-10-15 | Амерікан Хоум Продактс Корпорейшн | Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів |
| US5622866A (en) * | 1994-06-23 | 1997-04-22 | Merck & Co., Inc. | Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces |
| GB9618952D0 (en) * | 1996-09-11 | 1996-10-23 | Sandoz Ltd | Process |
| US5616595A (en) * | 1995-06-07 | 1997-04-01 | Abbott Laboratories | Process for recovering water insoluble compounds from a fermentation broth |
| NZ510819A (en) * | 1998-10-02 | 2004-03-26 | Kosan Biosciences Inc | Polyketide synthase enzymes and recombinant DNA constructs therefor |
| AU1214400A (en) * | 1998-10-20 | 2000-05-08 | Ben Venue Laboratories, Inc. | Process for purification of solvents useful in the preparation of pharmaceuticalcompositions |
| CA2351222A1 (en) * | 1998-11-09 | 2000-05-18 | Aventis Pharma Deutschland Gmbh | Vancoresmycin, a process for its production and its use as a pharmaceutical |
| CN1154651C (zh) * | 1999-05-25 | 2004-06-23 | 藤泽药品工业株式会社 | 分离类似的有机化合物的方法 |
| TW553946B (en) * | 1999-09-08 | 2003-09-21 | Fujisawa Pharmaceutical Co | Method for separating lactone-containing high-molecular weight compounds |
| HRP20020683A2 (en) * | 2000-02-24 | 2004-12-31 | Biogal Gyogyszergyar | Method of purifying a fermentation broth |
| MXPA04007847A (es) * | 2002-02-13 | 2005-02-24 | Biogal Gyogyszergyar | Metodo para extraer un macrolido de biomateria. |
| TW200523266A (en) * | 2003-07-24 | 2005-07-16 | Biogal Gyogyszergyar | Method of purifying macrolides |
-
2005
- 2005-12-22 WO PCT/US2005/046856 patent/WO2006069333A1/en not_active Ceased
- 2005-12-22 TW TW094145958A patent/TW200637834A/zh unknown
- 2005-12-22 EP EP05855421A patent/EP1828204A1/en not_active Withdrawn
- 2005-12-22 CA CA002586700A patent/CA2586700A1/en not_active Abandoned
- 2005-12-22 JP JP2006554356A patent/JP2007523201A/ja active Pending
- 2005-12-22 EP EP05855772A patent/EP1828205A1/en not_active Withdrawn
- 2005-12-22 TW TW094145959A patent/TW200637835A/zh unknown
- 2005-12-22 US US11/317,155 patent/US20060142565A1/en not_active Abandoned
- 2005-12-22 WO PCT/US2005/047264 patent/WO2006069386A1/en not_active Ceased
- 2005-12-22 CA CA002586692A patent/CA2586692A1/en not_active Abandoned
- 2005-12-22 JP JP2006554355A patent/JP2007523200A/ja active Pending
- 2005-12-22 US US11/317,152 patent/US20060149057A1/en not_active Abandoned
- 2005-12-22 MX MX2007005867A patent/MX2007005867A/es unknown
- 2005-12-22 MX MX2007005868A patent/MX2007005868A/es not_active Application Discontinuation
-
2007
- 2007-05-15 IL IL183241A patent/IL183241A0/en unknown
- 2007-05-15 IL IL183240A patent/IL183240A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1828204A1 (en) | 2007-09-05 |
| IL183241A0 (en) | 2007-08-19 |
| CA2586700A1 (en) | 2006-06-29 |
| WO2006069333A1 (en) | 2006-06-29 |
| IL183240A0 (en) | 2007-08-19 |
| US20060142565A1 (en) | 2006-06-29 |
| WO2006069386A1 (en) | 2006-06-29 |
| JP2007523201A (ja) | 2007-08-16 |
| MX2007005868A (es) | 2007-07-04 |
| EP1828205A1 (en) | 2007-09-05 |
| CA2586692A1 (en) | 2006-06-29 |
| US20060149057A1 (en) | 2006-07-06 |
| JP2007523200A (ja) | 2007-08-16 |
| MX2007005867A (es) | 2007-07-04 |
| TW200637835A (en) | 2006-11-01 |
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