TW200634022A - Difluoronucleosides and process for preparation thereof - Google Patents
Difluoronucleosides and process for preparation thereofInfo
- Publication number
- TW200634022A TW200634022A TW094143372A TW94143372A TW200634022A TW 200634022 A TW200634022 A TW 200634022A TW 094143372 A TW094143372 A TW 094143372A TW 94143372 A TW94143372 A TW 94143372A TW 200634022 A TW200634022 A TW 200634022A
- Authority
- TW
- Taiwan
- Prior art keywords
- protected
- base
- preparation
- group
- difluorofuranose
- Prior art date
Links
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 239000002841 Lewis acid Substances 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 abstract 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 abstract 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63437604P | 2004-12-08 | 2004-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200634022A true TW200634022A (en) | 2006-10-01 |
Family
ID=36147231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094143372A TW200634022A (en) | 2004-12-08 | 2005-12-08 | Difluoronucleosides and process for preparation thereof |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20060173174A1 (enExample) |
| EP (1) | EP1819718A1 (enExample) |
| JP (1) | JP2007522151A (enExample) |
| KR (1) | KR20070073958A (enExample) |
| CN (1) | CN101076535A (enExample) |
| CA (1) | CA2586687A1 (enExample) |
| IL (1) | IL183702A0 (enExample) |
| MX (1) | MX2007006837A (enExample) |
| TW (1) | TW200634022A (enExample) |
| WO (1) | WO2006063105A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2778B1 (en) | 2007-10-16 | 2014-03-15 | ايساي انك | Certain Compounds, Compositions and Methods |
| US8609631B2 (en) | 2009-04-06 | 2013-12-17 | Eisai Inc. | Compositions and methods for treating cancer |
| TWI477508B (zh) | 2009-04-06 | 2015-03-21 | Otsuka Pharma Co Ltd | 用以治療癌症之組成物及方法 |
| EP2416781B1 (en) | 2009-04-06 | 2017-03-08 | Otsuka Pharmaceutical Co., Ltd. | Combination of cytidine-based antineoplastic drugs with cytidine deaminase inhibitor and use thereof in the treatment of cancer |
| UY32546A (es) | 2009-04-06 | 2010-10-29 | Eisai Inc | Composiciones y metodos para tratar cancer |
| CN105693795A (zh) * | 2014-08-13 | 2016-06-22 | 陈欣 | 能破坏细胞复制的二氟代核苷类抗癌药的制备方法 |
| WO2025235664A1 (en) * | 2024-05-07 | 2025-11-13 | Emory University | Purine nucleotide and nucleoside therapeutic compositions and uses related thereto |
| CN121949418B (zh) * | 2026-04-01 | 2026-07-28 | 山东安弘制药有限公司 | 一种盐酸吉西他滨的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU452961A3 (ru) * | 1969-04-11 | 1974-12-05 | Шеринг Аг. (Фирма) | Способ получени пиримидиннуклеозидов |
| US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
| DE3587500T2 (de) * | 1984-12-04 | 1993-12-16 | Lilly Co Eli | Tumorbehandlung bei Säugetieren. |
| US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
| US5606048A (en) * | 1992-06-22 | 1997-02-25 | Eli Lilly And Company | Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
| US5371210A (en) * | 1992-06-22 | 1994-12-06 | Eli Lilly And Company | Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
| BR9302431A (pt) * | 1992-06-22 | 1994-01-11 | Lilly Co Eli | Processo de glicosilacao de anion estereosseletivo |
| US5594124A (en) * | 1992-06-22 | 1997-01-14 | Eli Lilly And Company | Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof |
| US5401838A (en) * | 1992-06-22 | 1995-03-28 | Eli Lilly And Company | Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
| US6828346B2 (en) * | 1999-10-25 | 2004-12-07 | Supergen, Inc. | Methods for administration of paclitaxel |
| WO2004041203A2 (en) * | 2002-11-04 | 2004-05-21 | Xenoport, Inc. | Gemcitabine prodrugs, pharmaceutical compositions and uses thereof |
| CN1228342C (zh) * | 2003-04-08 | 2005-11-23 | 深圳市汉德森技术有限公司 | 以1，6－脱水－β－D－葡萄糖为原料制备2'－脱氧－2'，2'－二氟－β－核胞苷或其药用盐的方法 |
-
2005
- 2005-12-08 US US11/298,359 patent/US20060173174A1/en not_active Abandoned
- 2005-12-08 WO PCT/US2005/044369 patent/WO2006063105A1/en not_active Ceased
- 2005-12-08 TW TW094143372A patent/TW200634022A/zh unknown
- 2005-12-08 EP EP05853313A patent/EP1819718A1/en not_active Withdrawn
- 2005-12-08 KR KR1020077012245A patent/KR20070073958A/ko not_active Ceased
- 2005-12-08 MX MX2007006837A patent/MX2007006837A/es unknown
- 2005-12-08 CN CNA2005800423787A patent/CN101076535A/zh active Pending
- 2005-12-08 JP JP2006552382A patent/JP2007522151A/ja active Pending
- 2005-12-08 CA CA002586687A patent/CA2586687A1/en not_active Abandoned
-
2007
- 2007-06-05 IL IL183702A patent/IL183702A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1819718A1 (en) | 2007-08-22 |
| US20060173174A1 (en) | 2006-08-03 |
| IL183702A0 (en) | 2007-09-20 |
| WO2006063105A1 (en) | 2006-06-15 |
| JP2007522151A (ja) | 2007-08-09 |
| CA2586687A1 (en) | 2006-06-15 |
| MX2007006837A (es) | 2007-10-23 |
| CN101076535A (zh) | 2007-11-21 |
| KR20070073958A (ko) | 2007-07-10 |
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