MX2007005867A - Metodo de purificar macrolidos. - Google Patents

Metodo de purificar macrolidos.

Info

Publication number
MX2007005867A
MX2007005867A MX2007005867A MX2007005867A MX2007005867A MX 2007005867 A MX2007005867 A MX 2007005867A MX 2007005867 A MX2007005867 A MX 2007005867A MX 2007005867 A MX2007005867 A MX 2007005867A MX 2007005867 A MX2007005867 A MX 2007005867A
Authority
MX
Mexico
Prior art keywords
macrolide
purifying
eluent
bed
collected
Prior art date
Application number
MX2007005867A
Other languages
English (en)
Inventor
Vilmos Keri
Zoltan Czovek
Original Assignee
Teva Gyogyszergyar Zartkoeruen Mukoedo Reszvenytarsasag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Gyogyszergyar Zartkoeruen Mukoedo Reszvenytarsasag filed Critical Teva Gyogyszergyar Zartkoeruen Mukoedo Reszvenytarsasag
Publication of MX2007005867A publication Critical patent/MX2007005867A/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/22—Eight-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/18—Eight-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Se proporciona un metodo para purificar un macrolido, en donde se coloca una carga de macrolido en yuxtaposicion con un lecho de resina de sorcion humeda, la carga y el lecho se eluyen a una temperatura superior a 30 degree C con un eluyente de un solvente organico seleccionado del grupo formado por THF, acetonitrilo, alcohol n-propilico, alcohol iso-propilico, alcohol etilico y acetona, se recoge el corte central del eluyente y se recoge el macrolido purificado.
MX2007005867A 2004-12-22 2005-12-22 Metodo de purificar macrolidos. MX2007005867A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63862804P 2004-12-22 2004-12-22
US63881504P 2004-12-23 2004-12-23
PCT/US2005/046856 WO2006069333A1 (en) 2004-12-22 2005-12-22 Method of purifying macrolides

Publications (1)

Publication Number Publication Date
MX2007005867A true MX2007005867A (es) 2007-07-04

Family

ID=36128612

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2007005868A MX2007005868A (es) 2004-12-22 2005-12-22 Metodo de purificar tacrolimus.
MX2007005867A MX2007005867A (es) 2004-12-22 2005-12-22 Metodo de purificar macrolidos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2007005868A MX2007005868A (es) 2004-12-22 2005-12-22 Metodo de purificar tacrolimus.

Country Status (8)

Country Link
US (2) US20060149057A1 (es)
EP (2) EP1828205A1 (es)
JP (2) JP2007523201A (es)
CA (2) CA2586700A1 (es)
IL (2) IL183241A0 (es)
MX (2) MX2007005868A (es)
TW (2) TW200637834A (es)
WO (2) WO2006069333A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008059516A2 (en) * 2006-08-21 2008-05-22 Concord Biotech Limited Process for purification of macrolides
EP2090580B1 (en) * 2006-11-27 2014-06-04 Terumo Kabushiki Kaisha Process for producing o-alkylated rapamycin derivative, and o-alkylated rapamycin derivative
KR101003042B1 (ko) 2008-03-17 2010-12-21 종근당바이오 주식회사 고순도 타크로리무스의 정제 방법
GB201020032D0 (en) * 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
KR101344012B1 (ko) 2012-04-09 2013-12-23 인하대학교 산학협력단 모사이동층 크로마토그래피를 이용하여 타크로리무스와 아스코마이신의 혼합액으로부터 타크로리무스를 분리하는 방법
CN103554133B (zh) * 2013-10-31 2015-06-24 国药集团川抗制药有限公司 一种制备高纯度他克莫司的工艺
CN105301159B (zh) * 2015-10-29 2017-01-18 无锡福祈制药有限公司 一种西罗莫司的高效液相色谱分析方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3244592A (en) * 1962-06-09 1966-04-05 Arai Tadashi Ascomycin and process for its production
US3993749A (en) * 1974-04-12 1976-11-23 Ayerst Mckenna And Harrison Ltd. Rapamycin and process of preparation
US4160861A (en) * 1977-10-03 1979-07-10 Merck & Co., Inc. Method for the separation of antibiotic macrolides
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US5182207A (en) * 1984-09-14 1993-01-26 American Cyanamid Company Strains of streptomyces thermoarchaensis
US4874843A (en) * 1987-12-03 1989-10-17 Eli Lilly And Company Chromatographic purification process
JP2639737B2 (ja) * 1990-01-23 1997-08-13 寳酒造株式会社 新規ｒ１０６類化合物
US5116756A (en) * 1991-01-28 1992-05-26 Merck & Co., Inc. Process for producing FK-506
US5194378A (en) * 1991-01-28 1993-03-16 Merck & Co., Inc. Process for producing fk-506
US5091389A (en) * 1991-04-23 1992-02-25 Merck & Co., Inc. Lipophilic macrolide useful as an immunosuppressant
US5227295A (en) * 1991-11-08 1993-07-13 Dowelanco Process for isolating A83543 and its components
JP2564765B2 (ja) * 1992-03-02 1996-12-18 ファイザー・インコーポレーテッド マクロライド系抗生物質のフルオロ糖誘導体
ATE205496T1 (de) * 1992-03-02 2001-09-15 Pfizer Desosamino-derivate von makroliden als immunosuppressive und antifungale mittel
US5264355A (en) * 1992-07-02 1993-11-23 Merck & Co., Inc. Methlating enzyme from streptomyces MA6858
UA41884C2 (uk) * 1993-11-05 2001-10-15 Амерікан Хоум Продактс Корпорейшн Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів
US5622866A (en) * 1994-06-23 1997-04-22 Merck & Co., Inc. Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces
GB9618952D0 (en) * 1996-09-11 1996-10-23 Sandoz Ltd Process
US5616595A (en) * 1995-06-07 1997-04-01 Abbott Laboratories Process for recovering water insoluble compounds from a fermentation broth
NZ510819A (en) * 1998-10-02 2004-03-26 Kosan Biosciences Inc Polyketide synthase enzymes and recombinant DNA constructs therefor
DE19983660T1 (de) * 1998-10-20 2001-09-13 Ben Venue Lab Inc Verfahren zur Aufreinigung von Lösungsmitteln, die bei der Herstellung von pharmazeutischen Zusammensetzungen nützlich sind
UA70974C2 (uk) * 1998-11-09 2004-11-15 Авентіс Фарма Дойчланд Гмбх Ванкорезміцин (варіанти), штам amycolatopsis виду hil-006734, dsm 12216, що його продукує, та фармацевтична композиція, яка має антибіотичну активність
AU775075C (en) * 1999-05-25 2005-02-24 Astellas Pharma Inc. Method for separating analogous organic compounds
TW553946B (en) * 1999-09-08 2003-09-21 Fujisawa Pharmaceutical Co Method for separating lactone-containing high-molecular weight compounds
JP3740062B2 (ja) * 2000-02-24 2006-01-25 テバ ジョジセルジャール レースベニュタールシャシャーグ 培養液の精製方法
EP1474404A4 (en) * 2002-02-13 2006-01-11 Biogal Gyogyszergyar PROCESS FOR EXTRACTION OF A BIOLOGICAL MATERIAL
US7220357B2 (en) * 2003-07-24 2007-05-22 Teva Gyógyszergyár Zártkörúen Múkó´dó´Résvénytársaság Method of purifying macrolides

Also Published As

Publication number Publication date
US20060142565A1 (en) 2006-06-29
IL183241A0 (en) 2007-08-19
TW200637834A (en) 2006-11-01
MX2007005868A (es) 2007-07-04
US20060149057A1 (en) 2006-07-06
TW200637835A (en) 2006-11-01
JP2007523201A (ja) 2007-08-16
EP1828204A1 (en) 2007-09-05
CA2586700A1 (en) 2006-06-29
WO2006069386A1 (en) 2006-06-29
CA2586692A1 (en) 2006-06-29
IL183240A0 (en) 2007-08-19
EP1828205A1 (en) 2007-09-05
JP2007523200A (ja) 2007-08-16
WO2006069333A1 (en) 2006-06-29

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